glutaryl-CoA

Three steps

• ureaReach from here →
  1. glutaryl-CoA + H2O = glutarate + CoA + H(+)
  2. urate(in) + glutarate(out) = urate(out) + glutarate(in)
  3. Peroxidase

  Catalysed by ACOT8, ACOT4, SLC22A8, MPOinner side of the membrane, outer side of the membrane, nucleusOne of 3 routes

• 11-cis-retinyl hexadecanoateReach from here →
  1. Production of Glutaryl Carnitine
  2. Palmitate:CoA ligase (AMP-forming)
  3. Palmitoyl-CoA:retinol O-acyltransferase

  Catalysed by CPT1A, CPT1C, CPT1B, SLC27A2 and 12 morecytosolOne of 3 routes

• L-cystineReach from here →
  1. Production of Glutaryl Carnitine
  2. amino-acid N-acetyltransferase (N-acetyl-L-alanine)
  3. Transport of L-Cystine (L-Alanine antiport) by B0, +At Transporter

  Catalysed by CPT1A, CPT1C, CPT1B, SLC7A9 and 1 morecytosol, mitochondrial matrix, extracellular spaceOne of 5 routes

• (R)-3-aminoisobutyric acidReach from here →
  1. Production of Glutaryl Carnitine
  2. amino-acid N-acetyltransferase (N-acetyl-L-alanine)
  3. (R)-3-Amino-2-methylpropanoate:pyruvate aminotransferase

  Catalysed by CPT1A, CPT1C, CPT1B, AGXT2cytosol, mitochondrial matrix

• phosphatidic acidReach from here →
  1. Production of Glutaryl Carnitine
  2. acyl-CoA:sphingosine N-acyltransferase
  3. acyl-CoA:1-acyl-sn-glycerol-3-phosphate 2-O-acyltransferase

  Catalysed by CPT1A, CPT1C, CPT1B, ASAH1 and 12 morecytosol, Golgi apparatus, mitochondrial matrixOne of 7 routes

• L-citrullineReach from here →
  1. Production of Glutaryl Carnitine
  2. glycine N-acyltransferase (N-arachidonoylglycine)
  3. transport of citrulline and glycine (cytosol to extracellular)

  Catalysed by CPT1A, CPT1C, CPT1B, GLYAT and 5 morecytosol, mitochondrial matrix, extracellular spaceOne of 8 routes

• L-valineReach from here →
  1. Production of Glutaryl Carnitine
  2. glycine N-acyltransferase (N-arachidonoylglycine)
  3. transport of glycine and valine (cytosol to extracellular)

  Catalysed by CPT1A, CPT1C, CPT1B, GLYAT and 3 morecytosol, mitochondrial matrix, extracellular spaceOne of 20 routes

• L-arginineReach from here →
  1. Production of Glutaryl Carnitine
  2. glycine N-acyltransferase (N-arachidonoylglycine)
  3. transport of arginine and glycine (cytosol to extracellular)

  Catalysed by CPT1A, CPT1C, CPT1B, GLYAT and 3 morecytosol, mitochondrial matrix, extracellular spaceOne of 18 routes

• CHEBI:16523Reach from here →
  1. Production of Glutaryl Carnitine
  2. glycine N-acyltransferase (N-arachidonoylglycine)
  3. transport of D-serine and glycine (cytosol to extracellular)

  Catalysed by CPT1A, CPT1C, CPT1B, GLYAT and 4 morecytosol, mitochondrial matrix, extracellular spaceOne of 2 routes

• protein polypeptide chainReach from here →
  1. Production of Glutaryl Carnitine
  2. glycine N-acyltransferase (N-arachidonoylglycine)
  3. PROTEIN_BS

  Catalysed by CPT1A, CPT1C, CPT1B, GLYAT and 2 morecytosol, mitochondrial matrixOne of 5 routes

• CHEBI:16633Reach from here →
  1. Production of Glutaryl Carnitine
  2. amino-acid N-acetyltransferase (N-acetyl-L-alanine)
  3. L-selenocysteine selenide-lyase (L-alanine-forming)

  Catalysed by CPT1A, CPT1C, CPT1B, SCLYcytosol, mitochondrial matrix

• Met-tRNA(Met)Reach from here →
  1. Production of Glutaryl Carnitine
  2. N-acetylglutamate synthase (N-acetylmethionine)
  3. L-Methionine:tRNAMet ligase (AMP-forming)

  Catalysed by CPT1A, CPT1C, CPT1B, NAGS and 1 morecytosol, mitochondrial matrix

• (S)-lactateReach from here →
  1. glutaryl-CoA + H2O = glutarate + CoA + H(+)
  2. prostaglandin E2(out) + glutarate(in) = prostaglandin E2(in) + glutarate(out)
  3. prostaglandin E2(out) + 2 (S)-lactate(in) = prostaglandin E2(in) + 2 (S)-lactate(out)

  Catalysed by ACOT8, ACOT4, SLC22A8, SLCO2A1inner side of the membrane, outer side of the membraneOne of 5 routes

• 4-methylsulfanyl-2-oxobutanoateReach from here →
  1. Production of Glutaryl Carnitine
  2. N-acetylglutamate synthase (N-acetylmethionine)
  3. glyoxylate + L-methionine = 4-methylsulfanyl-2-oxobutanoate + glycine

  Catalysed by CPT1A, CPT1C, CPT1B, NAGS and 1 morecytosol, mitochondrial matrix

• 2-oxobutanoateReach from here →
  1. Production of Glutaryl Carnitine
  2. N-acetylglutamate synthase (N-acetyl-L-cystathionine)
  3. L-cystathionine cysteine-lyase (deaminating

  Catalysed by CPT1A, CPT1C, CPT1B, NAGS and 1 morecytosol, mitochondrial matrixOne of 2 routes

• CHEBI:16856Reach from here →
  1. Production of Glutaryl Carnitine
  2. N-acetyl-LTE4 to leukotriene E4 conversion
  3. transport of GSH and leukotriene E4 (cytosol to extracellular)

  Catalysed by CPT1A, CPT1C, CPT1B, ZDHHC11B and 32 morecytosol, extracellular spaceOne of 12 routes

• CHEBI:16857Reach from here →
  1. Production of Glutaryl Carnitine
  2. glycine N-acyltransferase (N-arachidonoylglycine)
  3. transport of glycine and threonine (cytosol to extracellular)

  Catalysed by CPT1A, CPT1C, CPT1B, GLYAT and 5 morecytosol, mitochondrial matrix, extracellular spaceOne of 19 routes

• pantetheine 4'-phosphateReach from here →
  1. Production of Glutaryl Carnitine
  2. acid phosphatase 2, lysosomal (CoA)
  3. Dephospho-CoA nucleotidohydrolase

  Catalysed by CPT1A, CPT1C, CPT1B, ACP2 and 2 morecytosol, lysosomeOne of 2 routes

• psychosineReach from here →
  1. Production of Glutaryl Carnitine
  2. acyl-CoA:sphingosine N-acyltransferase
  3. UDP-alpha-D-galactose:sphingosine 1-beta-galactosyltransferase

  Catalysed by CPT1A, CPT1C, CPT1B, ASAH1 and 3 morecytosol, Golgi apparatus

• glyoxylic acidReach from here →
  1. Production of Glutaryl Carnitine
  2. glycine N-acyltransferase (N-arachidonoylglycine)
  3. glycine:oxygen oxidoreductase (deaminating)

  Catalysed by CPT1A, CPT1C, CPT1B, GLYAT and 3 morecytosol, mitochondrial matrix, peroxisome

• 1-acyl-sn-glycerol 3-phosphateReach from here →
  1. Production of Glutaryl Carnitine
  2. acyl-CoA:sphingosine N-acyltransferase
  3. acyl-CoA:sn-glycerol-3-phosphate 1-O-acyltransferase

  Catalysed by CPT1A, CPT1C, CPT1B, ASAH1 and 7 morecytosol, Golgi apparatus, mitochondrial matrix

• a cholesterol esterReach from here →
  1. Production of Glutaryl Carnitine
  2. acyl-CoA:sphingosine N-acyltransferase
  3. an acyl-CoA + cholesterol = a cholesterol ester + CoA

  Catalysed by CPT1A, CPT1C, CPT1B, ASAH1 and 5 morecytosol, Golgi apparatus

• (R)-3-hydroxybutyric acidReach from here →
  1. 3-hydroxy-3-methylglutarate + glutaryl-CoA = (3S)-3-hydroxy-3-methylglutaryl-CoA + glutarate
  2. (3S)-3-hydroxy-3-methylglutaryl-CoA = acetoacetate + acetyl-CoA
  3. (R)-3-Hydroxybutanoate:NAD+ oxidoreductase

  Catalysed by SUGCT, HMGCL, HMGCLL1, BDH1 and 1 moremitochondrial matrixOne of 4 routes

• taurolithocholateReach from here →
  1. Production of Glutaryl Carnitine
  2. bile acid-CoA:amino acid N-acyltransferase (taurodeoxycholate)
  3. bile acid-CoA:amino acid N-acyltransferase (lithocholate)

  Catalysed by CPT1A, CPT1C, CPT1B, BAATcytosolOne of 2 routes

• L-isoleucineReach from here →
  1. Production of Glutaryl Carnitine
  2. glycine N-acyltransferase (N-arachidonoylglycine)
  3. transport of glycine and isoleucine (cytosol to extracellular)

  Catalysed by CPT1A, CPT1C, CPT1B, GLYAT and 3 morecytosol, mitochondrial matrix, extracellular spaceOne of 18 routes

• CHEBI:17203Reach from here →
  1. Production of Glutaryl Carnitine
  2. glycine N-acyltransferase (N-arachidonoylglycine)
  3. transport of glycine and proline (cytosol to extracellular)

  Catalysed by CPT1A, CPT1C, CPT1B, GLYAT and 4 morecytosol, mitochondrial matrix, extracellular spaceOne of 15 routes

• CHEBI:17208Reach from here →
  1. glutaryl-CoA + H2O = glutarate + CoA + H(+)
  2. urate(in) + glutarate(out) = urate(out) + glutarate(in)
  3. ascorbate to monodehydroascorbate conversion

  Catalysed by ACOT8, ACOT4, SLC22A8inner side of the membrane, outer side of the membrane, cytosol

• S-(4,8-dimethylnonanoyl)-4'-phosphopantetheineReach from here →
  1. Production of Glutaryl Carnitine
  2. Carnitine Dimethyl Nonanoyl Transferase, Revsible, Peroxisomal
  3. 4,8-dimethylnonanoyl-CoA + H2O = S-(4,8-dimethylnonanoyl)-4'-phosphopantetheine + adenosine 3',5'-bisphosphate + 2 H(+)

  Catalysed by CPT1A, CPT1C, CPT1B, CRAT and 2 morecytosol, peroxisome

• S-(9Z,12Z,15Z-octadecatrienoyl)-4'-phosphopantetheineReach from here →
  1. Production of Glutaryl Carnitine
  2. long-chain-fatty-acid-CoA ligase (linolenate)
  3. (9Z,12Z,15Z)-octadecatrienoyl-CoA + H2O = S-(9Z,12Z,15Z-octadecatrienoyl)-4'-phosphopantetheine + adenosine 3',5'-bisphosphate + 2 H(+)

  Catalysed by CPT1A, CPT1C, CPT1B, SLC27A2 and 8 morecytosol

• S-(9Z,12Z-octadecadienoyl)-4'-phosphopantetheineReach from here →
  1. Production of Glutaryl Carnitine
  2. long-chain-fatty-acid-CoA ligase ((6Z,9Z)-octadecadienoic acid)
  3. (9Z,12Z)-octadecadienoyl-CoA + H2O = S-(9Z,12Z-octadecadienoyl)-4'-phosphopantetheine + adenosine 3',5'-bisphosphate + 2 H(+)

  Catalysed by CPT1A, CPT1C, CPT1B, SLC27A2 and 8 morecytosol

• S-(9Z-hexadecenoyl)-4'-phosphopantetheineReach from here →
  1. Production of Glutaryl Carnitine
  2. long-chain-fatty-acid-CoA ligase (palmitolate)
  3. (9Z)-hexadecenoyl-CoA + H2O = S-(9Z-hexadecenoyl)-4'-phosphopantetheine + adenosine 3',5'-bisphosphate + 2 H(+)

  Catalysed by CPT1A, CPT1C, CPT1B, SLC27A2 and 8 morecytosol

• N-octadecanoyl-heptadecasphing-4-enineReach from here →
  1. Production of Glutaryl Carnitine
  2. long-chain-fatty-acid-CoA ligase (stearate)
  3. heptadecasphing-4-enine + octadecanoyl-CoA = N-octadecanoyl-heptadecasphing-4-enine + CoA + H(+)

  Catalysed by CPT1A, CPT1C, CPT1B, SLC27A2 and 7 morecytosol

• estroneReach from here →
  1. glutaryl-CoA + H2O = glutarate + CoA + H(+)
  2. estrone 3-sulfate(out) + glutarate(in) = estrone 3-sulfate(in) + glutarate(out)
  3. Estrone 3-sulfate sulfohydrolase

  Catalysed by ACOT8, ACOT4, SLC22A24, SLC22A8 and 2 moreinner side of the membrane, outer side of the membrane, cytosolOne of 3 routes

• propanoateReach from here →
  1. glutaryl-CoA + H2O = glutarate + CoA + H(+)
  2. estrone 3-sulfate(out) + glutarate(in) = estrone 3-sulfate(in) + glutarate(out)
  3. propanoate(in) + estrone 3-sulfate(out) = propanoate(out) + estrone 3-sulfate(in)

  Catalysed by ACOT8, ACOT4, SLC22A24, SLC22A8 and 2 moreinner side of the membrane, outer side of the membraneOne of 4 routes

• all-trans-retinolReach from here →
  1. Production of Glutaryl Carnitine
  2. Palmitoyl-CoA:retinol O-acyltransferase
  3. all-trans-Retinol 11-cis-trans-isomerase

  Catalysed by CPT1A, CPT1C, CPT1B, DGAT1 and 4 morecytosolOne of 2 routes

• linoleic acidReach from here →
  1. Production of Glutaryl Carnitine
  2. Carnitine O-Palmitoyltransferase
  3. Utilized Transport

  Catalysed by CPT1A, CPT1C, CPT1Bcytosol, endoplasmic reticulumOne of 3 routes

• 1-(alk-1-enyl)-2-acyl-sn-glycero-3-phosphoethanolamineReach from here →
  1. Production of Glutaryl Carnitine
  2. acyl-CoA:sphingosine N-acyltransferase
  3. Acyl-CoA:1-alkenylglycerophosphoethanolamine O-acyltransferase

  Catalysed by CPT1A, CPT1C, CPT1B, ASAH1 and 7 morecytosol, Golgi apparatus

• O-hexadecanoyl-(R)-carnitineReach from here →
  1. Production of Glutaryl Carnitine
  2. Carnitine O-Palmitoyltransferase
  3. palmitoyl-CoA:L-carnitine O-palmitoyltransferase

  Catalysed by CPT1A, CPT1C, CPT1B, CPT2cytosol, peroxisomeOne of 17 routes

• AH2Reach from here →
  1. Production of Glutaryl Carnitine
  2. bile acid-CoA:amino acid N-acyltransferase (taurodeoxycholate)
  3. uridine(34) in tRNA + 5,10-methylenetetrahydrofolate + taurine + GTP + A + H2O = 5-taurinomethyluridine(34) in tRNA + 7,8-dihydrofolate + GDP + AH2 + phosphate + H(+)

  Catalysed by CPT1A, CPT1C, CPT1B, BAAT and 1 morecytosolOne of 6 routes

• 1-O-acyl-sn-glycero-3-phosphocholine(1+)Reach from here →
  1. Production of Glutaryl Carnitine
  2. Palmitoyl-CoA:retinol O-acyltransferase
  3. Lecithin Retinol Acyltransferase (11-Cis)

  Catalysed by CPT1A, CPT1C, CPT1B, DGAT1 and 4 morecytosol

• S-methyl-5'-thioadenosineReach from here →
  1. Production of Glutaryl Carnitine
  2. diamine N-acetyltransferase (N1-acetylspermidine)
  3. S-adenosylmethioninamine:spermidine 3-aminopropyltransferase

  Catalysed by CPT1A, CPT1C, CPT1B, SAT1 and 3 morecytosolOne of 2 routes

• 5-aminolevulinic acidReach from here →
  1. Production of Glutaryl Carnitine
  2. glycine N-acyltransferase (N-arachidonoylglycine)
  3. succinyl-CoA:glycine C-succinyltransferase (decarboxylating)

  Catalysed by CPT1A, CPT1C, CPT1B, GLYAT and 5 morecytosol, mitochondrial matrixOne of 2 routes

• all-trans-retinyl hexadecanoateReach from here →
  1. Production of Glutaryl Carnitine
  2. Palmitoyl-CoA:retinol O-acyltransferase
  3. all-trans-retinyl hexadecanoate + H2O = 11-cis-retinol + hexadecanoate + H(+)

  Catalysed by CPT1A, CPT1C, CPT1B, DGAT1 and 5 morecytosol

• xanthineReach from here →
  1. glutaryl-CoA + H2O = glutarate + CoA + H(+)
  2. urate(in) + glutarate(out) = urate(out) + glutarate(in)
  3. xanthine + NAD(+) + H2O = urate + NADH + H(+)

  Catalysed by ACOT8, ACOT4, SLC22A8, XDHinner side of the membrane, outer side of the membraneOne of 2 routes

• Ala-tRNA(Ala)Reach from here →
  1. Production of Glutaryl Carnitine
  2. amino-acid N-acetyltransferase (N-acetyl-L-alanine)
  3. L-Alanine:tRNA(Ala) ligase (AMP-forming)

  Catalysed by CPT1A, CPT1C, CPT1B, AARS1cytosol, mitochondrial matrix

• glycine betaineReach from here →
  1. glutaryl-CoA + H2O = glutarate + CoA + H(+)
  2. glutarate(in) + (R)-carnitine(out) = glutarate(out) + (R)-carnitine(in)
  3. glycine betaine(out) + (R)-carnitine(in) = glycine betaine(in) + (R)-carnitine(out)

  Catalysed by ACOT8, ACOT4, SLC22A8, SLC22A5inner side of the membrane, outer side of the membraneOne of 2 routes

• CHEBI:17769Reach from here →
  1. Production of Glutaryl Carnitine
  2. diamine N-acetyltransferase (N1-acetylspermidine)
  3. spermidine:(acceptor) oxidoreductase

  Catalysed by CPT1A, CPT1C, CPT1B, SAT1 and 1 morecytosol

• 17beta-estradiol 17-O-(3-sulfo-beta-D-glucuronate)Reach from here →
  1. glutaryl-CoA + H2O = glutarate + CoA + H(+)
  2. 17beta-estradiol 17-O-(beta-D-glucuronate)(out) + glutarate(in) = 17beta-estradiol 17-O-(beta-D-glucuronate)(in) + glutarate(out)
  3. 17beta-estradiol 17-O-(beta-D-glucuronate) + 3'-phosphoadenylyl sulfate = 17beta-estradiol 17-O-(3-sulfo-beta-D-glucuronate) + adenosine 3',5'-bisphosphate + H(+)

  Catalysed by ACOT8, ACOT4, SLC22A24, CHST10inner side of the membrane, outer side of the membrane

• a 1,2-diacyl-sn-glycerolReach from here →
  1. Production of Glutaryl Carnitine
  2. acyl-CoA:sphingosine N-acyltransferase
  3. a 2-acylglycerol + an acyl-CoA = a 1,2-diacyl-sn-glycerol + CoA

  Catalysed by CPT1A, CPT1C, CPT1B, ASAH1 and 6 morecytosol, Golgi apparatus

• a triacylglycerolReach from here →
  1. Production of Glutaryl Carnitine
  2. acyl-CoA:sphingosine N-acyltransferase
  3. acyl-CoA:1,2-diacyl-sn-glycerol O-acyltransferase

  Catalysed by CPT1A, CPT1C, CPT1B, ASAH1 and 8 morecytosol, Golgi apparatus