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Proteins/UNIPROT:Q8N5Y8
Intracellular mono-ADP-ribosyltransferase that plays a role in different processes, such as protein translation and unfolded protein response (UPR), through the mono-ADP-ribosylation of proteins involved in those processes. Acts as an inhibitor of protein translation by catalyzing mono-ADP-ribosylation of ribosomal subunits, such as RPL14 and RPS6, thereby inhibiting polysome assembly and mRNA loading. Mono-ADP-ribosylation of ribosomal subunits is promoted by NMNAT2. Involved in the unfolded protein response (UPR) by ADP-ribosylating and activating EIF2AK3 and ERN1, two important UPR effectors. May also mediate mono-ADP-ribosylation of karyopherin KPNB1 a nuclear import factor. May not modify proteins on arginine or cysteine residues compared to other mono-ADP-ribosyltransferases..
Function from UniProtKB (Q8N5Y8), read 2026-09-23. CC BY 4.0.
Curated compounds routed: 1 · substrate of
1 compound
1 compound.
0 reported routes1 assembled route
33 statements
33 statements · 6 reference databases · Subject: PARP16 · Sources: Bgee, gene ontology, Hetionet, Human-GEM, Reactome, WikiPathways
4 reactions
5 names
Resolves to: PARP16
Human-GEM MAR09487CC BY 4.0Reference data
L-aspartyl-[protein]+NAD(1-)4-O-(ADP-D-ribosyl)-L-aspartyl-[protein]+nicotinamide
Catalysed by TNKS or PARP1 or PARP6 or PARP15 or PARP10 or TIPARP or PARP16 or PARP12 or TNKS2 or PARP11 or PARP2 or PARP4 and 1 more alternative
Reaction pageLeft to rightBalance undeterminable
Rhea RHEA:54424CC BY 4.0Reference data
L-lysyl-[protein]+NAD(1-)N(6)-(ADP-D-ribosyl)-L-lysyl-[protein]+nicotinamide+hydron
Catalysed by PARP10 or PARP16 or SIRT6 or PARP11 or PARP3
Reaction pageLeft to rightBalance undeterminable
Rhea RHEA:58220CC BY 4.0Reference data