L-cysteinylglycine

Two steps

• (R)-3-aminoisobutyric acidReach from here →
  1. gamma-glutamyltransferase (alanine)
  2. (R)-3-Amino-2-methylpropanoate:pyruvate aminotransferase

  Catalysed by GGTLC3, GGT1, GGT5, GGTLC2 and 3 morecytosol, mitochondrial matrix

• lithocholic acidReach from here →
  1. gamma-glutamyltransferase (alanine)
  2. transport of GSH and lithocholate (cytosol to extracellular)

  Catalysed by GGTLC3, GGT1, GGT5, GGTLC2 and 4 morecytosol, extracellular spaceOne of 2 routes

• L-citrullineReach from here →
  1. L-cysteinylglycine dipeptidase
  2. transport of citrulline and cysteine (cytosol to extracellular)

  Catalysed by ANPEP, LAP3, NPEPPS, SLC7A6cytosol, extracellular spaceOne of 5 routes

• L-valineReach from here →
  1. L-cysteinylglycine dipeptidase
  2. transport of cysteine and valine (cytosol to extracellular)

  Catalysed by ANPEP, LAP3, NPEPPS, SLC7A5cytosol, extracellular spaceOne of 13 routes

• L-arginineReach from here →
  1. L-cysteinylglycine dipeptidase
  2. transport of arginine and cysteine (cytosol to extracellular)

  Catalysed by ANPEP, LAP3, NPEPPS, SLC7A6cytosol, extracellular spaceOne of 10 routes

• CHEBI:16523Reach from here →
  1. L-cysteinylglycine dipeptidase
  2. transport of D-serine and glycine (cytosol to extracellular)

  Catalysed by ANPEP, LAP3, NPEPPS, SLC3A2 and 1 morecytosol, extracellular spaceOne of 2 routes

• protein polypeptide chainReach from here →
  1. L-cysteinylglycine dipeptidase
  2. PROTEIN_BS

  Catalysed by ANPEP, LAP3, NPEPPScytosolOne of 3 routes

• CHEBI:16633Reach from here →
  1. gamma-glutamyltransferase (alanine)
  2. L-selenocysteine selenide-lyase (L-alanine-forming)

  Catalysed by GGTLC3, GGT1, GGT5, GGTLC2 and 3 morecytosol

• CHEBI:16857Reach from here →
  1. L-cysteinylglycine dipeptidase
  2. transport of cysteine and threonine (cytosol to extracellular)

  Catalysed by ANPEP, LAP3, NPEPPS, SLC7A5cytosol, extracellular spaceOne of 12 routes

• glyoxylic acidReach from here →
  1. L-cysteinylglycine dipeptidase
  2. glycine:oxygen oxidoreductase (deaminating)

  Catalysed by ANPEP, LAP3, NPEPPS, DAOcytosol, peroxisome

• bilirubin IXalphaReach from here →
  1. gamma-glutamyltransferase (alanine)
  2. transport of bilirubin and GSH (cytosol to extracellular)

  Catalysed by GGTLC3, GGT1, GGT5, GGTLC2 and 4 morecytosol, extracellular spaceOne of 2 routes

• taurolithocholateReach from here →
  1. gamma-glutamyltransferase (alanine)
  2. transport of GSH and taurolithocholate (cytosol to extracellular)

  Catalysed by GGTLC3, GGT1, GGT5, GGTLC2 and 4 morecytosol, extracellular spaceOne of 2 routes

• L-isoleucineReach from here →
  1. L-cysteinylglycine dipeptidase
  2. transport of cysteine and isoleucine (cytosol to extracellular)

  Catalysed by ANPEP, LAP3, NPEPPS, SLC7A5cytosol, extracellular spaceOne of 11 routes

• CHEBI:17203Reach from here →
  1. L-cysteinylglycine dipeptidase
  2. transport of cysteine and proline (cytosol to extracellular)

  Catalysed by ANPEP, LAP3, NPEPPS, SLC7A5cytosol, extracellular spaceOne of 8 routes

• CHEBI:17208Reach from here →
  1. gamma-glutamyltransferase (alanine)
  2. glutathione:dehydroascorbate oxidoreductase

  Catalysed by GGTLC3, GGT1, GGT5, GGTLC2 and 2 morecytosol

• homocysteineReach from here →
  1. gamma-glutamyltransferase (alanine)
  2. Formation of Homocystine

  Catalysed by GGTLC3, GGT1, GGT5, GGTLC2 and 2 morecytosol

• sulfiteReach from here →
  1. glutathione = L-cysteinylglycine + 5-oxo-L-proline
  2. thiosulfate + 2 glutathione = glutathione disulfide + hydrogen sulfide + sulfite + 2 H(+)

  Catalysed by CHAC2, CHAC1, TSTD1One of 2 routes

• AH2Reach from here →
  1. gamma-glutamyltransferase (alanine)
  2. Mo-molybdopterin + L-cysteine + AH2 = thio-Mo-molybdopterin + L-alanine + A + H2O

  Catalysed by GGTLC3, GGT1, GGT5, GGTLC2 and 3 morecytosol

• 5-aminolevulinic acidReach from here →
  1. L-cysteinylglycine dipeptidase
  2. succinyl-CoA:glycine C-succinyltransferase (decarboxylating)

  Catalysed by ANPEP, LAP3, NPEPPS, ALAS1 and 2 morecytosol, mitochondrial matrix

• Ala-tRNA(Ala)Reach from here →
  1. gamma-glutamyltransferase (alanine)
  2. L-Alanine:tRNA(Ala) ligase (AMP-forming)

  Catalysed by GGTLC3, GGT1, GGT5, GGTLC2 and 3 morecytosol

• urateReach from here →
  1. glutathione = L-cysteinylglycine + 5-oxo-L-proline
  2. urate(out) + glutathione(in) = urate(in) + glutathione(out)

  Catalysed by CHAC2, CHAC1, SLC22A13inner side of the membrane, outer side of the membrane

• methylarsonous acidReach from here →
  1. glutathione = L-cysteinylglycine + 5-oxo-L-proline
  2. methylarsonate + 2 glutathione + H(+) = methylarsonous acid + glutathione disulfide + H2O

  Catalysed by CHAC2, CHAC1, GSTO1, GSTO2

• CHEBI:17895Reach from here →
  1. L-cysteinylglycine dipeptidase
  2. transport of cysteine and tyrosine (cytosol to extracellular)

  Catalysed by ANPEP, LAP3, NPEPPS, SLC7A5cytosol, extracellular spaceOne of 12 routes

• CHEBI:18019Reach from here →
  1. L-cysteinylglycine dipeptidase
  2. transport of cysteine and lysine (cytosol to extracellular)

  Catalysed by ANPEP, LAP3, NPEPPS, SLC7A6cytosol, extracellular spaceOne of 6 routes

• L-glutamineReach from here →
  1. L-cysteinylglycine dipeptidase
  2. transport of cysteine and glutamine (cytosol to extracellular)

  Catalysed by ANPEP, LAP3, NPEPPS, SLC3A2 and 2 morecytosol, extracellular spaceOne of 14 routes

• CHEBI:18095Reach from here →
  1. gamma-glutamyltransferase (alanine)
  2. Transport of Hydroxy-Proline

  Catalysed by GGTLC3, GGT1, GGT5, GGTLC2 and 3 morecytosol, extracellular space

• N(1)-(5-phospho-D-ribosyl)glycinamideReach from here →
  1. L-cysteinylglycine dipeptidase
  2. 5-Phospho-D-ribosylamine:glycine ligase (ADP-forming)

  Catalysed by ANPEP, LAP3, NPEPPS, GARTcytosol

• arsenic triglutathioneReach from here →
  1. glutathione = L-cysteinylglycine + 5-oxo-L-proline
  2. arsenic triglutathione + 3 [thioredoxin]-dithiol + 3 S-adenosyl-L-methionine = trimethylarsine + 3 [thioredoxin]-disulfide + 3 glutathione + 3 S-adenosyl-L-homocysteine + 3 H(+)

  Catalysed by CHAC2, CHAC1, AS3MTOne of 3 routes

• ophthalmateReach from here →
  1. L-cysteinylglycine dipeptidase
  2. gamma-L-glutamyl-(2S)-2-aminobutanoate + glycine + ATP = ophthalmate + ADP + phosphate + H(+)

  Catalysed by ANPEP, LAP3, NPEPPS, GSScytosol

• 2-aminoisobutanoateReach from here →
  1. gamma-glutamyltransferase (alanine)
  2. 2-aminoisobutanoate(out) + L-alanine(in) = 2-aminoisobutanoate(in) + L-alanine(out)

  Catalysed by GGTLC3, GGT1, GGT5, GGTLC2 and 3 morecytosol, inner side of the membrane, outer side of the membraneOne of 2 routes

• 15-deoxy-Delta(12,14)-prostaglandin J2-S-(R)-glutathioneReach from here →
  1. glutathione = L-cysteinylglycine + 5-oxo-L-proline
  2. 15-deoxy-Delta(12,14)-prostaglandin J2 + glutathione = 15-deoxy-Delta(12,14)-prostaglandin J2-S-(R)-glutathione

  Catalysed by CHAC2, CHAC1, MGST3

• (5S)-hydroxy-(6E,8Z,11Z,14Z,17Z)-eicosapentaenoateReach from here →
  1. glutathione = L-cysteinylglycine + 5-oxo-L-proline
  2. (5S)-hydroperoxy-(6E,8Z,11Z,14Z,17Z)-eicosapentaenoate + 2 glutathione = (5S)-hydroxy-(6E,8Z,11Z,14Z,17Z)-eicosapentaenoate + glutathione disulfide + H2O

  Catalysed by CHAC2, CHAC1, GPX1, GPX4

• (12S)-hydroxy-(5Z,8Z,10E,14Z,17Z)-eicosapentaenoateReach from here →
  1. glutathione = L-cysteinylglycine + 5-oxo-L-proline
  2. (12S)-hydroperoxy-(5Z,8Z,10E,14Z,17Z)-eicosapentaenoate + 2 glutathione = (12S)-hydroxy-(5Z,8Z,10E,14Z,17Z)-eicosapentaenoate + glutathione disulfide + H2O

  Catalysed by CHAC2, CHAC1, GPX1, GPX4

• (15S)-hydroxy-(11Z,13E)-eicosadienoateReach from here →
  1. glutathione = L-cysteinylglycine + 5-oxo-L-proline
  2. (15S)-hydroperoxy-(11Z,13E)-eicosadienoate + 2 glutathione = (15S)-hydroxy-(11Z,13E)-eicosadienoate + glutathione disulfide + H2O

  Catalysed by CHAC2, CHAC1, GPX1, GPX4

• (17S)-hydroxy-(4Z,7Z,10Z,13Z,15E,19Z)-docosahexaenoateReach from here →
  1. glutathione = L-cysteinylglycine + 5-oxo-L-proline
  2. (17S)-hydroperoxy-(4Z,7Z,10Z,13Z,15E,19Z)-docosahexaenoate + 2 glutathione = (17S)-hydroxy-(4Z,7Z,10Z,13Z,15E,19Z)-docosahexaenoate + glutathione disulfide + H2O

  Catalysed by CHAC2, CHAC1, GPX1, GPX4

• a hydroxy-1,2-diacyl-glycero-3-phosphocholineReach from here →
  1. glutathione = L-cysteinylglycine + 5-oxo-L-proline
  2. a hydroperoxy-1,2-diacyl-glycero-3-phosphocholine + 2 glutathione = a hydroxy-1,2-diacyl-glycero-3-phosphocholine + glutathione disulfide + H2O

  Catalysed by CHAC2, CHAC1, GPX4

• N(omega),N('omega)-dimethyl-L-arginineReach from here →
  1. L-cysteinylglycine dipeptidase
  2. N(omega),N('omega)-dimethyl-L-arginine + glyoxylate = 5-(3,3'-dimethylguanidino)-2-oxopentanoate + glycine

  Catalysed by ANPEP, LAP3, NPEPPS, AGXT2cytosolOne of 2 routes

• 5,6,7,8-tetrahydrofolic acidReach from here →
  1. L-cysteinylglycine dipeptidase
  2. 5,10-Methylenetetrahydrofolate:glycine hydroxymethyltransferase

  Catalysed by ANPEP, LAP3, NPEPPS, SHMT1cytosolOne of 2 routes

• S-disulfanyl-L-cysteineReach from here →
  1. L-cysteinylglycine dipeptidase
  2. S-sulfanyl-L-cysteine + L-cysteine = S-disulfanyl-L-cysteine + L-alanine

  Catalysed by ANPEP, LAP3, NPEPPS, CARS2cytosol

• 3-(glutathion-S-yl)-4-hydroxynonanalReach from here →
  1. glutathione = L-cysteinylglycine + 5-oxo-L-proline
  2. (E)-4-hydroxynon-2-enal + glutathione = 3-(glutathion-S-yl)-4-hydroxynonanal

  Catalysed by CHAC2, CHAC1, GSTP1

• CHEBI:240943Reach from here →
  1. L-cysteinylglycine dipeptidase
  2. glycine N-acyltransferase (2-methylbutyryl-CoA)

  Catalysed by ANPEP, LAP3, NPEPPS, GLYAT and 2 morecytosol, mitochondrial matrix

• a quinolReach from here →
  1. glutathione = L-cysteinylglycine + 5-oxo-L-proline
  2. a quinone + hydrogen sulfide + glutathione + H(+) = S-sulfanylglutathione + a quinol

  Catalysed by CHAC2, CHAC1, SQOR

• phenylacetylglycineReach from here →
  1. L-cysteinylglycine dipeptidase
  2. phenylacetyl-CoA:glycine N-phenylacetyltransferase

  Catalysed by ANPEP, LAP3, NPEPPS, GLYATcytosolOne of 3 routes

• 5(S)-HETEReach from here →
  1. gamma-glutamyltransferase (alanine)
  2. Glutathione: 5-HPETE oxidoreductase

  Catalysed by GGTLC3, GGT1, GGT5, GGTLC2 and 11 morecytosolOne of 2 routes

• CHEBI:28666Reach from here →
  1. L-cysteinylglycine dipeptidase
  2. LTD4 hydrolysis

  Catalysed by ANPEP, LAP3, NPEPPScytosolOne of 3 routes

• pyridoxine 5'-phosphateReach from here →
  1. gamma-glutamyltransferase (alanine)
  2. L-selenocysteine selenide-lyase (L-alanine-forming)

  Catalysed by GGTLC3, GGT1, GGT5, GGTLC2 and 3 morecytosol

• N-acetyl-L-cysteineReach from here →
  1. L-cysteinylglycine dipeptidase
  2. N-acetylglutamate synthase (N-acetyl-L-cysteine)

  Catalysed by ANPEP, LAP3, NPEPPS, NAGScytosol, mitochondrial matrix

• L-ascorbic acidReach from here →
  1. glutathione = L-cysteinylglycine + 5-oxo-L-proline
  2. L-dehydroascorbate + 2 glutathione = glutathione disulfide + L-ascorbate

  Catalysed by CHAC2, CHAC1, CLIC1, GSTO1 and 1 more

• K(+)Reach from here →
  1. L-cysteinylglycine dipeptidase
  2. K(+)(in) + L-cysteine(out) + 3 Na(+)(out) + H(+)(out) = K(+)(out) + L-cysteine(in) + 3 Na(+)(in) + H(+)(in)

  Catalysed by ANPEP, LAP3, NPEPPS, SLC1A1cytosol, inner side of the membrane, outer side of the membraneOne of 2 routes

• Cys-tRNA(Cys)Reach from here →
  1. L-cysteinylglycine dipeptidase
  2. L-Cysteine:tRNA(Cys) ligase (AMP-forming)

  Catalysed by ANPEP, LAP3, NPEPPS, CARS1cytosol