leukotriene C4

Two steps

• L-arginineReach from here →
  1. leukotriene C4 hydrolysis
  2. transport of arginine and glycine (cytosol to extracellular)

  Catalysed by SLC7A6cytosol, extracellular spaceOne of 2 routes

• CHEBI:16523Reach from here →
  1. leukotriene C4 hydrolysis
  2. transport of D-serine and glycine (cytosol to extracellular)

  Catalysed by SLC3A2, SLC7A10cytosol, extracellular spaceOne of 2 routes

• protein polypeptide chainReach from here →
  1. leukotriene C4 hydrolysis
  2. PROTEIN_BS

  No catalyst recordedcytosol

• CHEBI:16857Reach from here →
  1. leukotriene C4 hydrolysis
  2. transport of glycine and threonine (cytosol to extracellular)

  Catalysed by SLC3A2, SLC7A5, SLC7A10cytosol, extracellular spaceOne of 4 routes

• glyoxylic acidReach from here →
  1. leukotriene C4 hydrolysis
  2. glycine:oxygen oxidoreductase (deaminating)

  Catalysed by DAOcytosol, peroxisome

• bilirubin IXalphaReach from here →
  1. transport of GSH and leukotriene C4 (cytosol to extracellular)
  2. transport of bilirubin and GSH (cytosol to extracellular)

  Catalysed by SLCO1B1, SLCO1A2, SLCO1B3extracellular space, cytosolOne of 4 routes

• taurolithocholateReach from here →
  1. transport of GSH and leukotriene C4 (cytosol to extracellular)
  2. transport of GSH and taurolithocholate (cytosol to extracellular)

  Catalysed by SLCO1B1, SLCO1A2, SLCO1B3extracellular space, cytosolOne of 4 routes

• L-isoleucineReach from here →
  1. leukotriene C4 hydrolysis
  2. transport of glycine and isoleucine (cytosol to extracellular)

  Catalysed by SLC7A5cytosol, extracellular spaceOne of 4 routes

• CHEBI:17203Reach from here →
  1. leukotriene C4 hydrolysis
  2. transport of glycine and proline (cytosol to extracellular)

  Catalysed by SLC7A5, SLC7A6cytosol, extracellular spaceOne of 2 routes

• CHEBI:17208Reach from here →
  1. transport of GSH and leukotriene C4 (cytosol to extracellular)
  2. glutathione:dehydroascorbate oxidoreductase

  Catalysed by SLCO1B1extracellular space, cytosol

• homocysteineReach from here →
  1. transport of GSH and leukotriene C4 (cytosol to extracellular)
  2. Formation of Homocystine

  Catalysed by SLCO1B1extracellular space, cytosol

• sulfiteReach from here →
  1. leukotriene C4 = leukotriene A4 + glutathione
  2. thiosulfate + 2 glutathione = glutathione disulfide + hydrogen sulfide + sulfite + 2 H(+)

  Catalysed by MGST3, GSTM4, LTC4S, MGST2 and 1 moreOne of 2 routes

• 5-aminolevulinic acidReach from here →
  1. leukotriene C4 hydrolysis
  2. succinyl-CoA:glycine C-succinyltransferase (decarboxylating)

  Catalysed by ALAS1, ALAS2, CPNE7cytosol, mitochondrial matrix

• L-cysteineReach from here →
  1. transport of GSH and leukotriene C4 (cytosol to extracellular)
  2. cystine to cysteine conversion

  Catalysed by SLCO1B1extracellular space, cytosolOne of 5 routes

• urateReach from here →
  1. leukotriene C4 = leukotriene A4 + glutathione
  2. urate(out) + glutathione(in) = urate(in) + glutathione(out)

  Catalysed by MGST3, GSTM4, LTC4S, MGST2 and 1 moreinner side of the membrane, outer side of the membrane

• methylarsonous acidReach from here →
  1. leukotriene C4 = leukotriene A4 + glutathione
  2. methylarsonate + 2 glutathione + H(+) = methylarsonous acid + glutathione disulfide + H2O

  Catalysed by MGST3, GSTM4, LTC4S, MGST2 and 2 more

• CHEBI:17895Reach from here →
  1. leukotriene C4 hydrolysis
  2. transport of glycine and tyrosine (cytosol to extracellular)

  Catalysed by SLC7A5cytosol, extracellular spaceOne of 4 routes

• CHEBI:18019Reach from here →
  1. leukotriene C4 hydrolysis
  2. transport of glycine and lysine (cytosol to extracellular)

  Catalysed by SLC7A6cytosol, extracellular spaceOne of 2 routes

• L-glutamineReach from here →
  1. leukotriene C4 hydrolysis
  2. transport of glutamine and glycine (cytosol to extracellular)

  Catalysed by SLC7A5cytosol, extracellular spaceOne of 4 routes

• N(1)-(5-phospho-D-ribosyl)glycinamideReach from here →
  1. leukotriene C4 hydrolysis
  2. 5-Phospho-D-ribosylamine:glycine ligase (ADP-forming)

  Catalysed by GARTcytosol

• arsenic triglutathioneReach from here →
  1. leukotriene C4 = leukotriene A4 + glutathione
  2. arsenic triglutathione + 3 [thioredoxin]-dithiol + 3 S-adenosyl-L-methionine = trimethylarsine + 3 [thioredoxin]-disulfide + 3 glutathione + 3 S-adenosyl-L-homocysteine + 3 H(+)

  Catalysed by MGST3, GSTM4, LTC4S, MGST2 and 1 moreOne of 3 routes

• ophthalmateReach from here →
  1. leukotriene C4 hydrolysis
  2. gamma-L-glutamyl-(2S)-2-aminobutanoate + glycine + ATP = ophthalmate + ADP + phosphate + H(+)

  Catalysed by GSScytosol

• 15-deoxy-Delta(12,14)-prostaglandin J2-S-(R)-glutathioneReach from here →
  1. leukotriene C4 = leukotriene A4 + glutathione
  2. 15-deoxy-Delta(12,14)-prostaglandin J2 + glutathione = 15-deoxy-Delta(12,14)-prostaglandin J2-S-(R)-glutathione

  Catalysed by MGST3, GSTM4, LTC4S, MGST2

• (5S)-hydroxy-(6E,8Z,11Z,14Z,17Z)-eicosapentaenoateReach from here →
  1. leukotriene C4 = leukotriene A4 + glutathione
  2. (5S)-hydroperoxy-(6E,8Z,11Z,14Z,17Z)-eicosapentaenoate + 2 glutathione = (5S)-hydroxy-(6E,8Z,11Z,14Z,17Z)-eicosapentaenoate + glutathione disulfide + H2O

  Catalysed by MGST3, GSTM4, LTC4S, MGST2 and 2 more

• (12S)-hydroxy-(5Z,8Z,10E,14Z,17Z)-eicosapentaenoateReach from here →
  1. leukotriene C4 = leukotriene A4 + glutathione
  2. (12S)-hydroperoxy-(5Z,8Z,10E,14Z,17Z)-eicosapentaenoate + 2 glutathione = (12S)-hydroxy-(5Z,8Z,10E,14Z,17Z)-eicosapentaenoate + glutathione disulfide + H2O

  Catalysed by MGST3, GSTM4, LTC4S, MGST2 and 2 more

• (15S)-hydroxy-(11Z,13E)-eicosadienoateReach from here →
  1. leukotriene C4 = leukotriene A4 + glutathione
  2. (15S)-hydroperoxy-(11Z,13E)-eicosadienoate + 2 glutathione = (15S)-hydroxy-(11Z,13E)-eicosadienoate + glutathione disulfide + H2O

  Catalysed by MGST3, GSTM4, LTC4S, MGST2 and 2 more

• (17S)-hydroxy-(4Z,7Z,10Z,13Z,15E,19Z)-docosahexaenoateReach from here →
  1. leukotriene C4 = leukotriene A4 + glutathione
  2. (17S)-hydroperoxy-(4Z,7Z,10Z,13Z,15E,19Z)-docosahexaenoate + 2 glutathione = (17S)-hydroxy-(4Z,7Z,10Z,13Z,15E,19Z)-docosahexaenoate + glutathione disulfide + H2O

  Catalysed by MGST3, GSTM4, LTC4S, MGST2 and 2 more

• a hydroxy-1,2-diacyl-glycero-3-phosphocholineReach from here →
  1. leukotriene C4 = leukotriene A4 + glutathione
  2. a hydroperoxy-1,2-diacyl-glycero-3-phosphocholine + 2 glutathione = a hydroxy-1,2-diacyl-glycero-3-phosphocholine + glutathione disulfide + H2O

  Catalysed by MGST3, GSTM4, LTC4S, MGST2 and 1 more

• N(omega),N('omega)-dimethyl-L-arginineReach from here →
  1. leukotriene C4 hydrolysis
  2. N(omega),N('omega)-dimethyl-L-arginine + glyoxylate = 5-(3,3'-dimethylguanidino)-2-oxopentanoate + glycine

  Catalysed by AGXT2cytosol

• 5,6,7,8-tetrahydrofolic acidReach from here →
  1. leukotriene C4 hydrolysis
  2. 5,10-Methylenetetrahydrofolate:glycine hydroxymethyltransferase

  Catalysed by SHMT1cytosolOne of 2 routes

• 3-(glutathion-S-yl)-4-hydroxynonanalReach from here →
  1. leukotriene C4 = leukotriene A4 + glutathione
  2. (E)-4-hydroxynon-2-enal + glutathione = 3-(glutathion-S-yl)-4-hydroxynonanal

  Catalysed by MGST3, GSTM4, LTC4S, MGST2 and 1 more

• CHEBI:240943Reach from here →
  1. leukotriene C4 hydrolysis
  2. glycine N-acyltransferase (2-methylbutyryl-CoA)

  Catalysed by GLYAT, GLYATL2, GLYATL1cytosol, mitochondrial matrix

• a quinolReach from here →
  1. leukotriene C4 = leukotriene A4 + glutathione
  2. a quinone + hydrogen sulfide + glutathione + H(+) = S-sulfanylglutathione + a quinol

  Catalysed by MGST3, GSTM4, LTC4S, MGST2 and 1 more

• phenylacetylglycineReach from here →
  1. leukotriene C4 hydrolysis
  2. phenylacetyl-CoA:glycine N-phenylacetyltransferase

  Catalysed by GLYATcytosolOne of 3 routes

• 5(S)-HETEReach from here →
  1. transport of GSH and leukotriene C4 (cytosol to extracellular)
  2. Glutathione: 5-HPETE oxidoreductase

  Catalysed by SLCO1B1, GPX5, GPX1, GPX2 and 6 moreextracellular space, cytosolOne of 2 routes

• L-ascorbic acidReach from here →
  1. leukotriene C4 = leukotriene A4 + glutathione
  2. L-dehydroascorbate + 2 glutathione = glutathione disulfide + L-ascorbate

  Catalysed by MGST3, GSTM4, LTC4S, MGST2 and 3 more

• Gly-tRNA(Gly)Reach from here →
  1. leukotriene C4 hydrolysis
  2. glycine:tRNA(Gly) ligase (AMP-forming)

  Catalysed by GARS1cytosol

• chlorine(.)Reach from here →
  1. leukotriene C4 hydrolysis
  2. transport of chloride and glycine (cytosol to extracellular)

  Catalysed by SLC6A9, SLC6A14cytosol, extracellular spaceOne of 3 routes

• glycocholateReach from here →
  1. transport of GSH and leukotriene C4 (cytosol to extracellular)
  2. solute carrier organic anion transporter (glycocholate)

  Catalysed by SLCO1B1, SLCO1A2, SLCO1B3extracellular space, cytosolOne of 8 routes

• cholateReach from here →
  1. transport of GSH and leukotriene C4 (cytosol to extracellular)
  2. solute carrier organic anion transporter (cholate)

  Catalysed by SLCO1B1, SLCO1A2, SLCO1B3extracellular space, cytosolOne of 5 routes

• hydrogen sulfideReach from here →
  1. leukotriene C4 = leukotriene A4 + glutathione
  2. thiosulfate + 2 glutathione = glutathione disulfide + hydrogen sulfide + sulfite + 2 H(+)

  Catalysed by MGST3, GSTM4, LTC4S, MGST2 and 1 more

• an alcoholReach from here →
  1. leukotriene C4 = leukotriene A4 + glutathione
  2. a hydroperoxide + 2 glutathione = an alcohol + glutathione disulfide + H2O

  Catalysed by MGST3, GSTM4, LTC4S, MGST2 and 2 more

• (5Z,8Z,11Z,14Z)-eicosatetraenoateReach from here →
  1. transport of GSH and leukotriene C4 (cytosol to extracellular)
  2. transport of arachidonate and GSH (cytosol to extracellular)

  Catalysed by SLCO1B1extracellular space, cytosolOne of 4 routes

• serotoninReach from here →
  1. transport of GSH and leukotriene C4 (cytosol to extracellular)
  2. transport of GSH and serotonin (cytosol to extracellular)

  Catalysed by SLCO1B1, SLCO1A2, SLCO1B3extracellular space, cytosolOne of 4 routes

• 5-aminolevulinateReach from here →
  1. leukotriene C4 hydrolysis
  2. succinyl-CoA + glycine + H(+) = 5-aminolevulinate + CO2 + CoA

  Catalysed by ALAS1, ALAS2cytosol

• chenodeoxycholateReach from here →
  1. transport of leukotriene C4 (cytosol to extracellular)
  2. solute carrier organic anion transporter (chenodiol)

  Catalysed by SLCO1B1, SLCO1A2, SLCO1B3extracellular space, cytosolOne of 2 routes

• glycochenodeoxycholateReach from here →
  1. leukotriene C4 hydrolysis
  2. chenodeoxycholoyl-CoA + glycine = glycochenodeoxycholate + CoA + H(+)

  Catalysed by BAATcytosolOne of 2 routes

• taurocholateReach from here →
  1. transport of GSH and leukotriene C4 (cytosol to extracellular)
  2. solute carrier organic anion transporter (GSH)

  Catalysed by SLCO1B1, SLCO1A2, SLCO1B3extracellular space, cytosolOne of 5 routes

• glycochenodeoxycholic acidReach from here →
  1. leukotriene C4 hydrolysis
  2. bile acid-CoA: amino acid N-acyltransferase

  Catalysed by BAATcytosol, peroxisomeOne of 3 routes

• glyoxylateReach from here →
  1. leukotriene C4 hydrolysis
  2. glycine + 2-oxoglutarate = glyoxylate + L-glutamate

  Catalysed by AADATcytosolOne of 11 routes