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Proteins/UNIPROT:Q7Z2W4
Antiviral protein which inhibits the replication of viruses by recruiting the cellular RNA degradation machineries to degrade the viral mRNAs. Binds to a ZAP-responsive element (ZRE) present in the target viral mRNA, recruits cellular poly(A)-specific ribonuclease PARN to remove the poly(A) tail, and the 3'-5' exoribonuclease complex exosome to degrade the RNA body from the 3'-end. It also recruits the decapping complex DCP1-DCP2 through RNA helicase p72 (DDX17) to remove the cap structure of the viral mRNA to initiate its degradation from the 5'-end. Its target viruses belong to families which include retroviridae, including human immunodeficiency virus type 1, filoviridae: ebola virus (EBOV) and marburg virus (MARV), togaviridae: sindbis virus (SINV) and Ross river virus (RRV). Specifically targets the multiply spliced but not unspliced or singly spliced HIV-1 mRNAs for degradation..
[Isoform 1]: Exhibits stronger antiviral activity than isoform 2 against MuLV expression and Semliki forest virus infection. Increased antiviral activity may be due to more efficient targeting to endocytic membranes through S-farnesylation (By similarity). Similarly to isoform 2, prevents HIV-1 infection..
[Isoform 2]: Positive regulator of RIGI signaling during the innate antiviral immune response. Associates with RIGI to promote its oligomerization and ATPase activity stimulation, leading to robust activation of IRF3 and NF-kappa-B transcription factors and eventually to the expression of type I IFNs and IFN stimulated genes (ISGs). Similarly to isoform 1, prevents HIV-1 infection..
Function from UniProtKB (Q7Z2W4), read 2026-09-23. CC BY 4.0.
Curated compounds routed: 1 · substrate of
1 compound
1 compound.
0 reported routes1 assembled route
29 statements
29 statements · 5 reference databases · Subject: ZC3HAV1 · Sources: gene ontology, Hetionet, Human-GEM, Reactome, WikiPathways
1 reaction
8 names
Resolves to: ZC3HAV1
Human-GEM MAR09487CC BY 4.0Reference data