Compound

prostaglandin H1

A prostaglandin carboxylic acid anion that is the conjugate base of prostaglandin H1, obtained by deprotonation of the carboxy group; major species at pH 7.3.

Definition from ChEBI (CHEBI:90793), read 2026-09-23. CC BY 4.0.

CHEBI:90793ChEBI

Open in the graph

Structure

2D depiction

Class: Organic compound, anion
Formula: C20H33O5
Mass: 353.479 g/mol
Charge: -1
InChIKey: NTAYABHEVAQSJS-CDIPTNKSSA-M
SMILES: CCCCC[C@H](O)/C=C/[C@@H]1[C@@H](CCCCCCC(=O)[O-])[C@@H]2C[C@H]1OO2
Look it up: ChEBI By InChIKey

Identity from ChEBI. Not evidence.

What it touches on the way

Mechanistic reach

6 entities

6 entities reached.

0 reported hops6 assembled from the scaffold

What the reference databases state

Chemical structure

prostaglandin H1 has the functional parent prostaglandin G1CompoundChEBI CHEBI:90793Inferred only

Statements

14 statements

14 statements · 2 reference databases · Subject: prostaglandin H1 · Sources: Human-GEM, Rhea

Order

prostaglandin H1 is converted to prostaglandin E1CompoundHuman-GEM MAR01394Inferred only
prostaglandin H1 is converted to prostaglandin E1CompoundHuman-GEM MAR03985Inferred only
prostaglandin E1 is converted to prostaglandin H1CompoundHuman-GEM MAR01394Inferred only
prostaglandin E1 is converted to prostaglandin H1CompoundHuman-GEM MAR03985Inferred only
prostaglandin H1 is metabolised by CYP4F8ProteinRhea RHEA:48796Inferred only
prostaglandin H1 is a substrate of PTGESProteinHuman-GEM MAR01394Inferred only
prostaglandin H1 is a substrate of PTGES2ProteinHuman-GEM MAR01394Inferred only
prostaglandin H1 is a substrate of PTGES3ProteinHuman-GEM MAR01394Inferred only
prostaglandin H1 is a substrate of PTGES3ProteinHuman-GEM MAR03985Inferred only
prostaglandin H1 is a substrate of PTGS1ProteinHuman-GEM MAR01392Inferred only
prostaglandin H1 is a substrate of PTGS1ProteinHuman-GEM MAR01393Inferred only
prostaglandin H1 is a substrate of PTGS2ProteinRhea RHEA:50432Inferred only

Show the remaining 2

prostaglandin H1 is a substrate of PTGS2ProteinHuman-GEM MAR01392Inferred only
prostaglandin H1 is a substrate of PTGS2ProteinHuman-GEM MAR01393Inferred only

Reactions

9 reactions

11R-hydroperoxy-(5Z,8Z,12E,14Z)-eicosatetraenoate+15-oxoprostaglandin E1+MAM00014x+(18R)-hydroxy-(5Z,8Z,11Z,14Z,16E)-eicosapentaenoate+MAM00254c+MAM00254m+MAM00254x+20-hydroxy-(5Z,8Z,11Z,14Z)-eicosatetraenoate+20-hydroxy-(5Z,8Z,11Z,14Z)-eicosatetraenoate+MAM00274c+MAM00274r+MAM00276c+MAM00277c+MAM00278c+MAM00280c+MAM00282c+11beta-hydroxyandrost-4-ene-3,17-dione+11beta-hydroxyandrost-4-ene-3,17-dione+11beta-hydroxyandrost-4-ene-3,17-dione+MAM00293c+MAM00297c+MAM00298c+MAM00304c+MAM00306c+MAM00308c+MAM00318c+MAM00318r+MAM00319c+MAM00320c+MAM00321c+MAM00322c+MAM00323c+MAM00323r+MAM00324r+MAM00327c+MAM00327r+MAM00328c+MAM00328r+MAM00333r+12-oxo-(5Z,8Z,10E,14Z)-eicosatetraenoate+(13S)-hydroxy-(9Z,11E)-octadecadienoate+MAM00338c+MAM00340c+MAM00352r+13-hydroxy-(5Z,8Z,11Z,14Z)-eicosatetraenoate+MAM00364c+14,15-epoxy-(5Z,8Z,11Z)-eicosatrienoate+(15S)-hydroxy-(5Z,8Z,11Z,13E,17Z)-eicosapentaenoate+MAM00378c+MAM00382c+15-deoxy-Delta(12,14)-prostaglandin J2+MAM00384c+MAM00386c+MAM00386r+MAM00386x+MAM00387c+MAM00387r+MAM00387x+MAM00388c+MAM00388r+MAM00388x+MAM00389c+MAM00389r+MAM00389x+15-oxoprostaglandin F2alpha+MAM00395c+16(R)-hydroxy-(5Z,8Z,11Z,14Z)-eicosatetraenoate+MAM00398x+17-hydroxy-(5Z,8Z,11Z,14Z)-eicosatetraenoate+MAM00424m+MAM00425x+MAM00426c+18-hydroxy-(5Z,8Z,11Z,14Z)-eicosatetraenoate+MAM00430c+MAM00590c+MAM00595c+MAM00595r+MAM00598c+MAM00598r+MAM00602c+MAM00687m+MAM00687x+MAM01038n+MAM01039x+MAM01041n+MAM01046c+MAM01047c+MAM01049c+MAM01050c+MAM01051c+5,6-epoxy-(8Z,11Z,14Z)-eicosatrienoate+MAM01055c+MAM01120c+MAM01120r+MAM01122c+MAM01122r+MAM01150c+MAM01150m+MAM01150x+MAM01153c+MAM01153m+MAM01153r+MAM01153x+MAM01167c+MAM01168r+MAM01171c+MAM01171m+MAM01171x+MAM01172c+MAM01172m+MAM01172x+7-hydroxy-(5Z,8Z,11Z,14Z)-eicosatetraenoate+MAM01202c+MAM01208c+8,9-epoxy-(5Z,11Z,14Z)-eicosatrienoate+MAM01210c+MAM01213c+MAM01239c+(11S,15S)-dihydroxy-14(R)-S-glutathionyl-(5Z,8Z,12E)-eicosatrienoate+(11S,15S)-dihydroxy-14(R)-S-glutathionyl-(5Z,8Z,12E)-eicosatrienoate+MAM02368c+MAM02395n+MAM02395r+MAM02395x+MAM02396r+MAM02396x+malonaldehyde+MAM02538c+MAM02538n+MAM02649m+MAM02649x+prostaglandin E2+prostaglandin E3+prostaglandin H1+prostaglandin J2+MAM02797c+MAM02798c+MAM02799c+MAM02851c+MAM02852c+MAM02862c+MAM02863c+MAM02864c+MAM03055c+MAM03055r+MAM03055x+MAM03056cMAM10003e
Reaction pageLeft to rightBalance undeterminableGO:0005829, GO:0005777, GO:0005759, GO:0005783, GO:0005634, GO:0005615
Human-GEM MAR00036CC BY 4.0Reference data
2proton+MAM02791cwater+prostaglandin H1
Catalysed by PTGS2 or PTGS1
Reaction pageReversibleUnbalancedEC 1.14.99.1GO:0005829, GO:0005783
Human-GEM MAR01392CC BY 4.0Reference data
2proton+MAM02791rwater+prostaglandin H1
Catalysed by PTGS2 or PTGS1
Reaction pageReversibleUnbalancedEC 1.14.99.1GO:0005783
Human-GEM MAR01393CC BY 4.0Reference data
prostaglandin E1prostaglandin H1
Catalysed by PTGES3 or PTGES2 or PTGES
Reaction pageReversibleBalancedEC 5.3.99.3GO:0005829
Human-GEM MAR01394CC BY 4.0Reference data
prostaglandin H1prostaglandin E1
Catalysed by PTGES3
Reaction pageReversibleBalancedEC 5.3.99.3GO:0005634
Human-GEM MAR03985CC BY 4.0Reference data
prostaglandin H1+reduced [NADPH--hemoprotein reductase]+dioxygen19-hydroxyprostaglandin H1+oxidized [NADPH--hemoprotein reductase]+water+hydron
Catalysed by CYP4F8
Reaction pageLeft to rightBalance undeterminable
Rhea RHEA:48796CC BY 4.0Reference data
prostaglandin G1+AH2prostaglandin H1+A+water
Catalysed by PTGS2
Reaction pageLeft to rightBalance undeterminable
Rhea RHEA:50432CC BY 4.0Reference data
prostaglandin H1prostaglandin E1
Reaction pageDirection not assertedBalance undeterminable
Rhea RHEA:50436CC BY 4.0Reference data
prostaglandin H1CHEBI:79010
Reaction pageDirection not assertedBalance undeterminable
Rhea RHEA:50440CC BY 4.0Reference data

Other names

2 names

Resolves to: prostaglandin H1

Also called: PGH1
Systematic name: 7-{(1R,4S,5R,6R)-6-[(1E,3S)-3-hydroxyoct-1-en-1-yl]-2,3-dioxabicyclo[2.2.1]heptan-5-yl}heptanoate