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Proteins/UNIPROT:P36639
Oxidized purine nucleoside triphosphate hydrolase which is a prominent sanitizer of the oxidized nucleotide pool. Catalyzes the hydrolysis of 2-oxo-dATP (2-hydroxy-dATP) into 2-oxo-dAMP. Also has a significant hydrolase activity toward 2-oxo-ATP, 8-oxo-dGTP and 8-oxo-dATP. Through the hydrolysis of oxidized purine nucleoside triphosphates, prevents their incorporation into DNA and the subsequent transversions A:T to C:G and G:C to T:A. Also catalyzes the hydrolysis of methylated purine nucleoside triphosphate preventing their integration into DNA. Through this antimutagenic activity protects cells from oxidative stress..
Function from UniProtKB (P36639), read 2026-09-23. CC BY 4.0.
Curated compounds routed: 0
47 statements
47 statements · 3 reference databases · Subject: NUDT1 · Sources: Hetionet, Rhea, UniProt
7 reactions
CHEBI:77896+waterCHEBI:63224+diphosphate(3-)+hydron
Catalysed by NUDT1
Reaction pageLeft to rightBalanced
Rhea RHEA:31575CC BY 4.0Reference data
CHEBI:77897+waterCHEBI:63212+diphosphate(3-)+hydron
Catalysed by NUDT1
Reaction pageLeft to rightBalanced
Rhea RHEA:31583CC BY 4.0
7 names
Resolves to: NUDT1
CHEBI:172871+waterCHEBI:71361+diphosphate(3-)+hydron
Catalysed by NUDT1
Reaction pageLeft to rightBalanced
Rhea RHEA:65396CC BY 4.0Reference data
CHEBI:172878+waterCHEBI:71395+diphosphate(3-)+hydron
Catalysed by NUDT1
Reaction pageLeft to rightBalanced
Rhea RHEA:67392CC BY 4.0Reference data
CHEBI:169974+waterCHEBI:169975+diphosphate(3-)+hydron
Catalysed by NUDT1
Reaction pageLeft to rightBalanced
Rhea RHEA:67600CC BY 4.0Reference data
CHEBI:172872+waterCHEBI:169976+diphosphate(3-)+hydron
Catalysed by NUDT1
Reaction pageLeft to rightBalanced
Rhea RHEA:67604CC BY 4.0Reference data
N(6)-methyl-ATP+waterN(6)-methyl-AMP+diphosphate(3-)+hydron
Catalysed by NUDT1
Reaction pageLeft to rightBalanced
Rhea RHEA:67608CC BY 4.0Reference data