Proteins/UNIPROT:Q13219

PAPPA

ProteinUNIPROT:Q13219

Metalloproteinase which specifically cleaves IGFBP-4 and IGFBP-5, resulting in release of bound IGF. Cleavage of IGFBP-4 is dramatically enhanced by the presence of IGF, whereas cleavage of IGFBP-5 is slightly inhibited by the presence of IGF..

Function from UniProtKB (Q13219), read 2026-09-23. CC BY 4.0.

Curated compounds routed: 0

What the reference databases state

Statements

19 statements

19 statements · 3 reference databases · Subject: PAPPA · Sources: Hetionet, Reactome, UniProt

Order

PAPPA covaries with LCE1CProteinHetionet hetionet:covaries:353133-5069Inferred only
PAPPA interacts with ATF7IPProteinHetionet hetionet:interacts:5069-55729Inferred only
C3 interacts with PAPPAProteinHetionet hetionet:interacts:5069-718Inferred only
IGFBP4 interacts with PAPPAProteinHetionet hetionet:interacts:3487-5069Inferred only
PAPPA interacts with PLGProteinHetionet hetionet:interacts:5069-5340Inferred only
PAPPA interacts with PRG2ProteinHetionet hetionet:interacts:5069-5553Inferred only
PAPPA interacts with SKILProteinHetionet hetionet:interacts:5069-6498Inferred only
SMAD2 interacts with PAPPAProteinHetionet hetionet:interacts:4087-5069Inferred only
SMAD3 interacts with PAPPAProteinHetionet hetionet:interacts:4088-5069Inferred only
SMAD9 interacts with PAPPAProteinHetionet hetionet:interacts:4093-5069Inferred only
PAPPA interacts with TNNI3ProteinHetionet hetionet:interacts:5069-7137Inferred only
PAPPA participates in Metabolism of proteinsPathwayReactome R-HSA-392499Inferred only

Show the remaining 7

PAPPA participates in Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs)PathwayReactome R-HSA-381426Inferred only
ME2 decreases the expression of PAPPAProteinHetionet hetionet:regulates:4200-5069Inferred only
PRKCG increases the expression of PAPPAProteinHetionet hetionet:regulates:5582-5069Inferred only
RAB4A increases the expression of PAPPAProteinHetionet hetionet:regulates:5867-5069Inferred only
SETMAR increases the expression of PAPPAProteinHetionet hetionet:regulates:6419-5069Inferred only
SOX2 decreases the expression of PAPPAProteinHetionet hetionet:regulates:6657-5069Inferred only
PAPPA requires the cofactor Zn(2+)CompoundUniProt Q13219Inferred only

Other names

5 names

Resolves to: PAPPA

Also called: IGF-dependent IGFBP-4 proteaseIGFBP-4aseInsulin-like growth factor-dependent IGF-binding protein 4 proteasePAPP-APregnancy-associated plasma protein A

← Every protein Find it in the graph →