hydrogen sulfide

Two steps

• L-isoleucineReach from here →
  1. L-serine hydro-lyase (adding hydrogen sulfide, L-cysteine-forming)
  2. transport of cysteine and isoleucine (cytosol to extracellular)

  Catalysed by CBS, SLC7A5cytosol, extracellular spaceOne of 4 routes

• CHEBI:17203Reach from here →
  1. L-serine hydro-lyase (adding hydrogen sulfide, L-cysteine-forming)
  2. transport of cysteine and proline (cytosol to extracellular)

  Catalysed by CBS, SLC7A5cytosol, extracellular spaceOne of 3 routes

• sulfiteReach from here →
  1. Sulfide:glutathione,quinone oxidoreductase
  2. Persulfide dioxygenase

  Catalysed by SQOR, ETHE1mitochondrial matrixOne of 10 routes

• 3,3'-diiodo-L-thyronine sulfateReach from here →
  1. hydrogen sulfide + 2 O2 = sulfate + H(+)
  2. Steryl-Sulfatase

  Catalysed by SOD1, STSGolgi apparatusOne of 2 routes

• urateReach from here →
  1. thiosulfate + 2 glutathione = glutathione disulfide + hydrogen sulfide + sulfite + 2 H(+)
  2. urate(out) + glutathione(in) = urate(in) + glutathione(out)

  Catalysed by TSTD1, SLC22A13inner side of the membrane, outer side of the membrane

• methylarsonous acidReach from here →
  1. thiosulfate + 2 glutathione = glutathione disulfide + hydrogen sulfide + sulfite + 2 H(+)
  2. methylarsonate + 2 glutathione + H(+) = methylarsonous acid + glutathione disulfide + H2O

  Catalysed by TSTD1, GSTO1, GSTO2

• CHEBI:17895Reach from here →
  1. L-serine hydro-lyase (adding hydrogen sulfide, L-cysteine-forming)
  2. transport of cysteine and tyrosine (cytosol to extracellular)

  Catalysed by CBS, SLC7A5cytosol, extracellular spaceOne of 4 routes

• fumaric acidReach from here →
  1. thiosulfate + 2 glutathione = glutathione disulfide + hydrogen sulfide + sulfite + 2 H(+)
  2. transport of fumarate and thiosulfate (cytosol to mitochondria)

  Catalysed by TSTD1, SLC25A10mitochondrial matrix, cytosolOne of 4 routes

• CHEBI:18019Reach from here →
  1. L-serine hydro-lyase (adding hydrogen sulfide, L-cysteine-forming)
  2. transport of cysteine and lysine (cytosol to extracellular)

  Catalysed by CBS, SLC7A6cytosol, extracellular spaceOne of 2 routes

• thiocyanateReach from here →
  1. thiosulfate + 2 glutathione = glutathione disulfide + hydrogen sulfide + sulfite + 2 H(+)
  2. thiosulfate:cyanide sulfurtranserase

  Catalysed by TSTD1, MPST, TSTmitochondrial matrixOne of 3 routes

• L-glutamineReach from here →
  1. L-serine hydro-lyase (adding hydrogen sulfide, L-cysteine-forming)
  2. transport of cysteine and glutamine (cytosol to extracellular)

  Catalysed by CBS, SLC3A2, SLC7A5, SLC7A10cytosol, extracellular spaceOne of 4 routes

• arsenic triglutathioneReach from here →
  1. thiosulfate + 2 glutathione = glutathione disulfide + hydrogen sulfide + sulfite + 2 H(+)
  2. arsenic triglutathione + 3 [thioredoxin]-dithiol + 3 S-adenosyl-L-methionine = trimethylarsine + 3 [thioredoxin]-disulfide + 3 glutathione + 3 S-adenosyl-L-homocysteine + 3 H(+)

  Catalysed by TSTD1, AS3MTOne of 3 routes

• 15-deoxy-Delta(12,14)-prostaglandin J2-S-(R)-glutathioneReach from here →
  1. thiosulfate + 2 glutathione = glutathione disulfide + hydrogen sulfide + sulfite + 2 H(+)
  2. 15-deoxy-Delta(12,14)-prostaglandin J2 + glutathione = 15-deoxy-Delta(12,14)-prostaglandin J2-S-(R)-glutathione

  Catalysed by TSTD1, MGST3

• (5S)-hydroxy-(6E,8Z,11Z,14Z,17Z)-eicosapentaenoateReach from here →
  1. thiosulfate + 2 glutathione = glutathione disulfide + hydrogen sulfide + sulfite + 2 H(+)
  2. (5S)-hydroperoxy-(6E,8Z,11Z,14Z,17Z)-eicosapentaenoate + 2 glutathione = (5S)-hydroxy-(6E,8Z,11Z,14Z,17Z)-eicosapentaenoate + glutathione disulfide + H2O

  Catalysed by TSTD1, GPX1, GPX4

• (12S)-hydroxy-(5Z,8Z,10E,14Z,17Z)-eicosapentaenoateReach from here →
  1. thiosulfate + 2 glutathione = glutathione disulfide + hydrogen sulfide + sulfite + 2 H(+)
  2. (12S)-hydroperoxy-(5Z,8Z,10E,14Z,17Z)-eicosapentaenoate + 2 glutathione = (12S)-hydroxy-(5Z,8Z,10E,14Z,17Z)-eicosapentaenoate + glutathione disulfide + H2O

  Catalysed by TSTD1, GPX1, GPX4

• (15S)-hydroxy-(11Z,13E)-eicosadienoateReach from here →
  1. thiosulfate + 2 glutathione = glutathione disulfide + hydrogen sulfide + sulfite + 2 H(+)
  2. (15S)-hydroperoxy-(11Z,13E)-eicosadienoate + 2 glutathione = (15S)-hydroxy-(11Z,13E)-eicosadienoate + glutathione disulfide + H2O

  Catalysed by TSTD1, GPX1, GPX4

• (17S)-hydroxy-(4Z,7Z,10Z,13Z,15E,19Z)-docosahexaenoateReach from here →
  1. thiosulfate + 2 glutathione = glutathione disulfide + hydrogen sulfide + sulfite + 2 H(+)
  2. (17S)-hydroperoxy-(4Z,7Z,10Z,13Z,15E,19Z)-docosahexaenoate + 2 glutathione = (17S)-hydroxy-(4Z,7Z,10Z,13Z,15E,19Z)-docosahexaenoate + glutathione disulfide + H2O

  Catalysed by TSTD1, GPX1, GPX4

• a hydroxy-1,2-diacyl-glycero-3-phosphocholineReach from here →
  1. thiosulfate + 2 glutathione = glutathione disulfide + hydrogen sulfide + sulfite + 2 H(+)
  2. a hydroperoxy-1,2-diacyl-glycero-3-phosphocholine + 2 glutathione = a hydroxy-1,2-diacyl-glycero-3-phosphocholine + glutathione disulfide + H2O

  Catalysed by TSTD1, GPX4

• S-disulfanyl-L-cysteineReach from here →
  1. L-serine hydro-lyase (adding hydrogen sulfide, L-cysteine-forming)
  2. S-sulfanyl-L-cysteine + L-cysteine = S-disulfanyl-L-cysteine + L-alanine

  Catalysed by CBS, CARS2cytosol

• 3-(glutathion-S-yl)-4-hydroxynonanalReach from here →
  1. thiosulfate + 2 glutathione = glutathione disulfide + hydrogen sulfide + sulfite + 2 H(+)
  2. (E)-4-hydroxynon-2-enal + glutathione = 3-(glutathion-S-yl)-4-hydroxynonanal

  Catalysed by TSTD1, GSTP1

• folic acidReach from here →
  1. hydrogen sulfide + 2 O2 = sulfate + H(+)
  2. Folate Transport by Oats

  Catalysed by SOD1, SLC22A8, SLC22A7extracellular space, cytosolOne of 2 routes

• 3-mercaptolactic acidReach from here →
  1. 2-oxo-3-sulfanylpropanoate + [thioredoxin]-dithiol = [thioredoxin]-disulfide + hydrogen sulfide + pyruvate + H(+)
  2. 3-Mercaptolactate:NAD+ oxidoreductase

  Catalysed by MPST, LDHB, LDHC, LDHAL6A and 1 morecytosol

• N-acetyl-L-cysteineReach from here →
  1. L-serine hydro-lyase (adding hydrogen sulfide, L-cysteine-forming)
  2. N-acetylglutamate synthase (N-acetyl-L-cysteine)

  Catalysed by CBS, NAGScytosol, mitochondrial matrix

• a dicarboxylateReach from here →
  1. hydrogen sulfide + 2 O2 = sulfate + H(+)
  2. a dicarboxylate(in) + sulfate(out) = a dicarboxylate(out) + sulfate(in)

  Catalysed by SOD1, SLC25A35, SLC25A34inner side of the membrane, outer side of the membraneOne of 2 routes

• L-ascorbic acidReach from here →
  1. thiosulfate + 2 glutathione = glutathione disulfide + hydrogen sulfide + sulfite + 2 H(+)
  2. L-dehydroascorbate + 2 glutathione = glutathione disulfide + L-ascorbate

  Catalysed by TSTD1, CLIC1, GSTO1, GSTO2

• K(+)Reach from here →
  1. L-serine hydro-lyase (adding hydrogen sulfide, L-cysteine-forming)
  2. K(+)(in) + L-cysteine(out) + 3 Na(+)(out) + H(+)(out) = K(+)(out) + L-cysteine(in) + 3 Na(+)(in) + H(+)(in)

  Catalysed by CBS, SLC1A1cytosol, inner side of the membrane, outer side of the membraneOne of 2 routes

• Cys-tRNA(Cys)Reach from here →
  1. L-serine hydro-lyase (adding hydrogen sulfide, L-cysteine-forming)
  2. L-Cysteine:tRNA(Cys) ligase (AMP-forming)

  Catalysed by CBS, CARS1cytosol

• chlorine(.)Reach from here →
  1. L-serine hydro-lyase (adding hydrogen sulfide, L-cysteine-forming)
  2. transport of chloride and cysteine (cytosol to extracellular)

  Catalysed by CBS, SLC6A14cytosol, extracellular spaceOne of 3 routes

• glycocholateReach from here →
  1. thiosulfate + 2 glutathione = glutathione disulfide + hydrogen sulfide + sulfite + 2 H(+)
  2. glycocholate(in) + glutathione(in) + ATP + H2O = glycocholate(out) + glutathione(out) + ADP + phosphate + H(+)

  Catalysed by TSTD1, ABCC4inner side of the membrane, outer side of the membrane

• cholateReach from here →
  1. thiosulfate + 2 glutathione = glutathione disulfide + hydrogen sulfide + sulfite + 2 H(+)
  2. cholate(in) + glutathione(in) + ATP + H2O = cholate(out) + glutathione(out) + ADP + phosphate + H(+)

  Catalysed by TSTD1, ABCC4inner side of the membrane, outer side of the membrane

• D-aspartateReach from here →
  1. hydrogen sulfide + 2 O2 = sulfate + H(+)
  2. D-aspartate(in) + sulfate(out) = D-aspartate(out) + sulfate(in)

  Catalysed by SOD1, SLC25A14, SLC25A30inner side of the membrane, outer side of the membraneOne of 2 routes

• L-aspartateReach from here →
  1. hydrogen sulfide + 2 O2 = sulfate + H(+)
  2. L-aspartate(in) + sulfate(out) = L-aspartate(out) + sulfate(in)

  Catalysed by SOD1, SLC25A14, SLC25A30inner side of the membrane, outer side of the membraneOne of 2 routes

• oxalateReach from here →
  1. hydrogen sulfide + 2 O2 = sulfate + H(+)
  2. oxalate(in) + sulfate(out) = oxalate(out) + sulfate(in)

  Catalysed by SOD1, SLC25A14, SLC26A2, SLC25A30 and 2 moreinner side of the membrane, outer side of the membraneOne of 2 routes

• maleateReach from here →
  1. hydrogen sulfide + 2 O2 = sulfate + H(+)
  2. maleate(in) + sulfate(out) = maleate(out) + sulfate(in)

  Catalysed by SOD1, SLC25A14, SLC25A30inner side of the membrane, outer side of the membraneOne of 2 routes

• malonic acidReach from here →
  1. hydrogen sulfide + 2 O2 = sulfate + H(+)
  2. transport of malonate and sulfate (cytosol to mitochondria)

  Catalysed by SOD1, SLC25A10mitochondrial matrix, cytosolOne of 2 routes

• (S)-dihydroorotateReach from here →
  1. a quinone + hydrogen sulfide + glutathione + H(+) = S-sulfanylglutathione + a quinol
  2. (S)-dihydroorotate + a quinone = orotate + a quinol

  Catalysed by SQOR, DHODH

• an alcoholReach from here →
  1. thiosulfate + 2 glutathione = glutathione disulfide + hydrogen sulfide + sulfite + 2 H(+)
  2. a hydroperoxide + 2 glutathione = an alcohol + glutathione disulfide + H2O

  Catalysed by TSTD1, CP, PRDX6

• (2R,3R)-tartrateReach from here →
  1. hydrogen sulfide + 2 O2 = sulfate + H(+)
  2. (2R,3R)-tartrate(in) + sulfate(out) = (2R,3R)-tartrate(out) + sulfate(in)

  Catalysed by SOD1, SLC25A14, SLC25A30inner side of the membrane, outer side of the membraneOne of 2 routes

• (S,S)-tartrateReach from here →
  1. hydrogen sulfide + 2 O2 = sulfate + H(+)
  2. (S,S)-tartrate(in) + sulfate(out) = (S,S)-tartrate(out) + sulfate(in)

  Catalysed by SOD1, SLC25A14, SLC25A30inner side of the membrane, outer side of the membraneOne of 2 routes

• (3R)-citramalateReach from here →
  1. hydrogen sulfide + 2 O2 = sulfate + H(+)
  2. (3R)-citramalate(in) + sulfate(out) = (3R)-citramalate(out) + sulfate(in)

  Catalysed by SOD1, SLC25A14, SLC25A30inner side of the membrane, outer side of the membraneOne of 2 routes

• (3S)-citramalateReach from here →
  1. hydrogen sulfide + 2 O2 = sulfate + H(+)
  2. (3S)-citramalate(in) + sulfate(out) = (3S)-citramalate(out) + sulfate(in)

  Catalysed by SOD1, SLC25A14, SLC25A30inner side of the membrane, outer side of the membraneOne of 2 routes

• di-mu-sulfido-diiron(2+)Reach from here →
  1. L-serine hydro-lyase (adding hydrogen sulfide, L-cysteine-forming)
  2. De novo synthesis of 2Fe2S

  Catalysed by CBS, NDUFAB1, FDXR, FXN and 4 morecytosol, mitochondrial matrix

• an organic disulfideReach from here →
  1. L-cysteinyl-[sulfatase] + 2 a thiol + O2 = an organic disulfide + 3-oxo-L-alanyl-[sulfatase] + hydrogen sulfide + H2O + H(+)
  2. L-cysteinyl-[sulfatase] + 2 a thiol + O2 = an organic disulfide + 3-oxo-L-alanyl-[sulfatase] + hydrogen sulfide + H2O + H(+)

  Catalysed by SUMF1

• glycochenodeoxycholateReach from here →
  1. thiosulfate + 2 glutathione = glutathione disulfide + hydrogen sulfide + sulfite + 2 H(+)
  2. glycochenodeoxycholate(in) + glutathione(in) + ATP + H2O = glycochenodeoxycholate(out) + glutathione(out) + ADP + phosphate + H(+)

  Catalysed by TSTD1, ABCC4inner side of the membrane, outer side of the membrane

• taurocholateReach from here →
  1. thiosulfate + 2 glutathione = glutathione disulfide + hydrogen sulfide + sulfite + 2 H(+)
  2. taurocholate(in) + glutathione(in) + ATP + H2O = taurocholate(out) + glutathione(out) + ADP + phosphate + H(+)

  Catalysed by TSTD1, ABCC4inner side of the membrane, outer side of the membrane

• tert-butanolReach from here →
  1. thiosulfate + 2 glutathione = glutathione disulfide + hydrogen sulfide + sulfite + 2 H(+)
  2. tert-butyl hydroperoxide + 2 glutathione = tert-butanol + glutathione disulfide + H2O

  Catalysed by TSTD1, CLIC2, GPX1, GPX2 and 2 more

• L-ornithineReach from here →
  1. L-serine hydro-lyase (adding hydrogen sulfide, L-cysteine-forming)
  2. transport of cysteine and ornithine (cytosol to extracellular)

  Catalysed by CBS, SLC7A6cytosol, extracellular spaceOne of 2 routes

• a thioesterReach from here →
  1. L-cysteinyl-[sulfatase] + 2 a thiol + O2 = an organic disulfide + 3-oxo-L-alanyl-[sulfatase] + hydrogen sulfide + H2O + H(+)
  2. a thioester + H2O = a thiol + a carboxylate + H(+)

  Catalysed by SUMF1, PNKD

• 1-(beta-D-ribofuranosyl)-1,4-dihydronicotinamideReach from here →
  1. a quinone + hydrogen sulfide + glutathione + H(+) = S-sulfanylglutathione + a quinol
  2. 1-(beta-D-ribofuranosyl)-1,4-dihydronicotinamide + a quinone + H(+) = beta-nicotinamide D-riboside + a quinol

  Catalysed by SQOR, NQO2

• glycineReach from here →
  1. L-serine hydro-lyase (adding hydrogen sulfide, L-cysteine-forming)
  2. transport of cysteine and glycine (cytosol to extracellular)

  Catalysed by CBS, SLC3A2, SLC7A5, SLC7A8cytosol, extracellular spaceOne of 4 routes