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Proteins/UNIPROT:P08151
Transcription activator that acts as a key effector of the smoothened signaling pathway, and which plays a role in craniofacial development and digital development, as well as development of the central nervous system and gastrointestinal tract. Binds to the DNA consensus sequence 5'-GACCACCCA-3'. Activated in response to smoothened signaling: in presence of hedgehog (DHH, IHH or SHH) and subsequent activation of smoothened, GLI1 translocates to the nucleus and promotes expression of target genes. In contrast to GLI2 and GLI3, does not contain a repressor domain and only acts as a transcription activator..
[Isoform 2]: Acts as a transcriptional activator, but activates a different set of genes than isoform 1. Activates expression of CD24, unlike isoform 1..
Function from UniProtKB (P08151), read 2026-09-23. CC BY 4.0.
Curated compounds routed: 0
5 rows
245 statements
245 statements · 4 reference databases · Subject: GLI1 · Sources: gene ontology, Hetionet, Reactome, WikiPathways
3 names
Resolves to: GLI1