a quinone

Three steps

• 5-oxo-L-prolineReach from here →
  1. a quinone + hydrogen sulfide + glutathione + H(+) = S-sulfanylglutathione + a quinol
  2. S-sulfanylglutathione + O2 + H2O = sulfite + glutathione + 2 H(+)
  3. glutathione = L-cysteinylglycine + 5-oxo-L-proline

  Catalysed by SQOR, ETHE1, CHAC2, CHAC1

• histamineReach from here →
  1. a quinone + hydrogen sulfide + glutathione + H(+) = S-sulfanylglutathione + a quinol
  2. Persulfide dioxygenase
  3. transport of GSH and histamine (cytosol to extracellular)

  Catalysed by SQOR, ETHE1, SLCO1A2, SLCO1B3mitochondrial matrix, extracellular space, cytosolOne of 2 routes

• L-thyroxineReach from here →
  1. a quinone + hydrogen sulfide + glutathione + H(+) = S-sulfanylglutathione + a quinol
  2. Persulfide dioxygenase
  3. transport of GSH and thyroxine (cytosol to extracellular)

  Catalysed by SQOR, ETHE1, SLCO1A2, SLCO1B3mitochondrial matrix, extracellular space, cytosolOne of 2 routes

• 5-amino-1-(5-phospho-beta-D-ribosyl)imidazole-4-carboxamideReach from here →
  1. a quinone + succinate = fumarate + a quinol
  2. 1-(5'-Phosphoribosyl)-5-amino-4-(N-succinocarboxamide)-imidazole AMP-lyase
  3. 1-(5'-Phosphoribosyl)-5-amino-4-(N-succinocarboxamide)-imidazole AMP-lyase

  Catalysed by SDHB, ADSLcytosolOne of 2 routes

• phosphoenolpyruvateReach from here →
  1. (R)-malate + a quinone = enol-oxaloacetate + a quinol
  2. oxaloacetate = enol-oxaloacetate
  3. oxaloacetate + GTP = phosphoenolpyruvate + GDP + CO2

  Catalysed by SDHB, SDHA, FAHD2B, FAHD1 and 3 more

• an N-acyl-L-amino acidReach from here →
  1. (S)-dihydroorotate + a quinone = orotate + a quinol
  2. orotate(out) + a carboxylate(in) = orotate(in) + a carboxylate(out)
  3. an N-acyl-L-amino acid + H2O = an L-alpha-amino acid + a carboxylate

  Catalysed by DHODH, SLC22A13, ACY1, PM20D1inner side of the membrane, outer side of the membrane

• dopamineReach from here →
  1. a quinone + hydrogen sulfide + glutathione + H(+) = S-sulfanylglutathione + a quinol
  2. Persulfide dioxygenase
  3. transport of dopamine and GSH (cytosol to extracellular)

  Catalysed by SQOR, ETHE1, SLCO1A2, SLCO1B3mitochondrial matrix, extracellular space, cytosolOne of 2 routes

• glycolithocholate 3-sulfateReach from here →
  1. a quinone + hydrogen sulfide + glutathione + H(+) = S-sulfanylglutathione + a quinol
  2. Persulfide dioxygenase
  3. transport of GSH and sulfoglycolithocholate (cytosol to extracellular)

  Catalysed by SQOR, ETHE1, SLCO1A2, SLCO1B3mitochondrial matrix, extracellular space, cytosolOne of 2 routes

• estrone 3-sulfateReach from here →
  1. a quinone + succinate = fumarate + a quinol
  2. transport of fumarate and sulfate (cytosol to mitochondria)
  3. estrone 3-sulfate + H2O = estrone + sulfate + H(+)

  Catalysed by SDHB, SLC25A10, STSmitochondrial matrix, cytosol

• prostaglandin E2Reach from here →
  1. a quinone + hydrogen sulfide + glutathione + H(+) = S-sulfanylglutathione + a quinol
  2. Persulfide dioxygenase
  3. transport of GSH and prostaglandin E2 (cytosol to extracellular)

  Catalysed by SQOR, ETHE1, SLCO1A2, SLCO1B3mitochondrial matrix, extracellular space, cytosolOne of 2 routes

• L-cysteinylglycineReach from here →
  1. a quinone + hydrogen sulfide + glutathione + H(+) = S-sulfanylglutathione + a quinol
  2. Persulfide dioxygenase
  3. glutathione gamma-glutamylaminopeptidase

  Catalysed by SQOR, ETHE1, GGTLC3, GGT1 and 4 moremitochondrial matrix, cytosolOne of 6 routes

• (5-hydroxyindol-3-yl)acetateReach from here →
  1. a quinone + succinate = fumarate + a quinol
  2. transport of fumarate and sulfate (cytosol to mitochondria)
  3. Transport of 5-Hydroxyindoleacetate

  Catalysed by SDHB, SLC25A10, SLC4A1mitochondrial matrix, cytosol, extracellular spaceOne of 2 routes

• 2-deoxy-D-ribose 5-phosphateReach from here →
  1. a quinone + sn-glycerol 3-phosphate = dihydroxyacetone phosphate + a quinol
  2. D-glyceraldehyde 3-phosphate = dihydroxyacetone phosphate
  3. 2-deoxy-D-ribose 5-phosphate = D-glyceraldehyde 3-phosphate + acetaldehyde

  Catalysed by GPD2, TPI1, DERA

• ubiquinol-10Reach from here →
  1. a quinone + succinate = fumarate + a quinol
  2. transport of fumarate and sulfite (cytosol to mitochondria)
  3. ubiquinone-10 + hydrogen sulfide + sulfite + 2 H(+) = ubiquinol-10 + thiosulfate

  Catalysed by SDHB, SLC25A10, SQORmitochondrial matrix, cytosolOne of 2 routes

• (R)-noradrenalineReach from here →
  1. a quinone + hydrogen sulfide + glutathione + H(+) = S-sulfanylglutathione + a quinol
  2. Persulfide dioxygenase
  3. transport of GSH and noradrenaline (cytosol to extracellular)

  Catalysed by SQOR, ETHE1, SLCO1A2, SLCO1B3mitochondrial matrix, extracellular space, cytosolOne of 2 routes

• a 1-O-alkylglycerone 3-phosphateReach from here →
  1. a quinone + sn-glycerol 3-phosphate = dihydroxyacetone phosphate + a quinol
  2. dihydroxyacetone phosphate + an acyl-CoA = a 1-acylglycerone 3-phosphate + CoA
  3. a long chain fatty alcohol + a 1-acylglycerone 3-phosphate = a 1-O-alkylglycerone 3-phosphate + a long-chain fatty acid + H(+)

  Catalysed by GPD2, GNPAT, AGPS

• NAADP(+)Reach from here →
  1. (S)-dihydroorotate + a quinone = orotate + a quinol
  2. orotate(out) + nicotinate(in) = orotate(in) + nicotinate(out)
  3. nicotinate + NADP(+) = NAADP(+) + nicotinamide

  Catalysed by DHODH, SLC22A12, CD38inner side of the membrane, outer side of the membraneOne of 2 routes

• 20-hydroxy-(5Z,8Z,11Z,14Z)-eicosatetraenoateReach from here →
  1. a quinone + hydrogen sulfide + glutathione + H(+) = S-sulfanylglutathione + a quinol
  2. Persulfide dioxygenase
  3. Resistance-Nodulation-Cell Division (Rnd) Tcdb:2.A.60.1.2

  Catalysed by SQOR, ETHE1, SLCO2A1mitochondrial matrix, extracellular space, cytosolOne of 2 routes

• alpha-NAD(+)Reach from here →
  1. 1-(beta-D-ribofuranosyl)-1,4-dihydronicotinamide + a quinone + H(+) = beta-nicotinamide D-riboside + a quinol
  2. purine nucleoside phosphorylase (nicotinamide)
  3. alpha-NAD(+) + H2O = ADP-D-ribose + nicotinamide + H(+)

  Catalysed by NQO2, PNP, MACROD2, ADPRH and 3 morecytosol

• 1-O-hexadecylglycerone 3-phosphateReach from here →
  1. a quinone + sn-glycerol 3-phosphate = dihydroxyacetone phosphate + a quinol
  2. dihydroxyacetone phosphate + hexadecanoyl-CoA = 1-hexadecanoylglycerone 3-phosphate + CoA
  3. 1-hexadecanoylglycerone 3-phosphate + hexadecan-1-ol = 1-O-hexadecylglycerone 3-phosphate + hexadecanoate + H(+)

  Catalysed by GPD2, GNPAT, AGPS

• (9S)-hydroxy-(10E,12Z)-octadecadienoateReach from here →
  1. a quinone + hydrogen sulfide + glutathione + H(+) = S-sulfanylglutathione + a quinol
  2. S-sulfanylglutathione + O2 + H2O = sulfite + glutathione + 2 H(+)
  3. (9S)-hydroperoxy-(10E,12Z)-octadecadienoate + 2 glutathione = (9S)-hydroxy-(10E,12Z)-octadecadienoate + glutathione disulfide + H2O

  Catalysed by SQOR, ETHE1, GPX1, GPX4

• ursodeoxycholateReach from here →
  1. a quinone + hydrogen sulfide + glutathione + H(+) = S-sulfanylglutathione + a quinol
  2. Persulfide dioxygenase
  3. transport of GSH and ursodeoxycholate (cytosol to extracellular)

  Catalysed by SQOR, ETHE1, SLCO1A2, SLCO1B3mitochondrial matrix, extracellular space, cytosolOne of 2 routes

• hexadecanoateReach from here →
  1. a quinone + sn-glycerol 3-phosphate = dihydroxyacetone phosphate + a quinol
  2. dihydroxyacetone phosphate + hexadecanoyl-CoA = 1-hexadecanoylglycerone 3-phosphate + CoA
  3. 1-hexadecanoylglycerone 3-phosphate + hexadecan-1-ol = 1-O-hexadecylglycerone 3-phosphate + hexadecanoate + H(+)

  Catalysed by GPD2, GNPAT, AGPSOne of 2 routes

• prostaglandin G2Reach from here →
  1. a quinone + hydrogen sulfide + glutathione + H(+) = S-sulfanylglutathione + a quinol
  2. Persulfide dioxygenase
  3. transport of GSH and prostaglandin G2 (cytosol to extracellular)

  Catalysed by SQOR, ETHE1, SLCO2A1mitochondrial matrix, extracellular space, cytosolOne of 2 routes

• glycodeoxycholateReach from here →
  1. a quinone + hydrogen sulfide + glutathione + H(+) = S-sulfanylglutathione + a quinol
  2. S-sulfanylglutathione + O2 + H2O = sulfite + glutathione + 2 H(+)
  3. glycodeoxycholate(in) + glutathione(in) + ATP + H2O = glycodeoxycholate(out) + glutathione(out) + ADP + phosphate + H(+)

  Catalysed by SQOR, ETHE1, ABCC4inner side of the membrane, outer side of the membrane

• (12R)-hydroxy-(5Z,8Z,10E,14Z)-eicosatetraenoateReach from here →
  1. a quinone + hydrogen sulfide + glutathione + H(+) = S-sulfanylglutathione + a quinol
  2. S-sulfanylglutathione + O2 + H2O = sulfite + glutathione + 2 H(+)
  3. (12R)-hydroperoxy-(5Z,8Z,10E,14Z)-eicosatetraenoate + 2 glutathione = (12R)-hydroxy-(5Z,8Z,10E,14Z)-eicosatetraenoate + glutathione disulfide + H2O

  Catalysed by SQOR, ETHE1, GPX1, GPX2 and 1 more

• (5S)-hydroxy-(6E,8Z,11Z,14Z)-eicosatetraenoateReach from here →
  1. a quinone + hydrogen sulfide + glutathione + H(+) = S-sulfanylglutathione + a quinol
  2. S-sulfanylglutathione + O2 + H2O = sulfite + glutathione + 2 H(+)
  3. (5S)-hydroperoxy-(6E,8Z,11Z,14Z)-eicosatetraenoate + 2 glutathione = (5S)-hydroxy-(6E,8Z,11Z,14Z)-eicosatetraenoate + glutathione disulfide + H2O

  Catalysed by SQOR, ETHE1, PTGES, MGST3 and 4 more

• (12S)-hydroxy-(5Z,8Z,10E,14Z)-eicosatetraenoateReach from here →
  1. a quinone + hydrogen sulfide + glutathione + H(+) = S-sulfanylglutathione + a quinol
  2. S-sulfanylglutathione + O2 + H2O = sulfite + glutathione + 2 H(+)
  3. (12S)-hydroperoxy-(5Z,8Z,10E,14Z)-eicosatetraenoate + 2 glutathione = (12S)-hydroxy-(5Z,8Z,10E,14Z)-eicosatetraenoate + glutathione disulfide + H2O

  Catalysed by SQOR, ETHE1, GPX1, GPX4

• thromboxane B2Reach from here →
  1. a quinone + hydrogen sulfide + glutathione + H(+) = S-sulfanylglutathione + a quinol
  2. Persulfide dioxygenase
  3. transport of GSH and thromboxane B2 (cytosol to extracellular)

  Catalysed by SQOR, ETHE1, SLCO1B1mitochondrial matrix, extracellular space, cytosolOne of 2 routes

• an S-substituted glutathioneReach from here →
  1. a quinone + hydrogen sulfide + glutathione + H(+) = S-sulfanylglutathione + a quinol
  2. S-sulfanylglutathione + O2 + H2O = sulfite + glutathione + 2 H(+)
  3. RX + glutathione = an S-substituted glutathione + a halide anion + H(+)

  Catalysed by SQOR, ETHE1, GSTT4, GSTA4 and 21 moreOne of 2 routes

• (13S)-hydroxy-(9Z,11E)-octadecadienoateReach from here →
  1. a quinone + hydrogen sulfide + glutathione + H(+) = S-sulfanylglutathione + a quinol
  2. S-sulfanylglutathione + O2 + H2O = sulfite + glutathione + 2 H(+)
  3. (13S)-hydroperoxy-(9Z,11E)-octadecadienoate + 2 glutathione = (13S)-hydroxy-(9Z,11E)-octadecadienoate + glutathione disulfide + H2O

  Catalysed by SQOR, ETHE1, GPX1, GSTA1 and 2 more

• taurochenodeoxycholateReach from here →
  1. a quinone + hydrogen sulfide + glutathione + H(+) = S-sulfanylglutathione + a quinol
  2. Persulfide dioxygenase
  3. solute carrier organic anion transporter (GSH)

  Catalysed by SQOR, ETHE1, SLCO1A2, SLC7A9 and 1 moremitochondrial matrix, extracellular space, cytosolOne of 3 routes