Proteins/UNIPROT:O96004

HAND1

ProteinUNIPROT:O96004

Transcription factor that plays an essential role in both trophoblast giant cell differentiation and in cardiac morphogenesis (By similarity). Binds the DNA sequence 5'-NRTCTG-3' (non-canonical E-box) (By similarity). Acts as a transcriptional repressor of SOX15 (By similarity). In the adult, could be required for ongoing expression of cardiac-specific genes..

Function from UniProtKB (O96004), read 2026-09-23. CC BY 4.0.

Curated compounds routed: 0

What the reference databases state

GenCC submitters' classifications

1 row

congenital heart disease has a germline basis in HAND1DiseaseGenCC HGNC:4807|MONDO:0005453Inferred only

Statements

24 statements

24 statements · 4 reference databases · Subject: HAND1 · Sources: gene ontology, Hetionet, Reactome, WikiPathways

Order

HAND1 covaries with FNDC3BProteinHetionet hetionet:covaries:64778-9421Inferred only
ZKSCAN5 covaries with HAND1ProteinHetionet hetionet:covaries:23660-9421Inferred only
FHL2 interacts with HAND1ProteinHetionet hetionet:interacts:2274-9421Inferred only
HAND1 interacts with HAND2ProteinHetionet hetionet:interacts:9421-9464Inferred only
HAND1 interacts with HEY2ProteinHetionet hetionet:interacts:23493-9421Inferred only
HAND1 interacts with HEYLProteinHetionet hetionet:interacts:26508-9421Inferred only
MYOD1 interacts with HAND1ProteinHetionet hetionet:interacts:4654-9421Inferred only
PPP2R5D interacts with HAND1ProteinHetionet hetionet:interacts:5528-9421Inferred only
PRKACA interacts with HAND1ProteinHetionet hetionet:interacts:5566-9421Inferred only
PRKCA interacts with HAND1ProteinHetionet hetionet:interacts:5578-9421Inferred only
HAND1 interacts with SRA1ProteinHetionet hetionet:interacts:10011-9421Inferred only
TCF12 interacts with HAND1ProteinHetionet hetionet:interacts:6938-9421Inferred only

Show the remaining 12

TCF3 interacts with HAND1ProteinHetionet hetionet:interacts:6929-9421Inferred only
HAND1 participates in CardiogenesisPathwayReactome R-HSA-9733709Inferred only
HAND1 participates in Developmental BiologyPathwayReactome R-HSA-1266738Inferred only
HAND1 participates in Heart developmentPathwayWikiPathways WP1591Inferred only
HAND1 participates in Mesodermal commitment pathwayPathwayWikiPathways WP2857Inferred only
HAND1 participates in Neural crest differentiationPathwayWikiPathways WP2064Inferred only
HAND1 regulates negative regulation of transcription by RNA polymerase IIBiological processgene ontology O96004|GO:0000122Inferred only
HAND1 regulates positive regulation of transcription by RNA polymerase IIBiological processgene ontology O96004|GO:0045944Inferred only
HAND1 regulates regulation of transcription by RNA polymerase IIBiological processgene ontology O96004|GO:0006357Inferred only
HAND1 decreases the expression of HACD3ProteinHetionet hetionet:regulates:9421-51495Inferred only
HAND1 increases the expression of MAP7ProteinHetionet hetionet:regulates:9421-9053Inferred only
HAND1 decreases the expression of SMC1AProteinHetionet hetionet:regulates:9421-8243Inferred only

Other names

4 names

Resolves to: HAND1

Also called: BHLHA27Class A basic helix-loop-helix protein 27EHANDExtraembryonic tissues, heart, autonomic nervous system and neural crest derivatives-expressed protein 1

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