prostaglandin G2

Three steps

• 3',5'-diiodothyronamineReach from here →
  1. prostaglandin G2 + AH2 = prostaglandin H2 + A + H2O
  2. A + NADH + H(+) = AH2 + NAD(+)
  3. 3',5'-diiodothyronamine + iodide + A + H(+) = 3,3',5'-triiodothyronamine + AH2

  Catalysed by PTGS1, PTGS2, AIFM1, PYROXD1 and 1 more

• 3,3',5'-triiodothyronamineReach from here →
  1. prostaglandin G2 + AH2 = prostaglandin H2 + A + H2O
  2. A + NADH + H(+) = AH2 + NAD(+)
  3. 3,3',5'-triiodothyronamine + iodide + A + H(+) = 3,3',5,5'-tetraiodothyronamine + AH2

  Catalysed by PTGS1, PTGS2, AIFM1, PYROXD1 and 1 more

• L-homocysteine thiolactoneReach from here →
  1. transport of GSH and prostaglandin G2 (cytosol to extracellular)
  2. Formation of Homocystine
  3. arylesterase (homocysteine-thiolactone)

  Catalysed by SLCO2A1, PON1, PON2, PON3extracellular space, cytosol

• ursodeoxycholate 3-sulfateReach from here →
  1. transport of prostaglandin G2 (cytosol to extracellular)
  2. transport of S-glutathionyl-2-4-dinitrobenzene (cytosol to extracellular)
  3. ursodeoxycholate + 3'-phosphoadenylyl sulfate = ursodeoxycholate 3-sulfate + adenosine 3',5'-bisphosphate + H(+)

  Catalysed by SLCO1B1, SLCO1A2, SLCO1B3, SULT2A1extracellular space, cytosol

• tauroursodeoxycholate 3-sulfateReach from here →
  1. transport of prostaglandin G2 (cytosol to extracellular)
  2. transport of S-glutathionyl-2-4-dinitrobenzene (cytosol to extracellular)
  3. tauroursodeoxycholate + 3'-phosphoadenylyl sulfate = tauroursodeoxycholate 3-sulfate + adenosine 3',5'-bisphosphate + H(+)

  Catalysed by SLCO1B1, SLCO1A2, SLCO1B3, SULT2A1extracellular space, cytosol

• glycoursodeoxycholate 3-sulfateReach from here →
  1. transport of prostaglandin G2 (cytosol to extracellular)
  2. transport of glycoursodeoxycholate (cytosol to extracellular)
  3. glycoursodeoxycholate + 3'-phosphoadenylyl sulfate = glycoursodeoxycholate 3-sulfate + adenosine 3',5'-bisphosphate + H(+)

  Catalysed by SLCO1B1, SLCO1A2, SLCO1B3, SULT2A1extracellular space, cytosol

• chenodeoxycholate 3-sulfateReach from here →
  1. transport of prostaglandin G2 (cytosol to extracellular)
  2. solute carrier organic anion transporter (chenodiol)
  3. chenodeoxycholate + 3'-phosphoadenylyl sulfate = chenodeoxycholate 3-sulfate + adenosine 3',5'-bisphosphate + H(+)

  Catalysed by SLCO1B1, SLCO1A2, SLCO1B3, SULT2A1extracellular space, cytosol

• deoxycholateReach from here →
  1. transport of prostaglandin G2 (cytosol to extracellular)
  2. solute carrier organic anion transporter (cholate)
  3. cytochrome P450 (cholate)

  Catalysed by SLCO1B1, SLCO1A2, SLCO1B3, CYP7A1extracellular space, cytosolOne of 4 routes

• potassium atomReach from here →
  1. transport of prostaglandin G2 (cytosol to extracellular)
  2. transport of serotonin (cytosol to extracellular)
  3. transport of serotonin (cytosol to extracellular)

  Catalysed by SLCO1B1, SLCO1A2, SLCO1B3, SLC6A4extracellular space, cytosol

• N-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-ethanolamineReach from here →
  1. transport of prostaglandin G2 (cytosol to extracellular)
  2. transport of arachidonate (cytosol to extracellular)
  3. fatty acylamide amidohydrolase

  Catalysed by SLCO1B1, FAAHextracellular space, cytosol

• imidazole-4-acetaldehydeReach from here →
  1. transport of prostaglandin G2 (cytosol to extracellular)
  2. transport of histamine (cytosol to extracellular)
  3. amine oxidase copper containing (histamine)

  Catalysed by SLCO1B1, SLCO1A2, SLCO1B3, AOC2 and 2 moreextracellular space, cytosolOne of 2 routes

• folic acidReach from here →
  1. prostaglandin G2 + AH2 = prostaglandin H2 + A + H2O
  2. uridine(34) in tRNA + 5,10-methylenetetrahydrofolate + taurine + GTP + A + H2O = 5-taurinomethyluridine(34) in tRNA + 7,8-dihydrofolate + GDP + AH2 + phosphate + H(+)
  3. dihydrofolate:NAD+ oxidoreductase

  Catalysed by PTGS1, PTGS2, MTO1, DHFR and 1 morecytosolOne of 2 routes

• 3,4-dihydroxyphenylacetaldehydeReach from here →
  1. transport of prostaglandin G2 (cytosol to extracellular)
  2. transport of dopamine (cytosol to extracellular)
  3. monoamine oxidase (dopamine)

  Catalysed by SLCO1B1, SLCO1A2, SLCO1B3, AOC2 and 4 moreextracellular space, cytosolOne of 2 routes

• 3beta-hydroxyandrost-5-en-17-oneReach from here →
  1. transport of prostaglandin G2 (cytosol to extracellular)
  2. transport of dehydroepiandrosterone sulfate (cytosol to extracellular)
  3. 3beta-Hydroxyandrost-5-en-17-one 3-sulfate sulfohydrolase

  Catalysed by SLCO1B1, STSextracellular space, cytosolOne of 3 routes

• CHEBI:28701Reach from here →
  1. transport of prostaglandin G2 (cytosol to extracellular)
  2. solute carrier organic anion transporter (chenodiol)
  3. chenodeoxycholate:CoA ligase (AMP-forming)

  Catalysed by SLCO1B1, SLCO1A2, SLCO1B3, SLC27A5extracellular space, cytosolOne of 3 routes

• CHEBI:28918Reach from here →
  1. transport of prostaglandin G2 (cytosol to extracellular)
  2. transport of noradrenaline (cytosol to extracellular)
  3. S-Adenosyl-L-methionine:phenylethanolamine N-methyltransferase

  Catalysed by SLCO1B1, SLCO1A2, SLCO1B3, PNMTextracellular space, cytosol

• N-acetyl-L-cysteineReach from here →
  1. transport of GSH and prostaglandin G2 (cytosol to extracellular)
  2. cystine to cysteine conversion
  3. N-acetylglutamate synthase (N-acetyl-L-cysteine)

  Catalysed by SLCO2A1, NAGSextracellular space, cytosol, mitochondrial matrix

• a dicarboxylateReach from here →
  1. prostaglandin-endoperoxide synthase (prostaglandin G2)
  2. prostaglandin E synthase (prostaglandin H2)
  3. prostaglandin E2(out) + a dicarboxylate(in) = prostaglandin E2(in) + a dicarboxylate(out)

  Catalysed by PTGS1, PTGS2, PTGES, PTGES3 and 2 moreendoplasmic reticulum, cytosol, inner side of the membrane, outer side of the membraneOne of 4 routes

• iron(2+)Reach from here →
  1. transport of GSH and prostaglandin G2 (cytosol to extracellular)
  2. glutathione:dehydroascorbate oxidoreductase
  3. cytochrome b reductase (ascorbate)

  Catalysed by SLCO2A1, CYBRD1extracellular space, cytosol

• K(+)Reach from here →
  1. transport of prostaglandin G2 (cytosol to extracellular)
  2. transport of serotonin (cytosol to extracellular)
  3. serotonin(out) + K(+)(in) + Na(+)(out) + H(+)(in) = serotonin(in) + K(+)(out) + Na(+)(in) + H(+)(out)

  Catalysed by SLCO1B1, SLCO1A2, SLCO1B3, SLC6A4extracellular space, cytosol, inner side of the membrane, outer side of the membraneOne of 3 routes

• Cys-tRNA(Cys)Reach from here →
  1. transport of GSH and prostaglandin G2 (cytosol to extracellular)
  2. cystine to cysteine conversion
  3. L-Cysteine:tRNA(Cys) ligase (AMP-forming)

  Catalysed by SLCO2A1, CARS1extracellular space, cytosol

• chlorine(.)Reach from here →
  1. transport of GSH and prostaglandin G2 (cytosol to extracellular)
  2. cystine to cysteine conversion
  3. transport of chloride and cysteine (cytosol to extracellular)

  Catalysed by SLCO2A1, SLC6A14extracellular space, cytosolOne of 2 routes

• hydrogenselenideReach from here →
  1. prostaglandin G2 + AH2 = prostaglandin H2 + A + H2O
  2. A + NADH + H(+) = AH2 + NAD(+)
  3. L-selenocysteine + AH2 = hydrogenselenide + L-alanine + A + H(+)

  Catalysed by PTGS1, PTGS2, AIFM1, PYROXD1 and 1 more

• hydrogen sulfideReach from here →
  1. transport of GSH and prostaglandin G2 (cytosol to extracellular)
  2. cystine to cysteine conversion
  3. L-cysteine hydrogen-sulfide-lyase (deaminating

  Catalysed by SLCO2A1, CTHextracellular space, cytosolOne of 2 routes

• L-aspartateReach from here →
  1. prostaglandin G2 + AH2 = prostaglandin H2 + A + H2O
  2. (R)-malate + A = oxaloacetate + AH2
  3. L-Aspartate:2-oxoglutarate aminotransferase

  Catalysed by PTGS1, PTGS2, D2HGDH, GOT2mitochondrial matrixOne of 5 routes

• acetateReach from here →
  1. transport of prostaglandin G2 (cytosol to extracellular)
  2. transport of acetylcholine (cytosol to extracellular)
  3. Acetylcholine aectylhydrolase

  Catalysed by SLCO1B1, SLCO1B3, BCHE, ACHEextracellular space, cytosolOne of 3 routes

• formic acidReach from here →
  1. transport of GSH and prostaglandin G2 (cytosol to extracellular)
  2. alcohol dehydrogenase (formaldehyde)
  3. S-Formylglutathione hydrolase

  Catalysed by SLCO2A1, ADH1C, ADH1A, ADH5 and 4 moreextracellular space, cytosol

• citric acidReach from here →
  1. prostaglandin G2 + AH2 = prostaglandin H2 + A + H2O
  2. (R)-malate + A = oxaloacetate + AH2
  3. acetyl-CoA:oxaloacetate C-acetyltransferase (thioester-hydrolysing)

  Catalysed by PTGS1, PTGS2, D2HGDH, CSmitochondrial matrixOne of 2 routes

• glutarateReach from here →
  1. prostaglandin-endoperoxide synthase (prostaglandin G2)
  2. prostaglandin E synthase (prostaglandin H2)
  3. prostaglandin E2(out) + glutarate(in) = prostaglandin E2(in) + glutarate(out)

  Catalysed by PTGS1, PTGS2, PTGES, PTGES3 and 2 moreendoplasmic reticulum, cytosol, inner side of the membrane, outer side of the membraneOne of 12 routes

• 4-hydroxy-2-oxoglutaric acidReach from here →
  1. prostaglandin G2 + AH2 = prostaglandin H2 + A + H2O
  2. (R)-malate + A = oxaloacetate + AH2
  3. D-aspartate:2-oxoglutarate aminotransferase

  Catalysed by PTGS1, PTGS2, D2HGDH, GOT2mitochondrial matrix

• pentanoateReach from here →
  1. transport of prostaglandin G2 (cytosol to extracellular)
  2. transport of estrone 3-sulfate (cytosol to extracellular)
  3. pentanoate(in) + estrone 3-sulfate(out) = pentanoate(out) + estrone 3-sulfate(in)

  Catalysed by SLCO1B1, SLC22A9extracellular space, cytosol, inner side of the membrane, outer side of the membraneOne of 4 routes

• 3-oxopropanoateReach from here →
  1. prostaglandin-endoperoxide synthase (prostaglandin G2)
  2. thromboxane A synthase (12(S)-HHT)
  3. malonaldehyde + NAD(+) + H2O = 3-oxopropanoate + NADH + 2 H(+)

  Catalysed by PTGS1, PTGS2, TBXAS1, ALDH1A1 and 2 moreendoplasmic reticulum, cytosol

• methylarsonateReach from here →
  1. transport of GSH and prostaglandin G2 (cytosol to extracellular)
  2. Glutathione: 5-HPETE oxidoreductase
  3. methylarsonate + 2 glutathione + H(+) = methylarsonous acid + glutathione disulfide + H2O

  Catalysed by SLCO2A1, GPX5, GPX1, GPX2 and 8 moreextracellular space, cytosol

• thiosulfateReach from here →
  1. transport of GSH and prostaglandin G2 (cytosol to extracellular)
  2. Glutathione: 5-HPETE oxidoreductase
  3. thiosulfate + 2 glutathione = glutathione disulfide + hydrogen sulfide + sulfite + 2 H(+)

  Catalysed by SLCO2A1, GPX5, GPX1, GPX2 and 7 moreextracellular space, cytosolOne of 2 routes

• di-mu-sulfido-diiron(2+)Reach from here →
  1. transport of GSH and prostaglandin G2 (cytosol to extracellular)
  2. cystine to cysteine conversion
  3. De novo synthesis of 2Fe2S

  Catalysed by SLCO2A1, NDUFAB1, FDXR, FXN and 4 moreextracellular space, cytosol, mitochondrial matrix

• fatty acidReach from here →
  1. transport of prostaglandin G2 (cytosol to extracellular)
  2. transport of arachidonate (cytosol to extracellular)
  3. (10Z)-heptadecenoic acid formation

  Catalysed by SLCO1B1extracellular space, cytosolOne of 4 routes

• CHEBI:37946Reach from here →
  1. transport of prostaglandin G2 (cytosol to extracellular)
  2. transport of dopamine (cytosol to extracellular)
  3. aryl sulfotransferase (dopamine)

  Catalysed by SLCO1B1, SLCO1A2, SLCO1B3, SULT1A3 and 3 moreextracellular space, cytosol

• (R)-lactic acidReach from here →
  1. transport of GSH and prostaglandin G2 (cytosol to extracellular)
  2. (R)-S-Lactoylglutathione methylglyoxal-lyase (isomerizing)
  3. (R)-S-Lactoylglutathione hydrolase

  Catalysed by SLCO2A1, GLO1, GLOD4, HAGH and 1 moreextracellular space, cytosolOne of 2 routes

• (S)-lactic acidReach from here →
  1. transport of prostaglandin G2 (cytosol to extracellular)
  2. transport of prostaglandin A2 (cytosol to extracellular)
  3. Transport of Prostaglandin A2, Lactate Antiport

  Catalysed by SLCO1B1extracellular space, cytosolOne of 4 routes

• 25-hydroxycholesterolReach from here →
  1. prostaglandin G2 + AH2 = prostaglandin H2 + A + H2O
  2. A + NADH + H(+) = AH2 + NAD(+)
  3. cholesterol + AH2 + O2 = 25-hydroxycholesterol + A + H2O

  Catalysed by PTGS1, PTGS2, AIFM1, PYROXD1 and 1 more

• all-trans-4-oxoretinolReach from here →
  1. prostaglandin G2 + AH2 = prostaglandin H2 + A + H2O
  2. all-trans-13,14-dihydroretinol + A = all-trans-retinol + AH2
  3. cytochrome P450 (retinol)

  Catalysed by PTGS1, PTGS2, RETSAT, CYP26A1cytosol

• phosphoenolpyruvic acidReach from here →
  1. prostaglandin G2 + AH2 = prostaglandin H2 + A + H2O
  2. (R)-malate + A = oxaloacetate + AH2
  3. GTP:oxaloacetate carboxy-lyase (adding GTP

  Catalysed by PTGS1, PTGS2, D2HGDH, PCK1cytosolOne of 2 routes

• 13-cis-retinolReach from here →
  1. prostaglandin G2 + AH2 = prostaglandin H2 + A + H2O
  2. all-trans-13,14-dihydroretinol + A = all-trans-retinol + AH2
  3. retinol binding protein (retinol)

  Catalysed by PTGS1, PTGS2, RETSAT, RBP1 and 1 morecytosolOne of 2 routes

• L-ornithineReach from here →
  1. transport of GSH and prostaglandin G2 (cytosol to extracellular)
  2. cystine to cysteine conversion
  3. transport of cysteine and ornithine (cytosol to extracellular)

  Catalysed by SLCO2A1, SLC7A6extracellular space, cytosolOne of 2 routes

• N-methylserotoninReach from here →
  1. transport of prostaglandin G2 (cytosol to extracellular)
  2. transport of serotonin (cytosol to extracellular)
  3. S-Adenosyl-L-methionine:amine N-methyltransferase

  Catalysed by SLCO1B1, SLCO1A2, SLCO1B3, INMTextracellular space, cytosol

• (5-hydroxyindol-3-yl)acetaldehydeReach from here →
  1. transport of prostaglandin G2 (cytosol to extracellular)
  2. transport of serotonin (cytosol to extracellular)
  3. 5-Hydroxytryptamine:oxygen oxidoreductase(deaminating)(flavin-containing)

  Catalysed by SLCO1B1, SLCO1A2, SLCO1B3, MAOA and 1 moreextracellular space, cytosolOne of 2 routes

• all-trans-13,14-dihydroretinolReach from here →
  1. prostaglandin G2 + AH2 = prostaglandin H2 + A + H2O
  2. A + NADH + H(+) = AH2 + NAD(+)
  3. all-trans-13,14-dihydroretinol + A = all-trans-retinol + AH2

  Catalysed by PTGS1, PTGS2, AIFM1, PYROXD1 and 1 moreOne of 2 routes

• 2-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-glycerolReach from here →
  1. transport of prostaglandin G2 (cytosol to extracellular)
  2. transport of arachidonate (cytosol to extracellular)
  3. fatty acid amide hydrolase (2-arachidonoylglycerol)

  Catalysed by SLCO1B1, FAAHextracellular space, cytosol

• 3,3',5'-triiodo-L-thyronineReach from here →
  1. transport of prostaglandin G2 (cytosol to extracellular)
  2. transport of S-glutathionyl-2-4-dinitrobenzene (cytosol to extracellular)
  3. 3,3',5'-triiodo-L-thyronine + iodide + A + H(+) = L-thyroxine + AH2

  Catalysed by SLCO1B1, SLCO1A2, SLCO1B3, DIO1 and 1 moreextracellular space, cytosolOne of 2 routes

• glycineReach from here →
  1. transport of prostaglandin G2 (cytosol to extracellular)
  2. transport of leukotriene C4 (cytosol to extracellular)
  3. leukotriene C4 hydrolysis

  Catalysed by SLCO1B1extracellular space, cytosolOne of 11 routes