hexadecanoic acid

Two steps

• all-cis-docosa-4,7,10,13,16,19-hexaenoic acidReach from here →
  1. (10Z)-heptadecenoic acid formation
  2. (10Z)-heptadecenoic acid formation

  No catalyst recordedcytosol, extracellular spaceOne of 12 routes

• CHEBI:28701Reach from here →
  1. Fas180
  2. Propanoyl-CoA:acetyl-CoA C-acyltransferase

  Catalysed by ACAA1, SCP2, MYO5Bcytosol, peroxisomeOne of 7 routes

• chlorine(.)Reach from here →
  1. Utilized Transport
  2. Carnitine Transport by Atb0

  Catalysed by SLC6A14endoplasmic reticulum, cytosol, extracellular space

• tetradecanoateReach from here →
  1. (10Z)-heptadecenoic acid formation
  2. (10Z)-heptadecenoic acid formation

  No catalyst recordedcytosol, extracellular spaceOne of 12 routes

• (9Z)-octadecenoateReach from here →
  1. (10Z)-heptadecenoic acid formation
  2. (10Z)-heptadecenoic acid formation

  No catalyst recordedcytosol, extracellular spaceOne of 14 routes

• hexacosanoateReach from here →
  1. (10Z)-heptadecenoic acid formation
  2. (10Z)-heptadecenoic acid formation

  No catalyst recordedcytosol, extracellular spaceOne of 12 routes

• tetracosanoateReach from here →
  1. (10Z)-heptadecenoic acid formation
  2. (10Z)-heptadecenoic acid formation

  No catalyst recordedcytosol, extracellular spaceOne of 12 routes

• an N-acylsphinganineReach from here →
  1. (10Z)-heptadecenoic acid formation
  2. N-acylsphingosine amidohydrolase

  Catalysed by ASAH1, ACER2, ACER1, ASAH2 and 1 morecytosol

• eicosanoateReach from here →
  1. (10Z)-heptadecenoic acid formation
  2. (10Z)-heptadecenoic acid formation

  No catalyst recordedcytosol, extracellular spaceOne of 12 routes

• (9Z)-hexadecenoateReach from here →
  1. (10Z)-heptadecenoic acid formation
  2. (10Z)-heptadecenoic acid formation

  No catalyst recordedcytosol, extracellular spaceOne of 18 routes

• (15Z)-tetracosenoateReach from here →
  1. (10Z)-heptadecenoic acid formation
  2. (10Z)-heptadecenoic acid formation

  No catalyst recordedcytosol, extracellular spaceOne of 12 routes

• (5Z,8Z,11Z,14Z)-eicosatetraenoateReach from here →
  1. (10Z)-heptadecenoic acid formation
  2. (10Z)-heptadecenoic acid formation

  No catalyst recordedcytosol, extracellular spaceOne of 14 routes

• (11Z)-eicosenoateReach from here →
  1. (10Z)-heptadecenoic acid formation
  2. (10Z)-heptadecenoic acid formation

  No catalyst recordedcytosol, extracellular spaceOne of 12 routes

• cholesteryl hexadecanoateReach from here →
  1. Palmitate:CoA ligase (AMP-forming)
  2. Acyl-CoA:cholesterol O-acyltransferase

  Catalysed by SLC27A2, ACSL4, ACSL3, ACSL1 and 6 morecytosol, endoplasmic reticulum

• taurineReach from here →
  1. Fas180
  2. bile acid-CoA:amino acid N-acyltransferase (taurodeoxycholate)

  Catalysed by BAATcytosolOne of 2 routes

• glycineReach from here →
  1. Fas180
  2. glycine N-acyltransferase (N-arachidonoylglycine)

  Catalysed by GLYAT, GLYATL2, GLYATL1cytosol, mitochondrial matrixOne of 10 routes

• (R)-methylmalonyl-CoAReach from here →
  1. Fas180
  2. aldehyde dehydrogenase (2-methyl-3-oxopropanoate)

  Catalysed by ALDH6A1cytosol, mitochondrial matrixOne of 2 routes

• (S)-methylmalonyl-CoAReach from here →
  1. Fas180
  2. (S)-methylmalonyl-CoA hydrolase

  No catalyst recordedcytosol, mitochondrial matrix

• 3'-dephospho-CoAReach from here →
  1. Fas180
  2. acid phosphatase 2, lysosomal (CoA)

  Catalysed by ACP2cytosol, lysosomeOne of 2 routes

• (2E)-dodecenoyl-CoAReach from here →
  1. Fas180
  2. (2E)-dodecenoyl-CoA formation

  No catalyst recordedcytosol, mitochondrial matrixOne of 3 routes

• 4,8,12-trimethyltridecanoyl-CoAReach from here →
  1. Fas180
  2. propanoyl-CoA C-acyltransferase (3-ketopristanoyl-CoA)

  Catalysed by ACAA1, MYO5Bcytosol, peroxisomeOne of 2 routes

• (6Z,9Z,12Z)-octadecatrienoyl-CoAReach from here →
  1. Fas180
  2. long-chain-fatty-acid-CoA ligase (gamma-linolenate)

  Catalysed by SLC27A2, ACSL4, ACSL3, ACSL1 and 4 morecytosolOne of 7 routes

• butanoyl-CoAReach from here →
  1. Utilized Transport
  2. transport of butyryl-CoA and L-carnitine (cytosol to mitochondria)

  Catalysed by SLC33A1, ESCO2, OXSMendoplasmic reticulum, cytosol, mitochondrial matrixOne of 11 routes

• dodecanoyl-CoAReach from here →
  1. Fas180
  2. long-chain-fatty-acid-CoA ligase (lauric acid)

  Catalysed by SLC27A2, ACSL4, ACSL3, ACSL1 and 4 morecytosolOne of 9 routes

• glutaryl-CoAReach from here →
  1. Fas180
  2. Production of Glutaryl Carnitine

  Catalysed by CPT1A, CPT1C, CPT1BcytosolOne of 2 routes

• eicosanoyl-CoAReach from here →
  1. Fas180
  2. long-chain-fatty-acid-CoA ligase (eicosanoate)

  Catalysed by SLC27A2, ACSL4, ACSL3, ACSL1 and 4 morecytosolOne of 12 routes

• itaconyl-CoAReach from here →
  1. Fas180
  2. Itaconate:CoA ligase (GDP-forming)

  Catalysed by SUCLG1, SUCLG2, SUCLA2cytosol, mitochondrial matrixOne of 2 routes

• (9Z,12Z)-octadecadienoyl-CoAReach from here →
  1. Fas180
  2. long-chain-fatty-acid-CoA ligase ((6Z,9Z)-octadecadienoic acid)

  Catalysed by SLC27A2, ACSL4, ACSL3, ACSL1 and 4 morecytosolOne of 13 routes

• tetradecanoyl-CoAReach from here →
  1. Palmitate:CoA ligase (AMP-forming)
  2. Fatty Acid Beta Oxidation (C16->C14), Mitochondrial

  Catalysed by SLC27A2, ACSL4, ACSL3, ACSL1 and 7 morecytosol, mitochondrial matrixOne of 13 routes

• octanoyl-CoAReach from here →
  1. Palmitate:CoA ligase (AMP-forming)
  2. Beta Oxidation of Long Chain Fatty Acid

  Catalysed by SLC27A2, ACSL4, ACSL3, ACSL1 and 6 morecytosol, mitochondrial matrixOne of 22 routes

• phytanoyl-CoAReach from here →
  1. Fas180
  2. phytanate-CoA ligase

  No catalyst recordedcytosolOne of 5 routes

• octadecanoyl-CoAReach from here →
  1. Palmitate:CoA ligase (AMP-forming)
  2. fatty-acyl-CoA synthase (N-C18:0CoA)

  Catalysed by SLC27A2, ACSL4, ACSL3, ACSL1 and 4 morecytosolOne of 22 routes

• 1-hexadecanoyl-sn-glycero-3-phosphateReach from here →
  1. Palmitate:CoA ligase (AMP-forming)
  2. glycerol-3-phosphate 1-O-acyltransferase (palmitoyl-CoA)

  Catalysed by SLC27A2, ACSL4, ACSL3, ACSL1 and 8 morecytosol

• (R)-2-hydroxyoctadecanoateReach from here →
  1. Fas180
  2. octadecanoate + 2 Fe(II)-[cytochrome b5] + O2 + 2 H(+) = (R)-2-hydroxyoctadecanoate + 2 Fe(III)-[cytochrome b5] + H2O

  Catalysed by FA2Hcytosol

• O-acetyl-(R)-carnitineReach from here →
  1. Utilized Transport
  2. Acetyl-CoA:carnitine O-acetyltransferase

  Catalysed by CPT1A, CPT1C, CPT1Bendoplasmic reticulum, cytosolOne of 9 routes

• sphing-4-enineReach from here →
  1. Fas180
  2. acyl-CoA:sphingosine N-acyltransferase

  Catalysed by ASAH1, ACER2, ACER1, ASAH2cytosol, Golgi apparatusOne of 2 routes

• spermidineReach from here →
  1. Fas180
  2. diamine N-acetyltransferase (N1-acetylspermidine)

  Catalysed by SAT1, SAT2cytosolOne of 3 routes

• L-methionineReach from here →
  1. Fas180
  2. N-acetylglutamate synthase (N-acetylmethionine)

  Catalysed by NAGScytosol, mitochondrial matrix

• sphinganine 1-phosphateReach from here →
  1. 2 H+[c] + NADH[c] + palmitate[c] = H2O[c] + hexadecanal[c] + NAD+[c]
  2. Sphinganine-1-phosphate pamlmitaldehyde-lyase

  Catalysed by ALDH3B1, ALDH3B2, ALDH3A2, SGPL1cytosol

• L-alanineReach from here →
  1. Fas180
  2. amino-acid N-acetyltransferase (N-acetyl-L-alanine)

  No catalyst recordedcytosol, mitochondrial matrix

• L-asparagineReach from here →
  1. Fas180
  2. N-acetylglutamate synthase (N-acetyl-L-asparagine)

  Catalysed by NAGScytosol, mitochondrial matrix

• L,L-cystathionineReach from here →
  1. Fas180
  2. N-acetylglutamate synthase (N-acetyl-L-cystathionine)

  Catalysed by NAGScytosol, mitochondrial matrix

• 3-oxosphinganineReach from here →
  1. Palmitate:CoA ligase (AMP-forming)
  2. Palmitoyl-CoA:L-serine C-palmitoyltransferase (decarboxylating)

  Catalysed by SLC27A2, ACSL4, ACSL3, ACSL1 and 7 morecytosol

• 1-hexadecanoylglycerone 3-phosphateReach from here →
  1. Palmitate:CoA ligase (AMP-forming)
  2. glyceronephosphate O-acyltransferase (DHAP)

  Catalysed by SLC27A2, ACSL4, ACSL3, ACSL1 and 5 morecytosol, peroxisome

• an acyl-CoAReach from here →
  1. Palmitate:CoA ligase (AMP-forming)
  2. acyl-CoA pool formation and breakdown

  Catalysed by SLC27A2, ACSL4, ACSL3, ACSL1 and 4 morecytosolOne of 3 routes

• (3Z)-dodecenoyl-CoAReach from here →
  1. Fas180
  2. acetyl-CoA C-acyltransferase (3-oxomyrist-5-enoyl-CoA)

  Catalysed by HADHA, ACAA2, HADHBcytosol, mitochondrial matrixOne of 3 routes

• (5Z,8Z,11Z,14Z,17Z)-eicosapentaenoateReach from here →
  1. (10Z)-heptadecenoic acid formation
  2. (10Z)-heptadecenoic acid formation

  No catalyst recordedcytosol, extracellular spaceOne of 12 routes

• (25R)-3alpha,7alpha,12alpha-trihydroxy-5beta-cholestan-26-oyl-CoAReach from here →
  1. Fas180
  2. 3alpha,7alpha,12alpha-trihydroxy-5beta-cholestanoate:CoA ligase (AMP-forming)

  Catalysed by SLC27A2, SLC27A5cytosol, endoplasmic reticulumOne of 3 routes

• deoxycholoyl-CoAReach from here →
  1. Fas180
  2. cholate-CoA ligase (3alpha,12alpha-dihydroxy-5beta-cholanate)

  Catalysed by SLC27A2, SLC27A5cytosolOne of 4 routes

• decanoyl-CoAReach from here →
  1. Fas180
  2. medium-chain acyl-CoA ligase (decanoic acid)

  Catalysed by ACSM4, ACSM1, ACSM2A, ACSM3 and 2 morecytosolOne of 7 routes