(6S)-5,6,7,8-tetrahydrofolate

1. (6R)-5,10-methylene-5,6,7,8-tetrahydrofolate + glycine + H2O = (6S)-5,6,7,8-tetrahydrofolate + L-serine
2. bile acid-CoA: amino acid N-acyltransferase

Catalysed by SHMT1, SHMT2, BAATperoxisomeOne of 3 routes

1. (6R)-5,10-methylene-5,6,7,8-tetrahydrofolate + glycine + H2O = (6S)-5,6,7,8-tetrahydrofolate + L-serine
2. succinyl-CoA + glycine + H(+) = 5-aminolevulinate + CO2 + CoA

Catalysed by SHMT1, SHMT2, ALAS1, ALAS2

1. (6R)-5,10-methylene-5,6,7,8-tetrahydrofolate + glycine + H2O = (6S)-5,6,7,8-tetrahydrofolate + L-serine
2. chenodeoxycholoyl-CoA + glycine = glycochenodeoxycholate + CoA + H(+)

Catalysed by SHMT1, SHMT2, BAAT

1. (6R)-5,10-methylene-5,6,7,8-tetrahydrofolate + glycine + H2O = (6S)-5,6,7,8-tetrahydrofolate + L-serine
2. bile acid-CoA: amino acid N-acyltransferase

Catalysed by SHMT1, SHMT2, BAATperoxisomeOne of 3 routes

1. (6R)-5,10-methylene-5,6,7,8-tetrahydrofolate + glycine + H2O = (6S)-5,6,7,8-tetrahydrofolate + L-serine
2. glycine + 2-oxoglutarate = glyoxylate + L-glutamate

Catalysed by SHMT1, SHMT2, AADATOne of 11 routes

1. (6R)-5,10-methylene-5,6,7,8-tetrahydrofolate + glycine + H2O = (6S)-5,6,7,8-tetrahydrofolate + L-serine
2. bile acid-CoA:amino acid N-acyltransferase (glycine)

Catalysed by SHMT1, SHMT2, BAATcytosolOne of 2 routes

1. (6R)-5,10-methylene-5,6,7,8-tetrahydrofolate + glycine + H2O = (6S)-5,6,7,8-tetrahydrofolate + L-serine
2. Acetyl-CoA:glycine C-acetyltransferase

Catalysed by SHMT1, SHMT2, GCATmitochondrial matrix

1. (6R)-5,10-methylene-5,6,7,8-tetrahydrofolate + glycine + H2O = (6S)-5,6,7,8-tetrahydrofolate + L-serine
2. L-Arginine:glycine amidinotransferase

Catalysed by SHMT1, SHMT2, GATMcytosolOne of 5 routes

1. (6R)-5,10-methylene-5,6,7,8-tetrahydrofolate + glycine + H2O = (6S)-5,6,7,8-tetrahydrofolate + L-serine
2. dihydrolipoyl dehydrogenase ([protein]-N6-(lipoyl)lysine)

Catalysed by SHMT1, SHMT2, GLDC, GCSHmitochondrial matrix

1. (6R)-5,10-methylene-5,6,7,8-tetrahydrofolate + glycine + H2O = (6S)-5,6,7,8-tetrahydrofolate + L-serine
2. sarcosine + O2 + H2O = formaldehyde + glycine + H2O2

Catalysed by SHMT1, SHMT2, PIPOXOne of 2 routes

1. (6R)-5,10-methylene-5,6,7,8-tetrahydrofolate + glycine + H2O = (6S)-5,6,7,8-tetrahydrofolate + L-serine
2. dUMP + (6R)-5,10-methylene-5,6,7,8-tetrahydrofolate = 7,8-dihydrofolate + dTMP

Catalysed by SHMT1, SHMT2, TYMS

1. 5-formimidoyltetrahydrofolate + L-glutamate = N-formimidoyl-L-glutamate + (6S)-5,6,7,8-tetrahydrofolate
2. 5-Formiminotetrahydrofolate ammonia-lyase (cyclizing)

Catalysed by FTCDcytosolOne of 5 routes

1. (6R)-5,10-methylene-5,6,7,8-tetrahydrofolate + glycine + H2O = (6S)-5,6,7,8-tetrahydrofolate + L-serine
2. an acyl-CoA + glycine = an N-acylglycine + CoA + H(+)

Catalysed by SHMT1, SHMT2, GLYATL3, GLYAT and 1 more

1. (6R)-5,10-methylene-5,6,7,8-tetrahydrofolate + glycine + H2O = (6S)-5,6,7,8-tetrahydrofolate + L-serine
2. L-Arginine:glycine amidinotransferase

Catalysed by SHMT1, SHMT2, GATMcytosolOne of 2 routes

1. (6R)-5,10-methylene-5,6,7,8-tetrahydrofolate + glycine + H2O = (6S)-5,6,7,8-tetrahydrofolate + L-serine
2. transport of glycine and methionine (cytosol to extracellular)

Catalysed by SHMT1, SHMT2, SLC7A5extracellular space, cytosolOne of 5 routes

1. (6R)-5,10-methylene-5,6,7,8-tetrahydrofolate + glycine + H2O = (6S)-5,6,7,8-tetrahydrofolate + L-serine
2. transport of glycine and tryptophan (cytosol to extracellular)

Catalysed by SHMT1, SHMT2, SLC7A5extracellular space, cytosolOne of 5 routes

1. (6R)-5,10-methylene-5,6,7,8-tetrahydrofolate + glycine + H2O = (6S)-5,6,7,8-tetrahydrofolate + L-serine
2. gamma-L-glutamyl-L-cysteine + glycine + ATP = glutathione + ADP + phosphate + H(+)

Catalysed by SHMT1, SHMT2, GSS

1. (6R)-5,10-methylene-5,6,7,8-tetrahydrofolate + glycine + H2O = (6S)-5,6,7,8-tetrahydrofolate + L-serine
2. transport of alanine and glycine (cytosol to extracellular)

Catalysed by SHMT1, SHMT2, SLC3A2, SLC7A5 and 1 moreextracellular space, cytosolOne of 6 routes

1. (6R)-5,10-methylene-5,6,7,8-tetrahydrofolate + glycine + H2O = (6S)-5,6,7,8-tetrahydrofolate + L-serine
2. leukotriene C4 hydrolysis

Catalysed by SHMT1, SHMT2cytosol

1. (6R)-5,10-methylene-5,6,7,8-tetrahydrofolate + glycine + H2O = (6S)-5,6,7,8-tetrahydrofolate + L-serine
2. transport of asparagine and glycine (cytosol to extracellular)

Catalysed by SHMT1, SHMT2extracellular space, cytosolOne of 4 routes

1. (6R)-5,10-methylene-5,6,7,8-tetrahydrofolate + glycine + H2O = (6S)-5,6,7,8-tetrahydrofolate + L-serine
2. transport of glycine and phenylalanine (cytosol to extracellular)

Catalysed by SHMT1, SHMT2, SLC7A5extracellular space, cytosolOne of 7 routes

1. (6R)-5,10-methylene-5,6,7,8-tetrahydrofolate + glycine + H2O = (6S)-5,6,7,8-tetrahydrofolate + L-serine
2. L-tyrosine + glyoxylate = 3-(4-hydroxyphenyl)pyruvate + glycine

Catalysed by SHMT1, SHMT2, AADAT

1. (6R)-5,10-methylene-5,6,7,8-tetrahydrofolate + glycine + H2O = (6S)-5,6,7,8-tetrahydrofolate + L-serine
2. N(omega),N(omega)-dimethyl-L-arginine + glyoxylate = 5-(3,3-dimethylguanidino)-2-oxopentanoate + glycine

Catalysed by SHMT1, SHMT2, AGXT2

1. (6S)-5,6,7,8-tetrahydrofolate + formate + ATP = (6R)-10-formyltetrahydrofolate + ADP + phosphate
2. (6R)-10-formyltetrahydrofolate + 5-amino-1-(5-phospho-beta-D-ribosyl)imidazole-4-carboxamide = 5-formamido-1-(5-phospho-D-ribosyl)imidazole-4-carboxamide + (6S)-5,6,7,8-tetrahydrofolate

Catalysed by MTHFD1, MTHFD1L, ATIC

1. 5-formimidoyltetrahydrofolate + L-glutamate = N-formimidoyl-L-glutamate + (6S)-5,6,7,8-tetrahydrofolate
2. 5-Formiminotetrahydrofolate:L-glutamate N-formiminotransferase

Catalysed by FTCDcytosol

1. (6R)-5,10-methylene-5,6,7,8-tetrahydrofolate + glycine + H2O = (6S)-5,6,7,8-tetrahydrofolate + L-serine
2. (5Z,8Z,11Z,14Z)-eicosatetraenoyl-CoA + glycine = N-(5Z,8Z,11Z,14Z)-eicosatetraenoyl-glycine + CoA + H(+)

Catalysed by SHMT1, SHMT2, GLYATL2One of 2 routes

1. (6R)-5,10-methylene-5,6,7,8-tetrahydrofolate + glycine + H2O = (6S)-5,6,7,8-tetrahydrofolate + L-serine
2. Hippurate (Benzoylglycinate) Formation

Catalysed by SHMT1, SHMT2mitochondrial matrixOne of 2 routes

1. (6R)-5,10-methylene-5,6,7,8-tetrahydrofolate + glycine + H2O = (6S)-5,6,7,8-tetrahydrofolate + L-serine
2. dUMP + (6R)-5,10-methylene-5,6,7,8-tetrahydrofolate = 7,8-dihydrofolate + dTMP

Catalysed by SHMT1, SHMT2, TYMS

1. (6R)-5,10-methylene-5,6,7,8-tetrahydrofolate + glycine + H2O = (6S)-5,6,7,8-tetrahydrofolate + L-serine
2. (2S)-2-aminobutanoate + glyoxylate = 2-oxobutanoate + glycine

Catalysed by SHMT1, SHMT2, AGXT2

1. (6R)-5,10-methylene-5,6,7,8-tetrahydrofolate + glycine + H2O = (6S)-5,6,7,8-tetrahydrofolate + L-serine
2. Glycodeoxycholate amidohydrolase

Catalysed by SHMT1, SHMT2cytosolOne of 2 routes

1. (6R)-5,10-methylene-5,6,7,8-tetrahydrofolate + glycine + H2O = (6S)-5,6,7,8-tetrahydrofolate + L-serine
2. tetradecanoyl-CoA + glycine = N-tetradecanoylglycine + CoA + H(+)

Catalysed by SHMT1, SHMT2, GLYATL2

1. (6R)-5,10-methylene-5,6,7,8-tetrahydrofolate + glycine + H2O = (6S)-5,6,7,8-tetrahydrofolate + L-serine
2. eicosanoyl-CoA + glycine = N-eicosanoylglycinate + CoA + H(+)

Catalysed by SHMT1, SHMT2, BAAT

1. (6R)-5,10-methylene-5,6,7,8-tetrahydrofolate + glycine + H2O = (6S)-5,6,7,8-tetrahydrofolate + L-serine
2. docosanoyl-CoA + glycine = N-docosanoylglycine + CoA + H(+)

Catalysed by SHMT1, SHMT2, BAAT

1. (6R)-5,10-methylene-5,6,7,8-tetrahydrofolate + glycine + H2O = (6S)-5,6,7,8-tetrahydrofolate + L-serine
2. hexacosanoyl-CoA + glycine = N-hexacosanoylglycine + CoA + H(+)

Catalysed by SHMT1, SHMT2, BAAT

1. (6R)-5,10-methylene-5,6,7,8-tetrahydrofolate + glycine + H2O = (6S)-5,6,7,8-tetrahydrofolate + L-serine
2. transport of glycine and tryptophan (cytosol to extracellular)
3. beta-carboline hydrolysis

Catalysed by SHMT1, SHMT2, SLC7A5extracellular space, cytosol

1. (6R)-5,10-methylene-5,6,7,8-tetrahydrofolate + glycine + H2O = (6S)-5,6,7,8-tetrahydrofolate + L-serine
2. bile acid-CoA: amino acid N-acyltransferase
3. Carnitine O-Palmitoyltransferase

Catalysed by and 2 more