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Proteins/UNIPROT:Q9H2K2
Poly-ADP-ribosyltransferase involved in various processes such as Wnt signaling pathway, telomere length and vesicle trafficking. Acts as an activator of the Wnt signaling pathway by mediating poly-ADP-ribosylation of AXIN1 and AXIN2, 2 key components of the beta-catenin destruction complex: poly-ADP-ribosylated target proteins are recognized by RNF146, which mediates their ubiquitination and subsequent degradation. Also mediates poly-ADP-ribosylation of BLZF1 and CASC3, followed by recruitment of RNF146 and subsequent ubiquitination. Mediates poly-ADP-ribosylation of TERF1, thereby contributing to the regulation of telomere length. Stimulates 26S proteasome activity..
Function from UniProtKB (Q9H2K2), read 2026-09-23. CC BY 4.0.
Curated compounds routed: 1 · substrate of
1 compound
1 compound.
0 reported routes1 assembled route
84 statements
84 statements · 6 reference databases · Subject: TNKS2 · Sources: Bgee, gene ontology, Hetionet, Human-GEM, Reactome, WikiPathways
3 reactions
14 names
Resolves to: TNKS2
Human-GEM MAR09487CC BY 4.0Reference data
L-aspartyl-[protein]+NAD(1-)4-O-(ADP-D-ribosyl)-L-aspartyl-[protein]+nicotinamide
Catalysed by TNKS or PARP1 or PARP6 or PARP15 or PARP10 or TIPARP or PARP16 or PARP12 or TNKS2 or PARP11 or PARP2 or PARP4 and 1 more alternative
Reaction pageLeft to rightBalance undeterminable
Rhea RHEA:54424CC BY 4.0Reference data