N-acetyl-D-glucosamine 6-phosphate

Three steps

• cholineReach from here →
  1. N-Acetyl-D-glucosamine-6-phosphate amidohydrolase
  2. acetyl-CoA:D-glucosamine-6-phosphate N-acetyltransferase
  3. Acetyl-CoA:choline O-acetyltransferase

  Catalysed by CEMP1, AMDHD2, GNPNAT1, CHATcytosol, nucleus

• CHEBI:15380Reach from here →
  1. N-Acetyl-D-glucosamine-6-phosphate amidohydrolase
  2. acetyl-CoA:D-glucosamine-6-phosphate N-acetyltransferase
  3. 5-aminolevulinate synthase (2-amino-3-oxoadipate)

  Catalysed by CEMP1, AMDHD2, GNPNAT1, ALAS1 and 1 morecytosol, mitochondrial matrixOne of 8 routes

• CHEBI:15477Reach from here →
  1. N-Acetyl-D-glucosamine-6-phosphate amidohydrolase
  2. acetyl-CoA:D-glucosamine-6-phosphate N-acetyltransferase
  3. glycine N-acyltransferase (2-methylbutyryl-CoA)

  Catalysed by CEMP1, AMDHD2, GNPNAT1, GLYAT and 2 morecytosol, mitochondrial matrixOne of 2 routes

• 2-methylcrotonoyl-CoAReach from here →
  1. N-Acetyl-D-glucosamine-6-phosphate amidohydrolase
  2. acetyl-CoA:D-glucosamine-6-phosphate N-acetyltransferase
  3. Production of Tiglylcarnitine

  Catalysed by CEMP1, AMDHD2, GNPNAT1, CPT1A and 1 morecytosolOne of 2 routes

• isobutyryl-CoAReach from here →
  1. N-Acetyl-D-glucosamine-6-phosphate amidohydrolase
  2. acetyl-CoA:D-glucosamine-6-phosphate N-acetyltransferase
  3. acetyl-CoA C-acyltransferase (3-oxo-4-methyl-pentanoyl-CoA)

  Catalysed by CEMP1, AMDHD2, GNPNAT1, HADHA and 2 morecytosol, mitochondrial matrixOne of 3 routes

• 3-methylbut-2-enoyl-CoAReach from here →
  1. N-Acetyl-D-glucosamine-6-phosphate amidohydrolase
  2. acetyl-CoA:D-glucosamine-6-phosphate N-acetyltransferase
  3. glycine-N-acyltransferase (3-methylcrotonoylglycine)

  Catalysed by CEMP1, AMDHD2, GNPNAT1, GLYATcytosol, mitochondrial matrix

• isovaleryl-CoAReach from here →
  1. N-Acetyl-D-glucosamine-6-phosphate amidohydrolase
  2. acetyl-CoA:D-glucosamine-6-phosphate N-acetyltransferase
  3. glycine N-acyltransferase (isovalerylglycine)

  Catalysed by CEMP1, AMDHD2, GNPNAT1, GLYAT and 2 morecytosol, mitochondrial matrixOne of 3 routes

• arachidonoyl-CoAReach from here →
  1. N-Acetyl-D-glucosamine-6-phosphate amidohydrolase
  2. acetyl-CoA:D-glucosamine-6-phosphate N-acetyltransferase
  3. Arachidonate:CoA ligase (AMP-forming)

  Catalysed by CEMP1, AMDHD2, GNPNAT1, SLC27A2 and 7 morecytosolOne of 11 routes

• CHEBI:15519Reach from here →
  1. N-Acetyl-D-glucosamine-6-phosphate amidohydrolase
  2. acetyl-CoA:D-glucosamine-6-phosphate N-acetyltransferase
  3. propanoyl-CoA C-acyltransferase

  Catalysed by CEMP1, AMDHD2, GNPNAT1, ACAA1 and 2 morecytosol, peroxisomeOne of 2 routes

• palmitoyl-CoAReach from here →
  1. N-Acetyl-D-glucosamine-6-phosphate amidohydrolase
  2. acetyl-CoA:D-glucosamine-6-phosphate N-acetyltransferase
  3. Palmitate:CoA ligase (AMP-forming)

  Catalysed by CEMP1, AMDHD2, GNPNAT1, SLC27A2 and 7 morecytosolOne of 11 routes

• oleoyl-CoAReach from here →
  1. N-Acetyl-D-glucosamine-6-phosphate amidohydrolase
  2. acetyl-CoA:D-glucosamine-6-phosphate N-acetyltransferase
  3. Transport of octadecenoyl-CoA into Mitochondrial Matrix

  Catalysed by CEMP1, AMDHD2, GNPNAT1, CPT1A and 2 morecytosolOne of 11 routes

• phenylacetyl-CoAReach from here →
  1. N-Acetyl-D-glucosamine-6-phosphate amidohydrolase
  2. acetyl-CoA:D-glucosamine-6-phosphate N-acetyltransferase
  3. Phenylacetate:CoA ligase

  Catalysed by CEMP1, AMDHD2, GNPNAT1cytosolOne of 3 routes

• propionyl-CoAReach from here →
  1. N-Acetyl-D-glucosamine-6-phosphate amidohydrolase
  2. transport of acetate and propanoate (cytosol to extracellular)
  3. Propanoate:CoA ligase (AMP-forming)

  Catalysed by CEMP1, AMDHD2, SLC16A4, SLC16A5 and 5 morecytosol, extracellular spaceOne of 46 routes

• (S)-malateReach from here →
  1. N-Acetyl-D-glucosamine-6-phosphate amidohydrolase
  2. transport of acetate and pyruvate (cytosol to extracellular)
  3. (S)-malate + NAD(+) = pyruvate + CO2 + NADH

  Catalysed by CEMP1, AMDHD2, SLC16A4, SLC16A5 and 4 morecytosol, extracellular spaceOne of 2 routes

• 10-formyltetrahydrofolic acidReach from here →
  1. N-Acetyl-D-glucosamine-6-phosphate amidohydrolase
  2. transport of acetate and formate (cytosol to extracellular)
  3. Formate:tetrahydrofolate ligase (ADP-forming)

  Catalysed by CEMP1, AMDHD2, SLC16A4, SLC16A5 and 2 morecytosol, extracellular spaceOne of 2 routes

• CHEBI:15650Reach from here →
  1. N-Acetyl-D-glucosamine-6-phosphate amidohydrolase
  2. acetyl-CoA:D-glucosamine-6-phosphate N-acetyltransferase
  3. N-acetyl-LTE4 to leukotriene E4 conversion

  Catalysed by CEMP1, AMDHD2, GNPNAT1, ZDHHC11B and 31 morecytosolOne of 2 routes

• CHEBI:15727Reach from here →
  1. N-Acetyl-D-glucosamine-6-phosphate amidohydrolase
  2. acetyl-CoA:D-glucosamine-6-phosphate N-acetyltransferase
  3. N-alpha-acetyltransferase 10, NatA catalytic subunit (acetylcarnosine)

  Catalysed by CEMP1, AMDHD2, GNPNAT1, NAA10cytosol

• CHEBI:15746Reach from here →
  1. N-Acetyl-D-glucosamine-6-phosphate amidohydrolase
  2. acetyl-CoA:D-glucosamine-6-phosphate N-acetyltransferase
  3. diamine N-acetyltransferase (N1-acetylspermine)

  Catalysed by CEMP1, AMDHD2, GNPNAT1, SAT1 and 1 morecytosolOne of 2 routes

• dihydroxyacetoneReach from here →
  1. N-Acetyl-D-glucosamine-6-phosphate amidohydrolase
  2. alpha-D-glucosamine 6-phosphate + H2O = beta-D-fructose 6-phosphate + NH4(+)
  3. beta-D-fructose 6-phosphate = dihydroxyacetone + D-glyceraldehyde 3-phosphate

  Catalysed by CEMP1, AMDHD2, GNPDA1, GNPDA2 and 1 morecytosol

• 2-methyl-3-oxopropanoic acidReach from here →
  1. N-Acetyl-D-glucosamine-6-phosphate amidohydrolase
  2. transport of acetate and pyruvate (cytosol to extracellular)
  3. (R)-3-Amino-2-methylpropanoate:pyruvate aminotransferase

  Catalysed by CEMP1, AMDHD2, SLC16A4, SLC16A5 and 4 morecytosol, extracellular space, mitochondrial matrix

• 11-cis-retinolReach from here →
  1. N-Acetyl-D-glucosamine-6-phosphate amidohydrolase
  2. acetyl-CoA:D-glucosamine-6-phosphate N-acetyltransferase
  3. Palmitoyl-CoA:retinol O-acyltransferase

  Catalysed by CEMP1, AMDHD2, GNPNAT1, DGAT1 and 4 morecytosol

• CHEBI:16332Reach from here →
  1. N-Acetyl-D-glucosamine-6-phosphate amidohydrolase
  2. D-glucosamine-6-phosphate aminohydrolase (ketol isomerizing)
  3. D-Fructose 6-phosphate:D-glyceraldehyde-3-phosphate glycolaldehyde transferase

  Catalysed by CEMP1, AMDHD2, GNPDA1, GNPDA2 and 3 morecytosol

• (17R,20S)-17,20-dihydroxypregn-4-en-3-oneReach from here →
  1. N-Acetyl-D-glucosamine-6-phosphate amidohydrolase
  2. cytochrome P450 (17alpha-hydroxyprogesterone)
  3. (17R,20S)-17,20-dihydroxypregn-4-en-3-one + NAD(+) = 17alpha-hydroxyprogesterone + NADH + H(+)

  Catalysed by CEMP1, AMDHD2, CYP17A1, AKR1C1cytosol, endoplasmic reticulumOne of 2 routes

• androst-4-ene-3,17-dioneReach from here →
  1. N-Acetyl-D-glucosamine-6-phosphate amidohydrolase
  2. cytochrome P450 (17alpha-hydroxyprogesterone)
  3. cytochrome P450 (17alpha-hydroxyprogesterone)

  Catalysed by CEMP1, AMDHD2, CYP17A1cytosol, endoplasmic reticulumOne of 5 routes

• oxaloacetateReach from here →
  1. N-Acetyl-D-glucosamine-6-phosphate amidohydrolase
  2. transport of acetate and pyruvate (cytosol to extracellular)
  3. Pyruvate:carbon-dioxide ligase (ADP-forming)

  Catalysed by CEMP1, AMDHD2, SLC16A4, SLC16A5 and 4 morecytosol, extracellular space, mitochondrial matrixOne of 4 routes

• (S)-lactateReach from here →
  1. N-Acetyl-D-glucosamine-6-phosphate amidohydrolase
  2. transport of acetate and pyruvate (cytosol to extracellular)
  3. (S)-lactate + NAD(+) = pyruvate + NADH + H(+)

  Catalysed by CEMP1, AMDHD2, SLC16A4, SLC16A5 and 8 morecytosol, extracellular space

• 2-oxobutanoateReach from here →
  1. N-Acetyl-D-glucosamine-6-phosphate amidohydrolase
  2. transport of 2-hydroxybutyrate and acetate (cytosol to extracellular)
  3. 2-hydroxybutyrate:NAD+ oxidoreductase

  Catalysed by CEMP1, AMDHD2, SLC16A4, SLC16A5 and 6 morecytosol, extracellular spaceOne of 2 routes

• 2-oxoglutaramateReach from here →
  1. N-Acetyl-D-glucosamine-6-phosphate amidohydrolase
  2. transport of acetate and pyruvate (cytosol to extracellular)
  3. L-Glutamine:pyruvate aminotransferase

  Catalysed by CEMP1, AMDHD2, SLC16A4, SLC16A5 and 4 morecytosol, extracellular spaceOne of 2 routes

• 3-fumarylpyruvateReach from here →
  1. N-Acetyl-D-glucosamine-6-phosphate amidohydrolase
  2. transport of acetate and pyruvate (cytosol to extracellular)
  3. 3-fumarylpyruvate + H2O = fumarate + pyruvate + H(+)

  Catalysed by CEMP1, AMDHD2, SLC16A4, SLC16A5 and 4 morecytosol, extracellular space

• D-erythrose 4-phosphateReach from here →
  1. N-Acetyl-D-glucosamine-6-phosphate amidohydrolase
  2. D-glucosamine-6-phosphate aminohydrolase (ketol isomerizing)
  3. D-Fructose 6-phosphate:D-glyceraldehyde-3-phosphate glycolaldehyde transferase

  Catalysed by CEMP1, AMDHD2, GNPDA1, GNPDA2 and 3 morecytosol

• ferrocytochrome cReach from here →
  1. N-Acetyl-D-glucosamine-6-phosphate amidohydrolase
  2. transport of acetate and L-lactate (cytosol to extracellular)
  3. (S)-Lactate:ferricytochrome-c 2-oxidoreductase

  Catalysed by CEMP1, AMDHD2, SLC16A4, SLC16A5 and 5 morecytosol, extracellular space, mitochondrial matrix

• a beta-D-GlcNAc-(1->3)-beta-D-Gal-(1->4)-beta-D-Glc-(1<->1)-Cer(d18:1(4E))Reach from here →
  1. phosphoglucomutase (N-acetylglucosamine-6-phosphate)
  2. UDP-N-acetylglucosamine diphosphorylase (N-acetylglucosamine-1-phosphate)
  3. UDP-GlcNAc:betaGal beta-1,3-N-acetylglucosaminyltransferase (LacCer pool)

  Catalysed by PGM3, UAP1, UAP1L1, B3GNT5cytosolOne of 3 routes

• aldehydo-N-acetyl-D-mannosamineReach from here →
  1. phosphoglucomutase (N-acetylglucosamine-6-phosphate)
  2. UDP-N-acetylglucosamine diphosphorylase (N-acetylglucosamine-1-phosphate)
  3. UDP-N-acetyl-D-glucosamine 2-epimerase

  Catalysed by PGM3, UAP1, UAP1L1, GNEcytosol, endoplasmic reticulumOne of 3 routes

• 3-hydroxypyruvateReach from here →
  1. N-Acetyl-D-glucosamine-6-phosphate amidohydrolase
  2. transport of acetate and pyruvate (cytosol to extracellular)
  3. L-serine + pyruvate = 3-hydroxypyruvate + L-alanine

  Catalysed by CEMP1, AMDHD2, SLC16A4, SLC16A5 and 4 morecytosol, extracellular space

• 4-methylumbelliferoneReach from here →
  1. N-Acetyl-D-glucosamine-6-phosphate amidohydrolase
  2. 4-methylumbelliferyl acetate + H2O = 4-methylumbelliferone + acetate + H(+)
  3. 4-methylumbelliferyl acetate + H2O = 4-methylumbelliferone + acetate + H(+)

  Catalysed by CEMP1, AMDHD2, CES2, ESD and 1 morecytosol

• anilineReach from here →
  1. N-Acetyl-D-glucosamine-6-phosphate amidohydrolase
  2. acetyl-CoA:D-glucosamine-6-phosphate N-acetyltransferase
  3. Acetyl-CoA:arylamine N-acetyltransferase

  Catalysed by CEMP1, AMDHD2, GNPNAT1, NAT2 and 1 morecytosol

• aceneuramateReach from here →
  1. N-Acetyl-D-glucosamine-6-phosphate amidohydrolase
  2. transport of acetate and pyruvate (cytosol to extracellular)
  3. aceneuramate = aldehydo-N-acetyl-D-mannosamine + pyruvate

  Catalysed by CEMP1, AMDHD2, SLC16A4, SLC16A5 and 4 morecytosol, extracellular space

• CHEBI:17312Reach from here →
  1. N-Acetyl-D-glucosamine-6-phosphate amidohydrolase
  2. acetyl-CoA:D-glucosamine-6-phosphate N-acetyltransferase
  3. N1,N12-diacetylspermine to N1-acetylspermine conversion

  Catalysed by CEMP1, AMDHD2, GNPNAT1cytosolOne of 2 routes

• 5'-deoxyadenosineReach from here →
  1. N-Acetyl-D-glucosamine-6-phosphate amidohydrolase
  2. transport of acetate and pyruvate (cytosol to extracellular)
  3. N(1)-methylguanosine(37) in tRNA(Phe) + pyruvate + S-adenosyl-L-methionine = 4-demethylwyosine(37) in tRNA(Phe) + 5'-deoxyadenosine + L-methionine + CO2 + H2O

  Catalysed by CEMP1, AMDHD2, SLC16A4, SLC16A5 and 5 morecytosol, extracellular space

• L-cysteineReach from here →
  1. N-Acetyl-D-glucosamine-6-phosphate amidohydrolase
  2. acetyl-CoA:D-glucosamine-6-phosphate N-acetyltransferase
  3. N-acetylglutamate synthase (N-acetyl-L-cysteine)

  Catalysed by CEMP1, AMDHD2, GNPNAT1, NAGScytosol, mitochondrial matrix

• (7Z,10Z,13Z)-hexadecatrienoyl-CoAReach from here →
  1. N-Acetyl-D-glucosamine-6-phosphate amidohydrolase
  2. acetyl-CoA:D-glucosamine-6-phosphate N-acetyltransferase
  3. Fatty Acid Beta Oxidation (C18:3->C16:3), Mitochondrial

  Catalysed by CEMP1, AMDHD2, GNPNAT1, HADHA and 2 morecytosol, mitochondrial matrix

• urateReach from here →
  1. N-Acetyl-D-glucosamine-6-phosphate amidohydrolase
  2. transport of acetate and L-lactate (cytosol to extracellular)
  3. transport of L-lactate and urate (cytosol to extracellular)

  Catalysed by CEMP1, AMDHD2, SLC16A4, SLC16A5 and 5 morecytosol, extracellular space

• all-trans-retinalReach from here →
  1. N-Acetyl-D-glucosamine-6-phosphate amidohydrolase
  2. transport of acetate and retinoate (cytosol to extracellular)
  3. retinoate reduction

  Catalysed by CEMP1, AMDHD2, SLC16A4, SLC16A5 and 1 morecytosol, extracellular space

• CHEBI:17927Reach from here →
  1. N-Acetyl-D-glucosamine-6-phosphate amidohydrolase
  2. acetyl-CoA:D-glucosamine-6-phosphate N-acetyltransferase
  3. N1,N8-diacetylspermidine to N1-acetylspermidine conversion

  Catalysed by CEMP1, AMDHD2, GNPNAT1cytosol

• 4-fumarylacetoacetateReach from here →
  1. N-Acetyl-D-glucosamine-6-phosphate amidohydrolase
  2. transport of acetate and acetoacetate (cytosol to extracellular)
  3. 4-fumarylacetoacetate + H2O = acetoacetate + fumarate + H(+)

  Catalysed by CEMP1, AMDHD2, SLC16A4, SLC16A5 and 4 morecytosol, extracellular space

• dTDPReach from here →
  1. N-Acetyl-D-glucosamine-6-phosphate amidohydrolase
  2. transport of acetate and pyruvate (cytosol to extracellular)
  3. pyruvate kinase (dTDP)

  Catalysed by CEMP1, AMDHD2, SLC16A4, SLC16A5 and 5 morecytosol, extracellular space

• a ganglioside beta-D-GlcNAc-(1->6)-GA1Reach from here →
  1. N-acetyl-alpha-D-glucosamine 1-phosphate = N-acetyl-D-glucosamine 6-phosphate
  2. N-acetyl-alpha-D-glucosamine 1-phosphate + UTP + H(+) = UDP-N-acetyl-alpha-D-glucosamine + diphosphate
  3. a ganglioside GA1 + UDP-N-acetyl-alpha-D-glucosamine = a ganglioside beta-D-GlcNAc-(1->6)-GA1 + UDP + H(+)

  Catalysed by PGM3, UAP1, GCNT1

• 5-(3,3-dimethylguanidino)-2-oxopentanoateReach from here →
  1. N-Acetyl-D-glucosamine-6-phosphate amidohydrolase
  2. transport of acetate and pyruvate (cytosol to extracellular)
  3. N(omega),N(omega)-dimethyl-L-arginine + pyruvate = 5-(3,3-dimethylguanidino)-2-oxopentanoate + L-alanine

  Catalysed by CEMP1, AMDHD2, SLC16A4, SLC16A5 and 4 morecytosol, extracellular space

• 5-(3,3'-dimethylguanidino)-2-oxopentanoateReach from here →
  1. N-Acetyl-D-glucosamine-6-phosphate amidohydrolase
  2. transport of acetate and pyruvate (cytosol to extracellular)
  3. N(omega),N('omega)-dimethyl-L-arginine + pyruvate = 5-(3,3'-dimethylguanidino)-2-oxopentanoate + L-alanine

  Catalysed by CEMP1, AMDHD2, SLC16A4, SLC16A5 and 4 morecytosol, extracellular space

• 5-(3-methylguanidino)-2-oxopentanoateReach from here →
  1. N-Acetyl-D-glucosamine-6-phosphate amidohydrolase
  2. transport of acetate and pyruvate (cytosol to extracellular)
  3. N(omega)-methyl-L-arginine + pyruvate = 5-(3-methylguanidino)-2-oxopentanoate + L-alanine

  Catalysed by CEMP1, AMDHD2, SLC16A4, SLC16A5 and 4 morecytosol, extracellular space