Loading the page.
Proteins/UNIPROT:Q16222
Catalyzes the last step in biosynthesis of uridine diphosphate-N-acetylglucosamine (UDP-GlcNAc) by converting UTP and glucosamine 1-phosphate (GlcNAc-1-P) to the sugar nucleotide. Also converts UTP and galactosamine 1-phosphate (GalNAc-1-P) into uridine diphosphate-N-acetylgalactosamine (UDP-GalNAc). In addition to its role in metabolism, acts as a regulator of innate immunity in response to virus infection by mediating pyrophosphorylation of IRF3: catalyzes pyrophosphorylation of IRF3 phosphorylated at 'Ser-386' by TBK1, promoting IRF3 dimerization and activation, leading to type I interferon responses..
[Isoform AGX1]: Isoform AGX1 has 2 to 3 times higher activity towards galactosamine 1-phosphate (GalNAc-1-P)..
[Isoform AGX1]: Isoform AGX2 has 8 times more activity towards glucosamine 1-phosphate (GlcNAc-1-P)..
Function from UniProtKB (Q16222), read 2026-09-23. CC BY 4.0.
Curated compounds routed: 0
150 statements
150 statements · 7 reference databases · Subject: UAP1 · Sources: Bgee, gene ontology, Hetionet, Human-GEM, Reactome, Rhea, WikiPathways
4 reactions
proton+2-acetamido-2-deoxy-D-glucopyranose 1-phosphate+UTPdiphosphate(3-)+CHEBI:16264
Reaction pageLeft to rightBalancedEC 2.7.7.23cytosol
Human-GEM MAR04158CC BY 4.0Reference data
N-acetyl-alpha-D-glucosamine 1-phosphate+UTP+hydronUDP-N-acetyl-alpha-D-glucosamine+diphosphate(3-)
7 names
Resolves to: UAP1
Catalysed by UAP1
Reaction pageLeft to rightBalanced
Rhea RHEA:13509CC BY 4.0Reference data
N-acetyl-alpha-D-galactosamine 1-phosphate+UTP+hydronUDP-N-acetyl-alpha-D-galactosamine+diphosphate(3-)
Catalysed by UAP1
Reaction pageLeft to rightBalanced
Rhea RHEA:34363CC BY 4.0Reference data
CHEBI:58628+O-phospho-L-seryl-[protein]O-diphospho-L-seryl-[protein]+CHEBI:58130
Catalysed by UAP1
Reaction pageLeft to rightBalance undeterminable
Rhea RHEA:64104CC BY 4.0Reference data