(5S)-hydroxy-(6E,8Z,11Z,14Z)-eicosatetraenoate

362,296 routes · scope human · up to 3 steps · built 5 October 2026 · Reactions · API

137 compounds within 3 steps: 5 in 1, 10 in 2, 122 in 3

Three steps

CHEBI:16856Reach from here →
1. (5S)-hydroxy-(6E,8Z,11Z,14Z)-eicosatetraenoate + AH2 + O2 = (5S,11R)-dihydroxy-(6E,8Z,12E,14Z)-eicosatetraenoate + A + H2O
2. Mo-molybdopterin + L-cysteine + AH2 = thio-Mo-molybdopterin + L-alanine + A + H2O
3. cystine to cysteine conversion
Catalysed by PTGS2, MOCOScytosol
CHEBI:16857Reach from here →
1. (5S)-hydroxy-(6E,8Z,11Z,14Z)-eicosatetraenoate + AH2 + O2 = (5S,11R)-dihydroxy-(6E,8Z,12E,14Z)-eicosatetraenoate + A + H2O
2. Mo-molybdopterin + L-cysteine + AH2 = thio-Mo-molybdopterin + L-alanine + A + H2O
3. transport of cysteine and threonine (cytosol to extracellular)
Catalysed by PTGS2, MOCOS, SLC7A5extracellular space, cytosolOne of 4 routes
L-isoleucineReach from here →
1. (5S)-hydroxy-(6E,8Z,11Z,14Z)-eicosatetraenoate + AH2 + O2 = (5S,11R)-dihydroxy-(6E,8Z,12E,14Z)-eicosatetraenoate + A + H2O
2. Mo-molybdopterin + L-cysteine + AH2 = thio-Mo-molybdopterin + L-alanine + A + H2O
3. transport of cysteine and isoleucine (cytosol to extracellular)
Catalysed by PTGS2, MOCOS, SLC7A5extracellular space, cytosolOne of 4 routes
CHEBI:17203Reach from here →
1. (5S)-hydroxy-(6E,8Z,11Z,14Z)-eicosatetraenoate + AH2 + O2 = (5S,11R)-dihydroxy-(6E,8Z,12E,14Z)-eicosatetraenoate + A + H2O
2. Mo-molybdopterin + L-cysteine + AH2 = thio-Mo-molybdopterin + L-alanine + A + H2O
3. transport of cysteine and proline (cytosol to extracellular)
Catalysed by PTGS2, MOCOS, SLC7A5extracellular space, cytosolOne of 3 routes
5'-deoxyadenosineReach from here →
1. (5S)-hydroxy-(6E,8Z,11Z,14Z)-eicosatetraenoate + AH2 + O2 = (5S,11R)-dihydroxy-(6E,8Z,12E,14Z)-eicosatetraenoate + A + H2O
2. A + NADH + H(+) = AH2 + NAD(+)
3. N(6)-dimethylallyladenosine(37) in tRNA + (sulfur carrier)-SH + AH2 + 2 S-adenosyl-L-methionine = 2-methylsulfanyl-N(6)-dimethylallyladenosine(37) in tRNA + (sulfur carrier)-H + 5'-deoxyadenosine + L-methionine + A + S-adenosyl-L-homocysteine + 2 H(+)
Catalysed by PTGS2, AIFM1, PYROXD1, CDK5RAP1One of 4 routes
1-O-acyl-sn-glycero-3-phosphocholine(1+)Reach from here →
1. (5S)-hydroxy-(6E,8Z,11Z,14Z)-eicosatetraenoate + AH2 + O2 = (5S,11R)-dihydroxy-(6E,8Z,12E,14Z)-eicosatetraenoate + A + H2O
2. all-trans-13,14-dihydroretinol + A = all-trans-retinol + AH2
3. Lecithin Retinol Acyltransferase
Catalysed by PTGS2, RETSAT, LRATcytosol
all-trans-retinyl hexadecanoateReach from here →
1. (5S)-hydroxy-(6E,8Z,11Z,14Z)-eicosatetraenoate + AH2 + O2 = (5S,11R)-dihydroxy-(6E,8Z,12E,14Z)-eicosatetraenoate + A + H2O
2. all-trans-13,14-dihydroretinol + A = all-trans-retinol + AH2
3. all-trans-retinol + hexadecanoyl-CoA = all-trans-retinyl hexadecanoate + CoA
Catalysed by PTGS2, RETSAT, DGAT1, PNPLA4 and 3 moreOne of 2 routes
3,3',5'-triiodo-L-thyronine sulfateReach from here →
1. (5S)-hydroxy-(6E,8Z,11Z,14Z)-eicosatetraenoate + AH2 + O2 = (5S,11R)-dihydroxy-(6E,8Z,12E,14Z)-eicosatetraenoate + A + H2O
2. A + NADH + H(+) = AH2 + NAD(+)
3. 3,3',5'-triiodo-L-thyronine sulfate + iodide + A + H(+) = L-thyroxine sulfate + AH2
Catalysed by PTGS2, AIFM1, PYROXD1, DIO1
3,3'-diiodo-L-thyronineReach from here →
1. (5S)-hydroxy-(6E,8Z,11Z,14Z)-eicosatetraenoate + AH2 + O2 = (5S,11R)-dihydroxy-(6E,8Z,12E,14Z)-eicosatetraenoate + A + H2O
2. A + NADH + H(+) = AH2 + NAD(+)
3. 3,3'-diiodo-L-thyronine + iodide + A + H(+) = 3,3',5-triiodo-L-thyronine + AH2
Catalysed by PTGS2, AIFM1, PYROXD1, DIO1 and 1 moreOne of 2 routes
3,3'-diiodo-L-thyronine sulfateReach from here →
1. (5S)-hydroxy-(6E,8Z,11Z,14Z)-eicosatetraenoate + AH2 + O2 = (5S,11R)-dihydroxy-(6E,8Z,12E,14Z)-eicosatetraenoate + A + H2O
2. A + NADH + H(+) = AH2 + NAD(+)
3. 3,3'-diiodo-L-thyronine sulfate + iodide + A + H(+) = 3,3',5-triiodo-L-thyronine sulfate + AH2
Catalysed by PTGS2, AIFM1, PYROXD1, DIO1One of 2 routes
CHEBI:17724Reach from here →
1. (5S)-hydroxy-(6E,8Z,11Z,14Z)-eicosatetraenoate + AH2 + O2 = (5S,11R)-dihydroxy-(6E,8Z,12E,14Z)-eicosatetraenoate + A + H2O
2. N(6),N(6)-dimethyl-L-lysyl(4)-[histone H3] + 2 A + 2 H2O = L-lysyl(4)-[histone H3] + 2 formaldehyde + 2 AH2
3. dimethylglycine dehydrogenase (formaldehyde)
Catalysed by PTGS2, KDM1A, KDM1B, PDPR and 1 morecytosol
glycine betaineReach from here →
1. (5S)-hydroxy-(6E,8Z,11Z,14Z)-eicosatetraenoate + AH2 + O2 = (5S,11R)-dihydroxy-(6E,8Z,12E,14Z)-eicosatetraenoate + A + H2O
2. choline + A = betaine aldehyde + AH2
3. p-cumic alcohol:NAD+ oxidoreductase
Catalysed by PTGS2, CHDH, ALDH7A1cytosolOne of 4 routes
CHEBI:17895Reach from here →
1. (5S)-hydroxy-(6E,8Z,11Z,14Z)-eicosatetraenoate + AH2 + O2 = (5S,11R)-dihydroxy-(6E,8Z,12E,14Z)-eicosatetraenoate + A + H2O
2. Mo-molybdopterin + L-cysteine + AH2 = thio-Mo-molybdopterin + L-alanine + A + H2O
3. transport of cysteine and tyrosine (cytosol to extracellular)
Catalysed by PTGS2, MOCOS, SLC7A5extracellular space, cytosolOne of 4 routes
all-trans-retinalReach from here →
1. (5S)-hydroxy-(6E,8Z,11Z,14Z)-eicosatetraenoate + AH2 + O2 = (5S,11R)-dihydroxy-(6E,8Z,12E,14Z)-eicosatetraenoate + A + H2O
2. all-trans-13,14-dihydroretinol + A = all-trans-retinol + AH2
3. retinol: NADP+ oxidoreductase
Catalysed by PTGS2, RETSAT, DHRS3, RDH10 and 4 morecytosolOne of 6 routes
CHEBI:18019Reach from here →
1. (5S)-hydroxy-(6E,8Z,11Z,14Z)-eicosatetraenoate + AH2 + O2 = (5S,11R)-dihydroxy-(6E,8Z,12E,14Z)-eicosatetraenoate + A + H2O
2. Mo-molybdopterin + L-cysteine + AH2 = thio-Mo-molybdopterin + L-alanine + A + H2O
3. transport of cysteine and lysine (cytosol to extracellular)
Catalysed by PTGS2, MOCOS, SLC7A6extracellular space, cytosolOne of 2 routes
a diacylglycerolReach from here →
1. (5S)-hydroxy-(6E,8Z,11Z,14Z)-eicosatetraenoate + AH2 + O2 = (5S,11R)-dihydroxy-(6E,8Z,12E,14Z)-eicosatetraenoate + A + H2O
2. all-trans-13,14-dihydroretinol + A = all-trans-retinol + AH2
3. a triacylglycerol + all-trans-retinol = an all-trans-retinyl ester + a diacylglycerol
Catalysed by PTGS2, RETSAT, PNPLA4, PNPLA2
L-glutamineReach from here →
1. (5S)-hydroxy-(6E,8Z,11Z,14Z)-eicosatetraenoate + AH2 + O2 = (5S,11R)-dihydroxy-(6E,8Z,12E,14Z)-eicosatetraenoate + A + H2O
2. Mo-molybdopterin + L-cysteine + AH2 = thio-Mo-molybdopterin + L-alanine + A + H2O
3. transport of cysteine and glutamine (cytosol to extracellular)
Catalysed by PTGS2, MOCOS, SLC3A2, SLC7A5 and 1 moreextracellular space, cytosolOne of 4 routes
3',5'-diiodo-L-thyronineReach from here →
1. (5S)-hydroxy-(6E,8Z,11Z,14Z)-eicosatetraenoate + AH2 + O2 = (5S,11R)-dihydroxy-(6E,8Z,12E,14Z)-eicosatetraenoate + A + H2O
2. A + NADH + H(+) = AH2 + NAD(+)
3. 3',5'-diiodo-L-thyronine + iodide + A + H(+) = 3,3',5'-triiodo-L-thyronine + AH2
Catalysed by PTGS2, AIFM1, PYROXD1, DIO3
5-(3,3-dimethylguanidino)-2-oxopentanoateReach from here →
1. (5S)-hydroxy-(6E,8Z,11Z,14Z)-eicosatetraenoate + AH2 + O2 = (5S,11R)-dihydroxy-(6E,8Z,12E,14Z)-eicosatetraenoate + A + H2O
2. (R)-malate + A = oxaloacetate + AH2
3. N(omega),N(omega)-dimethyl-L-arginine + oxaloacetate = 5-(3,3-dimethylguanidino)-2-oxopentanoate + L-aspartate
Catalysed by PTGS2, D2HGDH, AGXT2
(6R)-5,10-methylenetetrahydrofolic acidReach from here →
1. (5S)-hydroxy-(6E,8Z,11Z,14Z)-eicosatetraenoate + AH2 + O2 = (5S,11R)-dihydroxy-(6E,8Z,12E,14Z)-eicosatetraenoate + A + H2O
2. N(6),N(6)-dimethyl-L-lysyl(4)-[histone H3] + 2 A + 2 H2O = L-lysyl(4)-[histone H3] + 2 formaldehyde + 2 AH2
3. formaldehyde to 5,10-methylene-THF conversion
Catalysed by PTGS2, KDM1A, KDM1Bcytosol
5,6,7,8-tetrahydrofolic acidReach from here →
1. (5S)-hydroxy-(6E,8Z,11Z,14Z)-eicosatetraenoate + AH2 + O2 = (5S,11R)-dihydroxy-(6E,8Z,12E,14Z)-eicosatetraenoate + A + H2O
2. uridine(34) in tRNA + 5,10-methylenetetrahydrofolate + taurine + GTP + A + H2O = 5-taurinomethyluridine(34) in tRNA + 7,8-dihydrofolate + GDP + AH2 + phosphate + H(+)
3. 5,6,7,8-tetrahydrofolate:NAD+ oxidoreductase
Catalysed by PTGS2, MTO1, DHFR, DHFR2cytosolOne of 3 routes
S-disulfanyl-L-cysteineReach from here →
1. (5S)-hydroxy-(6E,8Z,11Z,14Z)-eicosatetraenoate + AH2 + O2 = (5S,11R)-dihydroxy-(6E,8Z,12E,14Z)-eicosatetraenoate + A + H2O
2. Mo-molybdopterin + L-cysteine + AH2 = thio-Mo-molybdopterin + L-alanine + A + H2O
3. S-sulfanyl-L-cysteine + L-cysteine = S-disulfanyl-L-cysteine + L-alanine
Catalysed by PTGS2, MOCOS, CARS2
3-iodothyronamineReach from here →
1. (5S)-hydroxy-(6E,8Z,11Z,14Z)-eicosatetraenoate + AH2 + O2 = (5S,11R)-dihydroxy-(6E,8Z,12E,14Z)-eicosatetraenoate + A + H2O
2. A + NADH + H(+) = AH2 + NAD(+)
3. 3-iodothyronamine + iodide + A + H(+) = 3,5-diiodothyronamine + AH2
Catalysed by PTGS2, AIFM1, PYROXD1, DIO1 and 1 moreOne of 2 routes
3-iodo-L-thyronineReach from here →
1. (5S)-hydroxy-(6E,8Z,11Z,14Z)-eicosatetraenoate + AH2 + O2 = (5S,11R)-dihydroxy-(6E,8Z,12E,14Z)-eicosatetraenoate + A + H2O
2. A + NADH + H(+) = AH2 + NAD(+)
3. 3-iodo-L-thyronine + iodide + A + H(+) = 3,5-diiodo-L-thyronine + AH2
Catalysed by PTGS2, AIFM1, PYROXD1, DIO1 and 1 moreOne of 2 routes
3'-iodo-L-thyronineReach from here →
1. (5S)-hydroxy-(6E,8Z,11Z,14Z)-eicosatetraenoate + AH2 + O2 = (5S,11R)-dihydroxy-(6E,8Z,12E,14Z)-eicosatetraenoate + A + H2O
2. A + NADH + H(+) = AH2 + NAD(+)
3. 3'-iodo-L-thyronine + iodide + A + H(+) = 3',5'-diiodo-L-thyronine + AH2
Catalysed by PTGS2, AIFM1, PYROXD1, DIO1 and 1 moreOne of 2 routes
L-thyronineReach from here →
1. (5S)-hydroxy-(6E,8Z,11Z,14Z)-eicosatetraenoate + AH2 + O2 = (5S,11R)-dihydroxy-(6E,8Z,12E,14Z)-eicosatetraenoate + A + H2O
2. A + NADH + H(+) = AH2 + NAD(+)
3. L-thyronine + iodide + A + H(+) = 3-iodo-L-thyronine + AH2
Catalysed by PTGS2, AIFM1, PYROXD1, DIO3
thyronamineReach from here →
1. (5S)-hydroxy-(6E,8Z,11Z,14Z)-eicosatetraenoate + AH2 + O2 = (5S,11R)-dihydroxy-(6E,8Z,12E,14Z)-eicosatetraenoate + A + H2O
2. A + NADH + H(+) = AH2 + NAD(+)
3. thyronamine + iodide + A + H(+) = 3-iodothyronamine + AH2
Catalysed by PTGS2, AIFM1, PYROXD1, DIO3
3'-iodothyronamineReach from here →
1. (5S)-hydroxy-(6E,8Z,11Z,14Z)-eicosatetraenoate + AH2 + O2 = (5S,11R)-dihydroxy-(6E,8Z,12E,14Z)-eicosatetraenoate + A + H2O
2. A + NADH + H(+) = AH2 + NAD(+)
3. 3'-iodothyronamine + iodide + A + H(+) = 3',5'-diiodothyronamine + AH2
Catalysed by PTGS2, AIFM1, PYROXD1, DIO1 and 1 moreOne of 2 routes
3,3'-diiodothyronamineReach from here →
1. (5S)-hydroxy-(6E,8Z,11Z,14Z)-eicosatetraenoate + AH2 + O2 = (5S,11R)-dihydroxy-(6E,8Z,12E,14Z)-eicosatetraenoate + A + H2O
2. A + NADH + H(+) = AH2 + NAD(+)
3. 3,3'-diiodothyronamine + iodide + A + H(+) = 3,3',5'-triiodothyronamine + AH2
Catalysed by PTGS2, AIFM1, PYROXD1, DIO1 and 1 moreOne of 2 routes
3',5'-diiodothyronamineReach from here →
1. (5S)-hydroxy-(6E,8Z,11Z,14Z)-eicosatetraenoate + AH2 + O2 = (5S,11R)-dihydroxy-(6E,8Z,12E,14Z)-eicosatetraenoate + A + H2O
2. A + NADH + H(+) = AH2 + NAD(+)
3. 3',5'-diiodothyronamine + iodide + A + H(+) = 3,3',5'-triiodothyronamine + AH2
Catalysed by PTGS2, AIFM1, PYROXD1, DIO3
3,3',5'-triiodothyronamineReach from here →
1. (5S)-hydroxy-(6E,8Z,11Z,14Z)-eicosatetraenoate + AH2 + O2 = (5S,11R)-dihydroxy-(6E,8Z,12E,14Z)-eicosatetraenoate + A + H2O
2. A + NADH + H(+) = AH2 + NAD(+)
3. 3,3',5'-triiodothyronamine + iodide + A + H(+) = 3,3',5,5'-tetraiodothyronamine + AH2
Catalysed by PTGS2, AIFM1, PYROXD1, DIO3
folic acidReach from here →
1. (5S)-hydroxy-(6E,8Z,11Z,14Z)-eicosatetraenoate + AH2 + O2 = (5S,11R)-dihydroxy-(6E,8Z,12E,14Z)-eicosatetraenoate + A + H2O
2. uridine(34) in tRNA + 5,10-methylenetetrahydrofolate + taurine + GTP + A + H2O = 5-taurinomethyluridine(34) in tRNA + 7,8-dihydrofolate + GDP + AH2 + phosphate + H(+)
3. dihydrofolate:NAD+ oxidoreductase
Catalysed by PTGS2, MTO1, DHFR, DHFR2cytosolOne of 2 routes
N-acetyl-L-cysteineReach from here →
1. (5S)-hydroxy-(6E,8Z,11Z,14Z)-eicosatetraenoate + AH2 + O2 = (5S,11R)-dihydroxy-(6E,8Z,12E,14Z)-eicosatetraenoate + A + H2O
2. Mo-molybdopterin + L-cysteine + AH2 = thio-Mo-molybdopterin + L-alanine + A + H2O
3. N-acetylglutamate synthase (N-acetyl-L-cysteine)
Catalysed by PTGS2, MOCOS, NAGSmitochondrial matrix
K(+)Reach from here →
1. (5S)-hydroxy-(6E,8Z,11Z,14Z)-eicosatetraenoate + AH2 + O2 = (5S,11R)-dihydroxy-(6E,8Z,12E,14Z)-eicosatetraenoate + A + H2O
2. Mo-molybdopterin + L-cysteine + AH2 = thio-Mo-molybdopterin + L-alanine + A + H2O
3. K(+)(in) + L-cysteine(out) + 3 Na(+)(out) + H(+)(out) = K(+)(out) + L-cysteine(in) + 3 Na(+)(in) + H(+)(in)
Catalysed by PTGS2, MOCOS, SLC1A1inner side of the membrane, outer side of the membraneOne of 2 routes
Cys-tRNA(Cys)Reach from here →
1. (5S)-hydroxy-(6E,8Z,11Z,14Z)-eicosatetraenoate + AH2 + O2 = (5S,11R)-dihydroxy-(6E,8Z,12E,14Z)-eicosatetraenoate + A + H2O
2. Mo-molybdopterin + L-cysteine + AH2 = thio-Mo-molybdopterin + L-alanine + A + H2O
3. L-Cysteine:tRNA(Cys) ligase (AMP-forming)
Catalysed by PTGS2, MOCOS, CARS1cytosol
chlorine(.)Reach from here →
1. (5S)-hydroxy-(6E,8Z,11Z,14Z)-eicosatetraenoate + AH2 + O2 = (5S,11R)-dihydroxy-(6E,8Z,12E,14Z)-eicosatetraenoate + A + H2O
2. Mo-molybdopterin + L-cysteine + AH2 = thio-Mo-molybdopterin + L-alanine + A + H2O
3. transport of chloride and cysteine (cytosol to extracellular)
Catalysed by PTGS2, MOCOS, SLC6A14extracellular space, cytosolOne of 2 routes
hydrogenselenideReach from here →
1. (5S)-hydroxy-(6E,8Z,11Z,14Z)-eicosatetraenoate + AH2 + O2 = (5S,11R)-dihydroxy-(6E,8Z,12E,14Z)-eicosatetraenoate + A + H2O
2. A + NADH + H(+) = AH2 + NAD(+)
3. L-selenocysteine + AH2 = hydrogenselenide + L-alanine + A + H(+)
Catalysed by PTGS2, AIFM1, PYROXD1, SCLY
hydrogen sulfideReach from here →
1. (5S)-hydroxy-(6E,8Z,11Z,14Z)-eicosatetraenoate + AH2 + O2 = (5S,11R)-dihydroxy-(6E,8Z,12E,14Z)-eicosatetraenoate + A + H2O
2. Mo-molybdopterin + L-cysteine + AH2 = thio-Mo-molybdopterin + L-alanine + A + H2O
3. L-cysteine hydrogen-sulfide-lyase (deaminating
Catalysed by PTGS2, MOCOS, CTHcytosolOne of 2 routes
L-aspartateReach from here →
1. (5S)-hydroxy-(6E,8Z,11Z,14Z)-eicosatetraenoate + AH2 + O2 = (5S,11R)-dihydroxy-(6E,8Z,12E,14Z)-eicosatetraenoate + A + H2O
2. (R)-malate + A = oxaloacetate + AH2
3. L-Aspartate:2-oxoglutarate aminotransferase
Catalysed by PTGS2, D2HGDH, GOT2mitochondrial matrixOne of 5 routes
citric acidReach from here →
1. (5S)-hydroxy-(6E,8Z,11Z,14Z)-eicosatetraenoate + AH2 + O2 = (5S,11R)-dihydroxy-(6E,8Z,12E,14Z)-eicosatetraenoate + A + H2O
2. (R)-malate + A = oxaloacetate + AH2
3. acetyl-CoA:oxaloacetate C-acetyltransferase (thioester-hydrolysing)
Catalysed by PTGS2, D2HGDH, CSmitochondrial matrixOne of 2 routes
4-hydroxy-2-oxoglutaric acidReach from here →
1. (5S)-hydroxy-(6E,8Z,11Z,14Z)-eicosatetraenoate + AH2 + O2 = (5S,11R)-dihydroxy-(6E,8Z,12E,14Z)-eicosatetraenoate + A + H2O
2. (R)-malate + A = oxaloacetate + AH2
3. D-aspartate:2-oxoglutarate aminotransferase
Catalysed by PTGS2, D2HGDH, GOT2mitochondrial matrix
di-mu-sulfido-diiron(2+)Reach from here →
1. (5S)-hydroxy-(6E,8Z,11Z,14Z)-eicosatetraenoate + AH2 + O2 = (5S,11R)-dihydroxy-(6E,8Z,12E,14Z)-eicosatetraenoate + A + H2O
2. Mo-molybdopterin + L-cysteine + AH2 = thio-Mo-molybdopterin + L-alanine + A + H2O
3. De novo synthesis of 2Fe2S
Catalysed by PTGS2, MOCOS, NDUFAB1, FDXR and 5 moremitochondrial matrix
25-hydroxycholesterolReach from here →
1. (5S)-hydroxy-(6E,8Z,11Z,14Z)-eicosatetraenoate + AH2 + O2 = (5S,11R)-dihydroxy-(6E,8Z,12E,14Z)-eicosatetraenoate + A + H2O
2. A + NADH + H(+) = AH2 + NAD(+)
3. cholesterol + AH2 + O2 = 25-hydroxycholesterol + A + H2O
Catalysed by PTGS2, AIFM1, PYROXD1, CH25H
all-trans-4-oxoretinolReach from here →
1. (5S)-hydroxy-(6E,8Z,11Z,14Z)-eicosatetraenoate + AH2 + O2 = (5S,11R)-dihydroxy-(6E,8Z,12E,14Z)-eicosatetraenoate + A + H2O
2. all-trans-13,14-dihydroretinol + A = all-trans-retinol + AH2
3. cytochrome P450 (retinol)
Catalysed by PTGS2, RETSAT, CYP26A1cytosol
phosphoenolpyruvic acidReach from here →
1. (5S)-hydroxy-(6E,8Z,11Z,14Z)-eicosatetraenoate + AH2 + O2 = (5S,11R)-dihydroxy-(6E,8Z,12E,14Z)-eicosatetraenoate + A + H2O
2. (R)-malate + A = oxaloacetate + AH2
3. GTP:oxaloacetate carboxy-lyase (adding GTP
Catalysed by PTGS2, D2HGDH, PCK1cytosolOne of 2 routes
13-cis-retinolReach from here →
1. (5S)-hydroxy-(6E,8Z,11Z,14Z)-eicosatetraenoate + AH2 + O2 = (5S,11R)-dihydroxy-(6E,8Z,12E,14Z)-eicosatetraenoate + A + H2O
2. all-trans-13,14-dihydroretinol + A = all-trans-retinol + AH2
3. retinol binding protein (retinol)
Catalysed by PTGS2, RETSAT, RBP1, RBP2cytosolOne of 2 routes
L-ornithineReach from here →
1. (5S)-hydroxy-(6E,8Z,11Z,14Z)-eicosatetraenoate + AH2 + O2 = (5S,11R)-dihydroxy-(6E,8Z,12E,14Z)-eicosatetraenoate + A + H2O
2. Mo-molybdopterin + L-cysteine + AH2 = thio-Mo-molybdopterin + L-alanine + A + H2O
3. transport of cysteine and ornithine (cytosol to extracellular)
Catalysed by PTGS2, MOCOS, SLC7A6extracellular space, cytosolOne of 2 routes
all-trans-13,14-dihydroretinolReach from here →
1. (5S)-hydroxy-(6E,8Z,11Z,14Z)-eicosatetraenoate + AH2 + O2 = (5S,11R)-dihydroxy-(6E,8Z,12E,14Z)-eicosatetraenoate + A + H2O
2. A + NADH + H(+) = AH2 + NAD(+)
3. all-trans-13,14-dihydroretinol + A = all-trans-retinol + AH2
Catalysed by PTGS2, AIFM1, PYROXD1, RETSATOne of 2 routes
3,3',5-triiodo-L-thyronineReach from here →
1. (5S)-hydroxy-(6E,8Z,11Z,14Z)-eicosatetraenoate + AH2 + O2 = (5S,11R)-dihydroxy-(6E,8Z,12E,14Z)-eicosatetraenoate + A + H2O
2. A + NADH + H(+) = AH2 + NAD(+)
3. 3,3',5-triiodo-L-thyronine + iodide + A + H(+) = L-thyroxine + AH2
Catalysed by PTGS2, AIFM1, PYROXD1, DIO1 and 1 more
3,3',5'-triiodo-L-thyronineReach from here →
1. (5S)-hydroxy-(6E,8Z,11Z,14Z)-eicosatetraenoate + AH2 + O2 = (5S,11R)-dihydroxy-(6E,8Z,12E,14Z)-eicosatetraenoate + A + H2O
2. A + NADH + H(+) = AH2 + NAD(+)
3. 3,3',5'-triiodo-L-thyronine + iodide + A + H(+) = L-thyroxine + AH2
Catalysed by PTGS2, AIFM1, PYROXD1, DIO1 and 1 more