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Proteins/UNIPROT:Q03112
[Isoform 1]: Functions as a transcriptional regulator binding to DNA sequences in the promoter region of target genes and regulating positively or negatively their expression. Oncogene which plays a role in development, cell proliferation and differentiation. May also play a role in apoptosis through regulation of the JNK and TGF-beta signaling. Involved in hematopoiesis..
[Isoform 7]: Displays histone methyltransferase activity and monomethylates 'Lys-9' of histone H3 (H3K9me1). Probably catalyzes the monomethylation of free histone H3 in the cytoplasm which is then transported to the nucleus and incorporated into nucleosomes where SUV39H methyltransferases use it as a substrate to catalyze histone H3 'Lys-9' trimethylation. Likely to be one of the primary histone methyltransferases along with PRDM16 that direct cytoplasmic H3K9me1 methylation..
Function from UniProtKB (Q03112), read 2026-09-23. CC BY 4.0.
Curated compounds routed: 0
3 rows
146 statements
146 statements · 6 reference databases · Subject: MECOM · Sources: Bgee, gene ontology, Hetionet, Human Protein Atlas, Reactome, WikiPathways
1 reaction
L-lysyl(9)-[histone H3]+S-adenosyl-L-methionineN(6)-methyl-L-lysyl(9)-[histone H3]+S-adenosyl-L-homocysteine+hydron
Catalysed by MECOM or SETDB1 or EHMT2 or SETD5 or EHMT1 or PRDM16 or ASH1L
Reaction pageLeft to rightBalance undeterminable
Rhea RHEA:60280CC BY 4.0Reference data
8 names
Resolves to: MECOM