taurolithocholate

Three steps

• CHEBI:15971Reach from here →
  1. transport of GSH and taurolithocholate (cytosol to extracellular)
  2. cystine to cysteine conversion
  3. transport of cysteine and histidine (cytosol to extracellular)

  Catalysed by SLCO1A2, SLCO1B3, SLC7A6extracellular space, cytosolOne of 2 routes

• (R)-lactateReach from here →
  1. transport of GSH and taurolithocholate (cytosol to extracellular)
  2. (R)-S-Lactoylglutathione methylglyoxal-lyase (isomerizing)
  3. (R)-S-lactoylglutathione + H2O = (R)-lactate + glutathione + H(+)

  Catalysed by SLCO1A2, SLCO1B3, GLO1, GLOD4 and 1 moreextracellular space, cytosol

• octan-1-olReach from here →
  1. transport of S-glutathionyl-2-4-dinitrobenzene (cytosol to extracellular)
  2. solute carrier organic anion transporter (chenodiol)
  3. octyl beta-D-glucose + chenodeoxycholate = beta-D-glucosyl-(1->3)-O-chenodeoxycholate + octan-1-ol

  Catalysed by SLCO1A2, SLCO1B3, GBA2extracellular space, cytosol

• sulfateReach from here →
  1. transport of GSH and taurolithocholate (cytosol to extracellular)
  2. transport of GSH and sulfoglycolithocholate (cytosol to extracellular)
  3. steroid sulfatase (sulfoglycolithocholate)

  Catalysed by SLCO1A2, SLCO1B3, STSextracellular space, cytosolOne of 7 routes

• L-cystineReach from here →
  1. transport of GSH and taurolithocholate (cytosol to extracellular)
  2. Glutathione: 5-HPETE oxidoreductase
  3. cystine to cysteine conversion

  Catalysed by SLCO1A2, SLCO1B3, GPX5, GPX1 and 7 moreextracellular space, cytosolOne of 5 routes

• L-citrullineReach from here →
  1. transport of GSH and taurolithocholate (cytosol to extracellular)
  2. cystine to cysteine conversion
  3. transport of citrulline and cysteine (cytosol to extracellular)

  Catalysed by SLCO1A2, SLCO1B3, SLC7A6extracellular space, cytosolOne of 2 routes

• iodideReach from here →
  1. transport of GSH and taurolithocholate (cytosol to extracellular)
  2. transport of GSH and thyroxine (cytosol to extracellular)
  3. 3,3',5-triiodo-L-thyronine,iodide:acceptor oxidoreductase (iodinating)

  Catalysed by SLCO1A2, SLCO1B3, DIO1, DIO2extracellular space, cytosolOne of 9 routes

• L-valineReach from here →
  1. transport of GSH and taurolithocholate (cytosol to extracellular)
  2. cystine to cysteine conversion
  3. transport of cysteine and valine (cytosol to extracellular)

  Catalysed by SLCO1A2, SLCO1B3, SLC7A5extracellular space, cytosolOne of 3 routes

• L-arginineReach from here →
  1. transport of GSH and taurolithocholate (cytosol to extracellular)
  2. cystine to cysteine conversion
  3. transport of arginine and cysteine (cytosol to extracellular)

  Catalysed by SLCO1A2, SLCO1B3, SLC7A6extracellular space, cytosolOne of 5 routes

• protein polypeptide chainReach from here →
  1. transport of GSH and taurolithocholate (cytosol to extracellular)
  2. cystine to cysteine conversion
  3. PROTEIN_BS

  Catalysed by SLCO1A2, SLCO1B3extracellular space, cytosol

• (S)-lactateReach from here →
  1. transport of GSH and taurolithocholate (cytosol to extracellular)
  2. transport of GSH and prostaglandin E2 (cytosol to extracellular)
  3. prostaglandin E2(out) + 2 (S)-lactate(in) = prostaglandin E2(in) + 2 (S)-lactate(out)

  Catalysed by SLCO1A2, SLCO1B3, SLCO2A1extracellular space, cytosol, inner side of the membrane, outer side of the membraneOne of 14 routes

• taurochenodeoxycholate 3-sulfateReach from here →
  1. transport of GSH and taurolithocholate (cytosol to extracellular)
  2. solute carrier organic anion transporter (GSH)
  3. taurochenodeoxycholate + 3'-phosphoadenylyl sulfate = taurochenodeoxycholate 3-sulfate + adenosine 3',5'-bisphosphate + H(+)

  Catalysed by SLCO1A2, SLCO1B3, SLC7A9, SULT2A1extracellular space, cytosol

• dopamine quinoneReach from here →
  1. transport of GSH and taurolithocholate (cytosol to extracellular)
  2. transport of dopamine and GSH (cytosol to extracellular)
  3. Peroxidase

  Catalysed by SLCO1A2, SLCO1B3, MPOextracellular space, cytosol, lysosomeOne of 4 routes

• formaldehydeReach from here →
  1. transport of GSH and taurolithocholate (cytosol to extracellular)
  2. alcohol dehydrogenase (formaldehyde)
  3. alcohol dehydrogenase (formaldehyde)

  Catalysed by SLCO1A2, SLCO1B3, ADH1C, ADH1A and 4 moreextracellular space, cytosol

• CHEBI:16857Reach from here →
  1. transport of GSH and taurolithocholate (cytosol to extracellular)
  2. cystine to cysteine conversion
  3. transport of cysteine and threonine (cytosol to extracellular)

  Catalysed by SLCO1A2, SLCO1B3, SLC7A5extracellular space, cytosolOne of 4 routes

• (R)-lactaldehydeReach from here →
  1. transport of GSH and taurolithocholate (cytosol to extracellular)
  2. (R)-S-Lactoylglutathione methylglyoxal-lyase (isomerizing)
  3. (R)-Lactaldehyde:NAD+ oxidoreductase (glutathione-formylating)

  Catalysed by SLCO1A2, SLCO1B3, GLO1, GLOD4 and 7 moreextracellular space, cytosol

• L-isoleucineReach from here →
  1. transport of GSH and taurolithocholate (cytosol to extracellular)
  2. cystine to cysteine conversion
  3. transport of cysteine and isoleucine (cytosol to extracellular)

  Catalysed by SLCO1A2, SLCO1B3, SLC7A5extracellular space, cytosolOne of 4 routes

• CHEBI:17203Reach from here →
  1. transport of GSH and taurolithocholate (cytosol to extracellular)
  2. cystine to cysteine conversion
  3. transport of cysteine and proline (cytosol to extracellular)

  Catalysed by SLCO1A2, SLCO1B3, SLC7A5extracellular space, cytosolOne of 3 routes

• dehydroascorbic acidReach from here →
  1. transport of GSH and taurolithocholate (cytosol to extracellular)
  2. transport of dopamine and GSH (cytosol to extracellular)
  3. dopamine,ascorbate:oxygen oxidoreductase (beta-hydroxylating)

  Catalysed by SLCO1A2, SLCO1B3, DBHextracellular space, cytosolOne of 19 routes

• estroneReach from here →
  1. transport of S-glutathionyl-2-4-dinitrobenzene (cytosol to extracellular)
  2. transport of estrone 3-sulfate (cytosol to extracellular)
  3. Estrone 3-sulfate sulfohydrolase

  Catalysed by SLCO1A2, SLCO1B3, SLCO1B1, STSextracellular space, cytosolOne of 3 routes

• propanoateReach from here →
  1. transport of S-glutathionyl-2-4-dinitrobenzene (cytosol to extracellular)
  2. transport of estrone 3-sulfate (cytosol to extracellular)
  3. propanoate(in) + estrone 3-sulfate(out) = propanoate(out) + estrone 3-sulfate(in)

  Catalysed by SLCO1A2, SLCO1B3, SLCO1B1, SLC22A9extracellular space, cytosol, inner side of the membrane, outer side of the membraneOne of 4 routes

• sulfiteReach from here →
  1. transport of GSH and taurolithocholate (cytosol to extracellular)
  2. Sulfide:glutathione,quinone oxidoreductase
  3. Persulfide dioxygenase

  Catalysed by SLCO1A2, SLCO1B3, SQOR, ETHE1extracellular space, cytosol, mitochondrial matrixOne of 2 routes

• 3,3',5-triiodo-L-thyronine sulfateReach from here →
  1. transport of GSH and taurolithocholate (cytosol to extracellular)
  2. transport of GSH and triiodothyronine (cytosol to extracellular)
  3. aryl sulfotransferase (PAPS)

  Catalysed by SLCO1A2, SLCO1B3, SULT1A3, SULT1A4 and 2 moreextracellular space, cytosolOne of 2 routes

• L-thyroxine sulfateReach from here →
  1. transport of GSH and taurolithocholate (cytosol to extracellular)
  2. transport of GSH and thyroxine (cytosol to extracellular)
  3. L-thyroxine + 3'-phosphoadenylyl sulfate = L-thyroxine sulfate + adenosine 3',5'-bisphosphate + H(+)

  Catalysed by SLCO1A2, SLCO1B3, SULT1A3, SULT1A4 and 1 moreextracellular space, cytosol

• 3,3'-diiodo-L-thyronineReach from here →
  1. transport of GSH and taurolithocholate (cytosol to extracellular)
  2. transport of GSH and triiodothyronine (cytosol to extracellular)
  3. thyroxine 5'-deiodinase (3,3-diiodo-L-thyronine)

  Catalysed by SLCO1A2, SLCO1B3, DIO1, DIO3 and 1 moreextracellular space, cytosolOne of 3 routes

• N-acetylserotoninReach from here →
  1. transport of GSH and taurolithocholate (cytosol to extracellular)
  2. transport of GSH and serotonin (cytosol to extracellular)
  3. acetyl-CoA:aralkylamine N-acetyltransferase

  Catalysed by SLCO1A2, SLCO1B3, AANATextracellular space, cytosol

• CHEBI:17724Reach from here →
  1. transport of GSH and taurolithocholate (cytosol to extracellular)
  2. Formation of Homocystine
  3. Trimethylaminoacetate:L-homosysteine S-methyltransferase

  Catalysed by SLCO1A2, SLCO1B3, BHMT, BHMT2extracellular space, cytosol

• urateReach from here →
  1. transport of GSH and taurolithocholate (cytosol to extracellular)
  2. glutathione:dehydroascorbate oxidoreductase
  3. ascorbate to monodehydroascorbate conversion

  Catalysed by SLCO1A2, SLCO1B3extracellular space, cytosol

• 5-hydroxy-L-tryptophanReach from here →
  1. transport of GSH and taurolithocholate (cytosol to extracellular)
  2. transport of GSH and serotonin (cytosol to extracellular)
  3. 5-hydroxy-L-tryptophan + H(+) = serotonin + CO2

  Catalysed by SLCO1A2, SLCO1B3, DDCextracellular space, cytosol

• prostaglandin F1Reach from here →
  1. transport of GSH and taurolithocholate (cytosol to extracellular)
  2. transport of GSH and prostaglandin E1 (cytosol to extracellular)
  3. prostaglandin E1 + NADPH + H(+) = prostaglandin F1 + NADP(+)

  Catalysed by SLCO1A2, SLCO1B3, SLCO2A1, DHRS1extracellular space, cytosol

• CHEBI:17895Reach from here →
  1. transport of GSH and taurolithocholate (cytosol to extracellular)
  2. cystine to cysteine conversion
  3. transport of cysteine and tyrosine (cytosol to extracellular)

  Catalysed by SLCO1A2, SLCO1B3, SLC7A5extracellular space, cytosolOne of 4 routes

• butanoateReach from here →
  1. transport of S-glutathionyl-2-4-dinitrobenzene (cytosol to extracellular)
  2. transport of estrone 3-sulfate (cytosol to extracellular)
  3. butanoate(out) + estrone 3-sulfate(in) = butanoate(in) + estrone 3-sulfate(out)

  Catalysed by SLCO1A2, SLCO1B3, SLCO1B1, SLC22A9extracellular space, cytosol, inner side of the membrane, outer side of the membraneOne of 4 routes

• CHEBI:18019Reach from here →
  1. transport of GSH and taurolithocholate (cytosol to extracellular)
  2. cystine to cysteine conversion
  3. transport of cysteine and lysine (cytosol to extracellular)

  Catalysed by SLCO1A2, SLCO1B3, SLC7A6extracellular space, cytosolOne of 2 routes

• L-glutamineReach from here →
  1. transport of GSH and taurolithocholate (cytosol to extracellular)
  2. cystine to cysteine conversion
  3. transport of cysteine and glutamine (cytosol to extracellular)

  Catalysed by SLCO1A2, SLCO1B3, SLC3A2, SLC7A5 and 1 moreextracellular space, cytosolOne of 4 routes

• (R)-3,4-dihydroxymandelaldehydeReach from here →
  1. transport of GSH and taurolithocholate (cytosol to extracellular)
  2. transport of GSH and noradrenaline (cytosol to extracellular)
  3. (R)-noradrenaline + O2 + H2O = (R)-3,4-dihydroxymandelaldehyde + H2O2 + NH4(+)

  Catalysed by SLCO1A2, SLCO1B3, MAOA, MAOBextracellular space, cytosol

• CHEBI:18183Reach from here →
  1. transport of GSH and taurolithocholate (cytosol to extracellular)
  2. gamma-glutamyltransferase (alanine)
  3. gamma-glutamylcyclotransferase ((5-L-glutamyl)-L-amino acid)

  Catalysed by SLCO1A2, SLCO1B3, GGT1, GGT5 and 6 moreextracellular space, cytosol

• (R)-normetanephrineReach from here →
  1. transport of GSH and taurolithocholate (cytosol to extracellular)
  2. transport of GSH and noradrenaline (cytosol to extracellular)
  3. S-Adenosyl-L-methionine:catechol O-methyltransferase

  Catalysed by SLCO1A2, SLCO1B3, COMT, LRTOMTextracellular space, cytosol

• 5,6,7,8-tetrahydrofolic acidReach from here →
  1. transport of GSH and taurolithocholate (cytosol to extracellular)
  2. Formation of Homocystine
  3. 5-methyltetrahydrofolate:L-homocysteine S-methyltransferase

  Catalysed by SLCO1A2, SLCO1B3, MTRextracellular space, cytosol

• S-disulfanyl-L-cysteineReach from here →
  1. transport of GSH and taurolithocholate (cytosol to extracellular)
  2. cystine to cysteine conversion
  3. S-sulfanyl-L-cysteine + L-cysteine = S-disulfanyl-L-cysteine + L-alanine

  Catalysed by SLCO1A2, SLCO1B3, CARS2extracellular space, cytosol

• O-[(5Z),(8Z),(11Z),(14Z)-eicosatetraenoyl]-beta-D-glucuronateReach from here →
  1. transport of GSH and taurolithocholate (cytosol to extracellular)
  2. transport of arachidonate and GSH (cytosol to extracellular)
  3. (5Z,8Z,11Z,14Z)-eicosatetraenoate + UDP-alpha-D-glucuronate = O-[(5Z),(8Z),(11Z),(14Z)-eicosatetraenoyl]-beta-D-glucuronate + UDP

  Catalysed by SLCO1A2, SLCO1B3, UGT1A9, UGT2B7 and 4 moreextracellular space, cytosol

• 20-O-(beta-D-glucuronosyl)-(5Z,8Z,11Z,14Z)-eicosatetraenoateReach from here →
  1. transport of GSH and taurolithocholate (cytosol to extracellular)
  2. Resistance-Nodulation-Cell Division (Rnd) Tcdb:2.A.60.1.2
  3. 20-hydroxy-(5Z,8Z,11Z,14Z)-eicosatetraenoate + UDP-alpha-D-glucuronate = 20-O-(beta-D-glucuronosyl)-(5Z,8Z,11Z,14Z)-eicosatetraenoate + UDP + H(+)

  Catalysed by SLCO1A2, SLCO1B3, SLCO2A1, UGT2B7 and 2 moreextracellular space, cytosol

• 15-O-(beta-D-glucuronosyl)-prostaglandin B1Reach from here →
  1. transport of GSH and taurolithocholate (cytosol to extracellular)
  2. transport of GSH and prostaglandin B1 (cytosol to extracellular)
  3. prostaglandin B1 + UDP-alpha-D-glucuronate = 15-O-(beta-D-glucuronosyl)-prostaglandin B1 + UDP + H(+)

  Catalysed by SLCO1A2, SLCO1B3, SLCO2A1, UGT1A9 and 3 moreextracellular space, cytosol

• serotonin O-sulfateReach from here →
  1. transport of GSH and taurolithocholate (cytosol to extracellular)
  2. transport of GSH and serotonin (cytosol to extracellular)
  3. serotonin + 3'-phosphoadenylyl sulfate = serotonin O-sulfate + adenosine 3',5'-bisphosphate + H(+)

  Catalysed by SLCO1A2, SLCO1B3, SULT1A3, SULT1A4extracellular space, cytosol

• (R)-noradrenaline 4'-O-sulfateReach from here →
  1. transport of GSH and taurolithocholate (cytosol to extracellular)
  2. transport of GSH and noradrenaline (cytosol to extracellular)
  3. sulfotransferase (noradrenaline)

  Catalysed by SLCO1A2, SLCO1B3, SULT1A3extracellular space, cytosolOne of 2 routes

• L-homocysteine thiolactoneReach from here →
  1. transport of GSH and taurolithocholate (cytosol to extracellular)
  2. Formation of Homocystine
  3. arylesterase (homocysteine-thiolactone)

  Catalysed by SLCO1A2, SLCO1B3, PON1, PON2 and 1 moreextracellular space, cytosol

• ursodeoxycholate 3-sulfateReach from here →
  1. transport of GSH and taurolithocholate (cytosol to extracellular)
  2. transport of GSH and ursodeoxycholate (cytosol to extracellular)
  3. ursodeoxycholate + 3'-phosphoadenylyl sulfate = ursodeoxycholate 3-sulfate + adenosine 3',5'-bisphosphate + H(+)

  Catalysed by SLCO1A2, SLCO1B3, SULT2A1extracellular space, cytosol

• tauroursodeoxycholate 3-sulfateReach from here →
  1. transport of GSH and taurolithocholate (cytosol to extracellular)
  2. transport of GSH and tauroursodeoxycholate (cytosol to extracellular)
  3. tauroursodeoxycholate + 3'-phosphoadenylyl sulfate = tauroursodeoxycholate 3-sulfate + adenosine 3',5'-bisphosphate + H(+)

  Catalysed by SLCO1A2, SLCO1B3, SULT2A1extracellular space, cytosol

• glycoursodeoxycholate 3-sulfateReach from here →
  1. transport of GSH and taurolithocholate (cytosol to extracellular)
  2. transport of glycoursodeoxycholate and GSH (cytosol to extracellular)
  3. glycoursodeoxycholate + 3'-phosphoadenylyl sulfate = glycoursodeoxycholate 3-sulfate + adenosine 3',5'-bisphosphate + H(+)

  Catalysed by SLCO1A2, SLCO1B3, SULT2A1extracellular space, cytosol

• chenodeoxycholate 3-sulfateReach from here →
  1. transport of S-glutathionyl-2-4-dinitrobenzene (cytosol to extracellular)
  2. solute carrier organic anion transporter (chenodiol)
  3. chenodeoxycholate + 3'-phosphoadenylyl sulfate = chenodeoxycholate 3-sulfate + adenosine 3',5'-bisphosphate + H(+)

  Catalysed by SLCO1A2, SLCO1B3, SULT2A1extracellular space, cytosol

• deoxycholateReach from here →
  1. transport of GSH and taurolithocholate (cytosol to extracellular)
  2. solute carrier organic anion transporter (cholate)
  3. cytochrome P450 (cholate)

  Catalysed by SLCO1A2, SLCO1B3, CYP7A1extracellular space, cytosolOne of 4 routes