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Proteins/UNIPROT:Q7Z4W1
Catalyzes the NADPH-dependent reduction of several pentoses, tetroses, trioses, alpha-dicarbonyl compounds and L-xylulose. Can use both NAD and NADP as cosubstrate but shows higher activity with NADP. Participates in the uronate cycle of glucose metabolism. May play a role in the water absorption and cellular osmoregulation in the proximal renal tubules by producing xylitol, an osmolyte, thereby preventing osmolytic stress from occurring in the renal tubules..
Function from UniProtKB (Q7Z4W1), read 2026-09-23. CC BY 4.0.
Curated compounds routed: 0
1 row
175 statements
175 statements · 7 reference databases · Subject: DCXR · Sources: Bgee, gene ontology, Hetionet, Human Protein Atlas, Human-GEM, Reactome, Rhea
3 reactions
proton+L-xylulose+NADPH(4-)NADP(3-)+CHEBI:1305691
Catalysed by DCXR
Reaction pageLeft to rightBalancedEC 1.1.1.10cytosol
Human-GEM MAR04590CC BY 4.0Reference data
xylitol+NADP(3-)L-xylulose+NADPH(4-)+hydron
Catalysed by DCXR
7 names
Resolves to: DCXR
Rhea RHEA:17025CC BY 4.0Reference data
CHEBI:15688+NADP(3-)CHEBI:16583+NADPH(4-)+hydron
Reaction pageRight to leftBalanced
Rhea RHEA:35607CC BY 4.0Reference data