Proteins/UNIPROT:Q9NZJ4

SACS

ProteinUNIPROT:Q9NZJ4

Co-chaperone which acts as a regulator of the Hsp70 chaperone machinery and may be involved in the processing of other ataxia-linked proteins..

Function from UniProtKB (Q9NZJ4), read 2026-09-23. CC BY 4.0.

Curated compounds routed: 0

What the reference databases state

GenCC submitters' classifications

1 row

Charlevoix-Saguenay spastic ataxia has a germline basis in SACSDiseaseGenCC HGNC:10519|MONDO:0010041Inferred only

Statements

35 statements

35 statements · 3 reference databases · Subject: SACS · Sources: gene ontology, Hetionet, WikiPathways

Order

SACS covaries with SYT8ProteinHetionet hetionet:covaries:26278-90019Inferred only
ACTN4 interacts with SACSProteinHetionet hetionet:interacts:26278-81Inferred only
PICK1 interacts with SACSProteinHetionet hetionet:interacts:26278-9463Inferred only
SACS interacts with POLR1HProteinHetionet hetionet:interacts:26278-30834Inferred only
PPP1CA interacts with SACSProteinHetionet hetionet:interacts:26278-5499Inferred only
SACS interacts with TSC22D4ProteinHetionet hetionet:interacts:26278-81628Inferred only
UBC interacts with SACSProteinHetionet hetionet:interacts:26278-7316Inferred only
SACS participates in 13q12 12 copy number variationPathwayWikiPathways WP5406Inferred only
SACS participates in Disorders of mitochondrial homeostatis dynamics protein import and quality controlPathwayWikiPathways WP5504Inferred only
SACS regulates negative regulation of inclusion body assemblyBiological processgene ontology Q9NZJ4|GO:0090084Inferred only
ANO10 decreases the expression of SACSProteinHetionet hetionet:regulates:55129-26278Inferred only
ARHGAP35 decreases the expression of SACSProteinHetionet hetionet:regulates:2909-26278Inferred only

Show the remaining 23

CCNA1 decreases the expression of SACSProteinHetionet hetionet:regulates:8900-26278Inferred only
CCNC decreases the expression of SACSProteinHetionet hetionet:regulates:892-26278Inferred only
COASY increases the expression of SACSProteinHetionet hetionet:regulates:80347-26278Inferred only
CTSL decreases the expression of SACSProteinHetionet hetionet:regulates:1514-26278Inferred only
ERG decreases the expression of SACSProteinHetionet hetionet:regulates:2078-26278Inferred only
EXOSC4 decreases the expression of SACSProteinHetionet hetionet:regulates:54512-26278Inferred only
FOXJ3 decreases the expression of SACSProteinHetionet hetionet:regulates:22887-26278Inferred only
GRWD1 decreases the expression of SACSProteinHetionet hetionet:regulates:83743-26278Inferred only
HDGFL3 decreases the expression of SACSProteinHetionet hetionet:regulates:50810-26278Inferred only
IL6ST decreases the expression of SACSProteinHetionet hetionet:regulates:3572-26278Inferred only
LIG1 decreases the expression of SACSProteinHetionet hetionet:regulates:3978-26278Inferred only
MAP3K5 increases the expression of SACSProteinHetionet hetionet:regulates:4217-26278Inferred only
NSDHL increases the expression of SACSProteinHetionet hetionet:regulates:50814-26278Inferred only
OVOL2 decreases the expression of SACSProteinHetionet hetionet:regulates:58495-26278Inferred only
PIH1D1 decreases the expression of SACSProteinHetionet hetionet:regulates:55011-26278Inferred only
PROCR decreases the expression of SACSProteinHetionet hetionet:regulates:10544-26278Inferred only
PSMB7 decreases the expression of SACSProteinHetionet hetionet:regulates:5695-26278Inferred only
PSPH decreases the expression of SACSProteinHetionet hetionet:regulates:5723-26278Inferred only
QRSL1 decreases the expression of SACSProteinHetionet hetionet:regulates:55278-26278Inferred only
RASSF2 decreases the expression of SACSProteinHetionet hetionet:regulates:9770-26278Inferred only
STK25 decreases the expression of SACSProteinHetionet hetionet:regulates:10494-26278Inferred only
TIPARP decreases the expression of SACSProteinHetionet hetionet:regulates:25976-26278Inferred only
TLE1 decreases the expression of SACSProteinHetionet hetionet:regulates:7088-26278Inferred only

Other names

4 names

Resolves to: SACS

Also called: DnaJ homolog subfamily C member 29DNAJC29KIAA0730Sacsin

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