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Proteins/UNIPROT:Q9Y678
The coatomer is a cytosolic protein complex that binds to dilysine motifs and reversibly associates with Golgi non-clathrin-coated vesicles, which further mediate biosynthetic protein transport from the ER, via the Golgi up to the trans Golgi network. Coatomer complex is required for budding from Golgi membranes, and is essential for the retrograde Golgi-to-ER transport of dilysine-tagged proteins. In mammals, the coatomer can only be recruited by membranes associated to ADP-ribosylation factors (ARFs), which are small GTP-binding proteins; the complex also influences the Golgi structural integrity, as well as the processing, activity, and endocytic recycling of LDL receptors. Required for limiting lipid storage in lipid droplets. Involved in lipid homeostasis by regulating the presence of perilipin family members PLIN2 and PLIN3 at the lipid droplet surface and promoting the association of adipocyte triglyceride lipase (PNPLA2) with the lipid droplet surface to mediate lipolysis (By similarity)..
Function from UniProtKB (Q9Y678), read 2026-09-23. CC BY 4.0.
Curated compounds routed: 0
49 statements
49 statements · 4 reference databases · Subject: COPG1 · Sources: Hetionet, Human-GEM, Reactome, WikiPathways
4 reactions
Transported by ARCN1 or COPE or COPG2 or COPG1
Reaction pageReversibleBalancedcytosol, extracellular space
Human-GEM MAR04312CC BY 4.0Reference data
Transported by ARCN1 or COPE or COPG2 or COPG1
Reaction pageReversibleBalancedcytosol, Golgi apparatus
3 names
Resolves to: COPG1
Human-GEM MAR04313CC BY 4.0Reference data
Transported by ARCN1 or COPE or COPG2 or COPG1
Reaction pageReversibleBalancedcytosol, lysosome
Human-GEM MAR04314CC BY 4.0Reference data
Transported by ARCN1 or COPE or COPG2 or COPG1
Reaction pageReversibleBalancedcytosol, Golgi apparatus
Human-GEM MAR06578CC BY 4.0Reference data