1-hexadecanoylglycerone 3-phosphate

Three steps

• propionyl-CoAReach from here →
  1. glyceronephosphate O-acyltransferase (1-palmitoyl-dihydroxyacetone-phosphate)
  2. Utilized Transport
  3. Active Transport

  Catalysed by GNPATperoxisome, endoplasmic reticulum, cytosol, mitochondrial matrixOne of 45 routes

• a 1-hexadecanoyl-2-acylglycerolReach from here →
  1. 1-hexadecanoylglycerone 3-phosphate + hexadecan-1-ol = 1-O-hexadecylglycerone 3-phosphate + hexadecanoate + H(+)
  2. hexadecanoate + ATP + CoA = hexadecanoyl-CoA + AMP + diphosphate
  3. a 2-acylglycerol + hexadecanoyl-CoA = a 1-hexadecanoyl-2-acylglycerol + CoA

  Catalysed by AGPS, SLC27A2, ACSL4, ACSL3 and 9 more

• an hexadecanoyl-acylglycerolReach from here →
  1. 1-hexadecanoylglycerone 3-phosphate + hexadecan-1-ol = 1-O-hexadecylglycerone 3-phosphate + hexadecanoate + H(+)
  2. hexadecanoate + ATP + CoA = hexadecanoyl-CoA + AMP + diphosphate
  3. a 1-acylglycerol + hexadecanoyl-CoA = an hexadecanoyl-acylglycerol + CoA

  Catalysed by AGPS, SLC27A2, ACSL4, ACSL3 and 9 more

• 1-(10Z-heptadecenoyl)-2-hexadecanoyl-sn-glycero-3-phosphoethanolamineReach from here →
  1. 1-hexadecanoylglycerone 3-phosphate + hexadecan-1-ol = 1-O-hexadecylglycerone 3-phosphate + hexadecanoate + H(+)
  2. hexadecanoate + ATP + CoA = hexadecanoyl-CoA + AMP + diphosphate
  3. 1-(10Z-heptadecenoyl)-sn-glycero-3-phosphoethanolamine + hexadecanoyl-CoA = 1-(10Z-heptadecenoyl)-2-hexadecanoyl-sn-glycero-3-phosphoethanolamine + CoA

  Catalysed by AGPS, SLC27A2, ACSL4, ACSL3 and 9 more

• CHEBI:15650Reach from here →
  1. glyceronephosphate O-acyltransferase (1-palmitoyl-dihydroxyacetone-phosphate)
  2. Fas180
  3. N-acetyl-LTE4 to leukotriene E4 conversion

  Catalysed by GNPAT, ZDHHC11B, NAA10, ESCO2 and 29 moreperoxisome, cytosolOne of 2 routes

• CHEBI:15727Reach from here →
  1. glyceronephosphate O-acyltransferase (1-palmitoyl-dihydroxyacetone-phosphate)
  2. Fas180
  3. N-alpha-acetyltransferase 10, NatA catalytic subunit (acetylcarnosine)

  Catalysed by GNPAT, NAA10peroxisome, cytosol

• CHEBI:15746Reach from here →
  1. glyceronephosphate O-acyltransferase (1-palmitoyl-dihydroxyacetone-phosphate)
  2. Fas180
  3. diamine N-acetyltransferase (N1-acetylspermine)

  Catalysed by GNPAT, SAT1, SAT2peroxisome, cytosolOne of 2 routes

• 1-acylglycerone 3-phosphateReach from here →
  1. 1-hexadecanoyl-sn-glycero-3-phosphate + NADP(+) = 1-hexadecanoylglycerone 3-phosphate + NADPH + H(+)
  2. 1-acylglycerol-3P-LD-TG1 pool (liver tissue) formation
  3. aldo-keto reductase (1-acylglycerol-3P pool)

  Catalysed by DHRS7B, AKR1A1cytosol

• cholesterolReach from here →
  1. 1-hexadecanoylglycerone 3-phosphate + hexadecan-1-ol = 1-O-hexadecylglycerone 3-phosphate + hexadecanoate + H(+)
  2. N-hexadecanoylsphing-4-enine + H2O = sphing-4-enine + hexadecanoate
  3. beta-D-glucosyl-(1<->1')-N-hexadecanoylsphing-4-enine + cholesterol = cholesteryl 3-beta-D-glucoside + N-hexadecanoylsphing-4-enine

  Catalysed by AGPS, NAAA, ASAH1, ACER2 and 2 more

• hexadecan-1-olReach from here →
  1. glyceronephosphate O-acyltransferase (1-palmitoyl-dihydroxyacetone-phosphate)
  2. Palmitate:CoA ligase (AMP-forming)
  3. formate dehydrogenase (palmitoyl-CoA)

  Catalysed by GNPAT, SLC27A2, ACSL4, ACSL3 and 7 moreperoxisome, cytosolOne of 2 routes

• 11-cis-retinyl hexadecanoateReach from here →
  1. glyceronephosphate O-acyltransferase (1-palmitoyl-dihydroxyacetone-phosphate)
  2. Palmitate:CoA ligase (AMP-forming)
  3. Palmitoyl-CoA:retinol O-acyltransferase

  Catalysed by GNPAT, SLC27A2, ACSL4, ACSL3 and 10 moreperoxisome, cytosolOne of 2 routes

• 11-cis-retinolReach from here →
  1. glyceronephosphate O-acyltransferase (1-palmitoyl-dihydroxyacetone-phosphate)
  2. Fas180
  3. Palmitoyl-CoA:retinol O-acyltransferase

  Catalysed by GNPAT, DGAT1, LRAT, AWAT1 and 2 moreperoxisome, cytosolOne of 2 routes

• phosphatidic acidReach from here →
  1. 1-hexadecanoyl-sn-glycero-3-phosphate + NADP(+) = 1-hexadecanoylglycerone 3-phosphate + NADPH + H(+)
  2. 1-acylglycerol-3P-LD-TG1 pool (liver tissue) formation
  3. acyl-CoA:1-acyl-sn-glycerol-3-phosphate 2-O-acyltransferase

  Catalysed by DHRS7B, AGPAT2, LCLAT1, MBOAT1 and 6 morecytosol, mitochondrial matrixOne of 8 routes

• oxaloacetateReach from here →
  1. glyceronephosphate O-acyltransferase (1-palmitoyl-dihydroxyacetone-phosphate)
  2. Fas180
  3. ATP citrate lyase (citrate)

  Catalysed by GNPAT, ACLYperoxisome, cytosol

• octadecanalReach from here →
  1. glyceronephosphate O-acyltransferase (1-palmitoyl-dihydroxyacetone-phosphate)
  2. Fas180
  3. octadecanal + NAD(+) + H2O = octadecanoate + NADH + 2 H(+)

  Catalysed by GNPAT, ALDH3A2peroxisome, cytosol

• anilineReach from here →
  1. glyceronephosphate O-acyltransferase (1-palmitoyl-dihydroxyacetone-phosphate)
  2. Fas180
  3. Acetyl-CoA:arylamine N-acetyltransferase

  Catalysed by GNPAT, NAT2, NAT1peroxisome, cytosol

• CHEBI:17312Reach from here →
  1. glyceronephosphate O-acyltransferase (1-palmitoyl-dihydroxyacetone-phosphate)
  2. Fas180
  3. N1,N12-diacetylspermine to N1-acetylspermine conversion

  Catalysed by GNPATperoxisome, cytosolOne of 2 routes

• all-trans-retinolReach from here →
  1. 1-hexadecanoylglycerone 3-phosphate + hexadecan-1-ol = 1-O-hexadecylglycerone 3-phosphate + hexadecanoate + H(+)
  2. all-trans-retinyl hexadecanoate + H2O = 11-cis-retinol + hexadecanoate + H(+)
  3. all-trans-retinyl hexadecanoate + H2O = all-trans-retinol + hexadecanoate + H(+)

  Catalysed by AGPS, RPE65, PNLIP, PNPLA4 and 1 more

• linoleic acidReach from here →
  1. glyceronephosphate O-acyltransferase (1-palmitoyl-dihydroxyacetone-phosphate)
  2. (10Z)-heptadecenoic acid formation
  3. (10Z)-heptadecenoic acid formation

  Catalysed by GNPATperoxisome, cytosol, extracellular spaceOne of 14 routes

• O-hexadecanoyl-(R)-carnitineReach from here →
  1. glyceronephosphate O-acyltransferase (1-palmitoyl-dihydroxyacetone-phosphate)
  2. Palmitate:CoA ligase (AMP-forming)
  3. palmitoyl-CoA:L-carnitine O-palmitoyltransferase

  Catalysed by GNPAT, SLC27A2, ACSL4, ACSL3 and 7 moreperoxisome, cytosolOne of 15 routes

• L-cysteineReach from here →
  1. glyceronephosphate O-acyltransferase (1-palmitoyl-dihydroxyacetone-phosphate)
  2. Fas180
  3. N-acetylglutamate synthase (N-acetyl-L-cysteine)

  Catalysed by GNPAT, NAGSperoxisome, cytosol, mitochondrial matrix

• (7Z,10Z,13Z)-hexadecatrienoyl-CoAReach from here →
  1. glyceronephosphate O-acyltransferase (1-palmitoyl-dihydroxyacetone-phosphate)
  2. Fas180
  3. Fatty Acid Beta Oxidation (C18:3->C16:3), Mitochondrial

  Catalysed by GNPAT, HADHA, ACADVL, HADHBperoxisome, cytosol, mitochondrial matrix

• glycerolReach from here →
  1. 1-hexadecanoyl-sn-glycero-3-phosphate + NADP(+) = 1-hexadecanoylglycerone 3-phosphate + NADPH + H(+)
  2. 1-hexadecanoyl-sn-glycero-3-phosphate + H2O = sn-glycerol 3-phosphate + hexadecanoate + H(+)
  3. sn-glycerol 3-phosphate + H2O = glycerol + phosphate

  Catalysed by DHRS7B, LYPLA2, PNPLA7, PNPLA6 and 1 more

• CHEBI:17927Reach from here →
  1. glyceronephosphate O-acyltransferase (1-palmitoyl-dihydroxyacetone-phosphate)
  2. Fas180
  3. N1,N8-diacetylspermidine to N1-acetylspermidine conversion

  Catalysed by GNPATperoxisome, cytosol

• O-octanoyl-(R)-carnitineReach from here →
  1. glyceronephosphate O-acyltransferase (1-palmitoyl-dihydroxyacetone-phosphate)
  2. Utilized Transport
  3. solute carrier (L-carnitine)

  Catalysed by GNPAT, SLC25A20peroxisome, endoplasmic reticulum, cytosol, mitochondrial matrixOne of 7 routes

• dodecanoateReach from here →
  1. glyceronephosphate O-acyltransferase (1-palmitoyl-dihydroxyacetone-phosphate)
  2. (10Z)-heptadecenoic acid formation
  3. (10Z)-heptadecenoic acid formation

  Catalysed by GNPATperoxisome, cytosol, extracellular spaceOne of 12 routes

• (5Z)-dodecenoyl-CoAReach from here →
  1. glyceronephosphate O-acyltransferase (1-palmitoyl-dihydroxyacetone-phosphate)
  2. Fas180
  3. acetyl-CoA C-acyltransferase (3-oxomyrist-7-enoyl-CoA)

  Catalysed by GNPAT, HADHA, ACAA2, HADHBperoxisome, cytosol, mitochondrial matrixOne of 2 routes

• (11Z)-docosenoyl-CoA(4-)Reach from here →
  1. glyceronephosphate O-acyltransferase (1-palmitoyl-dihydroxyacetone-phosphate)
  2. Fas180
  3. long-chain-fatty-acid-CoA ligase (cis-cetoleic acid)

  Catalysed by GNPAT, SLC27A2, ACSL4, ACSL3 and 5 moreperoxisome, cytosolOne of 5 routes

• (7Z)-tetradecenoyl-CoAReach from here →
  1. glyceronephosphate O-acyltransferase (1-palmitoyl-dihydroxyacetone-phosphate)
  2. Fas180
  3. long-chain-fatty-acid-CoA ligase ((7Z)-tetradecenoic acid)

  Catalysed by GNPAT, SLC27A2, ACSL4, ACSL3 and 5 moreperoxisome, cytosolOne of 8 routes

• a 2-hexadecanoyl-6-alpha-D-glucosaminy-1-(1,2-diacyl-sn-glycero-3-phospho)-1D-myo-inositolReach from here →
  1. 1-hexadecanoylglycerone 3-phosphate + hexadecan-1-ol = 1-O-hexadecylglycerone 3-phosphate + hexadecanoate + H(+)
  2. hexadecanoate + ATP + CoA = hexadecanoyl-CoA + AMP + diphosphate
  3. a 6-(alpha-D-glucosaminyl)-1-(1,2-diacyl-sn-glycero-3-phospho)-1D-myo-inositol + hexadecanoyl-CoA = a 2-hexadecanoyl-6-alpha-D-glucosaminy-1-(1,2-diacyl-sn-glycero-3-phospho)-1D-myo-inositol + CoA

  Catalysed by AGPS, SLC27A2, ACSL4, ACSL3 and 9 more

• N-acetylcysteine methyl esterReach from here →
  1. 1-hexadecanoylglycerone 3-phosphate + hexadecan-1-ol = 1-O-hexadecylglycerone 3-phosphate + hexadecanoate + H(+)
  2. S-hexadecanoyl-N-acetylcysteine methyl ester + H2O = N-acetylcysteine methyl ester + hexadecanoate + H(+)
  3. S-hexadecanoyl-N-acetylcysteine methyl ester + H2O = N-acetylcysteine methyl ester + hexadecanoate + H(+)

  Catalysed by AGPS, PPT1

• (4Z,7Z,10Z,13Z)-hexadecatetraenoyl-CoAReach from here →
  1. glyceronephosphate O-acyltransferase (1-palmitoyl-dihydroxyacetone-phosphate)
  2. Fas180
  3. Fatty Acid Beta Oxidation (C18:4->C16:4), Mitochondrial

  Catalysed by GNPAT, HADHA, ACADVL, HADHBperoxisome, cytosol, mitochondrial matrixOne of 3 routes

• (7Z,10Z)-hexadecadienoyl-CoAReach from here →
  1. glyceronephosphate O-acyltransferase (1-palmitoyl-dihydroxyacetone-phosphate)
  2. Fas180
  3. Fatty Acid Beta Oxidation Trans (C18:2->C16:2), Mitochondrial

  Catalysed by GNPAT, HADHA, ACADVL, HADHBperoxisome, cytosol, mitochondrial matrix

• (4Z,7Z)-decadienoyl-CoAReach from here →
  1. glyceronephosphate O-acyltransferase (1-palmitoyl-dihydroxyacetone-phosphate)
  2. Fas180
  3. Fatty Acid Beta Oxidation (C12:3->C10:2), Mitochondrial

  Catalysed by GNPAT, ECHS1, ACAA2, HADHperoxisome, cytosol, mitochondrial matrixOne of 2 routes

• (5Z)-octenoyl-CoAReach from here →
  1. glyceronephosphate O-acyltransferase (1-palmitoyl-dihydroxyacetone-phosphate)
  2. Fas180
  3. Fatty Acid Beta Oxidation (C10:2->C8:1), Mitochondrial

  Catalysed by GNPAT, ECHS1, ACAA2, HADHperoxisome, cytosol, mitochondrial matrixOne of 2 routes

• docosanoateReach from here →
  1. glyceronephosphate O-acyltransferase (1-palmitoyl-dihydroxyacetone-phosphate)
  2. (10Z)-heptadecenoic acid formation
  3. (10Z)-heptadecenoic acid formation

  Catalysed by GNPATperoxisome, cytosol, extracellular spaceOne of 12 routes

• a quinolReach from here →
  1. 1-hexadecanoyl-sn-glycero-3-phosphate + NADP(+) = 1-hexadecanoylglycerone 3-phosphate + NADPH + H(+)
  2. 1-hexadecanoyl-sn-glycero-3-phosphate + H2O = sn-glycerol 3-phosphate + hexadecanoate + H(+)
  3. a quinone + sn-glycerol 3-phosphate = dihydroxyacetone phosphate + a quinol

  Catalysed by DHRS7B, LYPLA2, PNPLA7, PNPLA6 and 1 more

• alpha-linolenic acidReach from here →
  1. glyceronephosphate O-acyltransferase (1-palmitoyl-dihydroxyacetone-phosphate)
  2. (10Z)-heptadecenoic acid formation
  3. (10Z)-heptadecenoic acid formation

  Catalysed by GNPATperoxisome, cytosol, extracellular spaceOne of 13 routes

• CHEBI:27540Reach from here →
  1. glyceronephosphate O-acyltransferase (1-palmitoyl-dihydroxyacetone-phosphate)
  2. Fas180
  3. medium-chain acyl-CoA ligase (hexanoic acid)

  Catalysed by GNPAT, ACSM4, ACSM1, ACSM2A and 3 moreperoxisome, cytosolOne of 6 routes

• elaidic acidReach from here →
  1. glyceronephosphate O-acyltransferase (1-palmitoyl-dihydroxyacetone-phosphate)
  2. (10Z)-heptadecenoic acid formation
  3. (10Z)-heptadecenoic acid formation

  Catalysed by GNPATperoxisome, cytosol, extracellular spaceOne of 17 routes

• all-cis-docosa-4,7,10,13,16,19-hexaenoic acidReach from here →
  1. glyceronephosphate O-acyltransferase (1-palmitoyl-dihydroxyacetone-phosphate)
  2. (10Z)-heptadecenoic acid formation
  3. (10Z)-heptadecenoic acid formation

  Catalysed by GNPATperoxisome, cytosol, extracellular spaceOne of 12 routes

• CHEBI:28701Reach from here →
  1. glyceronephosphate O-acyltransferase (1-palmitoyl-dihydroxyacetone-phosphate)
  2. Fas180
  3. Propanoyl-CoA:acetyl-CoA C-acyltransferase

  Catalysed by GNPAT, ACAA1, SCP2, MYO5Bperoxisome, cytosolOne of 7 routes

• chlorine(.)Reach from here →
  1. glyceronephosphate O-acyltransferase (1-palmitoyl-dihydroxyacetone-phosphate)
  2. Utilized Transport
  3. Carnitine Transport by Atb0

  Catalysed by GNPAT, SLC6A14peroxisome, endoplasmic reticulum, cytosol, extracellular space

• tetradecanoateReach from here →
  1. glyceronephosphate O-acyltransferase (1-palmitoyl-dihydroxyacetone-phosphate)
  2. (10Z)-heptadecenoic acid formation
  3. (10Z)-heptadecenoic acid formation

  Catalysed by GNPATperoxisome, cytosol, extracellular spaceOne of 12 routes

• (9Z)-octadecenoateReach from here →
  1. glyceronephosphate O-acyltransferase (1-palmitoyl-dihydroxyacetone-phosphate)
  2. (10Z)-heptadecenoic acid formation
  3. (10Z)-heptadecenoic acid formation

  Catalysed by GNPATperoxisome, cytosol, extracellular spaceOne of 15 routes

• hexacosanoateReach from here →
  1. glyceronephosphate O-acyltransferase (1-palmitoyl-dihydroxyacetone-phosphate)
  2. (10Z)-heptadecenoic acid formation
  3. (10Z)-heptadecenoic acid formation

  Catalysed by GNPATperoxisome, cytosol, extracellular spaceOne of 12 routes

• tetracosanoateReach from here →
  1. glyceronephosphate O-acyltransferase (1-palmitoyl-dihydroxyacetone-phosphate)
  2. (10Z)-heptadecenoic acid formation
  3. (10Z)-heptadecenoic acid formation

  Catalysed by GNPATperoxisome, cytosol, extracellular spaceOne of 12 routes

• an N-acylsphinganineReach from here →
  1. glyceronephosphate O-acyltransferase (1-palmitoyl-dihydroxyacetone-phosphate)
  2. (10Z)-heptadecenoic acid formation
  3. N-acylsphingosine amidohydrolase

  Catalysed by GNPAT, ASAH1, ACER2, ACER1 and 2 moreperoxisome, cytosol

• eicosanoateReach from here →
  1. glyceronephosphate O-acyltransferase (1-palmitoyl-dihydroxyacetone-phosphate)
  2. (10Z)-heptadecenoic acid formation
  3. (10Z)-heptadecenoic acid formation

  Catalysed by GNPATperoxisome, cytosol, extracellular spaceOne of 12 routes

• (9Z)-hexadecenoateReach from here →
  1. glyceronephosphate O-acyltransferase (1-palmitoyl-dihydroxyacetone-phosphate)
  2. (10Z)-heptadecenoic acid formation
  3. (10Z)-heptadecenoic acid formation

  Catalysed by GNPATperoxisome, cytosol, extracellular spaceOne of 18 routes