5(S)-HPETE

Three steps

• 15-deoxy-Delta(12,14)-prostaglandin J2-S-(R)-glutathioneReach from here →
  1. Glutathione: 5-HPETE oxidoreductase
  2. 2 glutathione + NADP(+) = glutathione disulfide + NADPH + H(+)
  3. 15-deoxy-Delta(12,14)-prostaglandin J2 + glutathione = 15-deoxy-Delta(12,14)-prostaglandin J2-S-(R)-glutathione

  Catalysed by GPX5, GPX1, GPX2, GPX3 and 7 morecytosol

• (5S)-hydroxy-(6E,8Z,11Z,14Z,17Z)-eicosapentaenoateReach from here →
  1. Glutathione: 5-HPETE oxidoreductase
  2. 2 glutathione + NADP(+) = glutathione disulfide + NADPH + H(+)
  3. (5S)-hydroperoxy-(6E,8Z,11Z,14Z,17Z)-eicosapentaenoate + 2 glutathione = (5S)-hydroxy-(6E,8Z,11Z,14Z,17Z)-eicosapentaenoate + glutathione disulfide + H2O

  Catalysed by GPX5, GPX1, GPX2, GPX3 and 6 morecytosol

• (12S)-hydroxy-(5Z,8Z,10E,14Z,17Z)-eicosapentaenoateReach from here →
  1. Glutathione: 5-HPETE oxidoreductase
  2. 2 glutathione + NADP(+) = glutathione disulfide + NADPH + H(+)
  3. (12S)-hydroperoxy-(5Z,8Z,10E,14Z,17Z)-eicosapentaenoate + 2 glutathione = (12S)-hydroxy-(5Z,8Z,10E,14Z,17Z)-eicosapentaenoate + glutathione disulfide + H2O

  Catalysed by GPX5, GPX1, GPX2, GPX3 and 6 morecytosol

• (15S)-hydroxy-(11Z,13E)-eicosadienoateReach from here →
  1. Glutathione: 5-HPETE oxidoreductase
  2. 2 glutathione + NADP(+) = glutathione disulfide + NADPH + H(+)
  3. (15S)-hydroperoxy-(11Z,13E)-eicosadienoate + 2 glutathione = (15S)-hydroxy-(11Z,13E)-eicosadienoate + glutathione disulfide + H2O

  Catalysed by GPX5, GPX1, GPX2, GPX3 and 6 morecytosol

• (17S)-hydroxy-(4Z,7Z,10Z,13Z,15E,19Z)-docosahexaenoateReach from here →
  1. Glutathione: 5-HPETE oxidoreductase
  2. 2 glutathione + NADP(+) = glutathione disulfide + NADPH + H(+)
  3. (17S)-hydroperoxy-(4Z,7Z,10Z,13Z,15E,19Z)-docosahexaenoate + 2 glutathione = (17S)-hydroxy-(4Z,7Z,10Z,13Z,15E,19Z)-docosahexaenoate + glutathione disulfide + H2O

  Catalysed by GPX5, GPX1, GPX2, GPX3 and 6 morecytosol

• a hydroxy-1,2-diacyl-glycero-3-phosphocholineReach from here →
  1. Glutathione: 5-HPETE oxidoreductase
  2. 2 glutathione + NADP(+) = glutathione disulfide + NADPH + H(+)
  3. a hydroperoxy-1,2-diacyl-glycero-3-phosphocholine + 2 glutathione = a hydroxy-1,2-diacyl-glycero-3-phosphocholine + glutathione disulfide + H2O

  Catalysed by GPX5, GPX1, GPX2, GPX3 and 6 morecytosol

• 3-(glutathion-S-yl)-4-hydroxynonanalReach from here →
  1. Glutathione: 5-HPETE oxidoreductase
  2. 2 glutathione + NADP(+) = glutathione disulfide + NADPH + H(+)
  3. (E)-4-hydroxynon-2-enal + glutathione = 3-(glutathion-S-yl)-4-hydroxynonanal

  Catalysed by GPX5, GPX1, GPX2, GPX3 and 7 morecytosol

• a quinolReach from here →
  1. Glutathione: 5-HPETE oxidoreductase
  2. 2 glutathione + NADP(+) = glutathione disulfide + NADPH + H(+)
  3. a quinone + hydrogen sulfide + glutathione + H(+) = S-sulfanylglutathione + a quinol

  Catalysed by GPX5, GPX1, GPX2, GPX3 and 7 morecytosol

• CHEBI:28666Reach from here →
  1. arachidonate:oxygen 5-oxidoreductase
  2. leukotriene C4 synthase (GSH)
  3. gamma-glutamyltransferase (leukotriene C4)

  Catalysed by ALOX5, LTC4S, GGT1, GGT5 and 4 morecytosol, extracellular spaceOne of 7 routes

• 3-disulfanyl-L-alanineReach from here →
  1. Glutathione: 5-HPETE oxidoreductase
  2. cystine to cysteine conversion
  3. L-cystine thiocysteine-lyase (deaminating

  Catalysed by GPX5, GPX1, GPX2, GPX3 and 6 morecytosol

• L-ascorbic acidReach from here →
  1. Glutathione: 5-HPETE oxidoreductase
  2. 2 glutathione + NADP(+) = glutathione disulfide + NADPH + H(+)
  3. L-dehydroascorbate + 2 glutathione = glutathione disulfide + L-ascorbate

  Catalysed by GPX5, GPX1, GPX2, GPX3 and 9 morecytosol

• glycocholateReach from here →
  1. arachidonate:oxygen 5-oxidoreductase
  2. transport of leukotriene A4 (cytosol to extracellular)
  3. solute carrier organic anion transporter (glycocholate)

  Catalysed by ALOX5, SLCO1B1, SLCO1A2, SLCO1B3cytosol, extracellular spaceOne of 5 routes

• cholateReach from here →
  1. arachidonate:oxygen 5-oxidoreductase
  2. transport of leukotriene A4 (cytosol to extracellular)
  3. solute carrier organic anion transporter (cholate)

  Catalysed by ALOX5, SLCO1B1, SLCO1A2, SLCO1B3cytosol, extracellular spaceOne of 5 routes

• hydrogen sulfideReach from here →
  1. Glutathione: 5-HPETE oxidoreductase
  2. 2 glutathione + NADP(+) = glutathione disulfide + NADPH + H(+)
  3. thiosulfate + 2 glutathione = glutathione disulfide + hydrogen sulfide + sulfite + 2 H(+)

  Catalysed by GPX5, GPX1, GPX2, GPX3 and 7 morecytosolOne of 3 routes

• L-aspartateReach from here →
  1. Glutathione: 5-HPETE oxidoreductase
  2. cystine to cysteine conversion
  3. L-cystine(out) + L-aspartate(in) = L-cystine(in) + L-aspartate(out)

  Catalysed by GPX5, GPX1, GPX2, GPX3 and 6 morecytosol, inner side of the membrane, outer side of the membraneOne of 2 routes

• an alcoholReach from here →
  1. Glutathione: 5-HPETE oxidoreductase
  2. 2 glutathione + NADP(+) = glutathione disulfide + NADPH + H(+)
  3. a hydroperoxide + 2 glutathione = an alcohol + glutathione disulfide + H2O

  Catalysed by GPX5, GPX1, GPX2, GPX3 and 7 morecytosol

• (5Z,8Z,11Z,14Z)-eicosatetraenoateReach from here →
  1. arachidonate:oxygen 5-oxidoreductase
  2. transport of leukotriene A4 (cytosol to extracellular)
  3. transport of arachidonate (cytosol to extracellular)

  Catalysed by ALOX5, SLCO1B1cytosol, extracellular spaceOne of 4 routes

• serotoninReach from here →
  1. arachidonate:oxygen 5-oxidoreductase
  2. transport of leukotriene A4 (cytosol to extracellular)
  3. transport of serotonin (cytosol to extracellular)

  Catalysed by ALOX5, SLCO1B1, SLCO1A2, SLCO1B3cytosol, extracellular spaceOne of 4 routes

• chenodeoxycholateReach from here →
  1. arachidonate:oxygen 5-oxidoreductase
  2. transport of leukotriene A4 (cytosol to extracellular)
  3. solute carrier organic anion transporter (chenodiol)

  Catalysed by ALOX5, SLCO1B1, SLCO1A2, SLCO1B3cytosol, extracellular spaceOne of 2 routes

• glycochenodeoxycholateReach from here →
  1. Glutathione: 5-HPETE oxidoreductase
  2. 2 glutathione + NADP(+) = glutathione disulfide + NADPH + H(+)
  3. glycochenodeoxycholate(in) + glutathione(in) + ATP + H2O = glycochenodeoxycholate(out) + glutathione(out) + ADP + phosphate + H(+)

  Catalysed by GPX5, GPX1, GPX2, GPX3 and 7 morecytosol, inner side of the membrane, outer side of the membrane

• taurocholateReach from here →
  1. arachidonate:oxygen 5-oxidoreductase
  2. transport of leukotriene A4 (cytosol to extracellular)
  3. solute carrier organic anion transporter (S-glutathionyl-2-4-dinitrobenzene)

  Catalysed by ALOX5, SLCO1B1, SLCO1A2, SLCO1B3cytosol, extracellular spaceOne of 5 routes

• glycolithocholic acidReach from here →
  1. arachidonate:oxygen 5-oxidoreductase
  2. transport of leukotriene A4 (cytosol to extracellular)
  3. transport of glycolithocholate (cytosol to extracellular)

  Catalysed by ALOX5, SLCO1B1, SLCO1A2, SLCO1B3cytosol, extracellular spaceOne of 4 routes

• tert-butanolReach from here →
  1. Glutathione: 5-HPETE oxidoreductase
  2. 2 glutathione + NADP(+) = glutathione disulfide + NADPH + H(+)
  3. tert-butyl hydroperoxide + 2 glutathione = tert-butanol + glutathione disulfide + H2O

  Catalysed by GPX5, GPX1, GPX2, GPX3 and 7 morecytosol

• gamma-Glu-AlaReach from here →
  1. arachidonate:oxygen 5-oxidoreductase
  2. transport of GSH and leukotriene A4 (cytosol to extracellular)
  3. gamma-glutamyltransferase (alanine)

  Catalysed by ALOX5, SLCO2A1, GGT1, GGT5 and 4 morecytosol, extracellular space

• 3,3',5-triiodo-L-thyronineReach from here →
  1. arachidonate:oxygen 5-oxidoreductase
  2. transport of leukotriene A4 (cytosol to extracellular)
  3. transport of S-glutathionyl-2-4-dinitrobenzene (cytosol to extracellular)

  Catalysed by ALOX5, SLCO1B1, SLCO1A2, SLCO1B3cytosol, extracellular spaceOne of 4 routes

• glycineReach from here →
  1. arachidonate:oxygen 5-oxidoreductase
  2. leukotriene C4 synthase (GSH)
  3. leukotriene C4 hydrolysis

  Catalysed by ALOX5, LTC4ScytosolOne of 2 routes

• prostaglandin E1Reach from here →
  1. arachidonate:oxygen 5-oxidoreductase
  2. transport of leukotriene A4 (cytosol to extracellular)
  3. transport of prostaglandin E1 (cytosol to extracellular)

  Catalysed by ALOX5, SLCO1B1cytosol, extracellular spaceOne of 4 routes

• prostaglandin I2Reach from here →
  1. arachidonate:oxygen 5-oxidoreductase
  2. transport of leukotriene A4 (cytosol to extracellular)
  3. transport of prostaglandin I2 (cytosol to extracellular)

  Catalysed by ALOX5, SLCO1B1cytosol, extracellular spaceOne of 4 routes

• prostaglandin F2alphaReach from here →
  1. arachidonate:oxygen 5-oxidoreductase
  2. transport of leukotriene A4 (cytosol to extracellular)
  3. transport of prostaglandin F2alpha (cytosol to extracellular)

  Catalysed by ALOX5, SLCO1B1cytosol, extracellular spaceOne of 4 routes

• prostaglandin H2Reach from here →
  1. arachidonate:oxygen 5-oxidoreductase
  2. transport of leukotriene A4 (cytosol to extracellular)
  3. transport of prostaglandin H2 (cytosol to extracellular)

  Catalysed by ALOX5, SLCO1B1cytosol, extracellular spaceOne of 4 routes

• prostaglandin D2Reach from here →
  1. arachidonate:oxygen 5-oxidoreductase
  2. transport of leukotriene A4 (cytosol to extracellular)
  3. transport of prostaglandin D2 (cytosol to extracellular)

  Catalysed by ALOX5, SLCO1B1cytosol, extracellular spaceOne of 4 routes

• (15S)-hydroxy-(5Z,8Z,11Z,13E)-eicosatetraenoateReach from here →
  1. arachidonate:oxygen 5-oxidoreductase
  2. transport of GSH and leukotriene A4 (cytosol to extracellular)
  3. Glutathione: 15-HPETE oxidoreductase

  Catalysed by ALOX5, SLCO2A1, GPX5, GPX1 and 7 morecytosol, extracellular spaceOne of 3 routes

• (R)-S-lactoylglutathioneReach from here →
  1. arachidonate:oxygen 5-oxidoreductase
  2. transport of GSH and leukotriene A4 (cytosol to extracellular)
  3. (R)-S-Lactoylglutathione methylglyoxal-lyase (isomerizing)

  Catalysed by ALOX5, SLCO2A1, GLO1, GLOD4cytosol, extracellular spaceOne of 3 routes

• S-formylglutathioneReach from here →
  1. arachidonate:oxygen 5-oxidoreductase
  2. transport of GSH and leukotriene A4 (cytosol to extracellular)
  3. alcohol dehydrogenase (formaldehyde)

  Catalysed by ALOX5, SLCO2A1, ADH1C, ADH1A and 4 morecytosol, extracellular spaceOne of 2 routes

• dehydroepiandrosterone 3-sulfateReach from here →
  1. arachidonate:oxygen 5-oxidoreductase
  2. transport of leukotriene A4 (cytosol to extracellular)
  3. transport of dehydroepiandrosterone sulfate (cytosol to extracellular)

  Catalysed by ALOX5, SLCO1B1cytosol, extracellular spaceOne of 2 routes

• L-alanineReach from here →
  1. Glutathione: 5-HPETE oxidoreductase
  2. cystine to cysteine conversion
  3. Transport of L-Cystine (L-Alanine antiport) by B0, +At Transporter

  Catalysed by GPX5, GPX1, GPX2, GPX3 and 7 morecytosol, extracellular space

• taurolithocholate 3-sulfateReach from here →
  1. arachidonate:oxygen 5-oxidoreductase
  2. transport of leukotriene A4 (cytosol to extracellular)
  3. transport of S-glutathionyl-2-4-dinitrobenzene (cytosol to extracellular)

  Catalysed by ALOX5, SLCO1B1, SLCO1A2, SLCO1B3cytosol, extracellular spaceOne of 4 routes

• 5-oxo-L-prolineReach from here →
  1. Glutathione: 5-HPETE oxidoreductase
  2. 2 glutathione + NADP(+) = glutathione disulfide + NADPH + H(+)
  3. glutathione = L-cysteinylglycine + 5-oxo-L-proline

  Catalysed by GPX5, GPX1, GPX2, GPX3 and 8 morecytosol

• histamineReach from here →
  1. arachidonate:oxygen 5-oxidoreductase
  2. transport of leukotriene A4 (cytosol to extracellular)
  3. transport of histamine (cytosol to extracellular)

  Catalysed by ALOX5, SLCO1B1, SLCO1A2, SLCO1B3cytosol, extracellular spaceOne of 4 routes

• L-thyroxineReach from here →
  1. arachidonate:oxygen 5-oxidoreductase
  2. transport of leukotriene A4 (cytosol to extracellular)
  3. transport of S-glutathionyl-2-4-dinitrobenzene (cytosol to extracellular)

  Catalysed by ALOX5, SLCO1B1, SLCO1A2, SLCO1B3cytosol, extracellular spaceOne of 4 routes

• S-sulfanylglutathioneReach from here →
  1. arachidonate:oxygen 5-oxidoreductase
  2. transport of GSH and leukotriene A4 (cytosol to extracellular)
  3. Sulfide:glutathione,quinone oxidoreductase

  Catalysed by ALOX5, SLCO2A1, SQORcytosol, extracellular space, mitochondrial matrixOne of 6 routes

• dopamineReach from here →
  1. arachidonate:oxygen 5-oxidoreductase
  2. transport of leukotriene A4 (cytosol to extracellular)
  3. transport of dopamine (cytosol to extracellular)

  Catalysed by ALOX5, SLCO1B1, SLCO1A2, SLCO1B3cytosol, extracellular spaceOne of 4 routes

• glycolithocholate 3-sulfateReach from here →
  1. arachidonate:oxygen 5-oxidoreductase
  2. transport of leukotriene A4 (cytosol to extracellular)
  3. transport of S-glutathionyl-2-4-dinitrobenzene (cytosol to extracellular)

  Catalysed by ALOX5, SLCO1B1, SLCO1A2, SLCO1B3cytosol, extracellular spaceOne of 4 routes

• estrone 3-sulfateReach from here →
  1. arachidonate:oxygen 5-oxidoreductase
  2. transport of leukotriene A4 (cytosol to extracellular)
  3. transport of estrone 3-sulfate (cytosol to extracellular)

  Catalysed by ALOX5, SLCO1B1cytosol, extracellular spaceOne of 2 routes

• prostaglandin E2Reach from here →
  1. arachidonate:oxygen 5-oxidoreductase
  2. transport of leukotriene A4 (cytosol to extracellular)
  3. transport of prostaglandin E2 (cytosol to extracellular)

  Catalysed by ALOX5, SLCO1B1, SLCO1A2, SLCO1B3cytosol, extracellular spaceOne of 4 routes

• L-cysteinylglycineReach from here →
  1. arachidonate:oxygen 5-oxidoreductase
  2. transport of GSH and leukotriene A4 (cytosol to extracellular)
  3. glutathione gamma-glutamylaminopeptidase

  Catalysed by ALOX5, SLCO2A1, GGTLC3, GGT1 and 4 morecytosol, extracellular spaceOne of 6 routes

• leukotriene D4Reach from here →
  1. arachidonate:oxygen 5-oxidoreductase
  2. leukotriene C4 synthase (GSH)
  3. leukotriene C4 + H2O = leukotriene D4 + L-glutamate

  Catalysed by ALOX5, LTC4S, GGT1, GGT5cytosol

• ubiquinol-10Reach from here →
  1. Glutathione: 5-HPETE oxidoreductase
  2. 2 glutathione + NADP(+) = glutathione disulfide + NADPH + H(+)
  3. ubiquinone-10 + hydrogen sulfide + glutathione + H(+) = S-sulfanylglutathione + ubiquinol-10

  Catalysed by GPX5, GPX1, GPX2, GPX3 and 7 morecytosol

• (R)-noradrenalineReach from here →
  1. arachidonate:oxygen 5-oxidoreductase
  2. transport of leukotriene A4 (cytosol to extracellular)
  3. transport of noradrenaline (cytosol to extracellular)

  Catalysed by ALOX5, SLCO1B1, SLCO1A2, SLCO1B3cytosol, extracellular spaceOne of 4 routes

• 20-hydroxy-(5Z,8Z,11Z,14Z)-eicosatetraenoateReach from here →
  1. arachidonate:oxygen 5-oxidoreductase
  2. transport of leukotriene A4 (cytosol to extracellular)
  3. Resistance-Nodulation-Cell Division (Rnd) Tcdb:2.A.60.1.5

  Catalysed by ALOX5, SLCO1B1cytosol, extracellular spaceOne of 4 routes