O-octanoyl-(R)-carnitine

Three steps

• 16-hydroxyhexadecanoateReach from here →
  1. solute carrier (L-carnitine)
  2. Utilized Transport
  3. Fatty Acid Omega Oxidation (C16->W-Ohc16), Endoplasmatic Reticulum

  Catalysed by SLC25A20, CYP4F2, CYP4F3mitochondrial matrix, cytosol, endoplasmic reticulumOne of 2 routes

• glycineReach from here →
  1. solute carrier (L-carnitine)
  2. Carnitine O-Palmitoyltransferase
  3. glycine N-acyltransferase (N-arachidonoylglycine)

  Catalysed by SLC25A20, CPT1A, CPT1C, CPT1B and 3 moremitochondrial matrix, cytosolOne of 14 routes

• (R)-methylmalonyl-CoAReach from here →
  1. solute carrier (L-carnitine)
  2. Carnitine O-Palmitoyltransferase
  3. aldehyde dehydrogenase (2-methyl-3-oxopropanoate)

  Catalysed by SLC25A20, CPT1A, CPT1C, CPT1B and 1 moremitochondrial matrix, cytosolOne of 2 routes

• (S)-methylmalonyl-CoAReach from here →
  1. solute carrier (L-carnitine)
  2. Carnitine O-Palmitoyltransferase
  3. (S)-methylmalonyl-CoA hydrolase

  Catalysed by SLC25A20, CPT1A, CPT1C, CPT1Bmitochondrial matrix, cytosolOne of 2 routes

• 3'-dephospho-CoAReach from here →
  1. solute carrier (L-carnitine)
  2. Carnitine O-Palmitoyltransferase
  3. acid phosphatase 2, lysosomal (CoA)

  Catalysed by SLC25A20, CPT1A, CPT1C, CPT1B and 1 moremitochondrial matrix, cytosol, lysosomeOne of 2 routes

• (2E)-dodecenoyl-CoAReach from here →
  1. solute carrier (L-carnitine)
  2. Carnitine O-Palmitoyltransferase
  3. (2E)-dodecenoyl-CoA formation

  Catalysed by SLC25A20, CPT1A, CPT1C, CPT1Bmitochondrial matrix, cytosolOne of 3 routes

• (2E)-butenoyl-CoAReach from here →
  1. solute carrier (L-carnitine)
  2. transport of butyryl-CoA and L-carnitine (cytosol to mitochondria)
  3. butanoyl-CoA:electron-transfer flavoprotein 2,3-oxidoreductase

  Catalysed by SLC25A20, SLC33A1, ESCO2, OXSM and 2 moremitochondrial matrix, cytosolOne of 2 routes

• 4,8,12-trimethyltridecanoyl-CoAReach from here →
  1. solute carrier (L-carnitine)
  2. Carnitine O-Palmitoyltransferase
  3. propanoyl-CoA C-acyltransferase (3-ketopristanoyl-CoA)

  Catalysed by SLC25A20, CPT1A, CPT1C, CPT1B and 2 moremitochondrial matrix, cytosol, peroxisomeOne of 2 routes

• (6Z,9Z,12Z)-octadecatrienoyl-CoAReach from here →
  1. solute carrier (L-carnitine)
  2. Carnitine O-Palmitoyltransferase
  3. long-chain-fatty-acid-CoA ligase (gamma-linolenate)

  Catalysed by SLC25A20, CPT1A, CPT1C, CPT1B and 8 moremitochondrial matrix, cytosolOne of 8 routes

• acryloyl-CoAReach from here →
  1. solute carrier (L-carnitine)
  2. Active Transport
  3. medium-chain acyl-CoA dehydrogenase (propanoyl-CoA)

  Catalysed by SLC25A20, ACADS, ACADSBmitochondrial matrix, cytosol

• (5Z,8Z,11Z,14Z)-eicosatetraenoyl-CoAReach from here →
  1. solute carrier (L-carnitine)
  2. Utilized Transport
  3. (5Z,8Z,11Z,14Z)-eicosatetraenoate + ATP + CoA = (5Z,8Z,11Z,14Z)-eicosatetraenoyl-CoA + AMP + diphosphate

  Catalysed by SLC25A20, SLC27A2, ACSL4, ACSL3 and 8 moremitochondrial matrix, cytosol, endoplasmic reticulum

• dodecanoyl-CoAReach from here →
  1. solute carrier (L-carnitine)
  2. Carnitine O-Palmitoyltransferase
  3. long-chain-fatty-acid-CoA ligase (lauric acid)

  Catalysed by SLC25A20, CPT1A, CPT1C, CPT1B and 8 moremitochondrial matrix, cytosolOne of 14 routes

• glutaryl-CoAReach from here →
  1. solute carrier (L-carnitine)
  2. Carnitine O-Palmitoyltransferase
  3. Production of Glutaryl Carnitine

  Catalysed by SLC25A20, CPT1A, CPT1C, CPT1Bmitochondrial matrix, cytosolOne of 6 routes

• hexadecanoyl-CoAReach from here →
  1. solute carrier (L-carnitine)
  2. palmitoyl-CoA:L-carnitine O-palmitoyltransferase
  3. (R)-carnitine + hexadecanoyl-CoA = O-hexadecanoyl-(R)-carnitine + CoA

  Catalysed by SLC25A20, CPT2, CPT1A, CPT1Bmitochondrial matrix, cytosol, peroxisome

• eicosanoyl-CoAReach from here →
  1. solute carrier (L-carnitine)
  2. Carnitine O-Palmitoyltransferase
  3. long-chain-fatty-acid-CoA ligase (eicosanoate)

  Catalysed by SLC25A20, CPT1A, CPT1C, CPT1B and 8 moremitochondrial matrix, cytosolOne of 13 routes

• itaconyl-CoAReach from here →
  1. solute carrier (L-carnitine)
  2. Carnitine O-Palmitoyltransferase
  3. Itaconate:CoA ligase (GDP-forming)

  Catalysed by SLC25A20, CPT1A, CPT1C, CPT1B and 3 moremitochondrial matrix, cytosolOne of 2 routes

• (9Z,12Z)-octadecadienoyl-CoAReach from here →
  1. solute carrier (L-carnitine)
  2. Carnitine O-Palmitoyltransferase
  3. long-chain-fatty-acid-CoA ligase ((6Z,9Z)-octadecadienoic acid)

  Catalysed by SLC25A20, CPT1A, CPT1C, CPT1B and 8 moremitochondrial matrix, cytosolOne of 18 routes

• tetradecanoyl-CoAReach from here →
  1. solute carrier (L-carnitine)
  2. Carnitine O-Palmitoyltransferase
  3. long-chain-fatty-acid-CoA ligase (myristic acid)

  Catalysed by SLC25A20, CPT1A, CPT1C, CPT1B and 8 moremitochondrial matrix, cytosolOne of 12 routes

• (9Z)-octadecenoyl-CoAReach from here →
  1. solute carrier (L-carnitine)
  2. Utilized Transport
  3. (9Z)-octadecenoate + ATP + CoA = (9Z)-octadecenoyl-CoA + AMP + diphosphate

  Catalysed by SLC25A20, SLC27A2, ACSL3, ACSL1 and 5 moremitochondrial matrix, cytosol, endoplasmic reticulumOne of 2 routes

• phytanoyl-CoAReach from here →
  1. solute carrier (L-carnitine)
  2. Carnitine O-Palmitoyltransferase
  3. phytanate-CoA ligase

  Catalysed by SLC25A20, CPT1A, CPT1C, CPT1Bmitochondrial matrix, cytosolOne of 5 routes

• octadecanoyl-CoAReach from here →
  1. solute carrier (L-carnitine)
  2. Carnitine O-Palmitoyltransferase
  3. long-chain-fatty-acid-CoA ligase (stearate)

  Catalysed by SLC25A20, CPT1A, CPT1C, CPT1B and 7 moremitochondrial matrix, cytosolOne of 16 routes

• prostaglandin F2alphaReach from here →
  1. O-octanoyl-(R)-carnitine(in) + (R)-carnitine(out) = O-octanoyl-(R)-carnitine(out) + (R)-carnitine(in)
  2. glutarate(in) + (R)-carnitine(out) = glutarate(out) + (R)-carnitine(in)
  3. prostaglandin F2alpha(out) + glutarate(in) = prostaglandin F2alpha(in) + glutarate(out)

  Catalysed by SLC25A20, SLC22A8inner side of the membrane, outer side of the membraneOne of 2 routes

• prostaglandin H2Reach from here →
  1. solute carrier (L-carnitine)
  2. Utilized Transport
  3. prostaglandin-endoperoxide synthase (arachidonate)

  Catalysed by SLC25A20, PTGS1, PTGS2mitochondrial matrix, cytosol, endoplasmic reticulumOne of 3 routes

• (12S)-hydroperoxy-(5Z,8Z,10E,14Z)-eicosatetraenoateReach from here →
  1. solute carrier (L-carnitine)
  2. Utilized Transport
  3. (5Z,8Z,11Z,14Z)-eicosatetraenoate + O2 = (12S)-hydroperoxy-(5Z,8Z,10E,14Z)-eicosatetraenoate

  Catalysed by SLC25A20, ALOX5, ALOX15, ALOX12mitochondrial matrix, cytosol, endoplasmic reticulum

• (15S)-hydroperoxy-(5Z,8Z,11Z,13E)-eicosatetraenoateReach from here →
  1. solute carrier (L-carnitine)
  2. Utilized Transport
  3. (5Z,8Z,11Z,14Z)-eicosatetraenoate + O2 = (15S)-hydroperoxy-(5Z,8Z,11Z,13E)-eicosatetraenoate

  Catalysed by SLC25A20, ALOX15B, ALOX15, ALOX12mitochondrial matrix, cytosol, endoplasmic reticulum

• (5S)-hydroperoxy-(6E,8Z,11Z,14Z)-eicosatetraenoateReach from here →
  1. solute carrier (L-carnitine)
  2. Utilized Transport
  3. (5Z,8Z,11Z,14Z)-eicosatetraenoate + O2 = (5S)-hydroperoxy-(6E,8Z,11Z,14Z)-eicosatetraenoate

  Catalysed by SLC25A20, ALOX5mitochondrial matrix, cytosol, endoplasmic reticulum

• leukotriene A4Reach from here →
  1. solute carrier (L-carnitine)
  2. Utilized Transport
  3. (5Z,8Z,11Z,14Z)-eicosatetraenoate + O2 = leukotriene A4 + H2O

  Catalysed by SLC25A20, ALOX5mitochondrial matrix, cytosol, endoplasmic reticulum

• (13S)-hydroperoxy-(9Z,11E)-octadecadienoateReach from here →
  1. solute carrier (L-carnitine)
  2. Utilized Transport
  3. Linoleate:oxygen 13-oxidoreductase

  Catalysed by SLC25A20, ALOX15B, ALOX15mitochondrial matrix, cytosol, endoplasmic reticulum

• guanidinoacetateReach from here →
  1. solute carrier (L-carnitine)
  2. Carnitine Transport by Atb0
  3. Transport of Guanidinoacetic Acid

  Catalysed by SLC25A20, SLC6A14mitochondrial matrix, cytosol, extracellular space

• sphing-4-enineReach from here →
  1. solute carrier (L-carnitine)
  2. Carnitine O-Palmitoyltransferase
  3. acyl-CoA:sphingosine N-acyltransferase

  Catalysed by SLC25A20, CPT1A, CPT1C, CPT1B and 4 moremitochondrial matrix, cytosol, Golgi apparatusOne of 2 routes

• spermidineReach from here →
  1. solute carrier (L-carnitine)
  2. Carnitine O-Palmitoyltransferase
  3. diamine N-acetyltransferase (N1-acetylspermidine)

  Catalysed by SLC25A20, CPT1A, CPT1C, CPT1B and 2 moremitochondrial matrix, cytosolOne of 3 routes

• L-methionineReach from here →
  1. solute carrier (L-carnitine)
  2. Carnitine O-Palmitoyltransferase
  3. N-acetylglutamate synthase (N-acetylmethionine)

  Catalysed by SLC25A20, CPT1A, CPT1C, CPT1B and 1 moremitochondrial matrix, cytosolOne of 5 routes

• dehydroepiandrosterone 3-sulfateReach from here →
  1. O-octanoyl-(R)-carnitine(in) + (R)-carnitine(out) = O-octanoyl-(R)-carnitine(out) + (R)-carnitine(in)
  2. glutarate(in) + (R)-carnitine(out) = glutarate(out) + (R)-carnitine(in)
  3. dehydroepiandrosterone 3-sulfate(out) + glutarate(in) = dehydroepiandrosterone 3-sulfate(in) + glutarate(out)

  Catalysed by SLC25A20, SLC22A8, SLC22A24inner side of the membrane, outer side of the membraneOne of 2 routes

• L-tryptophanReach from here →
  1. solute carrier (L-carnitine)
  2. Carnitine Transport by Atb0
  3. Transport of L-Tryptophan by Atb0 Transporter

  Catalysed by SLC25A20, SLC6A14mitochondrial matrix, cytosol, extracellular spaceOne of 2 routes

• beta-alanineReach from here →
  1. solute carrier (L-carnitine)
  2. Carnitine Transport by Atb0
  3. transport of beta-alanine and chloride (cytosol to extracellular)

  Catalysed by SLC25A20, SLC6A14, SLC6A6mitochondrial matrix, cytosol, extracellular spaceOne of 2 routes

• L-alanineReach from here →
  1. solute carrier (L-carnitine)
  2. Carnitine O-Palmitoyltransferase
  3. amino-acid N-acetyltransferase (N-acetyl-L-alanine)

  Catalysed by SLC25A20, CPT1A, CPT1C, CPT1Bmitochondrial matrix, cytosolOne of 3 routes

• L-asparagineReach from here →
  1. solute carrier (L-carnitine)
  2. Carnitine O-Palmitoyltransferase
  3. N-acetylglutamate synthase (N-acetyl-L-asparagine)

  Catalysed by SLC25A20, CPT1A, CPT1C, CPT1B and 1 moremitochondrial matrix, cytosolOne of 3 routes

• L-phenylalanineReach from here →
  1. solute carrier (L-carnitine)
  2. Carnitine Transport by Atb0
  3. Transport of L-Phenylalanine by Atb0 Transporter

  Catalysed by SLC25A20, SLC6A14mitochondrial matrix, cytosol, extracellular spaceOne of 2 routes

• L,L-cystathionineReach from here →
  1. solute carrier (L-carnitine)
  2. Carnitine O-Palmitoyltransferase
  3. N-acetylglutamate synthase (N-acetyl-L-cystathionine)

  Catalysed by SLC25A20, CPT1A, CPT1C, CPT1B and 1 moremitochondrial matrix, cytosol

• N,N-dimethylglycineReach from here →
  1. O-octanoyl-(R)-carnitine(in) + (R)-carnitine(out) = O-octanoyl-(R)-carnitine(out) + (R)-carnitine(in)
  2. glycine betaine(out) + (R)-carnitine(in) = glycine betaine(in) + (R)-carnitine(out)
  3. L-homocysteine + glycine betaine = N,N-dimethylglycine + L-methionine

  Catalysed by SLC25A20, SLC22A5, BHMTinner side of the membrane, outer side of the membrane

• an acyl-CoAReach from here →
  1. solute carrier (L-carnitine)
  2. Carnitine O-Palmitoyltransferase
  3. acyl-CoA:sphingosine N-acyltransferase

  Catalysed by SLC25A20, CPT1A, CPT1C, CPT1B and 4 moremitochondrial matrix, cytosol, Golgi apparatusOne of 2 routes

• kynurenateReach from here →
  1. O-octanoyl-(R)-carnitine(in) + (R)-carnitine(out) = O-octanoyl-(R)-carnitine(out) + (R)-carnitine(in)
  2. glutarate(in) + (R)-carnitine(out) = glutarate(out) + (R)-carnitine(in)
  3. kynurenate(out) + glutarate(in) = kynurenate(in) + glutarate(out)

  Catalysed by SLC25A20, SLC22A8, SLC22A6inner side of the membrane, outer side of the membraneOne of 2 routes

• (3Z)-dodecenoyl-CoAReach from here →
  1. solute carrier (L-carnitine)
  2. Carnitine O-Palmitoyltransferase
  3. acetyl-CoA C-acyltransferase (3-oxomyrist-5-enoyl-CoA)

  Catalysed by SLC25A20, CPT1A, CPT1C, CPT1B and 3 moremitochondrial matrix, cytosolOne of 3 routes

• (25R)-3alpha,7alpha,12alpha-trihydroxy-5beta-cholestan-26-oyl-CoAReach from here →
  1. solute carrier (L-carnitine)
  2. Carnitine O-Palmitoyltransferase
  3. 3alpha,7alpha,12alpha-trihydroxy-5beta-cholestanoate:CoA ligase (AMP-forming)

  Catalysed by SLC25A20, CPT1A, CPT1C, CPT1B and 2 moremitochondrial matrix, cytosol, endoplasmic reticulumOne of 3 routes

• deoxycholoyl-CoAReach from here →
  1. solute carrier (L-carnitine)
  2. Carnitine O-Palmitoyltransferase
  3. cholate-CoA ligase (3alpha,12alpha-dihydroxy-5beta-cholanate)

  Catalysed by SLC25A20, CPT1A, CPT1C, CPT1B and 2 moremitochondrial matrix, cytosolOne of 4 routes

• N-(5Z,8Z,11Z,14Z)-eicosatetraenoyl-glycineReach from here →
  1. solute carrier (L-carnitine)
  2. Utilized Transport
  3. N-(5Z,8Z,11Z,14Z)-eicosatetraenoyl-glycine + H2O = (5Z,8Z,11Z,14Z)-eicosatetraenoate + glycine

  Catalysed by SLC25A20, FAAH, PM20D1mitochondrial matrix, cytosol, endoplasmic reticulum

• monodehydro-L-ascorbate radicalReach from here →
  1. Octanoyl-CoA:L-carnitine O-octanoyltransferase
  2. octanoyl-CoA + glycine = N-octanoylglycine + CoA + H(+)
  3. N-octanoylglycine + 2 L-ascorbate + O2 = N-octanoyl-(2S)-hydroxyglycine + 2 monodehydro-L-ascorbate radical + H2O

  Catalysed by CROT, GLYATL2, PAMmitochondrial matrix

• 4-aminobutanoateReach from here →
  1. solute carrier (L-carnitine)
  2. Carnitine Transport by Atb0
  3. transport of 4-aminobutyrate and chloride (cytosol to extracellular)

  Catalysed by SLC25A20, SLC6A14, SLC6A12mitochondrial matrix, cytosol, extracellular spaceOne of 4 routes

• estrone 3-sulfateReach from here →
  1. O-octanoyl-(R)-carnitine(in) + (R)-carnitine(out) = O-octanoyl-(R)-carnitine(out) + (R)-carnitine(in)
  2. glutarate(in) + (R)-carnitine(out) = glutarate(out) + (R)-carnitine(in)
  3. estrone 3-sulfate(out) + glutarate(in) = estrone 3-sulfate(in) + glutarate(out)

  Catalysed by SLC25A20, SLC22A8, SLC22A24, SLC22A11inner side of the membrane, outer side of the membraneOne of 2 routes

• prostaglandin E2Reach from here →
  1. O-octanoyl-(R)-carnitine(in) + (R)-carnitine(out) = O-octanoyl-(R)-carnitine(out) + (R)-carnitine(in)
  2. glutarate(in) + (R)-carnitine(out) = glutarate(out) + (R)-carnitine(in)
  3. prostaglandin E2(out) + glutarate(in) = prostaglandin E2(in) + glutarate(out)

  Catalysed by SLC25A20, SLC22A8inner side of the membrane, outer side of the membraneOne of 2 routes