(5-hydroxyindol-3-yl)acetate

Three steps

• glyoxylateReach from here →
  1. Transport of 5-Hydroxyindoleacetate
  2. transport of malate and sulfate (cytosol to mitochondria)
  3. glyoxylate + acetyl-CoA + H2O = (S)-malate + CoA + H(+)

  Catalysed by SLC4A1, SLC25A10, CLYBLextracellular space, cytosol, mitochondrial matrix

• L-erythro-7,8-dihydrobiopterinReach from here →
  1. Transport of 5-Hydroxyindoleacetate
  2. a dicarboxylate(in) + sulfate(out) = a dicarboxylate(out) + sulfate(in)
  3. L-erythro-7,8-dihydrobiopterin(out) + a dicarboxylate(in) = L-erythro-7,8-dihydrobiopterin(in) + a dicarboxylate(out)

  Catalysed by SLC4A1, SLC25A35, SLC25A34, SLC22A6 and 1 moreextracellular space, cytosol, inner side of the membrane, outer side of the membraneOne of 2 routes

• N-methylserotoninReach from here →
  1. (5-hydroxyindol-3-yl)acetaldehyde + NAD(+) + H2O = (5-hydroxyindol-3-yl)acetate + NADH + 2 H(+)
  2. serotonin + O2 + H2O = (5-hydroxyindol-3-yl)acetaldehyde + H2O2 + NH4(+)
  3. S-Adenosyl-L-methionine:amine N-methyltransferase

  Catalysed by ALDH9A1, MAOA, INMTcytosol

• taurineReach from here →
  1. Transport of 5-Hydroxyindoleacetate
  2. transport of chloride and sulfate (cytosol to extracellular)
  3. Neurotransmitter:Sodium Symporter (Nss) Tcdb:2.A.22.3.3

  Catalysed by SLC4A1, SLC26A6, SLC6A6extracellular space, cytosolOne of 2 routes

• glycineReach from here →
  1. Transport of 5-Hydroxyindoleacetate
  2. transport of chloride and sulfate (cytosol to extracellular)
  3. transport of chloride and glycine (cytosol to extracellular)

  Catalysed by SLC4A1, SLC26A6, SLC6A9, SLC6A14extracellular space, cytosolOne of 3 routes

• (S)-malyl-CoAReach from here →
  1. Transport of 5-Hydroxyindoleacetate
  2. transport of malate and sulfate (cytosol to mitochondria)
  3. (S)-malate + ATP + CoA = (S)-malyl-CoA + ADP + phosphate

  Catalysed by SLC4A1, SLC25A10, SUCLG1, SUCLA2extracellular space, cytosol, mitochondrial matrix

• prostaglandin F2alphaReach from here →
  1. Transport of 5-Hydroxyindoleacetate
  2. a dicarboxylate(in) + sulfate(out) = a dicarboxylate(out) + sulfate(in)
  3. prostaglandin F2alpha(out) + a dicarboxylate(in) = prostaglandin F2alpha(in) + a dicarboxylate(out)

  Catalysed by SLC4A1, SLC25A35, SLC25A34, SLC22A6extracellular space, cytosol, inner side of the membrane, outer side of the membraneOne of 2 routes

• 7,8-dihydrofolateReach from here →
  1. Transport of 5-Hydroxyindoleacetate
  2. Folate Transport by Oats
  3. dihydrofolate:NAD+ oxidoreductase

  Catalysed by SLC4A1, SLC22A8, SLC22A7, DHFR and 1 moreextracellular space, cytosolOne of 3 routes

• 2-(N(omega)-L-arginino)succinateReach from here →
  1. Transport of 5-Hydroxyindoleacetate
  2. transport of fumarate and sulfate (cytosol to mitochondria)
  3. 2-(Nomega-L-arginino)succinate arginine-lyase (fumarate-forming)

  Catalysed by SLC4A1, SLC25A10, ASLextracellular space, cytosol, mitochondrial matrixOne of 4 routes

• N(6)-(1,2-dicarboxyethyl)-AMPReach from here →
  1. Transport of 5-Hydroxyindoleacetate
  2. transport of fumarate and sulfate (cytosol to mitochondria)
  3. N6-(1,2-dicarboxyethyl)AMP AMP-lyase (fumarate-forming)

  Catalysed by SLC4A1, SLC25A10, ADSL, TNRC6Bextracellular space, cytosol, mitochondrial matrixOne of 4 routes

• guanidinoacetateReach from here →
  1. Transport of 5-Hydroxyindoleacetate
  2. transport of chloride and sulfate (cytosol to extracellular)
  3. Transport of Guanidinoacetic Acid

  Catalysed by SLC4A1, SLC26A6extracellular space, cytosol

• 3',5'-cyclic GMPReach from here →
  1. Transport of 5-Hydroxyindoleacetate
  2. a dicarboxylate(in) + sulfate(out) = a dicarboxylate(out) + sulfate(in)
  3. 3',5'-cyclic GMP(out) + a dicarboxylate(in) = 3',5'-cyclic GMP(in) + a dicarboxylate(out)

  Catalysed by SLC4A1, SLC25A35, SLC25A34, SLC22A6extracellular space, cytosol, inner side of the membrane, outer side of the membraneOne of 2 routes

• L-methionineReach from here →
  1. Transport of 5-Hydroxyindoleacetate
  2. transport of chloride and sulfate (cytosol to extracellular)
  3. transport of chloride and methionine (cytosol to extracellular)

  Catalysed by SLC4A1, SLC26A6, SLC6A14extracellular space, cytosolOne of 4 routes

• adenosine 5'-phosphoramidateReach from here →
  1. Transport of 5-Hydroxyindoleacetate
  2. ATP:sulfate adenylyltransferase
  3. adenosine 5'-phosphosulfate + NH4(+) = adenosine 5'-phosphoramidate + sulfate + 2 H(+)

  Catalysed by SLC4A1, PAPSS1, PAPSS2, FHITextracellular space, cytosol

• L-tryptophanReach from here →
  1. Transport of 5-Hydroxyindoleacetate
  2. transport of chloride and sulfate (cytosol to extracellular)
  3. Transport of L-Tryptophan by Atb0 Transporter

  Catalysed by SLC4A1, SLC26A6, SLC6A14extracellular space, cytosolOne of 4 routes

• glutathioneReach from here →
  1. Transport of 5-Hydroxyindoleacetate
  2. sulfite(in) + sulfate(out) = sulfite(out) + sulfate(in)
  3. thiosulfate + 2 glutathione = glutathione disulfide + hydrogen sulfide + sulfite + 2 H(+)

  Catalysed by SLC4A1, SLC25A14, SLC25A30, TSTD1extracellular space, cytosol, inner side of the membrane, outer side of the membraneOne of 2 routes

• beta-alanineReach from here →
  1. Transport of 5-Hydroxyindoleacetate
  2. transport of chloride and sulfate (cytosol to extracellular)
  3. transport of beta-alanine and chloride (cytosol to extracellular)

  Catalysed by SLC4A1, SLC26A6, SLC6A6, SLC6A14extracellular space, cytosolOne of 4 routes

• L-alanineReach from here →
  1. Transport of 5-Hydroxyindoleacetate
  2. transport of chloride and sulfate (cytosol to extracellular)
  3. transport of alanine and chloride (cytosol to extracellular)

  Catalysed by SLC4A1, SLC26A6, SLC6A14extracellular space, cytosolOne of 3 routes

• L-asparagineReach from here →
  1. Transport of 5-Hydroxyindoleacetate
  2. transport of chloride and sulfate (cytosol to extracellular)
  3. Transport of L-Asparagine by Atb0 Transporter

  Catalysed by SLC4A1, SLC26A6, SLC6A14extracellular space, cytosolOne of 4 routes

• N(4)-(beta-N-acetyl-D-glucosaminyl)-L-asparagineReach from here →
  1. Transport of 5-Hydroxyindoleacetate
  2. L-aspartate(in) + sulfate(out) = L-aspartate(out) + sulfate(in)
  3. N(4)-(beta-N-acetyl-D-glucosaminyl)-L-asparagine + H2O = N-acetyl-beta-D-glucosaminylamine + L-aspartate + H(+)

  Catalysed by SLC4A1, SLC25A14, SLC25A30, AGAextracellular space, cytosol, inner side of the membrane, outer side of the membrane

• L-phenylalanineReach from here →
  1. Transport of 5-Hydroxyindoleacetate
  2. transport of chloride and sulfate (cytosol to extracellular)
  3. Transport of L-Phenylalanine by Atb0 Transporter

  Catalysed by SLC4A1, SLC26A6, SLC6A14extracellular space, cytosolOne of 4 routes

• 3',5'-cyclic AMPReach from here →
  1. Transport of 5-Hydroxyindoleacetate
  2. a dicarboxylate(in) + sulfate(out) = a dicarboxylate(out) + sulfate(in)
  3. 3',5'-cyclic AMP(out) + a dicarboxylate(in) = 3',5'-cyclic AMP(in) + a dicarboxylate(out)

  Catalysed by SLC4A1, SLC25A35, SLC25A34, SLC22A6extracellular space, cytosol, inner side of the membrane, outer side of the membraneOne of 2 routes

• glutathione disulfideReach from here →
  1. Transport of 5-Hydroxyindoleacetate
  2. thiosulfate(in) + sulfate(out) = thiosulfate(out) + sulfate(in)
  3. thiosulfate + 2 glutathione = glutathione disulfide + hydrogen sulfide + sulfite + 2 H(+)

  Catalysed by SLC4A1, SLC25A14, SLC25A30, SLC26A1 and 2 moreextracellular space, cytosol, inner side of the membrane, outer side of the membrane

• L-tyrosineReach from here →
  1. Transport of 5-Hydroxyindoleacetate
  2. L-aspartate(in) + sulfate(out) = L-aspartate(out) + sulfate(in)
  3. L-tyrosine(out) + L-aspartate(in) = L-tyrosine(in) + L-aspartate(out)

  Catalysed by SLC4A1, SLC25A14, SLC25A30, SLC7A13extracellular space, cytosol, inner side of the membrane, outer side of the membraneOne of 2 routes

• N(omega),N(omega)-dimethyl-L-arginineReach from here →
  1. Transport of 5-Hydroxyindoleacetate
  2. L-aspartate(in) + sulfate(out) = L-aspartate(out) + sulfate(in)
  3. N(omega),N(omega)-dimethyl-L-arginine + oxaloacetate = 5-(3,3-dimethylguanidino)-2-oxopentanoate + L-aspartate

  Catalysed by SLC4A1, SLC25A14, SLC25A30, AGXT2extracellular space, cytosol, inner side of the membrane, outer side of the membrane

• (2S)-2-[5-amino-1-(5-phospho-beta-D-ribosyl)imidazole-4-carboxamido]succinateReach from here →
  1. Transport of 5-Hydroxyindoleacetate
  2. transport of fumarate and sulfate (cytosol to mitochondria)
  3. 1-(5'-Phosphoribosyl)-5-amino-4-(N-succinocarboxamide)-imidazole AMP-lyase

  Catalysed by SLC4A1, SLC25A10, ADSLextracellular space, cytosol, mitochondrial matrixOne of 4 routes

• kynurenateReach from here →
  1. Transport of 5-Hydroxyindoleacetate
  2. a dicarboxylate(in) + sulfate(out) = a dicarboxylate(out) + sulfate(in)
  3. kynurenate(out) + a dicarboxylate(in) = kynurenate(in) + a dicarboxylate(out)

  Catalysed by SLC4A1, SLC25A35, SLC25A34, SLC22A8extracellular space, cytosol, inner side of the membrane, outer side of the membraneOne of 2 routes

• D-glucosamineReach from here →
  1. Transport of 5-Hydroxyindoleacetate
  2. N-sulfo-D-glucosamine + H2O = D-glucosamine + sulfate
  3. N-sulfo-D-glucosamine + H2O = D-glucosamine + sulfate

  Catalysed by SLC4A1, SGSHextracellular space, cytosol

• S-sulfanylglutathioneReach from here →
  1. Transport of 5-Hydroxyindoleacetate
  2. sulfite(in) + sulfate(out) = sulfite(out) + sulfate(in)
  3. S-sulfanylglutathione + O2 + H2O = sulfite + glutathione + 2 H(+)

  Catalysed by SLC4A1, SLC25A14, SLC25A30, ETHE1extracellular space, cytosol, inner side of the membrane, outer side of the membraneOne of 2 routes

• (6R)-L-erythro-5,6,7,8-tetrahydrobiopterinReach from here →
  1. Transport of 5-Hydroxyindoleacetate
  2. a dicarboxylate(in) + sulfate(out) = a dicarboxylate(out) + sulfate(in)
  3. (6R)-L-erythro-5,6,7,8-tetrahydrobiopterin(out) + a dicarboxylate(in) = (6R)-L-erythro-5,6,7,8-tetrahydrobiopterin(in) + a dicarboxylate(out)

  Catalysed by SLC4A1, SLC25A35, SLC25A34, SLC22A6 and 1 moreextracellular space, cytosol, inner side of the membrane, outer side of the membraneOne of 2 routes

• 4-aminobutanoateReach from here →
  1. Transport of 5-Hydroxyindoleacetate
  2. transport of chloride and sulfate (cytosol to extracellular)
  3. transport of 4-aminobutyrate and chloride (cytosol to extracellular)

  Catalysed by SLC4A1, SLC26A6, SLC6A12extracellular space, cytosolOne of 4 routes

• prostaglandin E2Reach from here →
  1. Transport of 5-Hydroxyindoleacetate
  2. a dicarboxylate(in) + sulfate(out) = a dicarboxylate(out) + sulfate(in)
  3. prostaglandin E2(out) + a dicarboxylate(in) = prostaglandin E2(in) + a dicarboxylate(out)

  Catalysed by SLC4A1, SLC25A35, SLC25A34, SLC22A6extracellular space, cytosol, inner side of the membrane, outer side of the membraneOne of 2 routes

• N-benzoylglycineReach from here →
  1. Transport of 5-Hydroxyindoleacetate
  2. a dicarboxylate(in) + sulfate(out) = a dicarboxylate(out) + sulfate(in)
  3. N-benzoylglycine(out) + a dicarboxylate(in) = N-benzoylglycine(in) + a dicarboxylate(out)

  Catalysed by SLC4A1, SLC25A35, SLC25A34, SLC22A6 and 1 moreextracellular space, cytosol, inner side of the membrane, outer side of the membraneOne of 2 routes

• 3-sulfino-L-alanineReach from here →
  1. Transport of 5-Hydroxyindoleacetate
  2. L-aspartate(in) + sulfate(out) = L-aspartate(out) + sulfate(in)
  3. transport of 3-sulfinoalanine and aspartate (cytosol to mitochondria)

  Catalysed by SLC4A1, SLC25A14, SLC25A30, SLC25A12 and 1 moreextracellular space, cytosol, inner side of the membrane, outer side of the membrane, mitochondrial matrixOne of 4 routes

• ubiquinol-10Reach from here →
  1. Transport of 5-Hydroxyindoleacetate
  2. sulfite(in) + sulfate(out) = sulfite(out) + sulfate(in)
  3. ubiquinone-10 + hydrogen sulfide + sulfite + 2 H(+) = ubiquinol-10 + thiosulfate

  Catalysed by SLC4A1, SLC25A14, SLC25A30, SQORextracellular space, cytosol, inner side of the membrane, outer side of the membrane

• 16alpha-hydroxydehydroepiandrosterone 3-sulfateReach from here →
  1. Transport of 5-Hydroxyindoleacetate
  2. dehydroepiandrosterone 3-sulfate + H2O = 3beta-hydroxyandrost-5-en-17-one + sulfate + H(+)
  3. dehydroepiandrosterone 3-sulfate + reduced [NADPH--hemoprotein reductase] + O2 = 16alpha-hydroxydehydroepiandrosterone 3-sulfate + oxidized [NADPH--hemoprotein reductase] + H2O + H(+)

  Catalysed by SLC4A1, STS, CYP3A7extracellular space, cytosol