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Proteins/UNIPROT:Q02083
Degrades bioactive fatty acid amides to their corresponding acids, with the following preference: N-palmitoylethanolamine > N-myristoylethanolamine > N-lauroylethanolamine = N-stearoylethanolamine > N-arachidonoylethanolamine > N-oleoylethanolamine. Also exhibits weak hydrolytic activity against the ceramides N-lauroylsphingosine and N-palmitoylsphingosine..
Function from UniProtKB (Q02083), read 2026-09-23. CC BY 4.0.
Curated compounds routed: 0
35 statements
35 statements · 5 reference databases · Subject: NAAA · Sources: Bgee, Hetionet, Human-GEM, Reactome, Rhea
13 reactions
6 names
Resolves to: NAAA
water+N-hexadecanoylethanolamineethanolamine+hexadecanoic acid
Catalysed by NAAA
Reaction pageLeft to rightBalancedEC 3.5.1.60, 3.5.1.99cytosol
Human-GEM MAR20093CC BY 4.0Reference data
water+N-dodecanoylethanolamineethanolamine+dodecanoate
Catalysed by NAAA
Reaction pageLeft to rightBalancedEC 3.5.1.99cytosol
Human-GEM MAR20094CC BY 4.0Reference data
water+N-tetradecanoylethanolamineethanolamine+tetradecanoate
Catalysed by NAAA
Reaction pageLeft to rightBalancedEC 3.5.1.99cytosol
Human-GEM MAR20095CC BY 4.0Reference data
water+N-hexadecanoylsphing-4-eninehexadecanoic acid+sphing-4-enine
Catalysed by NAAA
Reaction pageLeft to rightBalancedEC 3.5.1.23cytosol, nucleus
Human-GEM MAR20096CC BY 4.0Reference data
water+N-dodecanoylsphing-4-eninedodecanoate+sphing-4-enine
Catalysed by NAAA
Reaction pageLeft to rightBalancedEC 3.5.1.23cytosol
Human-GEM MAR20097CC BY 4.0Reference data
an N-(long-chain fatty acyl)ethanolamine+watera long-chain fatty acid+ethanolamine
Catalysed by NAAA
Reaction pageLeft to rightBalance undeterminable
Rhea RHEA:17505CC BY 4.0Reference data
an N-acylsphing-4-enine+watersphing-4-enine+a fatty acid
Catalysed by NAAA or ASAH1 or ACER2 or ACER1 or ASAH2 or ACER3
Reaction pageLeft to rightBalance undeterminable
Rhea RHEA:20856CC BY 4.0Reference data
N-hexadecanoylsphing-4-enine+watersphing-4-enine+hexadecanoate
Catalysed by NAAA or ASAH1 or ACER2 or ASAH2
Reaction pageReversibleBalanced
Rhea RHEA:38891CC BY 4.0Reference data
N-dodecanoylsphing-4-enine+waterdodecanoate+sphing-4-enine
Catalysed by NAAA or ASAH1 or ACER2 or ASAH2
Reaction pageReversibleBalanced
Rhea RHEA:41291CC BY 4.0Reference data
N-hexadecanoylethanolamine+waterethanolamine+hexadecanoate
Catalysed by FAAH or NAAA or FAAH2
Reaction pageLeft to rightBalanced
Rhea RHEA:45064CC BY 4.0Reference data
N-tetradecanoylethanolamine+watertetradecanoate+ethanolamine
Catalysed by NAAA
Reaction pageLeft to rightBalanced
Rhea RHEA:45452CC BY 4.0Reference data