Compound

(2E)-hexacosenoyl-CoA

An acyl-CoA(4−) obtained by deprotonation of the phosphate and diphosphate OH groups of trans-2-hexacosenoyl-CoA.

Definition from ChEBI (CHEBI:74281), read 2026-09-23. CC BY 4.0.

CHEBI:74281ChEBI

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Structure

2D depiction

No three-dimensional record for this entry.

Class: Organic compound, anion
Formula: C47H80N7O17P3S
Mass: 1140.178 g/mol
Charge: -4
InChIKey: GGUUXBBWTGIIGE-KESUDTCVSA-J
SMILES: CCCCCCCCCCCCCCCCCCCCCCC/C=C/C(=O)SCCNC(=O)CCNC(=O)[C@H](O)C(C)(C)COP(=O)([O-])OP(=O)([O-])OC[C@H]1O[C@@H](n2cnc3c(N)ncnc32)[C@H](O)[C@@H]1OP(=O)([O-])[O-]
Look it up: ChEBI By InChIKey

Identity from ChEBI. Not evidence.

What it touches on the way

Mechanistic reach

8 entities

8 entities reached.

0 reported hops8 assembled from the scaffold

What the reference databases state

Statements

13 statements

13 statements · 2 reference databases · Subject: (2E)-hexacosenoyl-CoA · Sources: Human-GEM, Rhea

Order

(2E)-hexacosenoyl-CoA is converted to hexacosanoyl-CoACompoundHuman-GEM MAR02219Inferred only
(2E)-hexacosenoyl-CoA is converted to hexacosanoyl-CoACompoundRhea RHEA:39215Inferred only
hexacosanoyl-CoA is converted to (2E)-hexacosenoyl-CoACompoundHuman-GEM MAR03057Inferred only
hexacosanoyl-CoA is converted to (2E)-hexacosenoyl-CoACompoundRhea RHEA:39215Inferred only
hexacosanoyl-CoA is converted to (2E)-hexacosenoyl-CoACompoundRhea RHEA:78631Inferred only
(2E)-hexacosenoyl-CoA is a substrate of ECI1ProteinHuman-GEM MAR03058Inferred only
(2E)-hexacosenoyl-CoA is a substrate of EHHADHProteinHuman-GEM MAR03058Inferred only
(2E)-hexacosenoyl-CoA is a substrate of HACD1ProteinRhea RHEA:39211Inferred only
(2E)-hexacosenoyl-CoA is a substrate of HACD2ProteinRhea RHEA:39211Inferred only
(2E)-hexacosenoyl-CoA is a substrate of HADHAProteinHuman-GEM MAR03058Inferred only
(2E)-hexacosenoyl-CoA is a substrate of HSD17B4ProteinRhea RHEA:39211Inferred only
(2E)-hexacosenoyl-CoA is a substrate of TECRProteinHuman-GEM MAR02219Inferred only

Show the remaining 1

(2E)-hexacosenoyl-CoA is a substrate of TECRLProteinHuman-GEM MAR02219Inferred only

Reactions

8 reactions

MAM00783c(2E)-hexacosenoyl-CoA+water
Catalysed by HACD3 or HIGD2A or HACD1 or HACD4 or HACD2
Reaction pageLeft to rightBalancedEC 4.2.1.134cytosol
Human-GEM MAR02218CC BY 4.0Reference data
(2E)-hexacosenoyl-CoA+proton+NADPH(4-)hexacosanoyl-CoA+NADP(3-)
Catalysed by TECR or TECRL
Reaction pageLeft to rightBalancedEC 1.3.1.93cytosol
Human-GEM MAR02219CC BY 4.0Reference data
FAD+hexacosanoyl-CoA(2E)-hexacosenoyl-CoA+FADH2
Catalysed by ACOX3 or ACOX1
Reaction pageLeft to rightBalancedEC 1.3.3.6peroxisome
Human-GEM MAR03057CC BY 4.0Reference data
(2E)-hexacosenoyl-CoA+waterMAM00783x
Catalysed by HADHA & ECI1 & EHHADH
Reaction pageLeft to rightBalancedEC 4.2.1.17peroxisome
Human-GEM MAR03058CC BY 4.0Reference data
CHEBI:76378(2E)-hexacosenoyl-CoA+water
Catalysed by HACD1 or HSD17B4 or HACD2
Reaction pageReversibleBalanced
Rhea RHEA:39211CC BY 4.0Reference data
(2E)-hexacosenoyl-CoA+NADPH(4-)+hydronhexacosanoyl-CoA+NADP(3-)
Reaction pageDirection not assertedBalanced
Rhea RHEA:39215CC BY 4.0Reference data
hexacosanoyl-CoA+oxidized [electron-transfer flavoprotein]+hydron(2E)-hexacosenoyl-CoA+reduced [electron-transfer flavoprotein]
Reaction pageDirection not assertedBalance undeterminable
Rhea RHEA:48216CC BY 4.0Reference data
hexacosanoyl-CoA+dioxygen(2E)-hexacosenoyl-CoA+hydrogen peroxide
Catalysed by ACOX1
Reaction pageLeft to rightBalanced
Rhea RHEA:78631CC BY 4.0Reference data

Other names

7 names

Resolves to: (2E)-hexacosenoyl-CoA

Also called: (E)-2-hexacosenoyl-CoA(4-)(E)-2-hexacosenoyl-CoA(4−)(E)-2-hexacosenoyl-coenzyme A(4-)(E)-2-hexacosenoyl-coenzyme A(4−)trans-2-hexacosenoyl-coenzyme A(4-)trans-2-hexacosenoyl-coenzyme A(4−)
Systematic name: 3'-phosphonatoadenosine 5'-{3-[(3R)-4-({3-[(2-{[(2E)-hexacos-2-enoyl]sulfanyl}ethyl)amino]-3-hydroxy-3-oxopropyl}amino)-2,2-dimethyl-4-oxobutyl] diphosphate}