Loading the page.
Proteins/UNIPROT:O43820
Facilitates sperm penetration into the layer of cumulus cells surrounding the egg by digesting hyaluronic acid. Involved in induction of the acrosome reaction in the sperm. Involved in follicular atresia, the breakdown of immature ovarian follicles that are not selected to ovulate. Induces ovarian granulosa cell apoptosis, possibly via apoptotic signaling pathway involving CASP8 and CASP3 activation, and poly(ADP-ribose) polymerase (PARP) cleavage. Has no hyaluronidase activity in embryonic fibroblasts in vitro. Has no hyaluronidase activity in granulosa cells in vitro..
Function from UniProtKB (O43820), read 2026-09-23. CC BY 4.0.
Curated compounds routed: 0
44 statements
44 statements · 4 reference databases · Subject: HYAL3 · Sources: gene ontology, Hetionet, Reactome, WikiPathways
5 reactions
5 names
Resolves to: HYAL3
Reaction pageLeft to rightBalancedEC 3.2.1.35, 3.2.1.52lysosome
Human-GEM MAR07507CC BY 4.0Reference data
MAM01529l+2waterMAM01527l+proton+MAM02525l+sulfate
Catalysed by HEXB or HYAL2 or HYAL4 or SPAM1 or HYAL1 or HEXD or HYAL3 or HEXA
Reaction pageLeft to rightBalancedEC 3.2.1.35, 3.2.1.52lysosome
Human-GEM MAR07515CC BY 4.0Reference data