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Proteins/UNIPROT:Q9NR21
Mono-ADP-ribosyltransferase that mediates mono-ADP-ribosylation of target proteins. Plays a role in nuclear envelope stability and nuclear remodeling during spermiogenesis (By similarity). Inhibits the type I interferon activated signaling pathway. Mechanistically, mono-ADP-ribosylates beta-TrCP/BTRC to promote IFNAR1 ubiquitination and protect BTRC from ubiquitin-proteasome degradation. Additionally, acts as an antiviral factor by cooperating with PARP12 to suppress Zika virus replication, independent of IFNAR1 regulation or intrinsic PARP enzymatic activity. Instead, facilitates the degradation of viral NS1 and NS3 proteins, potentially disrupting viral replication..
Function from UniProtKB (Q9NR21), read 2026-09-23. CC BY 4.0.
Curated compounds routed: 0
4 statements
4 statements · 3 reference databases · Subject: PARP11 · Sources: Hetionet, Human-GEM, WikiPathways
5 reactions
5 names
Resolves to: PARP11
Human-GEM MAR09487CC BY 4.0Reference data
L-aspartyl-[protein]+NAD(1-)4-O-(ADP-D-ribosyl)-L-aspartyl-[protein]+nicotinamide
Catalysed by TNKS or PARP1 or PARP6 or PARP15 or PARP10 or TIPARP or PARP16 or PARP12 or TNKS2 or PARP11 or PARP2 or PARP4 and 1 more alternative
Reaction pageLeft to rightBalance undeterminable
Rhea RHEA:54424CC BY 4.0Reference data
L-cysteinyl-[protein]+NAD(1-)S-(ADP-D-ribosyl)-L-cysteinyl-[protein]+nicotinamide+hydron
Catalysed by PARP6 or TIPARP or PARP8 or PARP12 or PARP11 or SIRT4
Reaction pageLeft to rightBalance undeterminable
Rhea RHEA:56612CC BY 4.0Reference data
L-lysyl-[protein]+NAD(1-)N(6)-(ADP-D-ribosyl)-L-lysyl-[protein]+nicotinamide+hydron
Catalysed by PARP10 or PARP16 or SIRT6 or PARP11 or PARP3
Reaction pageLeft to rightBalance undeterminable
Rhea RHEA:58220CC BY 4.0Reference data