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Proteins/UNIPROT:Q9H237
Protein-serine O-palmitoleoyltransferase that acts as a key regulator of the Wnt signaling pathway by mediating the attachment of palmitoleate, a 16-carbon monounsaturated fatty acid (C16:1(9Z)), to Wnt proteins. Serine palmitoleoylation of WNT proteins is required for efficient binding to frizzled receptors..
Function from UniProtKB (Q9H237), read 2026-09-23. CC BY 4.0.
Curated compounds routed: 0
2 rows
42 statements
42 statements · 8 reference databases · Subject: PORCN · Sources: Bgee, gene ontology, Hetionet, Human Protein Atlas, Human-GEM, Reactome, Rhea, WikiPathways
2 reactions
CHEBI:1146900+proton+MAM02538nCHEBI:15351+CHEBI:15650
Catalysed by ZDHHC6 or LPCAT2 or NAT14 or SH3GLB1 or ZDHHC8 or NAA10 or PORCN or ZDHHC15 or PLA2G15 or ZDHHC2 or NAA60 or PLAAT2 and 21 more alternatives
4 names
Resolves to: PORCN
Human-GEM MAR01091CC BY 4.0Reference data
[Wnt protein]-L-serine+(9Z)-hexadecenoyl-CoA[Wnt protein]-O-(9Z)-hexadecenoyl-L-serine+coenzyme A(4-)
Catalysed by PORCN
Reaction pageDirection not assertedBalance undeterminable
Rhea RHEA:45336CC BY 4.0Reference data