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Proteins/UNIPROT:Q14197
Essential peptidyl-tRNA hydrolase component of the mitochondrial large ribosomal subunit. Acts as a codon-independent translation release factor that has lost all stop codon specificity and directs the termination of translation in mitochondrion, possibly in case of abortive elongation. Involved in the hydrolysis of peptidyl-tRNAs that have been prematurely terminated and thus in the recycling of stalled mitochondrial ribosomes..
Function from UniProtKB (Q14197), read 2026-09-23. CC BY 4.0.
Curated compounds routed: 0
234 statements
234 statements · 2 reference databases · Subject: MRPL58 · Sources: Hetionet, Reactome
2 reactions
water+MAM02626cMAM02625c+MAM03083c
Catalysed by PTRH2 or MRPL58 or PTRH1
Reaction pageLeft to rightBalance undeterminableEC 3.1.1.29cytosol
Human-GEM MAR09522CC BY 4.0Reference data
an N-acyl-L-alpha-aminoacyl-tRNA+wateran N-acyl-L-amino acid+a tRNA+hydron
8 names
Resolves to: MRPL58
Reaction pageLeft to rightBalance undeterminable
Rhea RHEA:54448CC BY 4.0Reference data