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Proteins/UNIPROT:A1Z1Q3
Removes ADP-ribose from aspartate and glutamate residues in proteins bearing a single ADP-ribose moiety. Inactive towards proteins bearing poly-ADP-ribose. Deacetylates O-acetyl-ADP ribose, a signaling molecule generated by the deacetylation of acetylated lysine residues in histones and other proteins..
Function from UniProtKB (A1Z1Q3), read 2026-09-23. CC BY 4.0.
Curated compounds routed: 0
44 statements
44 statements · 4 reference databases · Subject: MACROD2 · Sources: Human Protein Atlas, Human-GEM, Rhea, WikiPathways
7 reactions
5 names
Resolves to: MACROD2
water+2''-O-acetyl-ADP-D-riboseacetate+ADP-D-ribose+proton
Catalysed by MACROD2 or MACROD1 or OARD1
Reaction pageLeft to rightBalancedEC 3.1.1.106nucleus
Human-GEM MAR20099CC BY 4.0Reference data
water+alpha-NAD(+)ADP-D-ribose+proton+nicotinamide
Catalysed by MACROD2 or MACROD1 or OARD1
Reaction pageLeft to rightBalancedEC 3.1.1.106nucleus
Human-GEM MAR20100CC BY 4.0Reference data
4-O-(ADP-D-ribosyl)-L-aspartyl-[protein]+waterL-aspartyl-[protein]+ADP-D-ribose+hydron
Catalysed by MACROD2 or MACROD1
Reaction pageLeft to rightBalance undeterminable
Rhea RHEA:54428CC BY 4.0Reference data
2''-O-acetyl-ADP-D-ribose+waterADP-D-ribose+acetate+hydron
Catalysed by MACROD2 or MACROD1 or OARD1
Reaction pageLeft to rightBalanced
Rhea RHEA:57060CC BY 4.0Reference data
5-O-(ADP-D-ribosyl)-L-glutamyl-[protein]+waterL-glutamyl-[protein]+ADP-D-ribose+hydron
Catalysed by MACROD2 or MACROD1 or OARD1
Reaction pageLeft to rightBalance undeterminable
Rhea RHEA:58248CC BY 4.0Reference data
alpha-NAD(+)+waterADP-D-ribose+nicotinamide+hydron
Catalysed by MACROD2 or ADPRH or MACROD1 or ADPRS or OARD1
Reaction pageDirection not assertedBalanced
Rhea RHEA:68792CC BY 4.0Reference data