CMP-N-acetyl-beta-neuraminate

362,296 routes · scope human · up to 3 steps · built 5 October 2026 · Reactions · API

200 compounds within 3 steps: 51 in 1, 18 in 2, 131 in 3

Three steps

a globoside Gb3Cer (d18:1(4E))Reach from here →
1. ST3 beta-galactoside alpha-2,3-sialyltransferase (CMP-N-acetylneuraminate)
2. exo-alpha-sialidase (GM3)
3. alpha 1,4-galactosyltransferase (P blood group) (LacCer pool)
Catalysed by ST3GAL5, NEU4, NEU1, NEU3 and 2 morecytosolOne of 3 routes
D-glucosyl-N-acylsphingosineReach from here →
1. ST3 beta-galactoside alpha-2,3-sialyltransferase (CMP-N-acetylneuraminate)
2. exo-alpha-sialidase (GM3)
3. beta-D-Galactosyl-1,4-beta-D-glucosylceramide galactohydrolase
Catalysed by ST3GAL5, NEU4, NEU1, NEU3 and 5 morecytosol, lysosome
(5Z)-dodecenoyl-CoAReach from here →
1. ST8 alpha-N-acetyl-neuraminide alpha-2,8-sialyltransferase (CMP-N-acetylneuraminate)
2. solute carrier (acetyl-CoA)
3. acetyl-CoA C-acyltransferase (3-oxomyrist-7-enoyl-CoA)
Catalysed by ST8SIA1, SLC33A1, HADHA, ACAA2 and 1 morecytosol, mitochondrial matrixOne of 2 routes
(11Z)-docosenoyl-CoA(4-)Reach from here →
1. ST8 alpha-N-acetyl-neuraminide alpha-2,8-sialyltransferase (CMP-N-acetylneuraminate)
2. solute carrier (acetyl-CoA)
3. long-chain-fatty-acid-CoA ligase (cis-cetoleic acid)
Catalysed by ST8SIA1, SLC33A1, SLC27A2, ACSL4 and 6 morecytosolOne of 5 routes
(7Z)-tetradecenoyl-CoAReach from here →
1. ST8 alpha-N-acetyl-neuraminide alpha-2,8-sialyltransferase (CMP-N-acetylneuraminate)
2. solute carrier (acetyl-CoA)
3. long-chain-fatty-acid-CoA ligase ((7Z)-tetradecenoic acid)
Catalysed by ST8SIA1, SLC33A1, SLC27A2, ACSL4 and 6 morecytosolOne of 8 routes
(4Z,7Z,10Z,13Z)-hexadecatetraenoyl-CoAReach from here →
1. ST8 alpha-N-acetyl-neuraminide alpha-2,8-sialyltransferase (CMP-N-acetylneuraminate)
2. solute carrier (acetyl-CoA)
3. Fatty Acid Beta Oxidation (C18:4->C16:4), Mitochondrial
Catalysed by ST8SIA1, SLC33A1, HADHA, ACADVL and 1 morecytosol, mitochondrial matrixOne of 3 routes
(7Z,10Z)-hexadecadienoyl-CoAReach from here →
1. ST8 alpha-N-acetyl-neuraminide alpha-2,8-sialyltransferase (CMP-N-acetylneuraminate)
2. solute carrier (acetyl-CoA)
3. Fatty Acid Beta Oxidation Trans (C18:2->C16:2), Mitochondrial
Catalysed by ST8SIA1, SLC33A1, HADHA, ACADVL and 1 morecytosol, mitochondrial matrix
(4Z,7Z)-decadienoyl-CoAReach from here →
1. ST8 alpha-N-acetyl-neuraminide alpha-2,8-sialyltransferase (CMP-N-acetylneuraminate)
2. solute carrier (acetyl-CoA)
3. Fatty Acid Beta Oxidation (C12:3->C10:2), Mitochondrial
Catalysed by ST8SIA1, SLC33A1, ECHS1, ACAA2 and 1 morecytosol, mitochondrial matrixOne of 2 routes
(5Z)-octenoyl-CoAReach from here →
1. ST8 alpha-N-acetyl-neuraminide alpha-2,8-sialyltransferase (CMP-N-acetylneuraminate)
2. solute carrier (acetyl-CoA)
3. Fatty Acid Beta Oxidation (C10:2->C8:1), Mitochondrial
Catalysed by ST8SIA1, SLC33A1, ECHS1, ACAA2 and 1 morecytosol, mitochondrial matrixOne of 2 routes
CHEBI:27540Reach from here →
1. ST8 alpha-N-acetyl-neuraminide alpha-2,8-sialyltransferase (CMP-N-acetylneuraminate)
2. solute carrier (acetyl-CoA)
3. medium-chain acyl-CoA ligase (hexanoic acid)
Catalysed by ST8SIA1, SLC33A1, ACSM4, ACSM1 and 4 morecytosolOne of 6 routes
beta-D-galactoseReach from here →
1. ST3 beta-galactoside alpha-2,3-sialyltransferase (CMP-N-acetylneuraminate)
2. beta-galactosidase (GM1)
3. galactose[n] = beta-D-galactose[n]
Catalysed by ST3GAL5, LCT, GLB1, GLB1L and 2 morecytosol, nucleusOne of 2 routes
elaidic acidReach from here →
1. ST8 alpha-N-acetyl-neuraminide alpha-2,8-sialyltransferase (CMP-N-acetylneuraminate)
2. solute carrier (acetyl-CoA)
3. long-chain-fatty-acid-CoA ligase (elaidate)
Catalysed by ST8SIA1, SLC33A1, SLC27A2, ACSL4 and 6 morecytosolOne of 5 routes
a neolactoside IV(2)-alpha-Fuc-nLc4Cer(d18:1(4E))Reach from here →
1. ST3 beta-galactoside alpha-2,3-sialyltransferase (CMP-N-acetylneuraminate)
2. a neolactoside IV(3)-alpha-NeuAc-nLc4Cer(d18:1(4E)) + H2O = a neolactoside nLc4Cer(d18:1(4E)) + N-acetylneuraminate
3. a neolactoside nLc4Cer(d18:1(4E)) + GDP-beta-L-fucose = a neolactoside IV(2)-alpha-Fuc-nLc4Cer(d18:1(4E)) + GDP + H(+)
Catalysed by ST3GAL6, NEU2, FUT1, FUT2cytosol
CHEBI:28701Reach from here →
1. ST8 alpha-N-acetyl-neuraminide alpha-2,8-sialyltransferase (CMP-N-acetylneuraminate)
2. solute carrier (acetyl-CoA)
3. Propanoyl-CoA:acetyl-CoA C-acyltransferase
Catalysed by ST8SIA1, SLC33A1, ACAA1, SCP2 and 1 morecytosol, peroxisomeOne of 7 routes
N-glycoloylneuraminateReach from here →
1. ST3 beta-galactoside alpha-2,3-sialyltransferase (CMP-N-acetylneuraminate)
2. Sialidase, Cytosol (Neu2)
3. CMP-N-acetylneuraminate monooxygenase (N-acetylneuraminate)
Catalysed by ST3GAL5, NEU2cytosol
D-glucoseReach from here →
1. a beta-D-galactosyl-(1<->1')-N-acylsphing-4-enine + CMP-N-acetyl-beta-neuraminate = a ganglioside GM4 (d18:1(4E)) + CMP + H(+)
2. Acylneuraminyl hydrolase
3. galactosylceramidase (D-galactosyl-N-acylsphingosine)
Catalysed by ST3GAL5, NEU4, NEU1, NEU3 and 2 morelysosome
taurineReach from here →
1. ST8 alpha-N-acetyl-neuraminide alpha-2,8-sialyltransferase (CMP-N-acetylneuraminate)
2. solute carrier (acetyl-CoA)
3. bile acid-CoA:amino acid N-acyltransferase (taurodeoxycholate)
Catalysed by ST8SIA1, SLC33A1, BAATcytosolOne of 2 routes
an isogloboside iGb3Cer (d18:1(4E))Reach from here →
1. ST3 beta-galactoside alpha-2,3-sialyltransferase (CMP-N-acetylneuraminate)
2. exo-alpha-sialidase (GM3)
3. a beta-D-Gal-(1->4)-beta-D-Glc-(1<->1)-Cer(d18:1(4E)) + UDP-alpha-D-galactose = an isogloboside iGb3Cer (d18:1(4E)) + UDP + H(+)
Catalysed by ST3GAL5, NEU4, NEU1, NEU3 and 2 morecytosol
an N-acylsphing-4-enineReach from here →
1. a beta-D-galactosyl-(1<->1')-N-acylsphing-4-enine + CMP-N-acetyl-beta-neuraminate = a ganglioside GM4 (d18:1(4E)) + CMP + H(+)
2. Acylneuraminyl hydrolase
3. galactosylceramidase (D-galactosyl-N-acylsphingosine)
Catalysed by ST3GAL5, NEU4, NEU1, NEU3 and 2 morelysosomeOne of 2 routes
glycineReach from here →
1. ST8 alpha-N-acetyl-neuraminide alpha-2,8-sialyltransferase (CMP-N-acetylneuraminate)
2. solute carrier (acetyl-CoA)
3. glycine N-acyltransferase (N-arachidonoylglycine)
Catalysed by ST8SIA1, SLC33A1, GLYAT, GLYATL2 and 1 morecytosol, mitochondrial matrixOne of 10 routes
(R)-methylmalonyl-CoAReach from here →
1. ST8 alpha-N-acetyl-neuraminide alpha-2,8-sialyltransferase (CMP-N-acetylneuraminate)
2. solute carrier (acetyl-CoA)
3. aldehyde dehydrogenase (2-methyl-3-oxopropanoate)
Catalysed by ST8SIA1, SLC33A1, ALDH6A1cytosol, mitochondrial matrixOne of 2 routes
(S)-methylmalonyl-CoAReach from here →
1. ST8 alpha-N-acetyl-neuraminide alpha-2,8-sialyltransferase (CMP-N-acetylneuraminate)
2. solute carrier (acetyl-CoA)
3. (S)-methylmalonyl-CoA hydrolase
Catalysed by ST8SIA1, SLC33A1cytosol, mitochondrial matrix
3'-dephospho-CoAReach from here →
1. ST8 alpha-N-acetyl-neuraminide alpha-2,8-sialyltransferase (CMP-N-acetylneuraminate)
2. solute carrier (acetyl-CoA)
3. acid phosphatase 2, lysosomal (CoA)
Catalysed by ST8SIA1, SLC33A1, ACP2cytosol, lysosomeOne of 2 routes
(2E)-dodecenoyl-CoAReach from here →
1. ST8 alpha-N-acetyl-neuraminide alpha-2,8-sialyltransferase (CMP-N-acetylneuraminate)
2. solute carrier (acetyl-CoA)
3. (2E)-dodecenoyl-CoA formation
Catalysed by ST8SIA1, SLC33A1cytosol, mitochondrial matrixOne of 3 routes
4,8,12-trimethyltridecanoyl-CoAReach from here →
1. ST8 alpha-N-acetyl-neuraminide alpha-2,8-sialyltransferase (CMP-N-acetylneuraminate)
2. solute carrier (acetyl-CoA)
3. propanoyl-CoA C-acyltransferase (3-ketopristanoyl-CoA)
Catalysed by ST8SIA1, SLC33A1, ACAA1, MYO5Bcytosol, peroxisomeOne of 2 routes
(6Z,9Z,12Z)-octadecatrienoyl-CoAReach from here →
1. ST8 alpha-N-acetyl-neuraminide alpha-2,8-sialyltransferase (CMP-N-acetylneuraminate)
2. solute carrier (acetyl-CoA)
3. long-chain-fatty-acid-CoA ligase (gamma-linolenate)
Catalysed by ST8SIA1, SLC33A1, SLC27A2, ACSL4 and 6 morecytosolOne of 7 routes
butanoyl-CoAReach from here →
1. ST8 alpha-N-acetyl-neuraminide alpha-2,8-sialyltransferase (CMP-N-acetylneuraminate)
2. solute carrier (acetyl-CoA)
3. Butanoate:CoA ligase (AMP-forming)
Catalysed by ST8SIA1, SLC33A1, ACSM4, ACSM1 and 4 morecytosolOne of 9 routes
dodecanoyl-CoAReach from here →
1. ST8 alpha-N-acetyl-neuraminide alpha-2,8-sialyltransferase (CMP-N-acetylneuraminate)
2. solute carrier (acetyl-CoA)
3. long-chain-fatty-acid-CoA ligase (lauric acid)
Catalysed by ST8SIA1, SLC33A1, SLC27A2, ACSL4 and 6 morecytosolOne of 9 routes
glutaryl-CoAReach from here →
1. ST8 alpha-N-acetyl-neuraminide alpha-2,8-sialyltransferase (CMP-N-acetylneuraminate)
2. solute carrier (acetyl-CoA)
3. Production of Glutaryl Carnitine
Catalysed by ST8SIA1, SLC33A1, CPT1A, CPT1C and 1 morecytosolOne of 2 routes
eicosanoyl-CoAReach from here →
1. ST8 alpha-N-acetyl-neuraminide alpha-2,8-sialyltransferase (CMP-N-acetylneuraminate)
2. solute carrier (acetyl-CoA)
3. long-chain-fatty-acid-CoA ligase (eicosanoate)
Catalysed by ST8SIA1, SLC33A1, SLC27A2, ACSL4 and 6 morecytosolOne of 12 routes
itaconyl-CoAReach from here →
1. ST8 alpha-N-acetyl-neuraminide alpha-2,8-sialyltransferase (CMP-N-acetylneuraminate)
2. solute carrier (acetyl-CoA)
3. Itaconate:CoA ligase (GDP-forming)
Catalysed by ST8SIA1, SLC33A1, SUCLG1, SUCLG2 and 1 morecytosol, mitochondrial matrixOne of 2 routes
(9Z,12Z)-octadecadienoyl-CoAReach from here →
1. ST8 alpha-N-acetyl-neuraminide alpha-2,8-sialyltransferase (CMP-N-acetylneuraminate)
2. solute carrier (acetyl-CoA)
3. long-chain-fatty-acid-CoA ligase ((6Z,9Z)-octadecadienoic acid)
Catalysed by ST8SIA1, SLC33A1, SLC27A2, ACSL4 and 6 morecytosolOne of 13 routes
tetradecanoyl-CoAReach from here →
1. ST8 alpha-N-acetyl-neuraminide alpha-2,8-sialyltransferase (CMP-N-acetylneuraminate)
2. solute carrier (acetyl-CoA)
3. long-chain-fatty-acid-CoA ligase (myristic acid)
Catalysed by ST8SIA1, SLC33A1, SLC27A2, ACSL4 and 6 morecytosolOne of 11 routes
octanoyl-CoAReach from here →
1. ST8 alpha-N-acetyl-neuraminide alpha-2,8-sialyltransferase (CMP-N-acetylneuraminate)
2. solute carrier (acetyl-CoA)
3. Octanoyl-CoA:L-carnitine O-octanoyltransferase
Catalysed by ST8SIA1, SLC33A1, CROTcytosol, mitochondrial matrixOne of 20 routes
phytanoyl-CoAReach from here →
1. ST8 alpha-N-acetyl-neuraminide alpha-2,8-sialyltransferase (CMP-N-acetylneuraminate)
2. solute carrier (acetyl-CoA)
3. phytanate-CoA ligase
Catalysed by ST8SIA1, SLC33A1cytosolOne of 5 routes
octadecanoyl-CoAReach from here →
1. ST8 alpha-N-acetyl-neuraminide alpha-2,8-sialyltransferase (CMP-N-acetylneuraminate)
2. solute carrier (acetyl-CoA)
3. long-chain-fatty-acid-CoA ligase (stearate)
Catalysed by ST8SIA1, SLC33A1, SLC27A2, ACSL4 and 5 morecytosolOne of 15 routes
sphing-4-enineReach from here →
1. ST8 alpha-N-acetyl-neuraminide alpha-2,8-sialyltransferase (CMP-N-acetylneuraminate)
2. solute carrier (acetyl-CoA)
3. acyl-CoA:sphingosine N-acyltransferase
Catalysed by ST8SIA1, SLC33A1, ASAH1, ACER2 and 2 morecytosol, Golgi apparatusOne of 2 routes
spermidineReach from here →
1. ST8 alpha-N-acetyl-neuraminide alpha-2,8-sialyltransferase (CMP-N-acetylneuraminate)
2. solute carrier (acetyl-CoA)
3. diamine N-acetyltransferase (N1-acetylspermidine)
Catalysed by ST8SIA1, SLC33A1, SAT1, SAT2cytosolOne of 3 routes
L-methionineReach from here →
1. ST8 alpha-N-acetyl-neuraminide alpha-2,8-sialyltransferase (CMP-N-acetylneuraminate)
2. solute carrier (acetyl-CoA)
3. N-acetylglutamate synthase (N-acetylmethionine)
Catalysed by ST8SIA1, SLC33A1, NAGScytosol, mitochondrial matrix
L-alanineReach from here →
1. ST8 alpha-N-acetyl-neuraminide alpha-2,8-sialyltransferase (CMP-N-acetylneuraminate)
2. solute carrier (acetyl-CoA)
3. amino-acid N-acetyltransferase (N-acetyl-L-alanine)
Catalysed by ST8SIA1, SLC33A1cytosol, mitochondrial matrix
L-asparagineReach from here →
1. ST8 alpha-N-acetyl-neuraminide alpha-2,8-sialyltransferase (CMP-N-acetylneuraminate)
2. solute carrier (acetyl-CoA)
3. N-acetylglutamate synthase (N-acetyl-L-asparagine)
Catalysed by ST8SIA1, SLC33A1, NAGScytosol, mitochondrial matrix
L,L-cystathionineReach from here →
1. ST8 alpha-N-acetyl-neuraminide alpha-2,8-sialyltransferase (CMP-N-acetylneuraminate)
2. solute carrier (acetyl-CoA)
3. N-acetylglutamate synthase (N-acetyl-L-cystathionine)
Catalysed by ST8SIA1, SLC33A1, NAGScytosol, mitochondrial matrix
alpha-D-galactose 1-phosphateReach from here →
1. ST3 beta-galactoside alpha-2,3-sialyltransferase (CMP-N-acetylneuraminate)
2. beta-galactosidase (GM1)
3. galactokinase (galactose)
Catalysed by ST3GAL5, LCT, GLB1, GLB1L and 3 morecytosolOne of 2 routes
an acyl-CoAReach from here →
1. ST8 alpha-N-acetyl-neuraminide alpha-2,8-sialyltransferase (CMP-N-acetylneuraminate)
2. solute carrier (acetyl-CoA)
3. acyl-CoA:sphingosine N-acyltransferase
Catalysed by ST8SIA1, SLC33A1, ASAH1, ACER2 and 2 morecytosol, Golgi apparatusOne of 2 routes
(3Z)-dodecenoyl-CoAReach from here →
1. ST8 alpha-N-acetyl-neuraminide alpha-2,8-sialyltransferase (CMP-N-acetylneuraminate)
2. solute carrier (acetyl-CoA)
3. acetyl-CoA C-acyltransferase (3-oxomyrist-5-enoyl-CoA)
Catalysed by ST8SIA1, SLC33A1, HADHA, ACAA2 and 1 morecytosol, mitochondrial matrixOne of 3 routes
(25R)-3alpha,7alpha,12alpha-trihydroxy-5beta-cholestan-26-oyl-CoAReach from here →
1. ST8 alpha-N-acetyl-neuraminide alpha-2,8-sialyltransferase (CMP-N-acetylneuraminate)
2. solute carrier (acetyl-CoA)
3. 3alpha,7alpha,12alpha-trihydroxy-5beta-cholestanoate:CoA ligase (AMP-forming)
Catalysed by ST8SIA1, SLC33A1, SLC27A2, SLC27A5cytosol, endoplasmic reticulumOne of 3 routes
deoxycholoyl-CoAReach from here →
1. ST8 alpha-N-acetyl-neuraminide alpha-2,8-sialyltransferase (CMP-N-acetylneuraminate)
2. solute carrier (acetyl-CoA)
3. cholate-CoA ligase (3alpha,12alpha-dihydroxy-5beta-cholanate)
Catalysed by ST8SIA1, SLC33A1, SLC27A2, SLC27A5cytosolOne of 4 routes
decanoyl-CoAReach from here →
1. ST8 alpha-N-acetyl-neuraminide alpha-2,8-sialyltransferase (CMP-N-acetylneuraminate)
2. solute carrier (acetyl-CoA)
3. medium-chain acyl-CoA ligase (decanoic acid)
Catalysed by ST8SIA1, SLC33A1, ACSM4, ACSM1 and 4 morecytosolOne of 7 routes
(2E)-hexadecenoyl-CoAReach from here →
1. ST8 alpha-N-acetyl-neuraminide alpha-2,8-sialyltransferase (CMP-N-acetylneuraminate)
2. solute carrier (acetyl-CoA)
3. Carnitine O-Palmitoyltransferase
Catalysed by ST8SIA1, SLC33A1, CPT1A, CPT1C and 1 morecytosolOne of 4 routes
(9Z)-hexadecenoyl-CoAReach from here →
1. ST8 alpha-N-acetyl-neuraminide alpha-2,8-sialyltransferase (CMP-N-acetylneuraminate)
2. solute carrier (acetyl-CoA)
3. long-chain-fatty-acid-CoA ligase (palmitolate)
Catalysed by ST8SIA1, SLC33A1, SLC27A2, ACSL4 and 6 morecytosolOne of 11 routes