3,3',5'-triiodo-L-thyronine

362,296 routes · scope human · up to 3 steps · built 5 October 2026 · Reactions · API

158 compounds within 3 steps: 5 in 1, 18 in 2, 135 in 3

Three steps

L-aspartateReach from here →
1. 3,3'-diiodo-L-thyronine + iodide + A + H(+) = 3,3',5'-triiodo-L-thyronine + AH2
2. (R)-malate + A = oxaloacetate + AH2
3. L-Aspartate:2-oxoglutarate aminotransferase
Catalysed by DIO1, DIO2, D2HGDH, GOT2mitochondrial matrixOne of 5 routes
formic acidReach from here →
1. 3,3'-diiodo-L-thyronine + iodide + A + H(+) = 3,3',5'-triiodo-L-thyronine + AH2
2. transport of chloride and iodide (cytosol to extracellular)
3. transport of chloride and formate (cytosol to extracellular)
Catalysed by DIO1, DIO2, SLC26A4extracellular space, cytosolOne of 2 routes
citric acidReach from here →
1. 3,3'-diiodo-L-thyronine + iodide + A + H(+) = 3,3',5'-triiodo-L-thyronine + AH2
2. (R)-malate + A = oxaloacetate + AH2
3. acetyl-CoA:oxaloacetate C-acetyltransferase (thioester-hydrolysing)
Catalysed by DIO1, DIO2, D2HGDH, CSmitochondrial matrixOne of 2 routes
malonic acidReach from here →
1. 3,3'-diiodo-L-thyronine + iodide + A + H(+) = 3,3',5'-triiodo-L-thyronine + AH2
2. transport of chloride and iodide (cytosol to extracellular)
3. Malonate Transport, Antiport with Chloride
Catalysed by DIO1, DIO2, SLC26A4extracellular space, cytosolOne of 2 routes
4-hydroxy-2-oxoglutaric acidReach from here →
1. 3,3'-diiodo-L-thyronine + iodide + A + H(+) = 3,3',5'-triiodo-L-thyronine + AH2
2. (R)-malate + A = oxaloacetate + AH2
3. D-aspartate:2-oxoglutarate aminotransferase
Catalysed by DIO1, DIO2, D2HGDH, GOT2mitochondrial matrix
di-mu-sulfido-diiron(2+)Reach from here →
1. 3,3'-diiodo-L-thyronine + iodide + A + H(+) = 3,3',5'-triiodo-L-thyronine + AH2
2. Mo-molybdopterin + L-cysteine + AH2 = thio-Mo-molybdopterin + L-alanine + A + H2O
3. De novo synthesis of 2Fe2S
Catalysed by DIO1, DIO2, MOCOS, NDUFAB1 and 6 moremitochondrial matrix
25-hydroxycholesterolReach from here →
1. 3,3'-diiodo-L-thyronine + iodide + A + H(+) = 3,3',5'-triiodo-L-thyronine + AH2
2. A + NADH + H(+) = AH2 + NAD(+)
3. cholesterol + AH2 + O2 = 25-hydroxycholesterol + A + H2O
Catalysed by DIO1, DIO2, AIFM1, PYROXD1 and 1 more
all-trans-4-oxoretinolReach from here →
1. 3,3'-diiodo-L-thyronine + iodide + A + H(+) = 3,3',5'-triiodo-L-thyronine + AH2
2. all-trans-13,14-dihydroretinol + A = all-trans-retinol + AH2
3. cytochrome P450 (retinol)
Catalysed by DIO1, DIO2, RETSAT, CYP26A1cytosol
phosphoenolpyruvic acidReach from here →
1. 3,3'-diiodo-L-thyronine + iodide + A + H(+) = 3,3',5'-triiodo-L-thyronine + AH2
2. (R)-malate + A = oxaloacetate + AH2
3. GTP:oxaloacetate carboxy-lyase (adding GTP
Catalysed by DIO1, DIO2, D2HGDH, PCK1cytosolOne of 2 routes
13-cis-retinolReach from here →
1. 3,3'-diiodo-L-thyronine + iodide + A + H(+) = 3,3',5'-triiodo-L-thyronine + AH2
2. all-trans-13,14-dihydroretinol + A = all-trans-retinol + AH2
3. retinol binding protein (retinol)
Catalysed by DIO1, DIO2, RETSAT, RBP1 and 1 morecytosolOne of 2 routes
L-ornithineReach from here →
1. 3,3'-diiodo-L-thyronine + iodide + A + H(+) = 3,3',5'-triiodo-L-thyronine + AH2
2. Mo-molybdopterin + L-cysteine + AH2 = thio-Mo-molybdopterin + L-alanine + A + H2O
3. transport of cysteine and ornithine (cytosol to extracellular)
Catalysed by DIO1, DIO2, MOCOS, SLC7A6extracellular space, cytosolOne of 2 routes
taurineReach from here →
1. 3,3'-diiodo-L-thyronine + iodide + A + H(+) = 3,3',5'-triiodo-L-thyronine + AH2
2. transport of chloride and iodide (cytosol to extracellular)
3. Neurotransmitter:Sodium Symporter (Nss) Tcdb:2.A.22.3.3
Catalysed by DIO1, DIO2, SLC26A4, SLC6A6extracellular space, cytosolOne of 2 routes
all-trans-13,14-dihydroretinolReach from here →
1. 3,3'-diiodo-L-thyronine + iodide + A + H(+) = 3,3',5'-triiodo-L-thyronine + AH2
2. A + NADH + H(+) = AH2 + NAD(+)
3. all-trans-13,14-dihydroretinol + A = all-trans-retinol + AH2
Catalysed by DIO1, DIO2, AIFM1, PYROXD1 and 1 moreOne of 2 routes
glycineReach from here →
1. 3,3'-diiodo-L-thyronine + iodide + A + H(+) = 3,3',5'-triiodo-L-thyronine + AH2
2. Mo-molybdopterin + L-cysteine + AH2 = thio-Mo-molybdopterin + L-alanine + A + H2O
3. transport of cysteine and glycine (cytosol to extracellular)
Catalysed by DIO1, DIO2, MOCOS, SLC3A2 and 2 moreextracellular space, cytosolOne of 7 routes
prostaglandin H2Reach from here →
1. 3,3'-diiodo-L-thyronine + iodide + A + H(+) = 3,3',5'-triiodo-L-thyronine + AH2
2. A + NADH + H(+) = AH2 + NAD(+)
3. (5Z,8Z,11Z,14Z)-eicosatetraenoate + AH2 + 2 O2 = prostaglandin H2 + A + H2O
Catalysed by DIO1, DIO2, AIFM1, PYROXD1 and 2 moreOne of 2 routes
(15S)-hydroxy-(5Z,8Z,11Z,13E)-eicosatetraenoateReach from here →
1. 3,3'-diiodo-L-thyronine + iodide + A + H(+) = 3,3',5'-triiodo-L-thyronine + AH2
2. A + NADH + H(+) = AH2 + NAD(+)
3. (15S)-hydroperoxy-(5Z,8Z,11Z,13E)-eicosatetraenoate + AH2 = (15S)-hydroxy-(5Z,8Z,11Z,13E)-eicosatetraenoate + A + H2O
Catalysed by DIO1, DIO2, AIFM1, PYROXD1 and 3 more
sarcosineReach from here →
1. 3,3'-diiodo-L-thyronine + iodide + A + H(+) = 3,3',5'-triiodo-L-thyronine + AH2
2. N(6),N(6)-dimethyl-L-lysyl(4)-[histone H3] + 2 A + 2 H2O = L-lysyl(4)-[histone H3] + 2 formaldehyde + 2 AH2
3. sarcosine + O2 + H2O = formaldehyde + glycine + H2O2
Catalysed by DIO1, DIO2, KDM1A, KDM1B and 1 more
(6S)-5,6,7,8-tetrahydrofolateReach from here →
1. 3,3'-diiodo-L-thyronine + iodide + A + H(+) = 3,3',5'-triiodo-L-thyronine + AH2
2. uridine(34) in tRNA + 5,10-methylenetetrahydrofolate + taurine + GTP + A + H2O = 5-taurinomethyluridine(34) in tRNA + 7,8-dihydrofolate + GDP + AH2 + phosphate + H(+)
3. (6S)-5,6,7,8-tetrahydrofolate + NADP(+) = 7,8-dihydrofolate + NADPH + H(+)
Catalysed by DIO1, DIO2, MTO1, DHFR and 1 more
3,5-diiodo-L-tyrosineReach from here →
1. 3,3'-diiodo-L-thyronine + iodide + A + H(+) = 3,3',5'-triiodo-L-thyronine + AH2
2. iodide:hydrogen-peroxide oxidoreductase
3. thyroid peroxidase (3-iodo-L-tyrosine)
Catalysed by DIO1, DIO2, TPOcytosolOne of 2 routes
2-oxo-3-sulfanylpropanoateReach from here →
1. 3,3'-diiodo-L-thyronine + iodide + A + H(+) = 3,3',5'-triiodo-L-thyronine + AH2
2. Mo-molybdopterin + L-cysteine + AH2 = thio-Mo-molybdopterin + L-alanine + A + H2O
3. L-Cysteine:2-oxoglutarate aminotransferase
Catalysed by DIO1, DIO2, MOCOS, GOT2 and 1 morecytosolOne of 3 routes
S-formylglutathioneReach from here →
1. 3,3'-diiodo-L-thyronine + iodide + A + H(+) = 3,3',5'-triiodo-L-thyronine + AH2
2. N(6),N(6)-dimethyl-L-lysyl(4)-[histone H3] + 2 A + 2 H2O = L-lysyl(4)-[histone H3] + 2 formaldehyde + 2 AH2
3. alcohol dehydrogenase (formaldehyde)
Catalysed by DIO1, DIO2, KDM1A, KDM1B and 6 morecytosol
guanidinoacetateReach from here →
1. 3,3'-diiodo-L-thyronine + iodide + A + H(+) = 3,3',5'-triiodo-L-thyronine + AH2
2. transport of chloride and iodide (cytosol to extracellular)
3. Transport of Guanidinoacetic Acid
Catalysed by DIO1, DIO2, SLC26A4extracellular space, cytosol
L-methionineReach from here →
1. 3,3'-diiodo-L-thyronine + iodide + A + H(+) = 3,3',5'-triiodo-L-thyronine + AH2
2. A + NADH + H(+) = AH2 + NAD(+)
3. N(6)-dimethylallyladenosine(37) in tRNA + (sulfur carrier)-SH + AH2 + 2 S-adenosyl-L-methionine = 2-methylsulfanyl-N(6)-dimethylallyladenosine(37) in tRNA + (sulfur carrier)-H + 5'-deoxyadenosine + L-methionine + A + S-adenosyl-L-homocysteine + 2 H(+)
Catalysed by DIO1, DIO2, AIFM1, PYROXD1 and 1 moreOne of 12 routes
L-tryptophanReach from here →
1. 3,3'-diiodo-L-thyronine + iodide + A + H(+) = 3,3',5'-triiodo-L-thyronine + AH2
2. Mo-molybdopterin + L-cysteine + AH2 = thio-Mo-molybdopterin + L-alanine + A + H2O
3. transport of cysteine and tryptophan (cytosol to extracellular)
Catalysed by DIO1, DIO2, MOCOS, SLC7A5extracellular space, cytosolOne of 6 routes
beta-alanineReach from here →
1. 3,3'-diiodo-L-thyronine + iodide + A + H(+) = 3,3',5'-triiodo-L-thyronine + AH2
2. transport of chloride and iodide (cytosol to extracellular)
3. transport of beta-alanine and chloride (cytosol to extracellular)
Catalysed by DIO1, DIO2, SLC26A4, SLC6A6 and 1 moreextracellular space, cytosolOne of 2 routes
L-alanineReach from here →
1. 3,3'-diiodo-L-thyronine + iodide + A + H(+) = 3,3',5'-triiodo-L-thyronine + AH2
2. A + NADH + H(+) = AH2 + NAD(+)
3. L-selenocysteine + AH2 = hydrogenselenide + L-alanine + A + H(+)
Catalysed by DIO1, DIO2, AIFM1, PYROXD1 and 1 moreOne of 19 routes
L-asparagineReach from here →
1. 3,3'-diiodo-L-thyronine + iodide + A + H(+) = 3,3',5'-triiodo-L-thyronine + AH2
2. Mo-molybdopterin + L-cysteine + AH2 = thio-Mo-molybdopterin + L-alanine + A + H2O
3. transport of asparagine and cysteine (cytosol to extracellular)
Catalysed by DIO1, DIO2, MOCOS, SLC7A5extracellular space, cytosolOne of 6 routes
L-phenylalanineReach from here →
1. 3,3'-diiodo-L-thyronine + iodide + A + H(+) = 3,3',5'-triiodo-L-thyronine + AH2
2. Mo-molybdopterin + L-cysteine + AH2 = thio-Mo-molybdopterin + L-alanine + A + H2O
3. transport of cysteine and phenylalanine (cytosol to extracellular)
Catalysed by DIO1, DIO2, MOCOS, SLC7A5extracellular space, cytosolOne of 8 routes
gamma-L-glutamyl-L-cysteineReach from here →
1. 3,3'-diiodo-L-thyronine + iodide + A + H(+) = 3,3',5'-triiodo-L-thyronine + AH2
2. Mo-molybdopterin + L-cysteine + AH2 = thio-Mo-molybdopterin + L-alanine + A + H2O
3. L-glutamate:L-cysteine gamma-ligase (ADP-forming)
Catalysed by DIO1, DIO2, MOCOS, GCLC and 1 morecytosolOne of 2 routes
S-sulfanyl-L-cysteineReach from here →
1. 3,3'-diiodo-L-thyronine + iodide + A + H(+) = 3,3',5'-triiodo-L-thyronine + AH2
2. Mo-molybdopterin + L-cysteine + AH2 = thio-Mo-molybdopterin + L-alanine + A + H2O
3. 2 L-cysteine = S-sulfanyl-L-cysteine + L-alanine
Catalysed by DIO1, DIO2, MOCOS, CARS2
phosphoenolpyruvateReach from here →
1. 3,3'-diiodo-L-thyronine + iodide + A + H(+) = 3,3',5'-triiodo-L-thyronine + AH2
2. (R)-malate + A = oxaloacetate + AH2
3. oxaloacetate + GTP = phosphoenolpyruvate + GDP + CO2
Catalysed by DIO1, DIO2, D2HGDH, PCK1 and 1 more
N-[(R)-4-phosphopantothenoyl]-L-cysteineReach from here →
1. 3,3'-diiodo-L-thyronine + iodide + A + H(+) = 3,3',5'-triiodo-L-thyronine + AH2
2. Mo-molybdopterin + L-cysteine + AH2 = thio-Mo-molybdopterin + L-alanine + A + H2O
3. (R)-4'-phosphopantothenate:L-cysteine ligase
Catalysed by DIO1, DIO2, MOCOS, PPCScytosolOne of 4 routes
4-aminobutanoateReach from here →
1. 3,3'-diiodo-L-thyronine + iodide + A + H(+) = 3,3',5'-triiodo-L-thyronine + AH2
2. transport of chloride and iodide (cytosol to extracellular)
3. transport of 4-aminobutyrate and chloride (cytosol to extracellular)
Catalysed by DIO1, DIO2, SLC26A4, SLC6A12extracellular space, cytosolOne of 4 routes
3-iodo-L-tyrosineReach from here →
1. 3,3'-diiodo-L-thyronine + iodide + A + H(+) = 3,3',5'-triiodo-L-thyronine + AH2
2. iodide:hydrogen-peroxide oxidoreductase
3. thyroid peroxidase (iodine)
Catalysed by DIO1, DIO2, TPOcytosolOne of 2 routes
3-sulfino-L-alanineReach from here →
1. 3,3'-diiodo-L-thyronine + iodide + A + H(+) = 3,3',5'-triiodo-L-thyronine + AH2
2. Mo-molybdopterin + L-cysteine + AH2 = thio-Mo-molybdopterin + L-alanine + A + H2O
3. L-Cysteine:oxygen oxidoreductase
Catalysed by DIO1, DIO2, MOCOS, CDO1cytosolOne of 2 routes
an all-trans-retinyl esterReach from here →
1. 3,3'-diiodo-L-thyronine + iodide + A + H(+) = 3,3',5'-triiodo-L-thyronine + AH2
2. all-trans-13,14-dihydroretinol + A = all-trans-retinol + AH2
3. Lecithin Retinol Acyltransferase
Catalysed by DIO1, DIO2, RETSAT, LRATcytosolOne of 4 routes
a 2,3-saturated acyl-CoAReach from here →
1. 3,3'-diiodo-L-thyronine + iodide + A + H(+) = 3,3',5'-triiodo-L-thyronine + AH2
2. A + NADH + H(+) = AH2 + NAD(+)
3. a 2,3-saturated acyl-CoA + A = a 2,3-dehydroacyl-CoA + AH2
Catalysed by DIO1, DIO2, AIFM1, PYROXD1 and 1 moreOne of 2 routes
all-trans-retinyl 9Z-octadecenoateReach from here →
1. 3,3'-diiodo-L-thyronine + iodide + A + H(+) = 3,3',5'-triiodo-L-thyronine + AH2
2. all-trans-13,14-dihydroretinol + A = all-trans-retinol + AH2
3. 1,2,3-tri-(9Z-octadecenoyl)-glycerol + all-trans-retinol = all-trans-retinyl 9Z-octadecenoate + di-(9Z)-octadecenoylglycerol
Catalysed by DIO1, DIO2, RETSAT, PNPLA4 and 1 more
di-(9Z)-octadecenoylglycerolReach from here →
1. 3,3'-diiodo-L-thyronine + iodide + A + H(+) = 3,3',5'-triiodo-L-thyronine + AH2
2. all-trans-13,14-dihydroretinol + A = all-trans-retinol + AH2
3. 1,2,3-tri-(9Z-octadecenoyl)-glycerol + all-trans-retinol = all-trans-retinyl 9Z-octadecenoate + di-(9Z)-octadecenoylglycerol
Catalysed by DIO1, DIO2, RETSAT, PNPLA4 and 1 more
2-hexadecanoyl-sn-glycero-3-phosphocholineReach from here →
1. 3,3'-diiodo-L-thyronine + iodide + A + H(+) = 3,3',5'-triiodo-L-thyronine + AH2
2. all-trans-13,14-dihydroretinol + A = all-trans-retinol + AH2
3. all-trans-retinol + 1,2-dihexadecanoyl-sn-glycero-3-phosphocholine = all-trans-retinyl hexadecanoate + 2-hexadecanoyl-sn-glycero-3-phosphocholine
Catalysed by DIO1, DIO2, RETSAT, LRAT
(9S)-hydroxy-(10E,12Z)-octadecadienoateReach from here →
1. 3,3'-diiodo-L-thyronine + iodide + A + H(+) = 3,3',5'-triiodo-L-thyronine + AH2
2. A + NADH + H(+) = AH2 + NAD(+)
3. (9Z,12Z)-octadecadienoate + AH2 + O2 = (9S)-hydroxy-(10E,12Z)-octadecadienoate + A + H2O
Catalysed by DIO1, DIO2, AIFM1, PYROXD1 and 2 more
(9R)-hydroxy-(10E,12Z)-octadecadienoateReach from here →
1. 3,3'-diiodo-L-thyronine + iodide + A + H(+) = 3,3',5'-triiodo-L-thyronine + AH2
2. A + NADH + H(+) = AH2 + NAD(+)
3. (9Z,12Z)-octadecadienoate + AH2 + O2 = (9R)-hydroxy-(10E,12Z)-octadecadienoate + A + H2O
Catalysed by DIO1, DIO2, AIFM1, PYROXD1 and 2 more
9-cis-retinolReach from here →
1. 3,3'-diiodo-L-thyronine + iodide + A + H(+) = 3,3',5'-triiodo-L-thyronine + AH2
2. all-trans-13,14-dihydroretinol + A = all-trans-retinol + AH2
3. retinol binding protein (retinol)
Catalysed by DIO1, DIO2, RETSAT, RBP1 and 1 morecytosolOne of 2 routes
(11R)-hydroxy-(5Z,8Z,12E,14Z)-eicosatetraenoateReach from here →
1. 3,3'-diiodo-L-thyronine + iodide + A + H(+) = 3,3',5'-triiodo-L-thyronine + AH2
2. A + NADH + H(+) = AH2 + NAD(+)
3. (5Z,8Z,11Z,14Z)-eicosatetraenoate + AH2 + O2 = (11R)-hydroxy-(5Z,8Z,12E,14Z)-eicosatetraenoate + A + H2O
Catalysed by DIO1, DIO2, AIFM1, PYROXD1 and 1 more
(15R)-hydroxy-(5Z,8Z,11Z,13E)-eicosatetraenoateReach from here →
1. 3,3'-diiodo-L-thyronine + iodide + A + H(+) = 3,3',5'-triiodo-L-thyronine + AH2
2. A + NADH + H(+) = AH2 + NAD(+)
3. (5Z,8Z,11Z,14Z)-eicosatetraenoate + AH2 + O2 = (15R)-hydroxy-(5Z,8Z,11Z,13E)-eicosatetraenoate + A + H2O
Catalysed by DIO1, DIO2, AIFM1, PYROXD1 and 1 more
thio-Mo-molybdopterinReach from here →
1. 3,3'-diiodo-L-thyronine + iodide + A + H(+) = 3,3',5'-triiodo-L-thyronine + AH2
2. A + NADH + H(+) = AH2 + NAD(+)
3. Mo-molybdopterin + L-cysteine + AH2 = thio-Mo-molybdopterin + L-alanine + A + H2O
Catalysed by DIO1, DIO2, AIFM1, PYROXD1 and 1 moreOne of 3 routes
2-glyceryl-prostaglandin H2Reach from here →
1. 3,3'-diiodo-L-thyronine + iodide + A + H(+) = 3,3',5'-triiodo-L-thyronine + AH2
2. A + NADH + H(+) = AH2 + NAD(+)
3. 2-glyceryl-prostaglandin G2 + AH2 = 2-glyceryl-prostaglandin H2 + A + H2O
Catalysed by DIO1, DIO2, AIFM1, PYROXD1 and 1 more
prostaglandin H1Reach from here →
1. 3,3'-diiodo-L-thyronine + iodide + A + H(+) = 3,3',5'-triiodo-L-thyronine + AH2
2. A + NADH + H(+) = AH2 + NAD(+)
3. prostaglandin G1 + AH2 = prostaglandin H1 + A + H2O
Catalysed by DIO1, DIO2, AIFM1, PYROXD1 and 1 more
(5S,11R)-dihydroxy-(6E,8Z,12E,14Z)-eicosatetraenoateReach from here →
1. 3,3'-diiodo-L-thyronine + iodide + A + H(+) = 3,3',5'-triiodo-L-thyronine + AH2
2. A + NADH + H(+) = AH2 + NAD(+)
3. (5S)-hydroxy-(6E,8Z,11Z,14Z)-eicosatetraenoate + AH2 + O2 = (5S,11R)-dihydroxy-(6E,8Z,12E,14Z)-eicosatetraenoate + A + H2O
Catalysed by DIO1, DIO2, AIFM1, PYROXD1 and 1 more
(5S,15R)-dihydroxy-(6E,8Z,11Z,13E)-eicosatetraenoateReach from here →
1. 3,3'-diiodo-L-thyronine + iodide + A + H(+) = 3,3',5'-triiodo-L-thyronine + AH2
2. A + NADH + H(+) = AH2 + NAD(+)
3. (5S)-hydroxy-(6E,8Z,11Z,14Z)-eicosatetraenoate + AH2 + O2 = (5S,15R)-dihydroxy-(6E,8Z,11Z,13E)-eicosatetraenoate + A + H2O
Catalysed by DIO1, DIO2, AIFM1, PYROXD1 and 1 more