2-oxo-3-sulfanylpropanoate

Three steps

• (25R)-3alpha,7alpha,12alpha-trihydroxy-5beta-cholestan-26-oyl-CoAReach from here →
  1. L-Cysteine:2-oxoglutarate aminotransferase
  2. N-acetylglutamate synthase (N-acetyl-L-cysteine)
  3. 3alpha,7alpha,12alpha-trihydroxy-5beta-cholestanoate:CoA ligase (AMP-forming)

  Catalysed by GOT2, GOT1, NAGS, SLC27A2 and 1 morecytosol, mitochondrial matrix, endoplasmic reticulumOne of 3 routes

• 5-phospho-beta-D-ribosylamineReach from here →
  1. L-Cysteine:2-oxoglutarate aminotransferase
  2. transport of cysteine and glutamine (cytosol to extracellular)
  3. phosphoribosyl pyrophosphate amidotransferase (glutamine)

  Catalysed by GOT2, GOT1, SLC3A2, SLC7A5 and 2 morecytosol, extracellular spaceOne of 2 routes

• phosphoenolpyruvateReach from here →
  1. 3-mercaptopyruvate:sulfide sulfurtransferase
  2. Pyruvate:carbon-dioxide ligase (ADP-forming)
  3. oxaloacetate + GTP = phosphoenolpyruvate + GDP + CO2

  Catalysed by MPST, TST, PC, PCK1 and 1 morecytosol, mitochondrial matrix

• an N-acetyl-L-cysteine-S-conjugateReach from here →
  1. 3-mercaptopyruvate:sulfide sulfurtransferase
  2. transport of acetate and pyruvate (cytosol to extracellular)
  3. an N-acetyl-L-cysteine-S-conjugate + H2O = an S-substituted L-cysteine + acetate

  Catalysed by MPST, TST, SLC16A4, SLC16A5 and 4 morecytosol, extracellular space

• D-glucosamine 6-phosphateReach from here →
  1. L-Cysteine:2-oxoglutarate aminotransferase
  2. transport of cysteine and glutamine (cytosol to extracellular)
  3. D-fructose 6-phosphate + L-glutamine = D-glucosamine 6-phosphate + L-glutamate

  Catalysed by GOT2, GOT1, SLC3A2, SLC7A5 and 3 morecytosol, extracellular space

• L-methionine (S)-S-oxideReach from here →
  1. L-Cysteine:2-oxoglutarate aminotransferase
  2. transport of cysteine and methionine (cytosol to extracellular)
  3. [thioredoxin]-disulfide + L-methionine + H2O = L-methionine (S)-S-oxide + [thioredoxin]-dithiol

  Catalysed by GOT2, GOT1, SLC7A5, MSRAcytosol, extracellular space

• L-methionine (R)-S-oxideReach from here →
  1. L-Cysteine:2-oxoglutarate aminotransferase
  2. transport of cysteine and methionine (cytosol to extracellular)
  3. [thioredoxin]-disulfide + L-methionine + H2O = L-methionine (R)-S-oxide + [thioredoxin]-dithiol

  Catalysed by GOT2, GOT1, SLC7A5, MSRB3 and 2 morecytosol, extracellular space

• deoxycholoyl-CoAReach from here →
  1. L-Cysteine:2-oxoglutarate aminotransferase
  2. N-acetylglutamate synthase (N-acetyl-L-cysteine)
  3. cholate-CoA ligase (3alpha,12alpha-dihydroxy-5beta-cholanate)

  Catalysed by GOT2, GOT1, NAGS, SLC27A2 and 1 morecytosol, mitochondrial matrixOne of 4 routes

• N-(5Z,8Z,11Z,14Z)-eicosatetraenoyl-glycineReach from here →
  1. L-Cysteine:2-oxoglutarate aminotransferase
  2. transport of cysteine and glycine (cytosol to extracellular)
  3. (5Z,8Z,11Z,14Z)-eicosatetraenoyl-CoA + glycine = N-(5Z,8Z,11Z,14Z)-eicosatetraenoyl-glycine + CoA + H(+)

  Catalysed by GOT2, GOT1, SLC3A2, SLC7A5 and 2 morecytosol, extracellular spaceOne of 2 routes

• (6R)-L-erythro-5,6,7,8-tetrahydrobiopterinReach from here →
  1. 2-oxo-3-sulfanylpropanoate + L-kynurenine = kynurenate + L-cysteine + H2O
  2. kynurenate(out) + a dicarboxylate(in) = kynurenate(in) + a dicarboxylate(out)
  3. (6R)-L-erythro-5,6,7,8-tetrahydrobiopterin(out) + a dicarboxylate(in) = (6R)-L-erythro-5,6,7,8-tetrahydrobiopterin(in) + a dicarboxylate(out)

  Catalysed by AADAT, SLC22A8, SLC22A6inner side of the membrane, outer side of the membraneOne of 2 routes

• 4-aminobutanoateReach from here →
  1. L-Cysteine:2-oxoglutarate aminotransferase
  2. transport of chloride and cysteine (cytosol to extracellular)
  3. transport of 4-aminobutyrate and chloride (cytosol to extracellular)

  Catalysed by GOT2, GOT1, SLC6A14, SLC6A12cytosol, extracellular spaceOne of 4 routes

• 3-iodo-L-tyrosineReach from here →
  1. L-Cysteine:2-oxoglutarate aminotransferase
  2. transport of cysteine and tyrosine (cytosol to extracellular)
  3. thyroid peroxidase (iodine)

  Catalysed by GOT2, GOT1, SLC7A5, TPOcytosol, extracellular spaceOne of 2 routes

• dopamineReach from here →
  1. L-Cysteine:2-oxoglutarate aminotransferase
  2. cystine to cysteine conversion
  3. transport of dopamine and GSH (cytosol to extracellular)

  Catalysed by GOT2, GOT1, SLCO1A2, SLCO1B3cytosol, extracellular spaceOne of 2 routes

• (2S)-2-phospholactateReach from here →
  1. 3-mercaptopyruvate:sulfide sulfurtransferase
  2. (S)-lactate + NAD(+) = pyruvate + NADH + H(+)
  3. (2S)-2-phospholactate + H2O = (S)-lactate + phosphate

  Catalysed by MPST, TST, LDHA, LDHB and 4 morecytosolOne of 2 routes

• glycolithocholate 3-sulfateReach from here →
  1. L-Cysteine:2-oxoglutarate aminotransferase
  2. cystine to cysteine conversion
  3. transport of GSH and sulfoglycolithocholate (cytosol to extracellular)

  Catalysed by GOT2, GOT1, SLCO1A2, SLCO1B3cytosol, extracellular spaceOne of 2 routes

• a 2,3-dehydroacyl-CoAReach from here →
  1. L-Cysteine:2-oxoglutarate aminotransferase
  2. Mo-molybdopterin + L-cysteine + AH2 = thio-Mo-molybdopterin + L-alanine + A + H2O
  3. a 2,3-saturated acyl-CoA + A = a 2,3-dehydroacyl-CoA + AH2

  Catalysed by GOT2, GOT1, MOCOS, ACAD10cytosol

• L-prolineReach from here →
  1. L-Cysteine:2-oxoglutarate aminotransferase
  2. transport of alanine and cysteine (cytosol to extracellular)
  3. L-proline(out) + L-alanine(in) + Na(+)(out) = L-proline(in) + L-alanine(out) + Na(+)(in)

  Catalysed by GOT2, GOT1, SLC7A5, SLC1A4cytosol, extracellular space, inner side of the membrane, outer side of the membraneOne of 3 routes

• estrone 3-sulfateReach from here →
  1. 3-mercaptopyruvate:sulfide sulfurtransferase
  2. 3alpha-hydroxysteroid 3-dehydrogenase (Si-specific) (H2S2O3)
  3. estrone 3-sulfate + H2O = estrone + sulfate + H(+)

  Catalysed by MPST, TST, STScytosolOne of 3 routes

• prostaglandin E2Reach from here →
  1. L-Cysteine:2-oxoglutarate aminotransferase
  2. cystine to cysteine conversion
  3. transport of GSH and prostaglandin E2 (cytosol to extracellular)

  Catalysed by GOT2, GOT1, SLCO1A2, SLCO1B3cytosol, extracellular spaceOne of 8 routes

• N-benzoylglycineReach from here →
  1. L-Cysteine:2-oxoglutarate aminotransferase
  2. transport of cysteine and glycine (cytosol to extracellular)
  3. Hippurate (Benzoylglycinate) Formation

  Catalysed by GOT2, GOT1, SLC3A2, SLC7A5 and 1 morecytosol, extracellular space, mitochondrial matrixOne of 4 routes

• decanoyl-CoAReach from here →
  1. L-Cysteine:2-oxoglutarate aminotransferase
  2. N-acetylglutamate synthase (N-acetyl-L-cysteine)
  3. medium-chain acyl-CoA ligase (decanoic acid)

  Catalysed by GOT2, GOT1, NAGS, ACSM4 and 5 morecytosol, mitochondrial matrixOne of 7 routes

• (2E)-hexadecenoyl-CoAReach from here →
  1. L-Cysteine:2-oxoglutarate aminotransferase
  2. N-acetylglutamate synthase (N-acetyl-L-cysteine)
  3. Carnitine O-Palmitoyltransferase

  Catalysed by GOT2, GOT1, NAGS, CPT1A and 2 morecytosol, mitochondrial matrixOne of 4 routes

• (9Z)-hexadecenoyl-CoAReach from here →
  1. L-Cysteine:2-oxoglutarate aminotransferase
  2. N-acetylglutamate synthase (N-acetyl-L-cysteine)
  3. long-chain-fatty-acid-CoA ligase (palmitolate)

  Catalysed by GOT2, GOT1, NAGS, SLC27A2 and 7 morecytosol, mitochondrial matrixOne of 11 routes

• L-cysteinylglycineReach from here →
  1. L-Cysteine:2-oxoglutarate aminotransferase
  2. transport of alanine and cysteine (cytosol to extracellular)
  3. gamma-glutamyltransferase (alanine)

  Catalysed by GOT2, GOT1, SLC7A5, GGTLC3 and 5 morecytosol, extracellular spaceOne of 8 routes

• Fe(II)-heme aReach from here →
  1. L-Cysteine:2-oxoglutarate aminotransferase
  2. Mo-molybdopterin + L-cysteine + AH2 = thio-Mo-molybdopterin + L-alanine + A + H2O
  3. Fe(II)-heme o + 2 A + H2O = Fe(II)-heme a + 2 AH2

  Catalysed by GOT2, GOT1, MOCOS, COX15cytosol

• (R)-4'-phosphopantetheineReach from here →
  1. L-Cysteine:2-oxoglutarate aminotransferase
  2. (R)-4'-phosphopantothenate:L-cysteine ligase
  3. N-[(R)-4-phosphopantothenoyl]-L-cysteine + H(+) = (R)-4'-phosphopantetheine + CO2

  Catalysed by GOT2, GOT1, PPCS, PPCDCcytosol

• 3-hydroxyisovaleryl-CoAReach from here →
  1. L-Cysteine:2-oxoglutarate aminotransferase
  2. N-acetylglutamate synthase (N-acetyl-L-cysteine)
  3. (3-Hydroxyisovalerylcoa->3-Hydroxyisovalerylcarnitine)

  Catalysed by GOT2, GOT1, NAGS, CPT1A and 1 morecytosol, mitochondrial matrix

• (5-hydroxyindol-3-yl)acetateReach from here →
  1. 3-mercaptopyruvate:sulfide sulfurtransferase
  2. 3alpha-hydroxysteroid 3-dehydrogenase (Si-specific) (H2S2O3)
  3. Transport of 5-Hydroxyindoleacetate

  Catalysed by MPST, TST, SLC4A1cytosol, extracellular spaceOne of 2 routes

• dTMPReach from here →
  1. 3-mercaptopyruvate:sulfide sulfurtransferase
  2. pyruvate kinase (dTDP)
  3. DTDP Diphosphohydrolase

  Catalysed by MPST, TST, PKM, PKLR and 3 morecytosol, extracellular spaceOne of 5 routes

• CHEBI:63544Reach from here →
  1. L-Cysteine:2-oxoglutarate aminotransferase
  2. N-acetylglutamate synthase (N-acetyl-L-cysteine)
  3. long-chain-fatty-acid-CoA ligase (adrenic acid)

  Catalysed by GOT2, GOT1, NAGS, SLC27A2 and 7 morecytosol, mitochondrial matrixOne of 7 routes

• 3-demethylubiquinol-10Reach from here →
  1. 2-oxo-3-sulfanylpropanoate + [thioredoxin]-dithiol = [thioredoxin]-disulfide + hydrogen sulfide + pyruvate + H(+)
  2. ubiquinone-10 + hydrogen sulfide + sulfite + 2 H(+) = ubiquinol-10 + thiosulfate
  3. 3-demethylubiquinol-10 + S-adenosyl-L-methionine = ubiquinol-10 + S-adenosyl-L-homocysteine + H(+)

  Catalysed by MPST, SQOR, COQ3

• hexacosanoyl-CoAReach from here →
  1. L-Cysteine:2-oxoglutarate aminotransferase
  2. N-acetylglutamate synthase (N-acetyl-L-cysteine)
  3. long-chain-fatty-acid-CoA ligase (cerotic acid)

  Catalysed by GOT2, GOT1, NAGS, SLC27A2 and 7 morecytosol, mitochondrial matrixOne of 5 routes

• tetracosanoyl-CoAReach from here →
  1. L-Cysteine:2-oxoglutarate aminotransferase
  2. N-acetylglutamate synthase (N-acetyl-L-cysteine)
  3. long-chain-fatty-acid-CoA ligase (lignocerate)

  Catalysed by GOT2, GOT1, NAGS, SLC27A2 and 7 morecytosol, mitochondrial matrixOne of 10 routes

• docosanoyl-CoAReach from here →
  1. L-Cysteine:2-oxoglutarate aminotransferase
  2. N-acetylglutamate synthase (N-acetyl-L-cysteine)
  3. long-chain-fatty-acid-CoA ligase (behenic acid)

  Catalysed by GOT2, GOT1, NAGS, SLC27A2 and 7 morecytosol, mitochondrial matrixOne of 9 routes

• N(5)-[(Z)-amino(hydroxyimino)methyl]ornithineReach from here →
  1. L-Cysteine:2-oxoglutarate aminotransferase
  2. transport of arginine and cysteine (cytosol to extracellular)
  3. L-arginine,NADPH:oxygen oxidoreductase (N-(omega)-hydroxyarginine-forming)

  Catalysed by GOT2, GOT1, SLC7A6, NOS3 and 2 morecytosol, extracellular space

• Mo-molybdopterinReach from here →
  1. L-Cysteine:2-oxoglutarate aminotransferase
  2. transport of alanine and cysteine (cytosol to extracellular)
  3. Mo-molybdopterin + L-cysteine + AH2 = thio-Mo-molybdopterin + L-alanine + A + H2O

  Catalysed by GOT2, GOT1, SLC7A5, MOCOScytosol, extracellular spaceOne of 3 routes

• (2E)-octadecenoyl-CoAReach from here →
  1. L-Cysteine:2-oxoglutarate aminotransferase
  2. N-acetylglutamate synthase (N-acetyl-L-cysteine)
  3. Carnitine O-Palmitoyltransferase

  Catalysed by GOT2, GOT1, NAGS, CPT1A and 2 morecytosol, mitochondrial matrixOne of 3 routes

• (6Z,9Z,12Z,15Z)-octadecatetraenoyl-CoAReach from here →
  1. L-Cysteine:2-oxoglutarate aminotransferase
  2. N-acetylglutamate synthase (N-acetyl-L-cysteine)
  3. long-chain-fatty-acid-CoA ligase (stearidonic acid)

  Catalysed by GOT2, GOT1, NAGS, SLC27A2 and 7 morecytosol, mitochondrial matrixOne of 8 routes

• (R)-noradrenalineReach from here →
  1. L-Cysteine:2-oxoglutarate aminotransferase
  2. cystine to cysteine conversion
  3. transport of GSH and noradrenaline (cytosol to extracellular)

  Catalysed by GOT2, GOT1, SLCO1A2, SLCO1B3cytosol, extracellular spaceOne of 2 routes

• (5Z,8Z,11Z,14Z,17Z)-eicosapentaenoyl-CoAReach from here →
  1. L-Cysteine:2-oxoglutarate aminotransferase
  2. N-acetylglutamate synthase (N-acetyl-L-cysteine)
  3. long-chain-fatty-acid-CoA ligase (EPA)

  Catalysed by GOT2, GOT1, NAGS, SLC27A2 and 7 morecytosol, mitochondrial matrixOne of 9 routes

• (7Z,10Z,13Z,16Z,19Z)-docosapentaenoyl-CoAReach from here →
  1. L-Cysteine:2-oxoglutarate aminotransferase
  2. N-acetylglutamate synthase (N-acetyl-L-cysteine)
  3. long-chain-fatty-acid-CoA ligase (DPA)

  Catalysed by GOT2, GOT1, NAGS, SLC27A2 and 7 morecytosol, mitochondrial matrixOne of 6 routes

• (9Z,12Z,15Z)-octadecatrienoyl-CoAReach from here →
  1. L-Cysteine:2-oxoglutarate aminotransferase
  2. N-acetylglutamate synthase (N-acetyl-L-cysteine)
  3. long-chain-fatty-acid-CoA ligase (linolenate)

  Catalysed by GOT2, GOT1, NAGS, SLC27A2 and 7 morecytosol, mitochondrial matrixOne of 7 routes

• (13Z)-docosenoyl-CoAReach from here →
  1. L-Cysteine:2-oxoglutarate aminotransferase
  2. N-acetylglutamate synthase (N-acetyl-L-cysteine)
  3. long-chain-fatty-acid-CoA ligase (cis-erucic acid)

  Catalysed by GOT2, GOT1, NAGS, SLC27A2 and 7 morecytosol, mitochondrial matrixOne of 6 routes

• (11Z)-eicosenoyl-CoAReach from here →
  1. L-Cysteine:2-oxoglutarate aminotransferase
  2. N-acetylglutamate synthase (N-acetyl-L-cysteine)
  3. long-chain-fatty-acid-CoA ligase (cis-gondoic acid)

  Catalysed by GOT2, GOT1, NAGS, SLC27A2 and 7 morecytosol, mitochondrial matrixOne of 7 routes

• (9Z,12Z,15Z,18Z,21Z)-tetracosapentaenoyl-CoAReach from here →
  1. L-Cysteine:2-oxoglutarate aminotransferase
  2. N-acetylglutamate synthase (N-acetyl-L-cysteine)
  3. long-chain-fatty-acid-CoA ligase ((9Z,12Z,15Z,18Z,21Z)-TPA)

  Catalysed by GOT2, GOT1, NAGS, SLC27A2 and 7 morecytosol, mitochondrial matrixOne of 5 routes

• (6Z,9Z,12Z,15Z,18Z,21Z)-tetracosahexaenoyl-CoAReach from here →
  1. L-Cysteine:2-oxoglutarate aminotransferase
  2. N-acetylglutamate synthase (N-acetyl-L-cysteine)
  3. long-chain-fatty-acid-CoA ligase ((6Z,9Z,12Z,15Z,18Z,21Z)-THA)

  Catalysed by GOT2, GOT1, NAGS, SLC27A2 and 7 morecytosol, mitochondrial matrixOne of 4 routes

• (15Z)-tetracosenoyl-CoAReach from here →
  1. L-Cysteine:2-oxoglutarate aminotransferase
  2. N-acetylglutamate synthase (N-acetyl-L-cysteine)
  3. long-chain-fatty-acid-CoA ligase (nervonic acid)

  Catalysed by GOT2, GOT1, NAGS, SLC27A2 and 7 morecytosol, mitochondrial matrixOne of 6 routes

• (17Z)-hexacosenoyl-CoAReach from here →
  1. L-Cysteine:2-oxoglutarate aminotransferase
  2. N-acetylglutamate synthase (N-acetyl-L-cysteine)
  3. long-chain-fatty-acid-CoA ligase (ximenic acid)

  Catalysed by GOT2, GOT1, NAGS, SLC27A2 and 7 morecytosol, mitochondrial matrixOne of 4 routes

• (8Z,11Z,14Z)-eicosatrienoyl-CoAReach from here →
  1. L-Cysteine:2-oxoglutarate aminotransferase
  2. N-acetylglutamate synthase (N-acetyl-L-cysteine)
  3. long-chain-fatty-acid-CoA ligase (dihomo-gamma-linolenate)

  Catalysed by GOT2, GOT1, NAGS, SLC27A2 and 7 morecytosol, mitochondrial matrixOne of 5 routes

• (8Z,11Z,14Z,17Z)-eicosatetraenoyl-CoAReach from here →
  1. L-Cysteine:2-oxoglutarate aminotransferase
  2. N-acetylglutamate synthase (N-acetyl-L-cysteine)
  3. long-chain-fatty-acid-CoA ligase (omega-3-arachidonic acid)

  Catalysed by GOT2, GOT1, NAGS, SLC27A2 and 7 morecytosol, mitochondrial matrixOne of 5 routes