a quinone

Three steps

• androsterone 3alpha-sulfateReach from here →
  1. a quinone + succinate = fumarate + a quinol
  2. transport of fumarate and sulfate (cytosol to mitochondria)
  3. steroid sulfatase (androsterone sulfate)

  Catalysed by SDHB, SLC25A10, STSmitochondrial matrix, cytosolOne of 3 routes

• prostaglandin E3Reach from here →
  1. a quinone + hydrogen sulfide + glutathione + H(+) = S-sulfanylglutathione + a quinol
  2. Persulfide dioxygenase
  3. transport of GSH and prostaglandin E3 (cytosol to extracellular)

  Catalysed by SQOR, ETHE1, SLCO2A1mitochondrial matrix, extracellular space, cytosolOne of 2 routes

• prostaglandin A2Reach from here →
  1. a quinone + hydrogen sulfide + glutathione + H(+) = S-sulfanylglutathione + a quinol
  2. Persulfide dioxygenase
  3. transport of GSH and prostaglandin A2 (cytosol to extracellular)

  Catalysed by SQOR, ETHE1, SLCO2A1mitochondrial matrix, extracellular space, cytosolOne of 2 routes

• prostaglandin B1Reach from here →
  1. a quinone + hydrogen sulfide + glutathione + H(+) = S-sulfanylglutathione + a quinol
  2. Persulfide dioxygenase
  3. transport of GSH and prostaglandin B1 (cytosol to extracellular)

  Catalysed by SQOR, ETHE1, SLCO2A1mitochondrial matrix, extracellular space, cytosolOne of 2 routes

• leukotriene F4Reach from here →
  1. a quinone + hydrogen sulfide + glutathione + H(+) = S-sulfanylglutathione + a quinol
  2. Persulfide dioxygenase
  3. transport of GSH and leukotriene F4 (cytosol to extracellular)

  Catalysed by SQOR, ETHE1mitochondrial matrix, extracellular space, cytosolOne of 2 routes

• prostaglandin A2-S-(R)-glutathioneReach from here →
  1. a quinone + hydrogen sulfide + glutathione + H(+) = S-sulfanylglutathione + a quinol
  2. S-sulfanylglutathione + O2 + H2O = sulfite + glutathione + 2 H(+)
  3. prostaglandin A2 + glutathione = prostaglandin A2-S-(R)-glutathione

  Catalysed by SQOR, ETHE1, GSTA1, GSTM1

• prostaglandin A2-S-(S)-glutathioneReach from here →
  1. a quinone + hydrogen sulfide + glutathione + H(+) = S-sulfanylglutathione + a quinol
  2. S-sulfanylglutathione + O2 + H2O = sulfite + glutathione + 2 H(+)
  3. prostaglandin A2 + glutathione = prostaglandin A2-S-(S)-glutathione

  Catalysed by SQOR, ETHE1, GSTP1, GSTM1

• prostaglandin J2-S-(R)-glutathioneReach from here →
  1. a quinone + hydrogen sulfide + glutathione + H(+) = S-sulfanylglutathione + a quinol
  2. S-sulfanylglutathione + O2 + H2O = sulfite + glutathione + 2 H(+)
  3. prostaglandin J2 + glutathione = prostaglandin J2-S-(R)-glutathione

  Catalysed by SQOR, ETHE1, GSTA1, GSTP1 and 1 more

• prostaglandin J2-S-(S)-glutathioneReach from here →
  1. a quinone + hydrogen sulfide + glutathione + H(+) = S-sulfanylglutathione + a quinol
  2. S-sulfanylglutathione + O2 + H2O = sulfite + glutathione + 2 H(+)
  3. prostaglandin J2 + glutathione = prostaglandin J2-S-(S)-glutathione

  Catalysed by SQOR, ETHE1, GSTP1, GSTM1

• 2,4-dinitrophenyl-S-glutathioneReach from here →
  1. a quinone + hydrogen sulfide + glutathione + H(+) = S-sulfanylglutathione + a quinol
  2. S-sulfanylglutathione + O2 + H2O = sulfite + glutathione + 2 H(+)
  3. 1-chloro-2,4-dinitrobenzene + glutathione = 2,4-dinitrophenyl-S-glutathione + chloride + H(+)

  Catalysed by SQOR, ETHE1, PTGES, LANCL1 and 2 more

• cholesterol sulfateReach from here →
  1. a quinone + succinate = fumarate + a quinol
  2. transport of fumarate and sulfate (cytosol to mitochondria)
  3. Steryl-Sulfatase

  Catalysed by SDHB, SLC25A10, STSmitochondrial matrix, cytosol, Golgi apparatusOne of 2 routes

• 5alpha-dihydrotestosterone sulfateReach from here →
  1. a quinone + succinate = fumarate + a quinol
  2. transport of fumarate and sulfate (cytosol to mitochondria)
  3. steroid sulfatase (5-alpha-dihydrotestosterone)

  Catalysed by SDHB, SLC25A10, STSmitochondrial matrix, cytosolOne of 3 routes

• acetoacetateReach from here →
  1. a quinone + succinate = fumarate + a quinol
  2. 4-fumarylacetoacetate + H2O = acetoacetate + fumarate + H(+)
  3. 4-fumarylacetoacetate fumarylhydrolase

  Catalysed by SDHB, FAHcytosolOne of 2 routes

• (13R)-S-glutathionyl-(14S)-hydroxy-(4Z,7Z,9E,11E,16Z,19Z)-docosahexaenoateReach from here →
  1. a quinone + hydrogen sulfide + glutathione + H(+) = S-sulfanylglutathione + a quinol
  2. S-sulfanylglutathione + O2 + H2O = sulfite + glutathione + 2 H(+)
  3. (13S,14S)-epoxy-(4Z,7Z,9E,11E,16Z,19Z)-docosahexaenoate + glutathione = (13R)-S-glutathionyl-(14S)-hydroxy-(4Z,7Z,9E,11E,16Z,19Z)-docosahexaenoate

  Catalysed by SQOR, ETHE1, GSTM4, LTC4S

• an N-acyl-aromatic L-alpha-amino acidReach from here →
  1. (S)-dihydroorotate + a quinone = orotate + a quinol
  2. orotate(out) + a carboxylate(in) = orotate(in) + a carboxylate(out)
  3. an N-acyl-aromatic L-alpha-amino acid + H2O = an aromatic L-alpha-amino acid + a carboxylate

  Catalysed by DHODH, SLC22A13, PM20D1, ACY3inner side of the membrane, outer side of the membrane

• an aryl sulfateReach from here →
  1. a quinone + succinate = fumarate + a quinol
  2. transport of fumarate and sulfate (cytosol to mitochondria)
  3. an aryl sulfate + H2O = a phenol + sulfate + H(+)

  Catalysed by SDHB, SLC25A10, ARSL, ARSF and 4 moremitochondrial matrix, cytosol

• S-methyl glutathioneReach from here →
  1. a quinone + hydrogen sulfide + glutathione + H(+) = S-sulfanylglutathione + a quinol
  2. S-sulfanylglutathione + O2 + H2O = sulfite + glutathione + 2 H(+)
  3. apo-[alkylcobalamin reductase] + methylcob(III)alamin + glutathione = S-methyl glutathione + cob(I)alamin-[alkylcobalamin reductase] + H(+)

  Catalysed by SQOR, ETHE1, MMACHC

• S-adenosylglutathioneReach from here →
  1. a quinone + hydrogen sulfide + glutathione + H(+) = S-sulfanylglutathione + a quinol
  2. S-sulfanylglutathione + O2 + H2O = sulfite + glutathione + 2 H(+)
  3. apo-[alkylcobalamin reductase] + adenosylcob(III)alamin + glutathione = S-adenosylglutathione + cob(I)alamin-[alkylcobalamin reductase] + H(+)

  Catalysed by SQOR, ETHE1, MMACHC

• acetylcholineReach from here →
  1. a quinone + hydrogen sulfide + glutathione + H(+) = S-sulfanylglutathione + a quinol
  2. Persulfide dioxygenase
  3. transport of acetylcholine and GSH (cytosol to extracellular)

  Catalysed by SQOR, ETHE1, SLCO1A2, SLCO1B3mitochondrial matrix, extracellular space, cytosolOne of 2 routes

• pyruvateReach from here →
  1. a quinone + sn-glycerol 3-phosphate = dihydroxyacetone phosphate + a quinol
  2. dihydroxyacetone phosphate = methylglyoxal + phosphate
  3. 2-Oxopropanal:NADP+ oxidoreductase

  Catalysed by GPD2, TPI1cytosolOne of 13 routes

• L-leucineReach from here →
  1. L-proline + a quinone = (S)-1-pyrroline-5-carboxylate + a quinol + H(+)
  2. L-Proline:NADP+ 5-oxidoreductase
  3. transport of leucine and proline (cytosol to extracellular)

  Catalysed by PRODH, PRODH2, PYCR3, PYCR2 and 1 morecytosol, extracellular spaceOne of 3 routes

• CHEBI:15650Reach from here →
  1. a quinone + hydrogen sulfide + glutathione + H(+) = S-sulfanylglutathione + a quinol
  2. Persulfide dioxygenase
  3. transport of GSH and leukotriene E4 (cytosol to extracellular)

  Catalysed by SQOR, ETHE1, SLCO1B1mitochondrial matrix, extracellular space, cytosolOne of 2 routes

• CHEBI:15699Reach from here →
  1. L-proline + a quinone = (S)-1-pyrroline-5-carboxylate + a quinol + H(+)
  2. L-Proline:NADP+ 5-oxidoreductase
  3. transport of homoserine and proline (cytosol to extracellular)

  Catalysed by PRODH, PRODH2, PYCR3, PYCR2cytosol, extracellular spaceOne of 4 routes

• hexadecanoic acidReach from here →
  1. a quinone + sn-glycerol 3-phosphate = dihydroxyacetone phosphate + a quinol
  2. dihydroxyacetone phosphate + hexadecanoyl-CoA = 1-hexadecanoylglycerone 3-phosphate + CoA
  3. glyceronephosphate O-acyltransferase (1-palmitoyl-dihydroxyacetone-phosphate)

  Catalysed by GPD2, GNPATperoxisome

• nicotinic acid D-ribonucleotideReach from here →
  1. 1-(beta-D-ribofuranosyl)-1,4-dihydronicotinamide + a quinone + H(+) = beta-nicotinamide D-riboside + a quinol
  2. ribosylnicotinamide kinase (nicotinamide ribonucleoside)
  3. nicotinamide-D-ribonucleotide amidohydrolase

  Catalysed by NQO2, NMRK2, NMRK1cytosol

• malonateReach from here →
  1. a quinone + succinate = fumarate + a quinol
  2. (S)-malate hydro-lyase (fumarate-forming)
  3. malonate(out) + (S)-malate(in) = malonate(in) + (S)-malate(out)

  Catalysed by SDHB, FH, SLC25A10cytosol, inner side of the membrane, outer side of the membraneOne of 4 routes

• bromideReach from here →
  1. a quinone + hydrogen sulfide + glutathione + H(+) = S-sulfanylglutathione + a quinol
  2. Persulfide dioxygenase
  3. 2-bromoacetaldehyde:glutathione S-(formylmethyl)transferase

  Catalysed by SQOR, ETHE1, MGST3, GSTA4 and 15 moremitochondrial matrix, cytosolOne of 2 routes

• N-carbamoyl-L-aspartic acidReach from here →
  1. a quinol + 2 Fe(III)-[cytochrome c](out) = a quinone + 2 Fe(II)-[cytochrome c](out) + 2 H(+)(out)
  2. (S)-dihydroorotate + a quinone = orotate + a quinol
  3. (S)-dihydroorotate amidohydrolase

  Catalysed by CYC1, UQCRFS1, DHODH, CADouter side of the membrane, cytosol

• CHEBI:15971Reach from here →
  1. L-proline + a quinone = (S)-1-pyrroline-5-carboxylate + a quinol + H(+)
  2. L-Proline:NADP+ 5-oxidoreductase
  3. transport of histidine and proline (cytosol to extracellular)

  Catalysed by PRODH, PRODH2, PYCR3, PYCR2 and 1 morecytosol, extracellular spaceOne of 2 routes

• a halide anionReach from here →
  1. a quinone + hydrogen sulfide + glutathione + H(+) = S-sulfanylglutathione + a quinol
  2. S-sulfanylglutathione + O2 + H2O = sulfite + glutathione + 2 H(+)
  3. RX + glutathione = an S-substituted glutathione + a halide anion + H(+)

  Catalysed by SQOR, ETHE1, GSTT4, GSTA4 and 21 more

• CHEBI:16108Reach from here →
  1. a quinone + sn-glycerol 3-phosphate = dihydroxyacetone phosphate + a quinol
  2. dihydroxyacetone + ATP = dihydroxyacetone phosphate + ADP + H(+)
  3. Glycerone phosphate phosphohydrolase

  Catalysed by GPD2, TKFC, ALPL, ALPP and 2 moreextracellular spaceOne of 2 routes

• lithocholic acidReach from here →
  1. a quinone + hydrogen sulfide + glutathione + H(+) = S-sulfanylglutathione + a quinol
  2. Persulfide dioxygenase
  3. transport of GSH and lithocholate (cytosol to extracellular)

  Catalysed by SQOR, ETHE1, SLCO1A2, SLCO1B3mitochondrial matrix, extracellular space, cytosolOne of 2 routes

• adenosineReach from here →
  1. 1-(beta-D-ribofuranosyl)-1,4-dihydronicotinamide + a quinone + H(+) = beta-nicotinamide D-riboside + a quinol
  2. purine nucleoside phosphorylase (nicotinamide)
  3. adenosine:phosphate alpha-D-ribosyltransferase

  Catalysed by NQO2, PNPcytosol

• L-citrullineReach from here →
  1. L-proline + a quinone = (S)-1-pyrroline-5-carboxylate + a quinol + H(+)
  2. L-Proline:NADP+ 5-oxidoreductase
  3. transport of citrulline and proline (cytosol to extracellular)

  Catalysed by PRODH, PRODH2, PYCR3, PYCR2 and 1 morecytosol, extracellular spaceOne of 3 routes

• L-valineReach from here →
  1. L-proline + a quinone = (S)-1-pyrroline-5-carboxylate + a quinol + H(+)
  2. L-Proline:NADP+ 5-oxidoreductase
  3. transport of proline and valine (cytosol to extracellular)

  Catalysed by PRODH, PRODH2, PYCR3, PYCR2 and 1 morecytosol, extracellular spaceOne of 4 routes

• L-arginineReach from here →
  1. L-proline + a quinone = (S)-1-pyrroline-5-carboxylate + a quinol + H(+)
  2. L-Proline:NADP+ 5-oxidoreductase
  3. transport of arginine and proline (cytosol to extracellular)

  Catalysed by PRODH, PRODH2, PYCR3, PYCR2 and 1 morecytosol, extracellular spaceOne of 4 routes

• protein polypeptide chainReach from here →
  1. L-proline + a quinone = (S)-1-pyrroline-5-carboxylate + a quinol + H(+)
  2. L-Proline:NADP+ 5-oxidoreductase
  3. PROTEIN_BS

  Catalysed by PRODH, PRODH2, PYCR3, PYCR2cytosol

• quinolinic acidReach from here →
  1. a quinone + succinate = fumarate + a quinol
  2. transport of fumarate and sulfate (cytosol to mitochondria)
  3. Transport of Quinolinic Acid

  Catalysed by SDHB, SLC25A10, SLC22A6mitochondrial matrix, cytosol, extracellular spaceOne of 2 routes

• uridineReach from here →
  1. 1-(beta-D-ribofuranosyl)-1,4-dihydronicotinamide + a quinone + H(+) = beta-nicotinamide D-riboside + a quinol
  2. purine nucleoside phosphorylase (nicotinamide)
  3. uridine:phosphate alpha-D-ribosyltransferase

  Catalysed by NQO2, PNP, UPP2, UPP1cytosol

• orotic acidReach from here →
  1. a quinol + 2 Fe(III)-[cytochrome c](out) = a quinone + 2 Fe(II)-[cytochrome c](out) + 2 H(+)(out)
  2. (S)-dihydroorotate + a quinone = orotate + a quinol
  3. (S)-dihydroorotate:NAD+ oxidoreductase

  Catalysed by CYC1, UQCRFS1, DHODHouter side of the membrane, cytosol

• guanosineReach from here →
  1. 1-(beta-D-ribofuranosyl)-1,4-dihydronicotinamide + a quinone + H(+) = beta-nicotinamide D-riboside + a quinol
  2. purine nucleoside phosphorylase (nicotinamide)
  3. guanosine:phosphate alpha-D-ribosyltransferase

  Catalysed by NQO2, PNPcytosol

• 1-methylnicotinamideReach from here →
  1. 1-(beta-D-ribofuranosyl)-1,4-dihydronicotinamide + a quinone + H(+) = beta-nicotinamide D-riboside + a quinol
  2. purine nucleoside phosphorylase (nicotinamide)
  3. S-Adenosyl-L-methionine:nicotinamide N-methyltransferase

  Catalysed by NQO2, PNP, NNMTcytosolOne of 2 routes

• CHEBI:16857Reach from here →
  1. L-proline + a quinone = (S)-1-pyrroline-5-carboxylate + a quinol + H(+)
  2. L-Proline:NADP+ 5-oxidoreductase
  3. transport of proline and threonine (cytosol to extracellular)

  Catalysed by PRODH, PRODH2, PYCR3, PYCR2cytosol, extracellular spaceOne of 4 routes

• D-erythrose 4-phosphateReach from here →
  1. a quinone + sn-glycerol 3-phosphate = dihydroxyacetone phosphate + a quinol
  2. D-glyceraldehyde 3-phosphate = dihydroxyacetone phosphate
  3. D-sedoheptulose 7-phosphate + D-glyceraldehyde 3-phosphate = D-erythrose 4-phosphate + beta-D-fructose 6-phosphate

  Catalysed by GPD2, TPI1, TALDO1

• ferrocytochrome cReach from here →
  1. a quinone + succinate = fumarate + a quinol
  2. transport of fumarate and sulfite (cytosol to mitochondria)
  3. sulfite:ferricytochrome-c oxidoreductase

  Catalysed by SDHB, SLC25A10, SUOXmitochondrial matrix, cytosol

• bilirubin IXalphaReach from here →
  1. a quinone + hydrogen sulfide + glutathione + H(+) = S-sulfanylglutathione + a quinol
  2. Persulfide dioxygenase
  3. transport of bilirubin and GSH (cytosol to extracellular)

  Catalysed by SQOR, ETHE1, SLCO1A2, SLCO1B3mitochondrial matrix, extracellular space, cytosolOne of 2 routes

• oxalic acidReach from here →
  1. a quinone + succinate = fumarate + a quinol
  2. transport of fumarate and sulfate (cytosol to mitochondria)
  3. transport of oxalate and sulfate (cytosol to extracellular)

  Catalysed by SDHB, SLC25A10, SLC26A6mitochondrial matrix, cytosol, extracellular space

• 4-maleylacetoacetateReach from here →
  1. a quinone + succinate = fumarate + a quinol
  2. 4-fumarylacetoacetate + H2O = acetoacetate + fumarate + H(+)
  3. 4-maleylacetoacetate = 4-fumarylacetoacetate

  Catalysed by SDHB, FAH, GSTZ1

• (R)-lactaldehydeReach from here →
  1. a quinone + sn-glycerol 3-phosphate = dihydroxyacetone phosphate + a quinol
  2. dihydroxyacetone phosphate = methylglyoxal + phosphate
  3. (R)-Lactaldehyde:NAD+ oxidoreductase

  Catalysed by GPD2, TPI1cytosolOne of 2 routes

• taurolithocholateReach from here →
  1. a quinone + hydrogen sulfide + glutathione + H(+) = S-sulfanylglutathione + a quinol
  2. Persulfide dioxygenase
  3. transport of GSH and taurolithocholate (cytosol to extracellular)

  Catalysed by SQOR, ETHE1, SLCO1A2, SLCO1B3mitochondrial matrix, extracellular space, cytosolOne of 2 routes