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Proteins/UNIPROT:Q15796
Receptor-regulated SMAD (R-SMAD) that is an intracellular signal transducer and transcriptional modulator activated by TGF-beta (transforming growth factor) and activin type 1 receptor kinases. Binds the TRE element in the promoter region of many genes that are regulated by TGF-beta and, on formation of the SMAD2/SMAD4 complex, activates transcription. Promotes TGFB1-mediated transcription of odontoblastic differentiation genes in dental papilla cells (By similarity). Positively regulates PDPK1 kinase activity by stimulating its dissociation from the 14-3-3 protein YWHAQ which acts as a negative regulator. May act as a tumor suppressor in colorectal carcinoma..
Function from UniProtKB (Q15796), read 2026-09-23. CC BY 4.0.
Curated compounds routed: 0
5 rows
569 statements
569 statements · 4 reference databases · Subject: SMAD2 · Sources: gene ontology, Hetionet, Reactome, WikiPathways · Rows fetched: 300
10 names
Resolves to: SMAD2