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Proteins/UNIPROT:Q6Y1H2
Catalyzes the third of the very long-chain fatty acids (VLCFA) elongation four-step cycle (condensation, reduction, dehydration, and reduction). This endoplasmic reticulum-elongation process is characterized by the addition of two carbons to the lipid chain through each cycle. This enzyme catalyzes the dehydration of the 3-hydroxyacyl-CoA intermediate into trans-2,3-enoyl-CoA, within each cycle of elongation. Therefore, it participates in the production of various VLCFAs involved in multiple biological processes as precursors of membrane lipids and lipid mediators..
Function from UniProtKB (Q6Y1H2), read 2026-09-23. CC BY 4.0.
Curated compounds routed: 0
21 statements
21 statements · 4 reference databases · Subject: HACD2 · Sources: Hetionet, Human-GEM, Reactome, Rhea
35 reactions
MAM00793c(2E)-octadecenoyl-CoA+water
Catalysed by HACD3 or HIGD2A or HACD1 or HACD4 or HACD2
Reaction pageLeft to rightBalancedEC 4.2.1.134cytosol
Human-GEM MAR02193CC BY 4.0Reference data
MAM00777c(2E)-eicosenoyl-CoA+water
4 names
Resolves to: HACD2
Reaction pageLeft to rightBalancedEC 4.2.1.134cytosol
Human-GEM MAR02203CC BY 4.0Reference data
MAM00776c(2E)-docosenoyl-CoA+water
Catalysed by HACD3 or HIGD2A or HACD1 or HACD4 or HACD2
Reaction pageLeft to rightBalancedEC 4.2.1.134cytosol
Human-GEM MAR02209CC BY 4.0Reference data
MAM00800c(2E)-tetracosenoyl-CoA+water
Catalysed by HACD3 or HIGD2A or HACD1 or HACD4 or HACD2
Reaction pageLeft to rightBalancedEC 4.2.1.134cytosol
Human-GEM MAR02213CC BY 4.0Reference data
MAM00783c(2E)-hexacosenoyl-CoA+water
Catalysed by HACD3 or HIGD2A or HACD1 or HACD4 or HACD2
Reaction pageLeft to rightBalancedEC 4.2.1.134cytosol
Human-GEM MAR02218CC BY 4.0Reference data
MAM00790cMAM00054c+water
Catalysed by HACD3 or HIGD2A or HACD1 or HACD4 or HACD2
Reaction pageLeft to rightBalancedEC 4.2.1.134cytosol
Human-GEM MAR02261CC BY 4.0Reference data
MAM00778cMAM00044c+water
Catalysed by HACD3 or HIGD2A or HACD1 or HACD4 or HACD2
Reaction pageLeft to rightBalancedEC 4.2.1.134cytosol
Human-GEM MAR02265CC BY 4.0Reference data
MAM00802cMAM00067c+water
Catalysed by HACD3 or HACD1 or HACD4 or HACD2
Reaction pageLeft to rightBalancedEC 4.2.1.134cytosol
Human-GEM MAR02269CC BY 4.0Reference data
MAM00700cwater+MAM03012c
Catalysed by HACD3 or HIGD2A or HACD1 or HACD4 or HACD2
Reaction pageLeft to rightBalancedEC 4.2.1.134cytosol
Human-GEM MAR02309CC BY 4.0Reference data
MAM00701cwater+MAM03013c
Catalysed by HACD3 or HIGD2A or HACD1 or HACD4 or HACD2
Reaction pageLeft to rightBalancedEC 4.2.1.134cytosol
Human-GEM MAR02319CC BY 4.0Reference data
MAM00709cwater+MAM03015c
Catalysed by HACD3 or HIGD2A or HACD1 or HACD4 or HACD2
Reaction pageLeft to rightBalancedEC 4.2.1.134cytosol
Human-GEM MAR02328CC BY 4.0Reference data
MAM00715cwater+MAM03016c
Catalysed by HACD3 or HIGD2A or HACD1 or HACD4 or HACD2
Reaction pageLeft to rightBalancedEC 4.2.1.134cytosol
Human-GEM MAR02336CC BY 4.0Reference data