an N(2)-acyl-L-glutamine

Three steps

• N(omega),N('omega)-dimethyl-L-arginineReach from here →
  1. an acyl-CoA + L-glutamine = an N(2)-acyl-L-glutamine + CoA + H(+)
  2. L-Glutamine:pyruvate aminotransferase
  3. N(omega),N('omega)-dimethyl-L-arginine + pyruvate = 5-(3,3'-dimethylguanidino)-2-oxopentanoate + L-alanine

  Catalysed by GLYATL1B, GLYATL1, KYAT1, AGXT2cytosolOne of 2 routes

• 1-eicosanoyl-2-(9Z-octadecenoyl)-glycerolReach from here →
  1. an acyl-CoA + L-glutamine = an N(2)-acyl-L-glutamine + CoA + H(+)
  2. acyl-CoA pool formation and breakdown
  3. eicosanoyl-CoA + 2-(9Z-octadecenoyl)-glycerol = 1-eicosanoyl-2-(9Z-octadecenoyl)-glycerol + CoA

  Catalysed by GLYATL1B, GLYATL1, MOGAT2, MOGAT1cytosol

• 5,6,7,8-tetrahydrofolic acidReach from here →
  1. an acyl-CoA + L-glutamine = an N(2)-acyl-L-glutamine + CoA + H(+)
  2. transport of glutamine and glycine (cytosol to extracellular)
  3. 5,10-Methylenetetrahydrofolate:glycine hydroxymethyltransferase

  Catalysed by GLYATL1B, GLYATL1, SLC7A5, SHMT1extracellular space, cytosolOne of 2 routes

• S-disulfanyl-L-cysteineReach from here →
  1. an acyl-CoA + L-glutamine = an N(2)-acyl-L-glutamine + CoA + H(+)
  2. transport of cysteine and glutamine (cytosol to extracellular)
  3. S-sulfanyl-L-cysteine + L-cysteine = S-disulfanyl-L-cysteine + L-alanine

  Catalysed by GLYATL1B, GLYATL1, SLC3A2, SLC7A5 and 2 moreextracellular space, cytosol

• (5Z)-dodecenoyl-CoAReach from here →
  1. an acyl-CoA + L-glutamine = an N(2)-acyl-L-glutamine + CoA + H(+)
  2. acyl-CoA:sn-glycerol-3-phosphate 1-O-acyltransferase
  3. acetyl-CoA C-acyltransferase (3-oxomyrist-7-enoyl-CoA)

  Catalysed by GLYATL1B, GLYATL1, GPAT3, GPAT2 and 5 moremitochondrial matrixOne of 2 routes

• 3-oxo-(9Z)-eicosenoyl-CoAReach from here →
  1. an acyl-CoA + L-glutamine = an N(2)-acyl-L-glutamine + CoA + H(+)
  2. acyl-CoA pool formation and breakdown
  3. very-long-chain 3-oxoacyl-CoA synthase ((7Z)-octadecenoyl-CoA)

  Catalysed by GLYATL1B, GLYATL1, ELOVL7, ELOVL1 and 5 morecytosol

• (4Z,7Z,10Z,13Z)-hexadecatetraenoyl-CoAReach from here →
  1. an acyl-CoA + L-glutamine = an N(2)-acyl-L-glutamine + CoA + H(+)
  2. acyl-CoA:sn-glycerol-3-phosphate 1-O-acyltransferase
  3. Fatty Acid Beta Oxidation (C18:4->C16:4), Mitochondrial

  Catalysed by GLYATL1B, GLYATL1, GPAT3, GPAT2 and 5 moremitochondrial matrixOne of 5 routes

• (2E,6Z,9Z,12Z)-octadecatetraenoyl-CoAReach from here →
  1. an acyl-CoA + L-glutamine = an N(2)-acyl-L-glutamine + CoA + H(+)
  2. acyl-CoA pool formation and breakdown
  3. (6Z,9Z,12Z)-octadecatrienoyl-CoA + oxidized [electron-transfer flavoprotein] + H(+) = (2E,6Z,9Z,12Z)-octadecatetraenoyl-CoA + reduced [electron-transfer flavoprotein]

  Catalysed by GLYATL1B, GLYATL1, ACADL, ACADVL and 1 morecytosolOne of 2 routes

• (7Z,10Z)-hexadecadienoyl-CoAReach from here →
  1. an acyl-CoA + L-glutamine = an N(2)-acyl-L-glutamine + CoA + H(+)
  2. acyl-CoA:sn-glycerol-3-phosphate 1-O-acyltransferase
  3. Fatty Acid Beta Oxidation Trans (C18:2->C16:2), Mitochondrial

  Catalysed by GLYATL1B, GLYATL1, GPAT3, GPAT2 and 5 moremitochondrial matrixOne of 2 routes

• (4Z,7Z)-decadienoyl-CoAReach from here →
  1. an acyl-CoA + L-glutamine = an N(2)-acyl-L-glutamine + CoA + H(+)
  2. acyl-CoA:sn-glycerol-3-phosphate 1-O-acyltransferase
  3. Fatty Acid Beta Oxidation (C12:3->C10:2), Mitochondrial

  Catalysed by GLYATL1B, GLYATL1, GPAT3, GPAT2 and 5 moremitochondrial matrixOne of 2 routes

• (5Z)-octenoyl-CoAReach from here →
  1. an acyl-CoA + L-glutamine = an N(2)-acyl-L-glutamine + CoA + H(+)
  2. acyl-CoA:sn-glycerol-3-phosphate 1-O-acyltransferase
  3. Fatty Acid Beta Oxidation (C10:2->C8:1), Mitochondrial

  Catalysed by GLYATL1B, GLYATL1, GPAT3, GPAT2 and 5 moremitochondrial matrixOne of 2 routes

• docosanoateReach from here →
  1. an acyl-CoA + L-glutamine = an N(2)-acyl-L-glutamine + CoA + H(+)
  2. acyl-CoA pool formation and breakdown
  3. Docosanoyl-CoA hydrolase

  Catalysed by GLYATL1B, GLYATL1, BAAT, ACOT6cytosolOne of 4 routes

• CHEBI:240943Reach from here →
  1. an acyl-CoA + L-glutamine = an N(2)-acyl-L-glutamine + CoA + H(+)
  2. transport of glutamine and glycine (cytosol to extracellular)
  3. glycine N-acyltransferase (2-methylbutyryl-CoA)

  Catalysed by GLYATL1B, GLYATL1, SLC7A5, GLYAT and 1 moreextracellular space, cytosol, mitochondrial matrixOne of 3 routes

• hypochlorous acidReach from here →
  1. an acyl-CoA + L-glutamine = an N(2)-acyl-L-glutamine + CoA + H(+)
  2. Transport of L-Glutamine by Atb0 Transporter
  3. Peroxidase

  Catalysed by GLYATL1B, GLYATL1, SLC6A14, LPOextracellular space, cytosolOne of 4 routes

• octadecanoateReach from here →
  1. an acyl-CoA + L-glutamine = an N(2)-acyl-L-glutamine + CoA + H(+)
  2. acyl-CoA pool formation and breakdown
  3. Stearoyl-CoA hydrolase

  Catalysed by GLYATL1B, GLYATL1, ACOT7, BAAT and 3 morecytosolOne of 4 routes

• potassium atomReach from here →
  1. an acyl-CoA + L-glutamine = an N(2)-acyl-L-glutamine + CoA + H(+)
  2. Transport of L-Glutamine by Atb0 Transporter
  3. transport of chloride (cytosol to extracellular)

  Catalysed by GLYATL1B, GLYATL1, SLC6A14, SLC12A2 and 1 moreextracellular space, cytosolOne of 3 routes

• alpha-linolenic acidReach from here →
  1. an acyl-CoA + L-glutamine = an N(2)-acyl-L-glutamine + CoA + H(+)
  2. acyl-CoA pool formation and breakdown
  3. Linolenoyl-CoA hydrolase

  Catalysed by GLYATL1B, GLYATL1, ACOT7, BAAT and 1 morecytosol

• phenylacetylglycineReach from here →
  1. an acyl-CoA + L-glutamine = an N(2)-acyl-L-glutamine + CoA + H(+)
  2. transport of glutamine and glycine (cytosol to extracellular)
  3. phenylacetyl-CoA:glycine N-phenylacetyltransferase

  Catalysed by GLYATL1B, GLYATL1, SLC7A5, GLYATextracellular space, cytosolOne of 3 routes

• CHEBI:27540Reach from here →
  1. an acyl-CoA + L-glutamine = an N(2)-acyl-L-glutamine + CoA + H(+)
  2. acyl-CoA:sn-glycerol-3-phosphate 1-O-acyltransferase
  3. medium-chain acyl-CoA ligase (hexanoic acid)

  Catalysed by GLYATL1B, GLYATL1, GPAT3, GPAT2 and 8 moremitochondrial matrix, cytosolOne of 6 routes

• all-cis-docosa-4,7,10,13,16,19-hexaenoic acidReach from here →
  1. an acyl-CoA + L-glutamine = an N(2)-acyl-L-glutamine + CoA + H(+)
  2. acyl-CoA pool formation and breakdown
  3. (4Z,7Z,10Z,13Z,16Z,19Z)-docosahexaenoyl-CoA hydrolase

  Catalysed by GLYATL1B, GLYATL1, BAAT, ACOT6cytosolOne of 2 routes

• 5-hydroxytryptophanReach from here →
  1. an acyl-CoA + L-glutamine = an N(2)-acyl-L-glutamine + CoA + H(+)
  2. transport of glutamine and tryptophan (cytosol to extracellular)
  3. L-Tryptophan, Tetrahydrobiopterin:Oxygen Oxidoreductase (5-Hydroxylating)

  Catalysed by GLYATL1B, GLYATL1, SLC7A5, TPH1 and 1 moreextracellular space, cytosolOne of 2 routes

• hexacosan-1-olReach from here →
  1. an acyl-CoA + L-glutamine = an N(2)-acyl-L-glutamine + CoA + H(+)
  2. acyl-CoA pool formation and breakdown
  3. hexacosanoyl-CoA + 2 NADPH + 2 H(+) = hexacosan-1-ol + 2 NADP(+) + CoA

  Catalysed by GLYATL1B, GLYATL1, FAR2cytosol

• CHEBI:28666Reach from here →
  1. an acyl-CoA + L-glutamine = an N(2)-acyl-L-glutamine + CoA + H(+)
  2. transport of glutamine and glycine (cytosol to extracellular)
  3. LTD4 hydrolysis

  Catalysed by GLYATL1B, GLYATL1, SLC7A5extracellular space, cytosol

• CHEBI:28701Reach from here →
  1. an acyl-CoA + L-glutamine = an N(2)-acyl-L-glutamine + CoA + H(+)
  2. acyl-CoA:sn-glycerol-3-phosphate 1-O-acyltransferase
  3. Propanoyl-CoA:acetyl-CoA C-acyltransferase

  Catalysed by GLYATL1B, GLYATL1, GPAT3, GPAT2 and 5 moremitochondrial matrix, peroxisomeOne of 7 routes

• pyridoxine 5'-phosphateReach from here →
  1. an acyl-CoA + L-glutamine = an N(2)-acyl-L-glutamine + CoA + H(+)
  2. L-Glutamine:pyruvate aminotransferase
  3. L-selenocysteine selenide-lyase (L-alanine-forming)

  Catalysed by GLYATL1B, GLYATL1, KYAT1, SCLYcytosol

• a fatty acidReach from here →
  1. an acyl-CoA + L-glutamine = an N(2)-acyl-L-glutamine + CoA + H(+)
  2. acyl-CoA:1,2-diacyl-sn-glycerol O-acyltransferase
  3. a triacylglycerol + H2O = a diacylglycerol + a fatty acid + H(+)

  Catalysed by GLYATL1B, GLYATL1, DGAT1, MOGAT2 and 22 morecytosolOne of 26 routes

• N-acetyl-L-cysteineReach from here →
  1. an acyl-CoA + L-glutamine = an N(2)-acyl-L-glutamine + CoA + H(+)
  2. transport of cysteine and glutamine (cytosol to extracellular)
  3. N-acetylglutamate synthase (N-acetyl-L-cysteine)

  Catalysed by GLYATL1B, GLYATL1, SLC3A2, SLC7A5 and 2 moreextracellular space, cytosol, mitochondrial matrix

• K(+)Reach from here →
  1. an acyl-CoA + L-glutamine = an N(2)-acyl-L-glutamine + CoA + H(+)
  2. transport of cysteine and glutamine (cytosol to extracellular)
  3. K(+)(in) + L-cysteine(out) + 3 Na(+)(out) + H(+)(out) = K(+)(out) + L-cysteine(in) + 3 Na(+)(in) + H(+)(in)

  Catalysed by GLYATL1B, GLYATL1, SLC3A2, SLC7A5 and 2 moreextracellular space, cytosol, inner side of the membrane, outer side of the membraneOne of 4 routes

• Cys-tRNA(Cys)Reach from here →
  1. an acyl-CoA + L-glutamine = an N(2)-acyl-L-glutamine + CoA + H(+)
  2. transport of cysteine and glutamine (cytosol to extracellular)
  3. L-Cysteine:tRNA(Cys) ligase (AMP-forming)

  Catalysed by GLYATL1B, GLYATL1, SLC3A2, SLC7A5 and 2 moreextracellular space, cytosol

• Phe-tRNA(Phe)Reach from here →
  1. an acyl-CoA + L-glutamine = an N(2)-acyl-L-glutamine + CoA + H(+)
  2. transport of glutamine and phenylalanine (cytosol to extracellular)
  3. L-Phenylalanine:tRNA(Ala) ligase (AMP-forming)

  Catalysed by GLYATL1B, GLYATL1, SLC7A5, FARSB and 1 moreextracellular space, cytosol

• Gly-tRNA(Gly)Reach from here →
  1. an acyl-CoA + L-glutamine = an N(2)-acyl-L-glutamine + CoA + H(+)
  2. transport of glutamine and glycine (cytosol to extracellular)
  3. glycine:tRNA(Gly) ligase (AMP-forming)

  Catalysed by GLYATL1B, GLYATL1, SLC7A5, GARS1extracellular space, cytosol

• Asp-tRNA(Asp)Reach from here →
  1. an acyl-CoA + L-glutamine = an N(2)-acyl-L-glutamine + CoA + H(+)
  2. L-aspartate(in) + L-glutamine(out) = L-aspartate(out) + L-glutamine(in)
  3. L-Aspartate:tRNA(Asp) ligase (AMP-forming)

  Catalysed by GLYATL1B, GLYATL1, SLC7A13, DARS1inner side of the membrane, outer side of the membrane, cytosol

• Trp-tRNA(Trp)Reach from here →
  1. an acyl-CoA + L-glutamine = an N(2)-acyl-L-glutamine + CoA + H(+)
  2. transport of glutamine and tryptophan (cytosol to extracellular)
  3. L-Tryptophan -tRNA(Trp) ligase (AMP-forming)

  Catalysed by GLYATL1B, GLYATL1, SLC7A5, WARS1extracellular space, cytosol

• Ile-tRNA(Ile)Reach from here →
  1. an acyl-CoA + L-glutamine = an N(2)-acyl-L-glutamine + CoA + H(+)
  2. transport of glutamine and isoleucine (cytosol to extracellular)
  3. L-Isoleucine:tRNA(Ile) ligase (AMP-forming)

  Catalysed by GLYATL1B, GLYATL1, SLC7A5, IARS1extracellular space, cytosol

• isocyanateReach from here →
  1. an acyl-CoA + L-glutamine = an N(2)-acyl-L-glutamine + CoA + H(+)
  2. transport of citrulline and glutamine (cytosol to extracellular)
  3. L-citrulline + H(+) = isocyanate + L-ornithine

  Catalysed by GLYATL1B, GLYATL1, SLC7A6, LACC1extracellular space, cytosol

• Asn-tRNA(Asn)Reach from here →
  1. an acyl-CoA + L-glutamine = an N(2)-acyl-L-glutamine + CoA + H(+)
  2. L-aspartate:L-glutamine amido-ligase (AMP-forming)
  3. L-Asparagine:tRNA(Asn) ligase (AMP-forming)

  Catalysed by GLYATL1B, GLYATL1, ASNS, NARS1cytosol

• phosphocholineReach from here →
  1. an acyl-CoA + L-glutamine = an N(2)-acyl-L-glutamine + CoA + H(+)
  2. a 2-acyl-sn-glycero-3-phosphocholine + an acyl-CoA = a 1,2-diacyl-sn-glycero-3-phosphocholine + CoA
  3. a 1,2-diacyl-sn-glycero-3-phosphocholine + H2O = phosphocholine + a 1,2-diacyl-sn-glycerol + H(+)

  Catalysed by GLYATL1B, GLYATL1, LPGAT1, SMPD1

• glycocholateReach from here →
  1. an acyl-CoA + L-glutamine = an N(2)-acyl-L-glutamine + CoA + H(+)
  2. transport of glutamine and glycine (cytosol to extracellular)
  3. bile acid-CoA: amino acid N-acyltransferase

  Catalysed by GLYATL1B, GLYATL1, SLC7A5, BAATextracellular space, cytosol, peroxisomeOne of 3 routes

• hydrogen sulfideReach from here →
  1. an acyl-CoA + L-glutamine = an N(2)-acyl-L-glutamine + CoA + H(+)
  2. transport of cysteine and glutamine (cytosol to extracellular)
  3. L-cysteine hydrogen-sulfide-lyase (deaminating

  Catalysed by GLYATL1B, GLYATL1, SLC3A2, SLC7A5 and 2 moreextracellular space, cytosolOne of 2 routes

• (9Z,12Z)-octadecadienoateReach from here →
  1. an acyl-CoA + L-glutamine = an N(2)-acyl-L-glutamine + CoA + H(+)
  2. acyl-CoA pool formation and breakdown
  3. (9Z,12Z)-octadecadienoyl-CoA + H2O = (9Z,12Z)-octadecadienoate + CoA + H(+)

  Catalysed by GLYATL1B, GLYATL1, ACOT8, ACOT2 and 2 morecytosol

• CHEBI:30249Reach from here →
  1. an acyl-CoA + L-glutamine = an N(2)-acyl-L-glutamine + CoA + H(+)
  2. transport of glutamine and tryptophan (cytosol to extracellular)
  3. L-tryptophan:oxygen 2,3-oxidoreductase (decyclizing)

  Catalysed by GLYATL1B, GLYATL1, SLC7A5, IDO1 and 2 moreextracellular space, cytosol

• formic acidReach from here →
  1. an acyl-CoA + L-glutamine = an N(2)-acyl-L-glutamine + CoA + H(+)
  2. Transport of L-Glutamine by Atb0 Transporter
  3. transport of chloride and formate (cytosol to extracellular)

  Catalysed by GLYATL1B, GLYATL1, SLC6A14, SLC26A4extracellular space, cytosolOne of 2 routes

• malonic acidReach from here →
  1. an acyl-CoA + L-glutamine = an N(2)-acyl-L-glutamine + CoA + H(+)
  2. Transport of L-Glutamine by Atb0 Transporter
  3. Malonate Transport, Antiport with Chloride

  Catalysed by GLYATL1B, GLYATL1, SLC6A14extracellular space, cytosolOne of 2 routes

• tetradecanoateReach from here →
  1. an acyl-CoA + L-glutamine = an N(2)-acyl-L-glutamine + CoA + H(+)
  2. acyl-CoA pool formation and breakdown
  3. Myristoyl-CoA hydrolase

  Catalysed by GLYATL1B, GLYATL1, ACOT7, BAAT and 3 morecytosolOne of 2 routes

• (9Z)-octadecenoateReach from here →
  1. an acyl-CoA + L-glutamine = an N(2)-acyl-L-glutamine + CoA + H(+)
  2. acyl-CoA pool formation and breakdown
  3. Oleoyl-CoA hydrolase

  Catalysed by GLYATL1B, GLYATL1, ACOT7, BAAT and 3 morecytosol

• a 1-O-alkyl-sn-glycero-3-phosphocholineReach from here →
  1. an acyl-CoA + L-glutamine = an N(2)-acyl-L-glutamine + CoA + H(+)
  2. Acyl-CoA:1-alkyl-sn-glycero-3-phosphocholine O-acyltransferase
  3. a 1-O-alkyl-2-acyl-sn-glycero-3-phosphocholine + H2O = a 1-O-alkyl-sn-glycero-3-phosphocholine + a fatty acid + H(+)

  Catalysed by GLYATL1B, GLYATL1, LPCAT4, LPCAT3 and 8 morecytosolOne of 3 routes

• docosan-1-olReach from here →
  1. an acyl-CoA + L-glutamine = an N(2)-acyl-L-glutamine + CoA + H(+)
  2. acyl-CoA pool formation and breakdown
  3. docosanoyl-CoA + 2 NADPH + 2 H(+) = docosan-1-ol + 2 NADP(+) + CoA

  Catalysed by GLYATL1B, GLYATL1, FAR2cytosol

• hexacosanoateReach from here →
  1. an acyl-CoA + L-glutamine = an N(2)-acyl-L-glutamine + CoA + H(+)
  2. acyl-CoA pool formation and breakdown
  3. Hexacosanoyl-CoA hydrolase

  Catalysed by GLYATL1B, GLYATL1, BAAT, ACOT6cytosolOne of 2 routes

• tetracosanoateReach from here →
  1. an acyl-CoA + L-glutamine = an N(2)-acyl-L-glutamine + CoA + H(+)
  2. acyl-CoA pool formation and breakdown
  3. Tetracosenoyl-CoA hydrolase

  Catalysed by GLYATL1B, GLYATL1, BAAT, THEM4cytosolOne of 4 routes

• an N-acyl-(4R)-4-hydroxysphinganineReach from here →
  1. an acyl-CoA + L-glutamine = an N(2)-acyl-L-glutamine + CoA + H(+)
  2. sphingosine N-acyltransferase (sphinganine)
  3. dihydroceramide,ferrocytochrome b5:oxygen oxidoreductase (C4-hydroxylating)

  Catalysed by GLYATL1B, GLYATL1, CERS1, CERS6 and 6 morecytosolOne of 3 routes