(12S)-hydroperoxy-(5Z,8Z,10E,14Z,17Z)-eicosapentaenoate

Three steps

• (15S)-hydroxy-(11Z,13E)-eicosadienoateReach from here →
  1. (12S)-hydroperoxy-(5Z,8Z,10E,14Z,17Z)-eicosapentaenoate + 2 glutathione = (12S)-hydroxy-(5Z,8Z,10E,14Z,17Z)-eicosapentaenoate + glutathione disulfide + H2O
  2. 2 glutathione + NADP(+) = glutathione disulfide + NADPH + H(+)
  3. (15S)-hydroperoxy-(11Z,13E)-eicosadienoate + 2 glutathione = (15S)-hydroxy-(11Z,13E)-eicosadienoate + glutathione disulfide + H2O

  Catalysed by GPX1, GPX4, GSR

• (17S)-hydroxy-(4Z,7Z,10Z,13Z,15E,19Z)-docosahexaenoateReach from here →
  1. (12S)-hydroperoxy-(5Z,8Z,10E,14Z,17Z)-eicosapentaenoate + 2 glutathione = (12S)-hydroxy-(5Z,8Z,10E,14Z,17Z)-eicosapentaenoate + glutathione disulfide + H2O
  2. 2 glutathione + NADP(+) = glutathione disulfide + NADPH + H(+)
  3. (17S)-hydroperoxy-(4Z,7Z,10Z,13Z,15E,19Z)-docosahexaenoate + 2 glutathione = (17S)-hydroxy-(4Z,7Z,10Z,13Z,15E,19Z)-docosahexaenoate + glutathione disulfide + H2O

  Catalysed by GPX1, GPX4, GSR

• a hydroxy-1,2-diacyl-glycero-3-phosphocholineReach from here →
  1. (12S)-hydroperoxy-(5Z,8Z,10E,14Z,17Z)-eicosapentaenoate + 2 glutathione = (12S)-hydroxy-(5Z,8Z,10E,14Z,17Z)-eicosapentaenoate + glutathione disulfide + H2O
  2. 2 glutathione + NADP(+) = glutathione disulfide + NADPH + H(+)
  3. a hydroperoxy-1,2-diacyl-glycero-3-phosphocholine + 2 glutathione = a hydroxy-1,2-diacyl-glycero-3-phosphocholine + glutathione disulfide + H2O

  Catalysed by GPX1, GPX4, GSR

• 3-(glutathion-S-yl)-4-hydroxynonanalReach from here →
  1. (12S)-hydroperoxy-(5Z,8Z,10E,14Z,17Z)-eicosapentaenoate + 2 glutathione = (12S)-hydroxy-(5Z,8Z,10E,14Z,17Z)-eicosapentaenoate + glutathione disulfide + H2O
  2. 2 glutathione + NADP(+) = glutathione disulfide + NADPH + H(+)
  3. (E)-4-hydroxynon-2-enal + glutathione = 3-(glutathion-S-yl)-4-hydroxynonanal

  Catalysed by GPX1, GPX4, GSR, GSTP1

• a quinolReach from here →
  1. (12S)-hydroperoxy-(5Z,8Z,10E,14Z,17Z)-eicosapentaenoate + 2 glutathione = (12S)-hydroxy-(5Z,8Z,10E,14Z,17Z)-eicosapentaenoate + glutathione disulfide + H2O
  2. 2 glutathione + NADP(+) = glutathione disulfide + NADPH + H(+)
  3. a quinone + hydrogen sulfide + glutathione + H(+) = S-sulfanylglutathione + a quinol

  Catalysed by GPX1, GPX4, GSR, SQOR

• 5(S)-HETEReach from here →
  1. (12S)-hydroperoxy-(5Z,8Z,10E,14Z,17Z)-eicosapentaenoate + 2 glutathione = (12S)-hydroxy-(5Z,8Z,10E,14Z,17Z)-eicosapentaenoate + glutathione disulfide + H2O
  2. Glutathione: 15-HPETE oxidoreductase
  3. Glutathione: 5-HPETE oxidoreductase

  Catalysed by GPX1, GPX4, GPX5, GPX2 and 5 morecytosolOne of 2 routes

• CHEBI:28666Reach from here →
  1. (12S)-hydroperoxy-(5Z,8Z,10E,14Z,17Z)-eicosapentaenoate + 2 glutathione = (12S)-hydroxy-(5Z,8Z,10E,14Z,17Z)-eicosapentaenoate + glutathione disulfide + H2O
  2. Glutathione: 15-HPETE oxidoreductase
  3. transport of GSH and LTD4 (cytosol to extracellular)

  Catalysed by GPX1, GPX4, GPX5, GPX2 and 6 morecytosol, extracellular spaceOne of 2 routes

• 3-disulfanyl-L-alanineReach from here →
  1. (12S)-hydroperoxy-(5Z,8Z,10E,14Z,17Z)-eicosapentaenoate + 2 glutathione = (12S)-hydroxy-(5Z,8Z,10E,14Z,17Z)-eicosapentaenoate + glutathione disulfide + H2O
  2. cystine to cysteine conversion
  3. L-cystine thiocysteine-lyase (deaminating

  Catalysed by GPX1, GPX4, CTHcytosol

• L-ascorbic acidReach from here →
  1. (12S)-hydroperoxy-(5Z,8Z,10E,14Z,17Z)-eicosapentaenoate + 2 glutathione = (12S)-hydroxy-(5Z,8Z,10E,14Z,17Z)-eicosapentaenoate + glutathione disulfide + H2O
  2. 2 glutathione + NADP(+) = glutathione disulfide + NADPH + H(+)
  3. L-dehydroascorbate + 2 glutathione = glutathione disulfide + L-ascorbate

  Catalysed by GPX1, GPX4, GSR, CLIC1 and 2 more

• glycocholateReach from here →
  1. (12S)-hydroperoxy-(5Z,8Z,10E,14Z,17Z)-eicosapentaenoate + 2 glutathione = (12S)-hydroxy-(5Z,8Z,10E,14Z,17Z)-eicosapentaenoate + glutathione disulfide + H2O
  2. Glutathione: 15-HPETE oxidoreductase
  3. solute carrier organic anion transporter (glycocholate)

  Catalysed by GPX1, GPX4, GPX5, GPX2 and 7 morecytosol, extracellular spaceOne of 3 routes

• cholateReach from here →
  1. (12S)-hydroperoxy-(5Z,8Z,10E,14Z,17Z)-eicosapentaenoate + 2 glutathione = (12S)-hydroxy-(5Z,8Z,10E,14Z,17Z)-eicosapentaenoate + glutathione disulfide + H2O
  2. Glutathione: 15-HPETE oxidoreductase
  3. solute carrier organic anion transporter (cholate)

  Catalysed by GPX1, GPX4, GPX5, GPX2 and 7 morecytosol, extracellular spaceOne of 3 routes

• hydrogen sulfideReach from here →
  1. (12S)-hydroperoxy-(5Z,8Z,10E,14Z,17Z)-eicosapentaenoate + 2 glutathione = (12S)-hydroxy-(5Z,8Z,10E,14Z,17Z)-eicosapentaenoate + glutathione disulfide + H2O
  2. 2 glutathione + NADP(+) = glutathione disulfide + NADPH + H(+)
  3. thiosulfate + 2 glutathione = glutathione disulfide + hydrogen sulfide + sulfite + 2 H(+)

  Catalysed by GPX1, GPX4, GSR, TSTD1One of 3 routes

• L-aspartateReach from here →
  1. (12S)-hydroperoxy-(5Z,8Z,10E,14Z,17Z)-eicosapentaenoate + 2 glutathione = (12S)-hydroxy-(5Z,8Z,10E,14Z,17Z)-eicosapentaenoate + glutathione disulfide + H2O
  2. cystine to cysteine conversion
  3. L-cystine(out) + L-aspartate(in) = L-cystine(in) + L-aspartate(out)

  Catalysed by GPX1, GPX4, SLC7A13cytosol, inner side of the membrane, outer side of the membraneOne of 2 routes

• an alcoholReach from here →
  1. (12S)-hydroperoxy-(5Z,8Z,10E,14Z,17Z)-eicosapentaenoate + 2 glutathione = (12S)-hydroxy-(5Z,8Z,10E,14Z,17Z)-eicosapentaenoate + glutathione disulfide + H2O
  2. 2 glutathione + NADP(+) = glutathione disulfide + NADPH + H(+)
  3. a hydroperoxide + 2 glutathione = an alcohol + glutathione disulfide + H2O

  Catalysed by GPX1, GPX4, GSR, CP and 1 more

• (5Z,8Z,11Z,14Z)-eicosatetraenoateReach from here →
  1. (12S)-hydroperoxy-(5Z,8Z,10E,14Z,17Z)-eicosapentaenoate + 2 glutathione = (12S)-hydroxy-(5Z,8Z,10E,14Z,17Z)-eicosapentaenoate + glutathione disulfide + H2O
  2. Glutathione: 15-HPETE oxidoreductase
  3. transport of arachidonate and GSH (cytosol to extracellular)

  Catalysed by GPX1, GPX4, GPX5, GPX2 and 5 morecytosol, extracellular spaceOne of 2 routes

• serotoninReach from here →
  1. (12S)-hydroperoxy-(5Z,8Z,10E,14Z,17Z)-eicosapentaenoate + 2 glutathione = (12S)-hydroxy-(5Z,8Z,10E,14Z,17Z)-eicosapentaenoate + glutathione disulfide + H2O
  2. Glutathione: 15-HPETE oxidoreductase
  3. transport of GSH and serotonin (cytosol to extracellular)

  Catalysed by GPX1, GPX4, GPX5, GPX2 and 7 morecytosol, extracellular spaceOne of 2 routes

• glycochenodeoxycholateReach from here →
  1. (12S)-hydroperoxy-(5Z,8Z,10E,14Z,17Z)-eicosapentaenoate + 2 glutathione = (12S)-hydroxy-(5Z,8Z,10E,14Z,17Z)-eicosapentaenoate + glutathione disulfide + H2O
  2. 2 glutathione + NADP(+) = glutathione disulfide + NADPH + H(+)
  3. glycochenodeoxycholate(in) + glutathione(in) + ATP + H2O = glycochenodeoxycholate(out) + glutathione(out) + ADP + phosphate + H(+)

  Catalysed by GPX1, GPX4, GSR, ABCC4inner side of the membrane, outer side of the membrane

• taurocholateReach from here →
  1. (12S)-hydroperoxy-(5Z,8Z,10E,14Z,17Z)-eicosapentaenoate + 2 glutathione = (12S)-hydroxy-(5Z,8Z,10E,14Z,17Z)-eicosapentaenoate + glutathione disulfide + H2O
  2. Glutathione: 15-HPETE oxidoreductase
  3. solute carrier organic anion transporter (GSH)

  Catalysed by GPX1, GPX4, GPX5, GPX2 and 7 morecytosol, extracellular spaceOne of 3 routes

• glycolithocholic acidReach from here →
  1. (12S)-hydroperoxy-(5Z,8Z,10E,14Z,17Z)-eicosapentaenoate + 2 glutathione = (12S)-hydroxy-(5Z,8Z,10E,14Z,17Z)-eicosapentaenoate + glutathione disulfide + H2O
  2. Glutathione: 15-HPETE oxidoreductase
  3. transport of glycolithocholate and GSH (cytosol to extracellular)

  Catalysed by GPX1, GPX4, GPX5, GPX2 and 7 morecytosol, extracellular spaceOne of 2 routes

• tert-butanolReach from here →
  1. (12S)-hydroperoxy-(5Z,8Z,10E,14Z,17Z)-eicosapentaenoate + 2 glutathione = (12S)-hydroxy-(5Z,8Z,10E,14Z,17Z)-eicosapentaenoate + glutathione disulfide + H2O
  2. 2 glutathione + NADP(+) = glutathione disulfide + NADPH + H(+)
  3. tert-butyl hydroperoxide + 2 glutathione = tert-butanol + glutathione disulfide + H2O

  Catalysed by GPX1, GPX4, GSR, CLIC2 and 2 more

• gamma-Glu-AlaReach from here →
  1. (12S)-hydroperoxy-(5Z,8Z,10E,14Z,17Z)-eicosapentaenoate + 2 glutathione = (12S)-hydroxy-(5Z,8Z,10E,14Z,17Z)-eicosapentaenoate + glutathione disulfide + H2O
  2. Glutathione: 15-HPETE oxidoreductase
  3. gamma-glutamyltransferase (alanine)

  Catalysed by GPX1, GPX4, GPX5, GPX2 and 11 morecytosol, extracellular space

• 3,3',5-triiodo-L-thyronineReach from here →
  1. (12S)-hydroperoxy-(5Z,8Z,10E,14Z,17Z)-eicosapentaenoate + 2 glutathione = (12S)-hydroxy-(5Z,8Z,10E,14Z,17Z)-eicosapentaenoate + glutathione disulfide + H2O
  2. Glutathione: 15-HPETE oxidoreductase
  3. transport of GSH and triiodothyronine (cytosol to extracellular)

  Catalysed by GPX1, GPX4, GPX5, GPX2 and 7 morecytosol, extracellular spaceOne of 2 routes

• prostaglandin E1Reach from here →
  1. (12S)-hydroperoxy-(5Z,8Z,10E,14Z,17Z)-eicosapentaenoate + 2 glutathione = (12S)-hydroxy-(5Z,8Z,10E,14Z,17Z)-eicosapentaenoate + glutathione disulfide + H2O
  2. Glutathione: 15-HPETE oxidoreductase
  3. transport of GSH and prostaglandin E1 (cytosol to extracellular)

  Catalysed by GPX1, GPX4, GPX5, GPX2 and 6 morecytosol, extracellular spaceOne of 2 routes

• prostaglandin I2Reach from here →
  1. (12S)-hydroperoxy-(5Z,8Z,10E,14Z,17Z)-eicosapentaenoate + 2 glutathione = (12S)-hydroxy-(5Z,8Z,10E,14Z,17Z)-eicosapentaenoate + glutathione disulfide + H2O
  2. Glutathione: 15-HPETE oxidoreductase
  3. transport of GSH and prostaglandin I2 (cytosol to extracellular)

  Catalysed by GPX1, GPX4, GPX5, GPX2 and 6 morecytosol, extracellular spaceOne of 2 routes

• prostaglandin F2alphaReach from here →
  1. (12S)-hydroperoxy-(5Z,8Z,10E,14Z,17Z)-eicosapentaenoate + 2 glutathione = (12S)-hydroxy-(5Z,8Z,10E,14Z,17Z)-eicosapentaenoate + glutathione disulfide + H2O
  2. Glutathione: 15-HPETE oxidoreductase
  3. transport of GSH and prostaglandin F2alpha (cytosol to extracellular)

  Catalysed by GPX1, GPX4, GPX5, GPX2 and 6 morecytosol, extracellular spaceOne of 2 routes

• prostaglandin H2Reach from here →
  1. (12S)-hydroperoxy-(5Z,8Z,10E,14Z,17Z)-eicosapentaenoate + 2 glutathione = (12S)-hydroxy-(5Z,8Z,10E,14Z,17Z)-eicosapentaenoate + glutathione disulfide + H2O
  2. Glutathione: 15-HPETE oxidoreductase
  3. transport of GSH and prostaglandin H2 (cytosol to extracellular)

  Catalysed by GPX1, GPX4, GPX5, GPX2 and 6 morecytosol, extracellular spaceOne of 2 routes

• prostaglandin D2Reach from here →
  1. (12S)-hydroperoxy-(5Z,8Z,10E,14Z,17Z)-eicosapentaenoate + 2 glutathione = (12S)-hydroxy-(5Z,8Z,10E,14Z,17Z)-eicosapentaenoate + glutathione disulfide + H2O
  2. Glutathione: 15-HPETE oxidoreductase
  3. transport of GSH and prostaglandin D2 (cytosol to extracellular)

  Catalysed by GPX1, GPX4, GPX5, GPX2 and 6 morecytosol, extracellular spaceOne of 2 routes

• (15S)-hydroxy-(5Z,8Z,11Z,13E)-eicosatetraenoateReach from here →
  1. (12S)-hydroperoxy-(5Z,8Z,10E,14Z,17Z)-eicosapentaenoate + 2 glutathione = (12S)-hydroxy-(5Z,8Z,10E,14Z,17Z)-eicosapentaenoate + glutathione disulfide + H2O
  2. Glutathione: 15-HPETE oxidoreductase
  3. Glutathione: 15-HPETE oxidoreductase

  Catalysed by GPX1, GPX4, GPX5, GPX2 and 5 morecytosolOne of 3 routes

• leukotriene A4Reach from here →
  1. (12S)-hydroperoxy-(5Z,8Z,10E,14Z,17Z)-eicosapentaenoate + 2 glutathione = (12S)-hydroxy-(5Z,8Z,10E,14Z,17Z)-eicosapentaenoate + glutathione disulfide + H2O
  2. Glutathione: 15-HPETE oxidoreductase
  3. transport of GSH and leukotriene A4 (cytosol to extracellular)

  Catalysed by GPX1, GPX4, GPX5, GPX2 and 6 morecytosol, extracellular spaceOne of 2 routes

• (R)-S-lactoylglutathioneReach from here →
  1. (12S)-hydroperoxy-(5Z,8Z,10E,14Z,17Z)-eicosapentaenoate + 2 glutathione = (12S)-hydroxy-(5Z,8Z,10E,14Z,17Z)-eicosapentaenoate + glutathione disulfide + H2O
  2. Glutathione: 15-HPETE oxidoreductase
  3. (R)-S-Lactoylglutathione methylglyoxal-lyase (isomerizing)

  Catalysed by GPX1, GPX4, GPX5, GPX2 and 7 morecytosolOne of 3 routes

• S-formylglutathioneReach from here →
  1. (12S)-hydroperoxy-(5Z,8Z,10E,14Z,17Z)-eicosapentaenoate + 2 glutathione = (12S)-hydroxy-(5Z,8Z,10E,14Z,17Z)-eicosapentaenoate + glutathione disulfide + H2O
  2. Glutathione: 15-HPETE oxidoreductase
  3. alcohol dehydrogenase (formaldehyde)

  Catalysed by GPX1, GPX4, GPX5, GPX2 and 11 morecytosolOne of 2 routes

• L-alanineReach from here →
  1. (12S)-hydroperoxy-(5Z,8Z,10E,14Z,17Z)-eicosapentaenoate + 2 glutathione = (12S)-hydroxy-(5Z,8Z,10E,14Z,17Z)-eicosapentaenoate + glutathione disulfide + H2O
  2. cystine to cysteine conversion
  3. Transport of L-Cystine (L-Alanine antiport) by B0, +At Transporter

  Catalysed by GPX1, GPX4, SLC7A9, SLC3A1cytosol, extracellular space

• leukotriene C4Reach from here →
  1. (12S)-hydroperoxy-(5Z,8Z,10E,14Z,17Z)-eicosapentaenoate + 2 glutathione = (12S)-hydroxy-(5Z,8Z,10E,14Z,17Z)-eicosapentaenoate + glutathione disulfide + H2O
  2. Glutathione: 15-HPETE oxidoreductase
  3. leukotriene C4 synthase (GSH)

  Catalysed by GPX1, GPX4, GPX5, GPX2 and 6 morecytosolOne of 5 routes

• taurolithocholate 3-sulfateReach from here →
  1. (12S)-hydroperoxy-(5Z,8Z,10E,14Z,17Z)-eicosapentaenoate + 2 glutathione = (12S)-hydroxy-(5Z,8Z,10E,14Z,17Z)-eicosapentaenoate + glutathione disulfide + H2O
  2. Glutathione: 15-HPETE oxidoreductase
  3. transport of GSH and sulfotaurolithocholate (cytosol to extracellular)

  Catalysed by GPX1, GPX4, GPX5, GPX2 and 7 morecytosol, extracellular spaceOne of 2 routes

• 5-oxo-L-prolineReach from here →
  1. (12S)-hydroperoxy-(5Z,8Z,10E,14Z,17Z)-eicosapentaenoate + 2 glutathione = (12S)-hydroxy-(5Z,8Z,10E,14Z,17Z)-eicosapentaenoate + glutathione disulfide + H2O
  2. 2 glutathione + NADP(+) = glutathione disulfide + NADPH + H(+)
  3. glutathione = L-cysteinylglycine + 5-oxo-L-proline

  Catalysed by GPX1, GPX4, GSR, CHAC2 and 1 more

• histamineReach from here →
  1. (12S)-hydroperoxy-(5Z,8Z,10E,14Z,17Z)-eicosapentaenoate + 2 glutathione = (12S)-hydroxy-(5Z,8Z,10E,14Z,17Z)-eicosapentaenoate + glutathione disulfide + H2O
  2. Glutathione: 15-HPETE oxidoreductase
  3. transport of GSH and histamine (cytosol to extracellular)

  Catalysed by GPX1, GPX4, GPX5, GPX2 and 7 morecytosol, extracellular spaceOne of 2 routes

• L-thyroxineReach from here →
  1. (12S)-hydroperoxy-(5Z,8Z,10E,14Z,17Z)-eicosapentaenoate + 2 glutathione = (12S)-hydroxy-(5Z,8Z,10E,14Z,17Z)-eicosapentaenoate + glutathione disulfide + H2O
  2. Glutathione: 15-HPETE oxidoreductase
  3. transport of GSH and thyroxine (cytosol to extracellular)

  Catalysed by GPX1, GPX4, GPX5, GPX2 and 7 morecytosol, extracellular spaceOne of 2 routes

• S-sulfanylglutathioneReach from here →
  1. (12S)-hydroperoxy-(5Z,8Z,10E,14Z,17Z)-eicosapentaenoate + 2 glutathione = (12S)-hydroxy-(5Z,8Z,10E,14Z,17Z)-eicosapentaenoate + glutathione disulfide + H2O
  2. Glutathione: 15-HPETE oxidoreductase
  3. Sulfide:glutathione,quinone oxidoreductase

  Catalysed by GPX1, GPX4, GPX5, GPX2 and 6 morecytosol, mitochondrial matrixOne of 6 routes

• dopamineReach from here →
  1. (12S)-hydroperoxy-(5Z,8Z,10E,14Z,17Z)-eicosapentaenoate + 2 glutathione = (12S)-hydroxy-(5Z,8Z,10E,14Z,17Z)-eicosapentaenoate + glutathione disulfide + H2O
  2. Glutathione: 15-HPETE oxidoreductase
  3. transport of dopamine and GSH (cytosol to extracellular)

  Catalysed by GPX1, GPX4, GPX5, GPX2 and 7 morecytosol, extracellular spaceOne of 2 routes

• glycolithocholate 3-sulfateReach from here →
  1. (12S)-hydroperoxy-(5Z,8Z,10E,14Z,17Z)-eicosapentaenoate + 2 glutathione = (12S)-hydroxy-(5Z,8Z,10E,14Z,17Z)-eicosapentaenoate + glutathione disulfide + H2O
  2. Glutathione: 15-HPETE oxidoreductase
  3. transport of GSH and sulfoglycolithocholate (cytosol to extracellular)

  Catalysed by GPX1, GPX4, GPX5, GPX2 and 7 morecytosol, extracellular spaceOne of 2 routes

• prostaglandin E2Reach from here →
  1. (12S)-hydroperoxy-(5Z,8Z,10E,14Z,17Z)-eicosapentaenoate + 2 glutathione = (12S)-hydroxy-(5Z,8Z,10E,14Z,17Z)-eicosapentaenoate + glutathione disulfide + H2O
  2. Glutathione: 15-HPETE oxidoreductase
  3. transport of GSH and prostaglandin E2 (cytosol to extracellular)

  Catalysed by GPX1, GPX4, GPX5, GPX2 and 7 morecytosol, extracellular spaceOne of 2 routes

• L-cysteinylglycineReach from here →
  1. (12S)-hydroperoxy-(5Z,8Z,10E,14Z,17Z)-eicosapentaenoate + 2 glutathione = (12S)-hydroxy-(5Z,8Z,10E,14Z,17Z)-eicosapentaenoate + glutathione disulfide + H2O
  2. Glutathione: 15-HPETE oxidoreductase
  3. glutathione gamma-glutamylaminopeptidase

  Catalysed by GPX1, GPX4, GPX5, GPX2 and 11 morecytosolOne of 6 routes

• ubiquinol-10Reach from here →
  1. (12S)-hydroperoxy-(5Z,8Z,10E,14Z,17Z)-eicosapentaenoate + 2 glutathione = (12S)-hydroxy-(5Z,8Z,10E,14Z,17Z)-eicosapentaenoate + glutathione disulfide + H2O
  2. 2 glutathione + NADP(+) = glutathione disulfide + NADPH + H(+)
  3. ubiquinone-10 + hydrogen sulfide + glutathione + H(+) = S-sulfanylglutathione + ubiquinol-10

  Catalysed by GPX1, GPX4, GSR, SQOR

• (R)-noradrenalineReach from here →
  1. (12S)-hydroperoxy-(5Z,8Z,10E,14Z,17Z)-eicosapentaenoate + 2 glutathione = (12S)-hydroxy-(5Z,8Z,10E,14Z,17Z)-eicosapentaenoate + glutathione disulfide + H2O
  2. Glutathione: 15-HPETE oxidoreductase
  3. transport of GSH and noradrenaline (cytosol to extracellular)

  Catalysed by GPX1, GPX4, GPX5, GPX2 and 7 morecytosol, extracellular spaceOne of 2 routes

• 20-hydroxy-(5Z,8Z,11Z,14Z)-eicosatetraenoateReach from here →
  1. (12S)-hydroperoxy-(5Z,8Z,10E,14Z,17Z)-eicosapentaenoate + 2 glutathione = (12S)-hydroxy-(5Z,8Z,10E,14Z,17Z)-eicosapentaenoate + glutathione disulfide + H2O
  2. Glutathione: 15-HPETE oxidoreductase
  3. Resistance-Nodulation-Cell Division (Rnd) Tcdb:2.A.60.1.2

  Catalysed by GPX1, GPX4, GPX5, GPX2 and 6 morecytosol, extracellular spaceOne of 2 routes

• (9S)-hydroxy-(10E,12Z)-octadecadienoateReach from here →
  1. (12S)-hydroperoxy-(5Z,8Z,10E,14Z,17Z)-eicosapentaenoate + 2 glutathione = (12S)-hydroxy-(5Z,8Z,10E,14Z,17Z)-eicosapentaenoate + glutathione disulfide + H2O
  2. 2 glutathione + NADP(+) = glutathione disulfide + NADPH + H(+)
  3. (9S)-hydroperoxy-(10E,12Z)-octadecadienoate + 2 glutathione = (9S)-hydroxy-(10E,12Z)-octadecadienoate + glutathione disulfide + H2O

  Catalysed by GPX1, GPX4, GSR

• ursodeoxycholateReach from here →
  1. (12S)-hydroperoxy-(5Z,8Z,10E,14Z,17Z)-eicosapentaenoate + 2 glutathione = (12S)-hydroxy-(5Z,8Z,10E,14Z,17Z)-eicosapentaenoate + glutathione disulfide + H2O
  2. Glutathione: 15-HPETE oxidoreductase
  3. transport of GSH and ursodeoxycholate (cytosol to extracellular)

  Catalysed by GPX1, GPX4, GPX5, GPX2 and 7 morecytosol, extracellular spaceOne of 2 routes

• prostaglandin G2Reach from here →
  1. (12S)-hydroperoxy-(5Z,8Z,10E,14Z,17Z)-eicosapentaenoate + 2 glutathione = (12S)-hydroxy-(5Z,8Z,10E,14Z,17Z)-eicosapentaenoate + glutathione disulfide + H2O
  2. Glutathione: 15-HPETE oxidoreductase
  3. transport of GSH and prostaglandin G2 (cytosol to extracellular)

  Catalysed by GPX1, GPX4, GPX5, GPX2 and 6 morecytosol, extracellular spaceOne of 2 routes

• glycodeoxycholateReach from here →
  1. (12S)-hydroperoxy-(5Z,8Z,10E,14Z,17Z)-eicosapentaenoate + 2 glutathione = (12S)-hydroxy-(5Z,8Z,10E,14Z,17Z)-eicosapentaenoate + glutathione disulfide + H2O
  2. 2 glutathione + NADP(+) = glutathione disulfide + NADPH + H(+)
  3. glycodeoxycholate(in) + glutathione(in) + ATP + H2O = glycodeoxycholate(out) + glutathione(out) + ADP + phosphate + H(+)

  Catalysed by GPX1, GPX4, GSR, ABCC4inner side of the membrane, outer side of the membrane

• (12R)-hydroxy-(5Z,8Z,10E,14Z)-eicosatetraenoateReach from here →
  1. (12S)-hydroperoxy-(5Z,8Z,10E,14Z,17Z)-eicosapentaenoate + 2 glutathione = (12S)-hydroxy-(5Z,8Z,10E,14Z,17Z)-eicosapentaenoate + glutathione disulfide + H2O
  2. 2 glutathione + NADP(+) = glutathione disulfide + NADPH + H(+)
  3. (12R)-hydroperoxy-(5Z,8Z,10E,14Z)-eicosatetraenoate + 2 glutathione = (12R)-hydroxy-(5Z,8Z,10E,14Z)-eicosatetraenoate + glutathione disulfide + H2O

  Catalysed by GPX1, GPX4, GSR, GPX2