deoxycholate

Three steps

• phenylacetyl-CoAReach from here →
  1. cholate-CoA ligase (3alpha,12alpha-dihydroxy-5beta-cholanate)
  2. bile acid-CoA:amino acid N-acyltransferase (taurodeoxycholate)
  3. Phenylacetate:CoA ligase

  Catalysed by SLC27A2, SLC27A5, BAATcytosolOne of 3 routes

• propionyl-CoAReach from here →
  1. cholate-CoA ligase (3alpha,12alpha-dihydroxy-5beta-cholanate)
  2. bile acid-CoA:amino acid N-acyltransferase (taurodeoxycholate)
  3. Propanoate:CoA ligase (AMP-forming)

  Catalysed by SLC27A2, SLC27A5, BAAT, ACSS3 and 2 morecytosolOne of 43 routes

• CHEBI:15570Reach from here →
  1. Glycodeoxycholate amidohydrolase
  2. Glycodeoxycholate amidohydrolase
  3. transport of D-alanine and glycine (cytosol to extracellular)

  Catalysed by SLC3A2, SLC7A10cytosol, extracellular spaceOne of 2 routes

• L-leucineReach from here →
  1. Glycodeoxycholate amidohydrolase
  2. Glycodeoxycholate amidohydrolase
  3. transport of glycine and leucine (cytosol to extracellular)

  Catalysed by SLC7A5cytosol, extracellular spaceOne of 5 routes

• CHEBI:15611Reach from here →
  1. Glycodeoxycholate amidohydrolase
  2. Glycodeoxycholate amidohydrolase
  3. S-Adenosyl-L-methionine:glycine N-methyltransferase

  Catalysed by GNMTcytosol

• CHEBI:15650Reach from here →
  1. cholate-CoA ligase (3alpha,12alpha-dihydroxy-5beta-cholanate)
  2. bile acid-CoA:amino acid N-acyltransferase (taurodeoxycholate)
  3. N-acetyl-LTE4 to leukotriene E4 conversion

  Catalysed by SLC27A2, SLC27A5, BAAT, ZDHHC11B and 31 morecytosolOne of 2 routes

• CHEBI:15699Reach from here →
  1. Glycodeoxycholate amidohydrolase
  2. Glycodeoxycholate amidohydrolase
  3. transport of glycine and homoserine (cytosol to extracellular)

  Catalysed by SLC7A5cytosol, extracellular spaceOne of 4 routes

• CHEBI:15727Reach from here →
  1. cholate-CoA ligase (3alpha,12alpha-dihydroxy-5beta-cholanate)
  2. bile acid-CoA:amino acid N-acyltransferase (taurodeoxycholate)
  3. N-alpha-acetyltransferase 10, NatA catalytic subunit (acetylcarnosine)

  Catalysed by SLC27A2, SLC27A5, BAAT, NAA10cytosol

• CHEBI:15746Reach from here →
  1. cholate-CoA ligase (3alpha,12alpha-dihydroxy-5beta-cholanate)
  2. bile acid-CoA:amino acid N-acyltransferase (taurodeoxycholate)
  3. diamine N-acetyltransferase (N1-acetylspermine)

  Catalysed by SLC27A2, SLC27A5, BAAT, SAT1 and 1 morecytosolOne of 2 routes

• CHEBI:15971Reach from here →
  1. Glycodeoxycholate amidohydrolase
  2. Glycodeoxycholate amidohydrolase
  3. transport of glycine and histidine (cytosol to extracellular)

  Catalysed by SLC7A6cytosol, extracellular spaceOne of 2 routes

• a halide anionReach from here →
  1. Glycodeoxycholate amidohydrolase
  2. glycodeoxycholate(in) + glutathione(in) + ATP + H2O = glycodeoxycholate(out) + glutathione(out) + ADP + phosphate + H(+)
  3. RX + glutathione = an S-substituted glutathione + a halide anion + H(+)

  Catalysed by ABCC4, GSTT4, GSTA4, GSTZ1 and 20 morecytosol, inner side of the membrane, outer side of the membrane

• 11-cis-retinolReach from here →
  1. cholate-CoA ligase (3alpha,12alpha-dihydroxy-5beta-cholanate)
  2. bile acid-CoA:amino acid N-acyltransferase (taurodeoxycholate)
  3. Palmitoyl-CoA:retinol O-acyltransferase

  Catalysed by SLC27A2, SLC27A5, BAAT, DGAT1 and 4 morecytosol

• L-citrullineReach from here →
  1. Glycodeoxycholate amidohydrolase
  2. Glycodeoxycholate amidohydrolase
  3. transport of citrulline and glycine (cytosol to extracellular)

  Catalysed by SLC7A9, SLC3A1, SLC7A6cytosol, extracellular space

• L-valineReach from here →
  1. Glycodeoxycholate amidohydrolase
  2. Glycodeoxycholate amidohydrolase
  3. transport of glycine and valine (cytosol to extracellular)

  Catalysed by SLC7A5cytosol, extracellular spaceOne of 4 routes

• oxaloacetateReach from here →
  1. cholate-CoA ligase (3alpha,12alpha-dihydroxy-5beta-cholanate)
  2. bile acid-CoA:amino acid N-acyltransferase (taurodeoxycholate)
  3. ATP citrate lyase (citrate)

  Catalysed by SLC27A2, SLC27A5, BAAT, ACLYcytosol

• L-arginineReach from here →
  1. Glycodeoxycholate amidohydrolase
  2. Glycodeoxycholate amidohydrolase
  3. transport of arginine and glycine (cytosol to extracellular)

  Catalysed by SLC7A6cytosol, extracellular spaceOne of 2 routes

• CHEBI:16523Reach from here →
  1. Glycodeoxycholate amidohydrolase
  2. Glycodeoxycholate amidohydrolase
  3. transport of D-serine and glycine (cytosol to extracellular)

  Catalysed by SLC3A2, SLC7A10cytosol, extracellular spaceOne of 2 routes

• protein polypeptide chainReach from here →
  1. Glycodeoxycholate amidohydrolase
  2. Glycodeoxycholate amidohydrolase
  3. PROTEIN_BS

  No catalyst recordedcytosol

• CHEBI:16856Reach from here →
  1. Glycodeoxycholate amidohydrolase
  2. Glycodeoxycholate amidohydrolase
  3. gamma-L-glutamyl-L-cysteine:glycine ligase (ADP-forming)

  Catalysed by GSScytosol

• CHEBI:16857Reach from here →
  1. Glycodeoxycholate amidohydrolase
  2. Glycodeoxycholate amidohydrolase
  3. transport of glycine and threonine (cytosol to extracellular)

  Catalysed by SLC3A2, SLC7A5, SLC7A10cytosol, extracellular spaceOne of 4 routes

• glyoxylic acidReach from here →
  1. Glycodeoxycholate amidohydrolase
  2. Glycodeoxycholate amidohydrolase
  3. glycine:oxygen oxidoreductase (deaminating)

  Catalysed by DAOcytosol, peroxisome

• L-isoleucineReach from here →
  1. Glycodeoxycholate amidohydrolase
  2. Glycodeoxycholate amidohydrolase
  3. transport of glycine and isoleucine (cytosol to extracellular)

  Catalysed by SLC7A5cytosol, extracellular spaceOne of 4 routes

• CHEBI:17203Reach from here →
  1. Glycodeoxycholate amidohydrolase
  2. Glycodeoxycholate amidohydrolase
  3. transport of glycine and proline (cytosol to extracellular)

  Catalysed by SLC7A5, SLC7A6cytosol, extracellular spaceOne of 2 routes

• anilineReach from here →
  1. cholate-CoA ligase (3alpha,12alpha-dihydroxy-5beta-cholanate)
  2. bile acid-CoA:amino acid N-acyltransferase (taurodeoxycholate)
  3. Acetyl-CoA:arylamine N-acetyltransferase

  Catalysed by SLC27A2, SLC27A5, BAAT, NAT2 and 1 morecytosol

• CHEBI:17312Reach from here →
  1. cholate-CoA ligase (3alpha,12alpha-dihydroxy-5beta-cholanate)
  2. bile acid-CoA:amino acid N-acyltransferase (taurodeoxycholate)
  3. N1,N12-diacetylspermine to N1-acetylspermine conversion

  Catalysed by SLC27A2, SLC27A5, BAATcytosolOne of 2 routes

• sulfiteReach from here →
  1. Glycodeoxycholate amidohydrolase
  2. glycodeoxycholate(in) + glutathione(in) + ATP + H2O = glycodeoxycholate(out) + glutathione(out) + ADP + phosphate + H(+)
  3. thiosulfate + 2 glutathione = glutathione disulfide + hydrogen sulfide + sulfite + 2 H(+)

  Catalysed by ABCC4, TSTD1cytosol, inner side of the membrane, outer side of the membraneOne of 2 routes

• 5-aminolevulinic acidReach from here →
  1. Glycodeoxycholate amidohydrolase
  2. Glycodeoxycholate amidohydrolase
  3. succinyl-CoA:glycine C-succinyltransferase (decarboxylating)

  Catalysed by ALAS1, ALAS2, CPNE7cytosol, mitochondrial matrix

• L-cysteineReach from here →
  1. cholate-CoA ligase (3alpha,12alpha-dihydroxy-5beta-cholanate)
  2. bile acid-CoA:amino acid N-acyltransferase (taurodeoxycholate)
  3. N-acetylglutamate synthase (N-acetyl-L-cysteine)

  Catalysed by SLC27A2, SLC27A5, BAAT, NAGScytosol, mitochondrial matrixOne of 5 routes

• (7Z,10Z,13Z)-hexadecatrienoyl-CoAReach from here →
  1. cholate-CoA ligase (3alpha,12alpha-dihydroxy-5beta-cholanate)
  2. bile acid-CoA:amino acid N-acyltransferase (taurodeoxycholate)
  3. Fatty Acid Beta Oxidation (C18:3->C16:3), Mitochondrial

  Catalysed by SLC27A2, SLC27A5, BAAT, HADHA and 2 morecytosol, mitochondrial matrix

• urateReach from here →
  1. Glycodeoxycholate amidohydrolase
  2. glycodeoxycholate(in) + glutathione(in) + ATP + H2O = glycodeoxycholate(out) + glutathione(out) + ADP + phosphate + H(+)
  3. urate(out) + glutathione(in) = urate(in) + glutathione(out)

  Catalysed by ABCC4, SLC22A13cytosol, inner side of the membrane, outer side of the membrane

• methylarsonous acidReach from here →
  1. Glycodeoxycholate amidohydrolase
  2. glycodeoxycholate(in) + glutathione(in) + ATP + H2O = glycodeoxycholate(out) + glutathione(out) + ADP + phosphate + H(+)
  3. methylarsonate + 2 glutathione + H(+) = methylarsonous acid + glutathione disulfide + H2O

  Catalysed by ABCC4, GSTO1, GSTO2cytosol, inner side of the membrane, outer side of the membrane

• CHEBI:17895Reach from here →
  1. Glycodeoxycholate amidohydrolase
  2. Glycodeoxycholate amidohydrolase
  3. transport of glycine and tyrosine (cytosol to extracellular)

  Catalysed by SLC7A5cytosol, extracellular spaceOne of 4 routes

• CHEBI:17927Reach from here →
  1. cholate-CoA ligase (3alpha,12alpha-dihydroxy-5beta-cholanate)
  2. bile acid-CoA:amino acid N-acyltransferase (taurodeoxycholate)
  3. N1,N8-diacetylspermidine to N1-acetylspermidine conversion

  Catalysed by SLC27A2, SLC27A5, BAATcytosol

• CHEBI:18019Reach from here →
  1. Glycodeoxycholate amidohydrolase
  2. Glycodeoxycholate amidohydrolase
  3. transport of glycine and lysine (cytosol to extracellular)

  Catalysed by SLC7A6cytosol, extracellular spaceOne of 2 routes

• L-glutamineReach from here →
  1. Glycodeoxycholate amidohydrolase
  2. Glycodeoxycholate amidohydrolase
  3. transport of glutamine and glycine (cytosol to extracellular)

  Catalysed by SLC7A5cytosol, extracellular spaceOne of 4 routes

• N(1)-(5-phospho-D-ribosyl)glycinamideReach from here →
  1. Glycodeoxycholate amidohydrolase
  2. Glycodeoxycholate amidohydrolase
  3. 5-Phospho-D-ribosylamine:glycine ligase (ADP-forming)

  Catalysed by GARTcytosol

• arsenic triglutathioneReach from here →
  1. Glycodeoxycholate amidohydrolase
  2. glycodeoxycholate(in) + glutathione(in) + ATP + H2O = glycodeoxycholate(out) + glutathione(out) + ADP + phosphate + H(+)
  3. arsenic triglutathione + 3 [thioredoxin]-dithiol + 3 S-adenosyl-L-methionine = trimethylarsine + 3 [thioredoxin]-disulfide + 3 glutathione + 3 S-adenosyl-L-homocysteine + 3 H(+)

  Catalysed by ABCC4, AS3MTcytosol, inner side of the membrane, outer side of the membraneOne of 3 routes

• ophthalmateReach from here →
  1. Glycodeoxycholate amidohydrolase
  2. Glycodeoxycholate amidohydrolase
  3. gamma-L-glutamyl-(2S)-2-aminobutanoate + glycine + ATP = ophthalmate + ADP + phosphate + H(+)

  Catalysed by GSScytosol

• 15-deoxy-Delta(12,14)-prostaglandin J2-S-(R)-glutathioneReach from here →
  1. Glycodeoxycholate amidohydrolase
  2. glycodeoxycholate(in) + glutathione(in) + ATP + H2O = glycodeoxycholate(out) + glutathione(out) + ADP + phosphate + H(+)
  3. 15-deoxy-Delta(12,14)-prostaglandin J2 + glutathione = 15-deoxy-Delta(12,14)-prostaglandin J2-S-(R)-glutathione

  Catalysed by ABCC4, MGST3cytosol, inner side of the membrane, outer side of the membrane

• (5S)-hydroxy-(6E,8Z,11Z,14Z,17Z)-eicosapentaenoateReach from here →
  1. Glycodeoxycholate amidohydrolase
  2. glycodeoxycholate(in) + glutathione(in) + ATP + H2O = glycodeoxycholate(out) + glutathione(out) + ADP + phosphate + H(+)
  3. (5S)-hydroperoxy-(6E,8Z,11Z,14Z,17Z)-eicosapentaenoate + 2 glutathione = (5S)-hydroxy-(6E,8Z,11Z,14Z,17Z)-eicosapentaenoate + glutathione disulfide + H2O

  Catalysed by ABCC4, GPX1, GPX4cytosol, inner side of the membrane, outer side of the membrane

• (12S)-hydroxy-(5Z,8Z,10E,14Z,17Z)-eicosapentaenoateReach from here →
  1. Glycodeoxycholate amidohydrolase
  2. glycodeoxycholate(in) + glutathione(in) + ATP + H2O = glycodeoxycholate(out) + glutathione(out) + ADP + phosphate + H(+)
  3. (12S)-hydroperoxy-(5Z,8Z,10E,14Z,17Z)-eicosapentaenoate + 2 glutathione = (12S)-hydroxy-(5Z,8Z,10E,14Z,17Z)-eicosapentaenoate + glutathione disulfide + H2O

  Catalysed by ABCC4, GPX1, GPX4cytosol, inner side of the membrane, outer side of the membrane

• (15S)-hydroxy-(11Z,13E)-eicosadienoateReach from here →
  1. Glycodeoxycholate amidohydrolase
  2. glycodeoxycholate(in) + glutathione(in) + ATP + H2O = glycodeoxycholate(out) + glutathione(out) + ADP + phosphate + H(+)
  3. (15S)-hydroperoxy-(11Z,13E)-eicosadienoate + 2 glutathione = (15S)-hydroxy-(11Z,13E)-eicosadienoate + glutathione disulfide + H2O

  Catalysed by ABCC4, GPX1, GPX4cytosol, inner side of the membrane, outer side of the membrane

• (17S)-hydroxy-(4Z,7Z,10Z,13Z,15E,19Z)-docosahexaenoateReach from here →
  1. Glycodeoxycholate amidohydrolase
  2. glycodeoxycholate(in) + glutathione(in) + ATP + H2O = glycodeoxycholate(out) + glutathione(out) + ADP + phosphate + H(+)
  3. (17S)-hydroperoxy-(4Z,7Z,10Z,13Z,15E,19Z)-docosahexaenoate + 2 glutathione = (17S)-hydroxy-(4Z,7Z,10Z,13Z,15E,19Z)-docosahexaenoate + glutathione disulfide + H2O

  Catalysed by ABCC4, GPX1, GPX4cytosol, inner side of the membrane, outer side of the membrane

• a hydroxy-1,2-diacyl-glycero-3-phosphocholineReach from here →
  1. Glycodeoxycholate amidohydrolase
  2. glycodeoxycholate(in) + glutathione(in) + ATP + H2O = glycodeoxycholate(out) + glutathione(out) + ADP + phosphate + H(+)
  3. a hydroperoxy-1,2-diacyl-glycero-3-phosphocholine + 2 glutathione = a hydroxy-1,2-diacyl-glycero-3-phosphocholine + glutathione disulfide + H2O

  Catalysed by ABCC4, GPX4cytosol, inner side of the membrane, outer side of the membrane

• taurodeoxycholate 3-sulfateReach from here →
  1. cholate-CoA ligase (3alpha,12alpha-dihydroxy-5beta-cholanate)
  2. bile acid-CoA:amino acid N-acyltransferase (taurodeoxycholate)
  3. taurodeoxycholate + 3'-phosphoadenylyl sulfate = taurodeoxycholate 3-sulfate + adenosine 3',5'-bisphosphate + H(+)

  Catalysed by SLC27A2, SLC27A5, BAAT, SULT2A1cytosol

• N(omega),N('omega)-dimethyl-L-arginineReach from here →
  1. Glycodeoxycholate amidohydrolase
  2. Glycodeoxycholate amidohydrolase
  3. N(omega),N('omega)-dimethyl-L-arginine + glyoxylate = 5-(3,3'-dimethylguanidino)-2-oxopentanoate + glycine

  Catalysed by AGXT2cytosol

• 5,6,7,8-tetrahydrofolic acidReach from here →
  1. Glycodeoxycholate amidohydrolase
  2. Glycodeoxycholate amidohydrolase
  3. 5,10-Methylenetetrahydrofolate:glycine hydroxymethyltransferase

  Catalysed by SHMT1cytosolOne of 2 routes

• (5Z)-dodecenoyl-CoAReach from here →
  1. cholate-CoA ligase (3alpha,12alpha-dihydroxy-5beta-cholanate)
  2. bile acid-CoA:amino acid N-acyltransferase (taurodeoxycholate)
  3. acetyl-CoA C-acyltransferase (3-oxomyrist-7-enoyl-CoA)

  Catalysed by SLC27A2, SLC27A5, BAAT, HADHA and 2 morecytosol, mitochondrial matrixOne of 2 routes

• (11Z)-docosenoyl-CoA(4-)Reach from here →
  1. cholate-CoA ligase (3alpha,12alpha-dihydroxy-5beta-cholanate)
  2. bile acid-CoA:amino acid N-acyltransferase (taurodeoxycholate)
  3. long-chain-fatty-acid-CoA ligase (cis-cetoleic acid)

  Catalysed by SLC27A2, SLC27A5, BAAT, ACSL4 and 6 morecytosolOne of 5 routes

• (7Z)-tetradecenoyl-CoAReach from here →
  1. cholate-CoA ligase (3alpha,12alpha-dihydroxy-5beta-cholanate)
  2. bile acid-CoA:amino acid N-acyltransferase (taurodeoxycholate)
  3. long-chain-fatty-acid-CoA ligase ((7Z)-tetradecenoic acid)

  Catalysed by SLC27A2, SLC27A5, BAAT, ACSL4 and 6 morecytosolOne of 8 routes