Biological process
negative regulation of gene expression
Any process that decreases the frequency, rate or extent of gene expression. Gene expression is the process in which a gene's coding sequence is converted into a mature gene product (protein or RNA).
Definition from the Gene Ontology (GO:0010629), read 2026-09-23. CC BY 4.0.
GO:0010629Gene Ontology
What the reference databases state
Statements
203 statements
203 statements · 1 reference database · Subject: negative regulation of gene expression · Sources: gene ontology
- ABCC2 regulates negative regulation of gene expressionProteingene ontology Q92887|GO:0010629Inferred only
- ACE regulates negative regulation of gene expressionProteingene ontology P12821|GO:0010629Inferred only
- ACVRL1 regulates negative regulation of gene expressionProteingene ontology P37023|GO:0010629Inferred only
- ADAM10 regulates negative regulation of gene expressionProteingene ontology O14672|GO:0010629Inferred only
- ADNP regulates negative regulation of gene expressionProteingene ontology Q9H2P0|GO:0010629Inferred only
- ANAPC2 regulates negative regulation of gene expressionProteingene ontology Q9UJX6|GO:0010629Inferred only
- ANXA7 regulates negative regulation of gene expressionProteingene ontology P20073|GO:0010629Inferred only
- APLN regulates negative regulation of gene expressionProteingene ontology Q9ULZ1|GO:0010629Inferred only
- APLNR regulates negative regulation of gene expressionProteingene ontology P35414|GO:0010629Inferred only
- APOE regulates negative regulation of gene expressionProteingene ontology P02649|GO:0010629Inferred only
- APP regulates negative regulation of gene expressionProteingene ontology P05067|GO:0010629Inferred only
- ATOH8 regulates negative regulation of gene expressionProteingene ontology Q96SQ7|GO:0010629Inferred only
Show the remaining 191
- ATP2B4 regulates negative regulation of gene expressionProteingene ontology P23634|GO:0010629Inferred only
- AURKA regulates negative regulation of gene expressionProteingene ontology O14965|GO:0010629Inferred only
- BAK1 regulates negative regulation of gene expressionProteingene ontology Q16611|GO:0010629Inferred only
- BMP2 regulates negative regulation of gene expressionProteingene ontology P12643|GO:0010629Inferred only
- BMP4 regulates negative regulation of gene expressionProteingene ontology P12644|GO:0010629Inferred only
- BMPR1A regulates negative regulation of gene expressionProteingene ontology P36894|GO:0010629Inferred only
- C1QTNF3 regulates negative regulation of gene expressionProteingene ontology Q9BXJ4|GO:0010629Inferred only
- CCDC3 regulates negative regulation of gene expressionProteingene ontology Q9BQI4|GO:0010629Inferred only
- CCL3 regulates negative regulation of gene expressionProteingene ontology P10147|GO:0010629Inferred only
- CCNB1 regulates negative regulation of gene expressionProteingene ontology P14635|GO:0010629Inferred only
- CCR1 regulates negative regulation of gene expressionProteingene ontology P32246|GO:0010629Inferred only
- CD28 regulates negative regulation of gene expressionProteingene ontology P10747|GO:0010629Inferred only
- CD34 regulates negative regulation of gene expressionProteingene ontology P28906|GO:0010629Inferred only
- CD36 regulates negative regulation of gene expressionProteingene ontology P16671|GO:0010629Inferred only
- CD3E regulates negative regulation of gene expressionProteingene ontology P07766|GO:0010629Inferred only
- CELF1 regulates negative regulation of gene expressionProteingene ontology Q92879|GO:0010629Inferred only
- CHD4 regulates negative regulation of gene expressionProteingene ontology Q14839|GO:0010629Inferred only
- CHMP1A regulates negative regulation of gene expressionProteingene ontology Q9HD42|GO:0010629Inferred only
- CILP regulates negative regulation of gene expressionProteingene ontology O75339|GO:0010629Inferred only
- CITED2 regulates negative regulation of gene expressionProteingene ontology Q99967|GO:0010629Inferred only
- CLDN19 regulates negative regulation of gene expressionProteingene ontology Q8N6F1|GO:0010629Inferred only
- CLDN3 regulates negative regulation of gene expressionProteingene ontology O15551|GO:0010629Inferred only
- CLDN5 regulates negative regulation of gene expressionProteingene ontology O00501|GO:0010629Inferred only
- CNOT7 regulates negative regulation of gene expressionProteingene ontology Q9UIV1|GO:0010629Inferred only
- CNPY2 regulates negative regulation of gene expressionProteingene ontology Q9Y2B0|GO:0010629Inferred only
- CPNE1 regulates negative regulation of gene expressionProteingene ontology Q99829|GO:0010629Inferred only
- CREB1 regulates negative regulation of gene expressionProteingene ontology P16220|GO:0010629Inferred only
- CREB3L1 regulates negative regulation of gene expressionProteingene ontology Q96BA8|GO:0010629Inferred only
- CRKL regulates negative regulation of gene expressionProteingene ontology P46109|GO:0010629Inferred only
- CTCF regulates negative regulation of gene expressionProteingene ontology P49711|GO:0010629Inferred only
- CTNNB1 regulates negative regulation of gene expressionProteingene ontology P35222|GO:0010629Inferred only
- CXCL8 regulates negative regulation of gene expressionProteingene ontology P10145|GO:0010629Inferred only
- DAXX regulates negative regulation of gene expressionProteingene ontology Q9UER7|GO:0010629Inferred only
- DDRGK1 regulates negative regulation of gene expressionProteingene ontology Q96HY6|GO:0010629Inferred only
- DDX3X regulates negative regulation of gene expressionProteingene ontology O00571|GO:0010629Inferred only
- DDX3Y regulates negative regulation of gene expressionProteingene ontology O15523|GO:0010629Inferred only
- DGKQ regulates negative regulation of gene expressionProteingene ontology P52824|GO:0010629Inferred only
- DICER1 regulates negative regulation of gene expressionProteingene ontology Q9UPY3|GO:0010629Inferred only
- DIP2A regulates negative regulation of gene expressionProteingene ontology Q14689|GO:0010629Inferred only
- DLL4 regulates negative regulation of gene expressionProteingene ontology Q9NR61|GO:0010629Inferred only
- DNMT1 regulates negative regulation of gene expressionProteingene ontology P26358|GO:0010629Inferred only
- EDN1 regulates negative regulation of gene expressionProteingene ontology P05305|GO:0010629Inferred only
- EMILIN1 regulates negative regulation of gene expressionProteingene ontology Q9Y6C2|GO:0010629Inferred only
- ENG regulates negative regulation of gene expressionProteingene ontology P17813|GO:0010629Inferred only
- ERP29 regulates negative regulation of gene expressionProteingene ontology P30040|GO:0010629Inferred only
- ESR1 regulates negative regulation of gene expressionProteingene ontology P03372|GO:0010629Inferred only
- FBXW7 regulates negative regulation of gene expressionProteingene ontology Q969H0|GO:0010629Inferred only
- FERMT1 regulates negative regulation of gene expressionProteingene ontology Q9BQL6|GO:0010629Inferred only
- FGF19 regulates negative regulation of gene expressionProteingene ontology O95750|GO:0010629Inferred only
- FGF2 regulates negative regulation of gene expressionProteingene ontology P09038|GO:0010629Inferred only
- FLOT2 regulates negative regulation of gene expressionProteingene ontology Q14254|GO:0010629Inferred only
- FOXP1 regulates negative regulation of gene expressionProteingene ontology Q9H334|GO:0010629Inferred only
- FYN regulates negative regulation of gene expressionProteingene ontology P06241|GO:0010629Inferred only
- GATA2 regulates negative regulation of gene expressionProteingene ontology P23769|GO:0010629Inferred only
- GATA4 regulates negative regulation of gene expressionProteingene ontology P43694|GO:0010629Inferred only
- GATA5 regulates negative regulation of gene expressionProteingene ontology Q9BWX5|GO:0010629Inferred only
- GPER1 regulates negative regulation of gene expressionProteingene ontology Q99527|GO:0010629Inferred only
- GSK3B regulates negative regulation of gene expressionProteingene ontology P49841|GO:0010629Inferred only
- HAND2 regulates negative regulation of gene expressionProteingene ontology P61296|GO:0010629Inferred only
- HAVCR2 regulates negative regulation of gene expressionProteingene ontology Q8TDQ0|GO:0010629Inferred only
- HDAC1 regulates negative regulation of gene expressionProteingene ontology Q13547|GO:0010629Inferred only
- HES1 regulates negative regulation of gene expressionProteingene ontology Q14469|GO:0010629Inferred only
- HEY2 regulates negative regulation of gene expressionProteingene ontology Q9UBP5|GO:0010629Inferred only
- HIF1A regulates negative regulation of gene expressionProteingene ontology Q16665|GO:0010629Inferred only
- HINFP regulates negative regulation of gene expressionProteingene ontology Q9BQA5|GO:0010629Inferred only
- HMGB2 regulates negative regulation of gene expressionProteingene ontology P26583|GO:0010629Inferred only
- HRAS regulates negative regulation of gene expressionProteingene ontology P01112|GO:0010629Inferred only
- ID2 regulates negative regulation of gene expressionProteingene ontology Q02363|GO:0010629Inferred only
- IFNA2 regulates negative regulation of gene expressionProteingene ontology P01563|GO:0010629Inferred only
- IFNG regulates negative regulation of gene expressionProteingene ontology P01579|GO:0010629Inferred only
- IGF1 regulates negative regulation of gene expressionProteingene ontology P05019|GO:0010629Inferred only
- INS regulates negative regulation of gene expressionProteingene ontology P01308|GO:0010629Inferred only
- ITGB8 regulates negative regulation of gene expressionProteingene ontology P26012|GO:0010629Inferred only
- KDM4A regulates negative regulation of gene expressionProteingene ontology O75164|GO:0010629Inferred only
- KDR regulates negative regulation of gene expressionProteingene ontology P35968|GO:0010629Inferred only
- KLF4 regulates negative regulation of gene expressionProteingene ontology O43474|GO:0010629Inferred only
- LDLR regulates negative regulation of gene expressionProteingene ontology P01130|GO:0010629Inferred only
- LGALS9 regulates negative regulation of gene expressionProteingene ontology O00182|GO:0010629Inferred only
- LGMN regulates negative regulation of gene expressionProteingene ontology Q99538|GO:0010629Inferred only
- LRP1 regulates negative regulation of gene expressionProteingene ontology Q07954|GO:0010629Inferred only
- LRP3 regulates negative regulation of gene expressionProteingene ontology O75074|GO:0010629Inferred only
- MAP2K1 regulates negative regulation of gene expressionProteingene ontology Q02750|GO:0010629Inferred only
- MAP3K7 regulates negative regulation of gene expressionProteingene ontology O43318|GO:0010629Inferred only
- MAPT regulates negative regulation of gene expressionProteingene ontology P10636|GO:0010629Inferred only
- MARK1 regulates negative regulation of gene expressionProteingene ontology Q9P0L2|GO:0010629Inferred only
- MECP2 regulates negative regulation of gene expressionProteingene ontology P51608|GO:0010629Inferred only
- MEF2C regulates negative regulation of gene expressionProteingene ontology Q06413|GO:0010629Inferred only
- MIF regulates negative regulation of gene expressionProteingene ontology P14174|GO:0010629Inferred only
- MORC1 regulates negative regulation of gene expressionProteingene ontology Q86VD1|GO:0010629Inferred only
- MSR1 regulates negative regulation of gene expressionProteingene ontology P21757|GO:0010629Inferred only
- MSX1 regulates negative regulation of gene expressionProteingene ontology P28360|GO:0010629Inferred only
- MYADM regulates negative regulation of gene expressionProteingene ontology Q96S97|GO:0010629Inferred only
- MYCN regulates negative regulation of gene expressionProteingene ontology P04198|GO:0010629Inferred only
- NFKB1 regulates negative regulation of gene expressionProteingene ontology P19838|GO:0010629Inferred only
- NKX3-1 regulates negative regulation of gene expressionProteingene ontology Q99801|GO:0010629Inferred only
- NOCT regulates negative regulation of gene expressionProteingene ontology Q9UK39|GO:0010629Inferred only
- NOS2 regulates negative regulation of gene expressionProteingene ontology P35228|GO:0010629Inferred only
- NOTCH1 regulates negative regulation of gene expressionProteingene ontology P46531|GO:0010629Inferred only
- NOTCH2 regulates negative regulation of gene expressionProteingene ontology Q04721|GO:0010629Inferred only
- NR0B2 regulates negative regulation of gene expressionProteingene ontology Q15466|GO:0010629Inferred only
- NR1H2 regulates negative regulation of gene expressionProteingene ontology P55055|GO:0010629Inferred only
- NTS regulates negative regulation of gene expressionProteingene ontology P30990|GO:0010629Inferred only
- OCLN regulates negative regulation of gene expressionProteingene ontology Q16625|GO:0010629Inferred only
- OLFM1 regulates negative regulation of gene expressionProteingene ontology Q99784|GO:0010629Inferred only
- OPRD1 regulates negative regulation of gene expressionProteingene ontology P41143|GO:0010629Inferred only
- OVOL2 regulates negative regulation of gene expressionProteingene ontology Q9BRP0|GO:0010629Inferred only
- PARK7 regulates negative regulation of gene expressionProteingene ontology Q99497|GO:0010629Inferred only
- PARP10 regulates negative regulation of gene expressionProteingene ontology Q53GL7|GO:0010629Inferred only
- PARP14 regulates negative regulation of gene expressionProteingene ontology Q460N5|GO:0010629Inferred only
- PARP15 regulates negative regulation of gene expressionProteingene ontology Q460N3|GO:0010629Inferred only
- PARP9 regulates negative regulation of gene expressionProteingene ontology Q8IXQ6|GO:0010629Inferred only
- PAWR regulates negative regulation of gene expressionProteingene ontology Q96IZ0|GO:0010629Inferred only
- PC regulates negative regulation of gene expressionProteingene ontology P11498|GO:0010629Inferred only
- PDCD10 regulates negative regulation of gene expressionProteingene ontology Q9BUL8|GO:0010629Inferred only
- PDGFB regulates negative regulation of gene expressionProteingene ontology P01127|GO:0010629Inferred only
- PGR regulates negative regulation of gene expressionProteingene ontology P06401|GO:0010629Inferred only
- PICALM regulates negative regulation of gene expressionProteingene ontology Q13492|GO:0010629Inferred only
- PIK3CA regulates negative regulation of gene expressionProteingene ontology P42336|GO:0010629Inferred only
- PINK1 regulates negative regulation of gene expressionProteingene ontology Q9BXM7|GO:0010629Inferred only
- PLA2G3 regulates negative regulation of gene expressionProteingene ontology Q9NZ20|GO:0010629Inferred only
- PLAG1 regulates negative regulation of gene expressionProteingene ontology Q6DJT9|GO:0010629Inferred only
- POU3F2 regulates negative regulation of gene expressionProteingene ontology P20265|GO:0010629Inferred only
- POU4F1 regulates negative regulation of gene expressionProteingene ontology Q01851|GO:0010629Inferred only
- PPARG regulates negative regulation of gene expressionProteingene ontology P37231|GO:0010629Inferred only
- PPP2CB regulates negative regulation of gene expressionProteingene ontology P62714|GO:0010629Inferred only
- PRKAA1 regulates negative regulation of gene expressionProteingene ontology Q13131|GO:0010629Inferred only
- PRKAA2 regulates negative regulation of gene expressionProteingene ontology P54646|GO:0010629Inferred only
- PRKAR1A regulates negative regulation of gene expressionProteingene ontology P10644|GO:0010629Inferred only
- PRKN regulates negative regulation of gene expressionProteingene ontology O60260|GO:0010629Inferred only
- PSEN1 regulates negative regulation of gene expressionProteingene ontology P49768|GO:0010629Inferred only
- PTH regulates negative regulation of gene expressionProteingene ontology P01270|GO:0010629Inferred only
- PTPN22 regulates negative regulation of gene expressionProteingene ontology Q9Y2R2|GO:0010629Inferred only
- PTRH2 regulates negative regulation of gene expressionProteingene ontology Q9Y3E5|GO:0010629Inferred only
- RACK1 regulates negative regulation of gene expressionProteingene ontology P63244|GO:0010629Inferred only
- RB1 regulates negative regulation of gene expressionProteingene ontology P06400|GO:0010629Inferred only
- RBL1 regulates negative regulation of gene expressionProteingene ontology P28749|GO:0010629Inferred only
- RBL2 regulates negative regulation of gene expressionProteingene ontology Q08999|GO:0010629Inferred only
- RBMS3 regulates negative regulation of gene expressionProteingene ontology Q6XE24|GO:0010629Inferred only
- RCOR1 regulates negative regulation of gene expressionProteingene ontology Q9UKL0|GO:0010629Inferred only
- REL regulates negative regulation of gene expressionProteingene ontology Q04864|GO:0010629Inferred only
- REST regulates negative regulation of gene expressionProteingene ontology Q13127|GO:0010629Inferred only
- ROBO1 regulates negative regulation of gene expressionProteingene ontology Q9Y6N7|GO:0010629Inferred only
- ROCK2 regulates negative regulation of gene expressionProteingene ontology O75116|GO:0010629Inferred only
- SCX regulates negative regulation of gene expressionProteingene ontology Q7RTU7|GO:0010629Inferred only
- SERPINF1 regulates negative regulation of gene expressionProteingene ontology P36955|GO:0010629Inferred only
- SETDB1 regulates negative regulation of gene expressionProteingene ontology Q15047|GO:0010629Inferred only
- SETDB2 regulates negative regulation of gene expressionProteingene ontology Q96T68|GO:0010629Inferred only
- SFMBT2 regulates negative regulation of gene expressionProteingene ontology Q5VUG0|GO:0010629Inferred only
- SFRP1 regulates negative regulation of gene expressionProteingene ontology Q8N474|GO:0010629Inferred only
- SFRP2 regulates negative regulation of gene expressionProteingene ontology Q96HF1|GO:0010629Inferred only
- SH3GL2 regulates negative regulation of gene expressionProteingene ontology Q99962|GO:0010629Inferred only
- SHH regulates negative regulation of gene expressionProteingene ontology Q15465|GO:0010629Inferred only
- SIRT1 regulates negative regulation of gene expressionProteingene ontology Q96EB6|GO:0010629Inferred only
- SLC24A3 regulates negative regulation of gene expressionProteingene ontology Q9HC58|GO:0010629Inferred only
- SLC2A10 regulates negative regulation of gene expressionProteingene ontology O95528|GO:0010629Inferred only
- SLC7A5 regulates negative regulation of gene expressionProteingene ontology Q01650|GO:0010629Inferred only
- SMAD3 regulates negative regulation of gene expressionProteingene ontology P84022|GO:0010629Inferred only
- SMAD5 regulates negative regulation of gene expressionProteingene ontology Q99717|GO:0010629Inferred only
- SMCR8 regulates negative regulation of gene expressionProteingene ontology Q8TEV9|GO:0010629Inferred only
- SNX12 regulates negative regulation of gene expressionProteingene ontology Q9UMY4|GO:0010629Inferred only
- SOX11 regulates negative regulation of gene expressionProteingene ontology P35716|GO:0010629Inferred only
- SPI1 regulates negative regulation of gene expressionProteingene ontology P17947|GO:0010629Inferred only
- STAT3 regulates negative regulation of gene expressionProteingene ontology P40763|GO:0010629Inferred only
- STC2 regulates negative regulation of gene expressionProteingene ontology O76061|GO:0010629Inferred only
- STOX1 regulates negative regulation of gene expressionProteingene ontology Q6ZVD7|GO:0010629Inferred only
- TAF1 regulates negative regulation of gene expressionProteingene ontology P21675|GO:0010629Inferred only
- TARDBP regulates negative regulation of gene expressionProteingene ontology Q13148|GO:0010629Inferred only
- TBK1 regulates negative regulation of gene expressionProteingene ontology Q9UHD2|GO:0010629Inferred only
- TFAP4 regulates negative regulation of gene expressionProteingene ontology Q01664|GO:0010629Inferred only
- TGFB1 regulates negative regulation of gene expressionProteingene ontology P01137|GO:0010629Inferred only
- TGFB2 regulates negative regulation of gene expressionProteingene ontology P61812|GO:0010629Inferred only
- TGIF1 regulates negative regulation of gene expressionProteingene ontology Q15583|GO:0010629Inferred only
- TIPARP regulates negative regulation of gene expressionProteingene ontology Q7Z3E1|GO:0010629Inferred only
- TLE5 regulates negative regulation of gene expressionProteingene ontology Q08117|GO:0010629Inferred only
- TNF regulates negative regulation of gene expressionProteingene ontology P01375|GO:0010629Inferred only
- TP53INP1 regulates negative regulation of gene expressionProteingene ontology Q96A56|GO:0010629Inferred only
- TRIM6 regulates negative regulation of gene expressionProteingene ontology Q9C030|GO:0010629Inferred only
- TTBK1 regulates negative regulation of gene expressionProteingene ontology Q5TCY1|GO:0010629Inferred only
- UCN regulates negative regulation of gene expressionProteingene ontology P55089|GO:0010629Inferred only
- VEGFA regulates negative regulation of gene expressionProteingene ontology P15692|GO:0010629Inferred only
- VEGFB regulates negative regulation of gene expressionProteingene ontology P49765|GO:0010629Inferred only
- VHL regulates negative regulation of gene expressionProteingene ontology P40337|GO:0010629Inferred only
- VPS35 regulates negative regulation of gene expressionProteingene ontology Q96QK1|GO:0010629Inferred only
- WNT4 regulates negative regulation of gene expressionProteingene ontology P56705|GO:0010629Inferred only
- YAP1 regulates negative regulation of gene expressionProteingene ontology P46937|GO:0010629Inferred only
- YY1 regulates negative regulation of gene expressionProteingene ontology P25490|GO:0010629Inferred only
- ZNF148 regulates negative regulation of gene expressionProteingene ontology Q9UQR1|GO:0010629Inferred only
- ZNF281 regulates negative regulation of gene expressionProteingene ontology Q9Y2X9|GO:0010629Inferred only
- ZNF410 regulates negative regulation of gene expressionProteingene ontology Q86VK4|GO:0010629Inferred only
- ZNF503 regulates negative regulation of gene expressionProteingene ontology Q96F45|GO:0010629Inferred only
- ZNF808 regulates negative regulation of gene expressionProteingene ontology Q8N4W9|GO:0010629Inferred only