phosphoenolpyruvate

Three steps

• N(omega),N('omega)-dimethyl-L-arginineReach from here →
  1. pyruvate + ATP = phosphoenolpyruvate + ADP + H(+)
  2. (R)-3-Amino-2-methylpropanoate:pyruvate aminotransferase
  3. N(omega),N('omega)-dimethyl-L-arginine + pyruvate = 5-(3,3'-dimethylguanidino)-2-oxopentanoate + L-alanine

  Catalysed by PKM, PKLR, AGXT2mitochondrial matrixOne of 3 routes

• (5Z)-dodecenoyl-CoAReach from here →
  1. oxaloacetate + GTP = phosphoenolpyruvate + GDP + CO2
  2. acetyl-CoA:oxaloacetate C-acetyltransferase (thioester-hydrolysing)
  3. acetyl-CoA C-acyltransferase (3-oxomyrist-7-enoyl-CoA)

  Catalysed by PCK1, PCK2, CS, HADHA and 2 moremitochondrial matrixOne of 2 routes

• (S)-lactoyl-AMPReach from here →
  1. pyruvate + ATP = phosphoenolpyruvate + ADP + H(+)
  2. (S)-lactate + NAD(+) = pyruvate + NADH + H(+)
  3. (S)-lactate + ATP + H(+) = (S)-lactoyl-AMP + diphosphate

  Catalysed by PKM, PKLR, LDHA, LDHB and 5 more

• (S)-lactoyl-CoAReach from here →
  1. pyruvate + ATP = phosphoenolpyruvate + ADP + H(+)
  2. (S)-lactate + NAD(+) = pyruvate + NADH + H(+)
  3. (S)-lactate + ATP + CoA = (S)-lactoyl-CoA + AMP + diphosphate

  Catalysed by PKM, PKLR, LDHA, LDHB and 4 more

• (11Z)-docosenoyl-CoA(4-)Reach from here →
  1. oxaloacetate + GTP = phosphoenolpyruvate + GDP + CO2
  2. acetyl-CoA:oxaloacetate C-acetyltransferase (thioester-hydrolysing)
  3. long-chain-fatty-acid-CoA ligase (cis-cetoleic acid)

  Catalysed by PCK1, PCK2, CS, SLC27A2 and 7 moremitochondrial matrix, cytosolOne of 5 routes

• (7Z)-tetradecenoyl-CoAReach from here →
  1. oxaloacetate + GTP = phosphoenolpyruvate + GDP + CO2
  2. acetyl-CoA:oxaloacetate C-acetyltransferase (thioester-hydrolysing)
  3. long-chain-fatty-acid-CoA ligase ((7Z)-tetradecenoic acid)

  Catalysed by PCK1, PCK2, CS, SLC27A2 and 7 moremitochondrial matrix, cytosolOne of 8 routes

• (4Z,7Z,10Z,13Z)-hexadecatetraenoyl-CoAReach from here →
  1. oxaloacetate + GTP = phosphoenolpyruvate + GDP + CO2
  2. acetyl-CoA:oxaloacetate C-acetyltransferase (thioester-hydrolysing)
  3. Fatty Acid Beta Oxidation (C18:4->C16:4), Mitochondrial

  Catalysed by PCK1, PCK2, CS, HADHA and 2 moremitochondrial matrixOne of 3 routes

• (7Z,10Z)-hexadecadienoyl-CoAReach from here →
  1. oxaloacetate + GTP = phosphoenolpyruvate + GDP + CO2
  2. acetyl-CoA:oxaloacetate C-acetyltransferase (thioester-hydrolysing)
  3. Fatty Acid Beta Oxidation Trans (C18:2->C16:2), Mitochondrial

  Catalysed by PCK1, PCK2, CS, HADHA and 2 moremitochondrial matrix

• (4Z,7Z)-decadienoyl-CoAReach from here →
  1. oxaloacetate + GTP = phosphoenolpyruvate + GDP + CO2
  2. acetyl-CoA:oxaloacetate C-acetyltransferase (thioester-hydrolysing)
  3. Fatty Acid Beta Oxidation (C12:3->C10:2), Mitochondrial

  Catalysed by PCK1, PCK2, CS, ECHS1 and 2 moremitochondrial matrixOne of 2 routes

• (5Z)-octenoyl-CoAReach from here →
  1. oxaloacetate + GTP = phosphoenolpyruvate + GDP + CO2
  2. acetyl-CoA:oxaloacetate C-acetyltransferase (thioester-hydrolysing)
  3. Fatty Acid Beta Oxidation (C10:2->C8:1), Mitochondrial

  Catalysed by PCK1, PCK2, CS, ECHS1 and 2 moremitochondrial matrixOne of 2 routes

• a quinolReach from here →
  1. oxaloacetate + GTP = phosphoenolpyruvate + GDP + CO2
  2. transport of malate and OAA (cytosol to mitochondria)
  3. (S)-malate + a quinone = enol-oxaloacetate + a quinol

  Catalysed by PCK1, PCK2, SDHB, SDHAmitochondrial matrix, cytosol

• potassium atomReach from here →
  1. oxaloacetate + GTP = phosphoenolpyruvate + GDP + CO2
  2. L-Aspartate:2-oxoglutarate aminotransferase
  3. transport of aspartate (cytosol to extracellular)

  Catalysed by PCK1, PCK2, GOT2, SLC1A7 and 4 moremitochondrial matrix, extracellular space, cytosol

• CHEBI:27540Reach from here →
  1. oxaloacetate + GTP = phosphoenolpyruvate + GDP + CO2
  2. acetyl-CoA:oxaloacetate C-acetyltransferase (thioester-hydrolysing)
  3. medium-chain acyl-CoA ligase (hexanoic acid)

  Catalysed by PCK1, PCK2, CS, ACSM4 and 5 moremitochondrial matrix, cytosolOne of 6 routes

• selenomethionineReach from here →
  1. pyruvate + ATP = phosphoenolpyruvate + ADP + H(+)
  2. 2-oxobutanoate + L-alanine = (2S)-2-aminobutanoate + pyruvate
  3. Selenomethionine methanethiol-lyase (deaminating)

  Catalysed by PKM, PKLR, AGXT2, CTHcytosol

• CHEBI:27760Reach from here →
  1. pyruvate + ATP = phosphoenolpyruvate + ADP + H(+)
  2. 2-oxobutanoate + L-alanine = (2S)-2-aminobutanoate + pyruvate
  3. Selenocystathionine Lysteine-lyase (deaminating)

  Catalysed by PKM, PKLR, AGXT2, CTHcytosol

• elaidic acidReach from here →
  1. oxaloacetate + GTP = phosphoenolpyruvate + GDP + CO2
  2. acetyl-CoA:oxaloacetate C-acetyltransferase (thioester-hydrolysing)
  3. long-chain-fatty-acid-CoA ligase (elaidate)

  Catalysed by PCK1, PCK2, CS, SLC27A2 and 7 moremitochondrial matrix, cytosolOne of 5 routes

• 3-mercaptolactic acidReach from here →
  1. pyruvate + ATP = phosphoenolpyruvate + ADP + H(+)
  2. 2-oxo-3-sulfanylpropanoate + [thioredoxin]-dithiol = [thioredoxin]-disulfide + hydrogen sulfide + pyruvate + H(+)
  3. 3-Mercaptolactate:NAD+ oxidoreductase

  Catalysed by PKM, PKLR, MPST, LDHB and 3 morecytosol

• 2-oxopentanoateReach from here →
  1. oxaloacetate + GTP = phosphoenolpyruvate + GDP + CO2
  2. N(omega),N(omega)-dimethyl-L-arginine + oxaloacetate = 5-(3,3-dimethylguanidino)-2-oxopentanoate + L-aspartate
  3. 2-oxopentanoate + N(omega),N(omega)-dimethyl-L-arginine = 5-(3,3-dimethylguanidino)-2-oxopentanoate + L-2-aminopentanoate

  Catalysed by PCK1, PCK2, AGXT2

• CHEBI:28701Reach from here →
  1. oxaloacetate + GTP = phosphoenolpyruvate + GDP + CO2
  2. acetyl-CoA:oxaloacetate C-acetyltransferase (thioester-hydrolysing)
  3. Propanoyl-CoA:acetyl-CoA C-acyltransferase

  Catalysed by PCK1, PCK2, CS, ACAA1 and 2 moremitochondrial matrix, peroxisomeOne of 7 routes

• 17alpha-hydroxypregnenoloneReach from here →
  1. pyruvate + ATP = phosphoenolpyruvate + ADP + H(+)
  2. transport of acetate and pyruvate (cytosol to extracellular)
  3. cytochrome P450 (17alpha-hydroxypregnenolone)

  Catalysed by PKM, PKLR, SLC16A4, SLC16A5 and 4 moreextracellular space, cytosol, endoplasmic reticulum

• pyridoxine 5'-phosphateReach from here →
  1. pyruvate + ATP = phosphoenolpyruvate + ADP + H(+)
  2. (R)-3-Amino-2-methylpropanoate:pyruvate aminotransferase
  3. L-selenocysteine selenide-lyase (L-alanine-forming)

  Catalysed by PKM, PKLR, AGXT2, SCLYmitochondrial matrix, cytosol

• N-glycoloylneuraminateReach from here →
  1. pyruvate + ATP = phosphoenolpyruvate + ADP + H(+)
  2. N-Acetylneuraminate pyruvate-lyase (N-acetyl-D-mannosamine-forming)
  3. CMP-N-acetylneuraminate monooxygenase (N-acetylneuraminate)

  Catalysed by PKM, PKLR, NPLcytosol

• a carboxylateReach from here →
  1. pyruvate + ATP = phosphoenolpyruvate + ADP + H(+)
  2. a 3-acylpyruvate + H2O = a carboxylate + pyruvate + H(+)
  3. a 3-acylpyruvate + H2O = a carboxylate + pyruvate + H(+)

  Catalysed by PKM, PKLR, FAHD1

• K(+)Reach from here →
  1. oxaloacetate + GTP = phosphoenolpyruvate + GDP + CO2
  2. L-Aspartate:2-oxoglutarate aminotransferase
  3. K(+)(in) + L-aspartate(out) + 3 Na(+)(out) + H(+)(out) = K(+)(out) + L-aspartate(in) + 3 Na(+)(in) + H(+)(in)

  Catalysed by PCK1, PCK2, GOT2, SLC1A7 and 4 moremitochondrial matrix, inner side of the membrane, outer side of the membraneOne of 2 routes

• Asp-tRNA(Asp)Reach from here →
  1. oxaloacetate + GTP = phosphoenolpyruvate + GDP + CO2
  2. L-Aspartate:2-oxoglutarate aminotransferase
  3. L-Aspartate:tRNA(Asp) ligase (AMP-forming)

  Catalysed by PCK1, PCK2, GOT2, DARS1mitochondrial matrix, cytosol

• chlorine(.)Reach from here →
  1. pyruvate + ATP = phosphoenolpyruvate + ADP + H(+)
  2. (R)-3-Amino-2-methylpropanoate:pyruvate aminotransferase
  3. transport of alanine and chloride (cytosol to extracellular)

  Catalysed by PKM, PKLR, AGXT2, SLC6A14mitochondrial matrix, extracellular space, cytosolOne of 7 routes

• hydrogen sulfideReach from here →
  1. pyruvate + ATP = phosphoenolpyruvate + ADP + H(+)
  2. 2-oxo-3-sulfanylpropanoate + [thioredoxin]-dithiol = [thioredoxin]-disulfide + hydrogen sulfide + pyruvate + H(+)
  3. 2-oxo-3-sulfanylpropanoate + [thioredoxin]-dithiol = [thioredoxin]-disulfide + hydrogen sulfide + pyruvate + H(+)

  Catalysed by PKM, PKLR, MPST

• N-carbamoyl-L-aspartateReach from here →
  1. oxaloacetate + GTP = phosphoenolpyruvate + GDP + CO2
  2. L-Aspartate:2-oxoglutarate aminotransferase
  3. carbamoyl phosphate + L-aspartate = N-carbamoyl-L-aspartate + phosphate + H(+)

  Catalysed by PCK1, PCK2, GOT2, CADmitochondrial matrix

• thiosulfateReach from here →
  1. oxaloacetate + GTP = phosphoenolpyruvate + GDP + CO2
  2. transport of malate and OAA (cytosol to mitochondria)
  3. transport of malate and thiosulfate (cytosol to mitochondria)

  Catalysed by PCK1, PCK2, SLC25A10mitochondrial matrix, cytosolOne of 4 routes

• 4-methylthio-2-oxobutanoic acidReach from here →
  1. pyruvate + ATP = phosphoenolpyruvate + ADP + H(+)
  2. N(1)-methylguanosine(37) in tRNA(Phe) + pyruvate + S-adenosyl-L-methionine = 4-demethylwyosine(37) in tRNA(Phe) + 5'-deoxyadenosine + L-methionine + CO2 + H2O
  3. L-Methionine:oxygen oxidoreductase (deaminating)

  Catalysed by PKM, PKLR, TYW1B, TYW1 and 1 morecytosol

• 2-oxohexanoateReach from here →
  1. oxaloacetate + GTP = phosphoenolpyruvate + GDP + CO2
  2. N(omega),N(omega)-dimethyl-L-arginine + oxaloacetate = 5-(3,3-dimethylguanidino)-2-oxopentanoate + L-aspartate
  3. 2-oxohexanoate + N(omega),N(omega)-dimethyl-L-arginine = L-2-aminohexanoate + 5-(3,3-dimethylguanidino)-2-oxopentanoate

  Catalysed by PCK1, PCK2, AGXT2

• D-cysteineReach from here →
  1. pyruvate + ATP = phosphoenolpyruvate + ADP + H(+)
  2. (R)-3-Amino-2-methylpropanoate:pyruvate aminotransferase
  3. D-cysteine(out) + L-alanine(in) = D-cysteine(in) + L-alanine(out)

  Catalysed by PKM, PKLR, AGXT2, SLC7A10mitochondrial matrix, inner side of the membrane, outer side of the membraneOne of 2 routes

• L-alpha-aminobutyric acidReach from here →
  1. pyruvate + ATP = phosphoenolpyruvate + ADP + H(+)
  2. 2-oxobutanoate + L-alanine = (2S)-2-aminobutanoate + pyruvate
  3. glutamic-pyruvic transaminase ((S)-2-aminobutanoate)

  Catalysed by PKM, PKLR, AGXT2, GPTcytosol

• glyoxylateReach from here →
  1. oxaloacetate + GTP = phosphoenolpyruvate + GDP + CO2
  2. transport of malate and OAA (cytosol to mitochondria)
  3. glyoxylate + acetyl-CoA + H2O = (S)-malate + CoA + H(+)

  Catalysed by PCK1, PCK2, CLYBLmitochondrial matrix, cytosolOne of 8 routes

• (3S)-3-hydroxy-3-methylglutaryl-CoAReach from here →
  1. pyruvate + ATP = phosphoenolpyruvate + ADP + H(+)
  2. transport of acetoacetate and pyruvate (cytosol to mitochondria)
  3. (3S)-3-hydroxy-3-methylglutaryl-CoA = acetoacetate + acetyl-CoA

  Catalysed by PKM, PKLR, HMGCL, HMGCLL1mitochondrial matrix, cytosol

• 13-cis-retinalReach from here →
  1. pyruvate + ATP = phosphoenolpyruvate + ADP + H(+)
  2. transport of pyruvate and retinoate (cytosol to extracellular)
  3. retinal dehydrogenase (13-cis-retinal)

  Catalysed by PKM, PKLR, SLC16A4, SLC16A5 and 6 moreextracellular space, cytosol, endoplasmic reticulum

• L-ornithineReach from here →
  1. pyruvate + ATP = phosphoenolpyruvate + ADP + H(+)
  2. (R)-3-Amino-2-methylpropanoate:pyruvate aminotransferase
  3. transport of alanine and ornithine (cytosol to extracellular)

  Catalysed by PKM, PKLR, AGXT2, SLC7A6mitochondrial matrix, extracellular space, cytosolOne of 7 routes

• N-(acetyl)-sphing-4-enineReach from here →
  1. pyruvate + ATP = phosphoenolpyruvate + ADP + H(+)
  2. transport of acetate and pyruvate (cytosol to extracellular)
  3. N-(acetyl)-sphing-4-enine + H2O = sphing-4-enine + acetate

  Catalysed by PKM, PKLR, SLC16A4, SLC16A5 and 4 moreextracellular space, cytosol

• gamma-Glu-AlaReach from here →
  1. pyruvate + ATP = phosphoenolpyruvate + ADP + H(+)
  2. (R)-3-Amino-2-methylpropanoate:pyruvate aminotransferase
  3. gamma-glutamyltransferase (alanine)

  Catalysed by PKM, PKLR, AGXT2, GGT1 and 5 moremitochondrial matrix, extracellular space, cytosol

• taurineReach from here →
  1. oxaloacetate + GTP = phosphoenolpyruvate + GDP + CO2
  2. acetyl-CoA:oxaloacetate C-acetyltransferase (thioester-hydrolysing)
  3. bile acid-CoA:amino acid N-acyltransferase (taurodeoxycholate)

  Catalysed by PCK1, PCK2, CS, BAATmitochondrial matrix, cytosolOne of 2 routes

• acetoacetyl-CoAReach from here →
  1. pyruvate + ATP = phosphoenolpyruvate + ADP + H(+)
  2. transport of acetoacetate and pyruvate (cytosol to mitochondria)
  3. acetoacetate + ATP + CoA = acetoacetyl-CoA + AMP + diphosphate

  Catalysed by PKM, PKLR, AACSmitochondrial matrix, cytosolOne of 2 routes

• glycineReach from here →
  1. oxaloacetate + GTP = phosphoenolpyruvate + GDP + CO2
  2. acetyl-CoA:oxaloacetate C-acetyltransferase (thioester-hydrolysing)
  3. glycine N-acyltransferase (N-arachidonoylglycine)

  Catalysed by PCK1, PCK2, CS, GLYAT and 2 moremitochondrial matrixOne of 24 routes

• (S)-malyl-CoAReach from here →
  1. oxaloacetate + GTP = phosphoenolpyruvate + GDP + CO2
  2. transport of malate and OAA (cytosol to mitochondria)
  3. (S)-malate + ATP + CoA = (S)-malyl-CoA + ADP + phosphate

  Catalysed by PCK1, PCK2, SUCLG1, SUCLA2mitochondrial matrix, cytosol

• (R)-methylmalonyl-CoAReach from here →
  1. oxaloacetate + GTP = phosphoenolpyruvate + GDP + CO2
  2. acetyl-CoA:oxaloacetate C-acetyltransferase (thioester-hydrolysing)
  3. aldehyde dehydrogenase (2-methyl-3-oxopropanoate)

  Catalysed by PCK1, PCK2, CS, ALDH6A1mitochondrial matrixOne of 3 routes

• (S)-methylmalonyl-CoAReach from here →
  1. oxaloacetate + GTP = phosphoenolpyruvate + GDP + CO2
  2. acetyl-CoA:oxaloacetate C-acetyltransferase (thioester-hydrolysing)
  3. (S)-methylmalonyl-CoA hydrolase

  Catalysed by PCK1, PCK2, CSmitochondrial matrix

• 3'-dephospho-CoAReach from here →
  1. oxaloacetate + GTP = phosphoenolpyruvate + GDP + CO2
  2. acetyl-CoA:oxaloacetate C-acetyltransferase (thioester-hydrolysing)
  3. acid phosphatase 2, lysosomal (CoA)

  Catalysed by PCK1, PCK2, CS, ACP2mitochondrial matrix, lysosomeOne of 2 routes

• (2E)-dodecenoyl-CoAReach from here →
  1. oxaloacetate + GTP = phosphoenolpyruvate + GDP + CO2
  2. acetyl-CoA:oxaloacetate C-acetyltransferase (thioester-hydrolysing)
  3. (2E)-dodecenoyl-CoA formation

  Catalysed by PCK1, PCK2, CSmitochondrial matrixOne of 3 routes

• 4,8,12-trimethyltridecanoyl-CoAReach from here →
  1. oxaloacetate + GTP = phosphoenolpyruvate + GDP + CO2
  2. acetyl-CoA:oxaloacetate C-acetyltransferase (thioester-hydrolysing)
  3. propanoyl-CoA C-acyltransferase (3-ketopristanoyl-CoA)

  Catalysed by PCK1, PCK2, CS, ACAA1 and 1 moremitochondrial matrix, peroxisomeOne of 2 routes

• (6Z,9Z,12Z)-octadecatrienoyl-CoAReach from here →
  1. oxaloacetate + GTP = phosphoenolpyruvate + GDP + CO2
  2. acetyl-CoA:oxaloacetate C-acetyltransferase (thioester-hydrolysing)
  3. long-chain-fatty-acid-CoA ligase (gamma-linolenate)

  Catalysed by PCK1, PCK2, CS, SLC27A2 and 7 moremitochondrial matrix, cytosolOne of 7 routes

• butanoyl-CoAReach from here →
  1. oxaloacetate + GTP = phosphoenolpyruvate + GDP + CO2
  2. acetyl-CoA:oxaloacetate C-acetyltransferase (thioester-hydrolysing)
  3. Butanoate:CoA ligase (AMP-forming)

  Catalysed by PCK1, PCK2, CS, ACSM4 and 5 moremitochondrial matrix, cytosolOne of 11 routes