beta-D-glucosyl-(1->3)-O-chenodeoxycholate

Three steps

• beta-D-fructoseReach from here →
  1. beta-D-glucosyl-(1->3)-O-chenodeoxycholate + H2O = chenodeoxycholate + D-glucose
  2. Aldehyde Reductase
  3. D-Glucitol:NAD+ 2-oxidoreductase

  Catalysed by GBA2, SORDcytosol

• CHEBI:28666Reach from here →
  1. beta-D-glucosyl-(1->3)-O-chenodeoxycholate + H2O = chenodeoxycholate + D-glucose
  2. solute carrier organic anion transporter (chenodiol)
  3. transport of LTD4 (cytosol to extracellular)

  Catalysed by GBA2, SLCO1A2, SLCO1B3, SLCO1B1extracellular space, cytosolOne of 2 routes

• glycocholateReach from here →
  1. beta-D-glucosyl-(1->3)-O-chenodeoxycholate + H2O = chenodeoxycholate + D-glucose
  2. solute carrier organic anion transporter (chenodiol)
  3. solute carrier organic anion transporter (glycocholate)

  Catalysed by GBA2, SLCO1A2, SLCO1B3extracellular space, cytosolOne of 2 routes

• (5Z,8Z,11Z,14Z)-eicosatetraenoateReach from here →
  1. beta-D-glucosyl-(1->3)-O-chenodeoxycholate + H2O = chenodeoxycholate + D-glucose
  2. solute carrier organic anion transporter (chenodiol)
  3. transport of arachidonate (cytosol to extracellular)

  Catalysed by GBA2, SLCO1A2, SLCO1B3, SLCO1B1extracellular space, cytosolOne of 2 routes

• serotoninReach from here →
  1. beta-D-glucosyl-(1->3)-O-chenodeoxycholate + H2O = chenodeoxycholate + D-glucose
  2. solute carrier organic anion transporter (chenodiol)
  3. transport of serotonin (cytosol to extracellular)

  Catalysed by GBA2, SLCO1A2, SLCO1B3extracellular space, cytosolOne of 2 routes

• glycochenodeoxycholateReach from here →
  1. beta-D-glucosyl-(1->3)-O-chenodeoxycholate + H2O = chenodeoxycholate + D-glucose
  2. chenodeoxycholate + ATP + CoA = chenodeoxycholoyl-CoA + AMP + diphosphate
  3. chenodeoxycholoyl-CoA + glycine = glycochenodeoxycholate + CoA + H(+)

  Catalysed by GBA2, SLC27A5, BAAT

• taurocholateReach from here →
  1. beta-D-glucosyl-(1->3)-O-chenodeoxycholate + H2O = chenodeoxycholate + D-glucose
  2. solute carrier organic anion transporter (chenodiol)
  3. solute carrier organic anion transporter (S-glutathionyl-2-4-dinitrobenzene)

  Catalysed by GBA2, SLCO1A2, SLCO1B3extracellular space, cytosolOne of 2 routes

• glycochenodeoxycholic acidReach from here →
  1. beta-D-glucosyl-(1->3)-O-chenodeoxycholate + H2O = chenodeoxycholate + D-glucose
  2. chenodeoxycholate:CoA ligase (AMP-forming)
  3. bile acid-CoA: amino acid N-acyltransferase

  Catalysed by GBA2, SLC27A5, BAATcytosol, peroxisomeOne of 2 routes

• glycolithocholic acidReach from here →
  1. beta-D-glucosyl-(1->3)-O-chenodeoxycholate + H2O = chenodeoxycholate + D-glucose
  2. solute carrier organic anion transporter (chenodiol)
  3. transport of glycolithocholate (cytosol to extracellular)

  Catalysed by GBA2, SLCO1A2, SLCO1B3extracellular space, cytosolOne of 2 routes

• keto-D-fructoseReach from here →
  1. beta-D-glucosyl-(1->3)-O-chenodeoxycholate + H2O = chenodeoxycholate + D-glucose
  2. Aldehyde Reductase
  3. keto-D-fructose + NADH + H(+) = D-sorbitol + NAD(+)

  Catalysed by GBA2, SORDcytosol

• 3,3',5-triiodo-L-thyronineReach from here →
  1. beta-D-glucosyl-(1->3)-O-chenodeoxycholate + H2O = chenodeoxycholate + D-glucose
  2. solute carrier organic anion transporter (chenodiol)
  3. transport of S-glutathionyl-2-4-dinitrobenzene (cytosol to extracellular)

  Catalysed by GBA2, SLCO1A2, SLCO1B3extracellular space, cytosolOne of 2 routes

• choloyl-CoAReach from here →
  1. beta-D-glucosyl-(1->3)-O-chenodeoxycholate + H2O = chenodeoxycholate + D-glucose
  2. chenodeoxycholate + reduced [NADPH--hemoprotein reductase] + O2 = cholate + oxidized [NADPH--hemoprotein reductase] + H2O + H(+)
  3. cholate + ATP + CoA = choloyl-CoA + AMP + diphosphate

  Catalysed by GBA2, CYP8B1, SLC27A5

• prostaglandin E1Reach from here →
  1. beta-D-glucosyl-(1->3)-O-chenodeoxycholate + H2O = chenodeoxycholate + D-glucose
  2. solute carrier organic anion transporter (chenodiol)
  3. transport of prostaglandin E1 (cytosol to extracellular)

  Catalysed by GBA2, SLCO1A2, SLCO1B3, SLCO1B1extracellular space, cytosolOne of 2 routes

• prostaglandin I2Reach from here →
  1. beta-D-glucosyl-(1->3)-O-chenodeoxycholate + H2O = chenodeoxycholate + D-glucose
  2. solute carrier organic anion transporter (chenodiol)
  3. transport of prostaglandin I2 (cytosol to extracellular)

  Catalysed by GBA2, SLCO1A2, SLCO1B3, SLCO1B1extracellular space, cytosolOne of 2 routes

• prostaglandin F2alphaReach from here →
  1. beta-D-glucosyl-(1->3)-O-chenodeoxycholate + H2O = chenodeoxycholate + D-glucose
  2. solute carrier organic anion transporter (chenodiol)
  3. transport of prostaglandin F2alpha (cytosol to extracellular)

  Catalysed by GBA2, SLCO1A2, SLCO1B3, SLCO1B1extracellular space, cytosolOne of 2 routes

• prostaglandin H2Reach from here →
  1. beta-D-glucosyl-(1->3)-O-chenodeoxycholate + H2O = chenodeoxycholate + D-glucose
  2. solute carrier organic anion transporter (chenodiol)
  3. transport of prostaglandin H2 (cytosol to extracellular)

  Catalysed by GBA2, SLCO1A2, SLCO1B3, SLCO1B1extracellular space, cytosolOne of 2 routes

• prostaglandin D2Reach from here →
  1. beta-D-glucosyl-(1->3)-O-chenodeoxycholate + H2O = chenodeoxycholate + D-glucose
  2. solute carrier organic anion transporter (chenodiol)
  3. transport of prostaglandin D2 (cytosol to extracellular)

  Catalysed by GBA2, SLCO1A2, SLCO1B3, SLCO1B1extracellular space, cytosolOne of 2 routes

• leukotriene A4Reach from here →
  1. beta-D-glucosyl-(1->3)-O-chenodeoxycholate + H2O = chenodeoxycholate + D-glucose
  2. solute carrier organic anion transporter (chenodiol)
  3. transport of leukotriene A4 (cytosol to extracellular)

  Catalysed by GBA2, SLCO1A2, SLCO1B3, SLCO1B1extracellular space, cytosolOne of 2 routes

• dCMPReach from here →
  1. beta-D-glucosyl-(1->3)-O-chenodeoxycholate + H2O = chenodeoxycholate + D-glucose
  2. dATP:D-glucose 6-phosphotransferase
  3. cytidine/uridine monophosphate kinase (dADP)

  Catalysed by GBA2, HK1, HK2, HK3 and 2 morecytosolOne of 2 routes

• dGMPReach from here →
  1. beta-D-glucosyl-(1->3)-O-chenodeoxycholate + H2O = chenodeoxycholate + D-glucose
  2. dATP:D-glucose 6-phosphotransferase
  3. dADP to dATP conversion

  Catalysed by GBA2, HK1, HK2, HK3 and 1 morecytosol, mitochondrial matrix

• dehydroepiandrosterone 3-sulfateReach from here →
  1. beta-D-glucosyl-(1->3)-O-chenodeoxycholate + H2O = chenodeoxycholate + D-glucose
  2. solute carrier organic anion transporter (chenodiol)
  3. transport of dehydroepiandrosterone sulfate (cytosol to extracellular)

  Catalysed by GBA2, SLCO1A2, SLCO1B3, SLCO1B1extracellular space, cytosolOne of 2 routes

• glutathioneReach from here →
  1. beta-D-glucosyl-(1->3)-O-chenodeoxycholate + H2O = chenodeoxycholate + D-glucose
  2. chenodeoxycholate + reduced [NADPH--hemoprotein reductase] + O2 = cholate + oxidized [NADPH--hemoprotein reductase] + H2O + H(+)
  3. cholate(in) + glutathione(in) + ATP + H2O = cholate(out) + glutathione(out) + ADP + phosphate + H(+)

  Catalysed by GBA2, CYP8B1, ABCC4inner side of the membrane, outer side of the membrane

• 6-phospho-D-glucono-1,5-lactoneReach from here →
  1. beta-D-glucosyl-(1->3)-O-chenodeoxycholate + H2O = chenodeoxycholate + D-glucose
  2. ATP:D-glucose 6-phosphotransferase
  3. D-glucose-6-phosphate:NADP+ 1-oxidoreductase

  Catalysed by GBA2, HK1, GCK, HK2 and 3 morecytosol, endoplasmic reticulumOne of 6 routes

• leukotriene C4Reach from here →
  1. beta-D-glucosyl-(1->3)-O-chenodeoxycholate + H2O = chenodeoxycholate + D-glucose
  2. solute carrier organic anion transporter (chenodiol)
  3. transport of leukotriene C4 (cytosol to extracellular)

  Catalysed by GBA2, SLCO1A2, SLCO1B3, SLCO1B1extracellular space, cytosolOne of 2 routes

• taurolithocholate 3-sulfateReach from here →
  1. beta-D-glucosyl-(1->3)-O-chenodeoxycholate + H2O = chenodeoxycholate + D-glucose
  2. solute carrier organic anion transporter (chenodiol)
  3. transport of S-glutathionyl-2-4-dinitrobenzene (cytosol to extracellular)

  Catalysed by GBA2, SLCO1A2, SLCO1B3extracellular space, cytosolOne of 2 routes

• 1D-myo-inositol 3-phosphateReach from here →
  1. beta-D-glucosyl-(1->3)-O-chenodeoxycholate + H2O = chenodeoxycholate + D-glucose
  2. ATP:D-glucose 6-phosphotransferase
  3. 1D-myo-inositol-3-phosphate lyase (isomerizing)

  Catalysed by GBA2, HK1, GCK, HK2 and 3 morecytosolOne of 2 routes

• histamineReach from here →
  1. beta-D-glucosyl-(1->3)-O-chenodeoxycholate + H2O = chenodeoxycholate + D-glucose
  2. solute carrier organic anion transporter (chenodiol)
  3. transport of histamine (cytosol to extracellular)

  Catalysed by GBA2, SLCO1A2, SLCO1B3extracellular space, cytosolOne of 2 routes

• L-thyroxineReach from here →
  1. beta-D-glucosyl-(1->3)-O-chenodeoxycholate + H2O = chenodeoxycholate + D-glucose
  2. solute carrier organic anion transporter (chenodiol)
  3. transport of S-glutathionyl-2-4-dinitrobenzene (cytosol to extracellular)

  Catalysed by GBA2, SLCO1A2, SLCO1B3extracellular space, cytosolOne of 2 routes

• D-mannose 6-phosphateReach from here →
  1. beta-D-glucosyl-(1->3)-O-chenodeoxycholate + H2O = chenodeoxycholate + D-glucose
  2. D-glucose + ADP = D-glucose 6-phosphate + AMP + H(+)
  3. D-glucose 6-phosphate = D-mannose 6-phosphate

  Catalysed by GBA2, ADPGK, GPI

• dopamineReach from here →
  1. beta-D-glucosyl-(1->3)-O-chenodeoxycholate + H2O = chenodeoxycholate + D-glucose
  2. solute carrier organic anion transporter (chenodiol)
  3. transport of dopamine (cytosol to extracellular)

  Catalysed by GBA2, SLCO1A2, SLCO1B3extracellular space, cytosolOne of 2 routes

• glycolithocholate 3-sulfateReach from here →
  1. beta-D-glucosyl-(1->3)-O-chenodeoxycholate + H2O = chenodeoxycholate + D-glucose
  2. solute carrier organic anion transporter (chenodiol)
  3. transport of S-glutathionyl-2-4-dinitrobenzene (cytosol to extracellular)

  Catalysed by GBA2, SLCO1A2, SLCO1B3extracellular space, cytosolOne of 2 routes

• estrone 3-sulfateReach from here →
  1. beta-D-glucosyl-(1->3)-O-chenodeoxycholate + H2O = chenodeoxycholate + D-glucose
  2. solute carrier organic anion transporter (chenodiol)
  3. transport of estrone 3-sulfate (cytosol to extracellular)

  Catalysed by GBA2, SLCO1A2, SLCO1B3, SLCO1B1extracellular space, cytosolOne of 2 routes

• prostaglandin E2Reach from here →
  1. beta-D-glucosyl-(1->3)-O-chenodeoxycholate + H2O = chenodeoxycholate + D-glucose
  2. solute carrier organic anion transporter (chenodiol)
  3. transport of prostaglandin E2 (cytosol to extracellular)

  Catalysed by GBA2, SLCO1A2, SLCO1B3extracellular space, cytosolOne of 2 routes

• dTMPReach from here →
  1. beta-D-glucosyl-(1->3)-O-chenodeoxycholate + H2O = chenodeoxycholate + D-glucose
  2. dATP:D-glucose 6-phosphotransferase
  3. deoxythymidylate kinase (dADP)

  Catalysed by GBA2, HK1, HK2, HK3 and 2 morecytosol, mitochondrial matrixOne of 2 routes

• (R)-noradrenalineReach from here →
  1. beta-D-glucosyl-(1->3)-O-chenodeoxycholate + H2O = chenodeoxycholate + D-glucose
  2. solute carrier organic anion transporter (chenodiol)
  3. transport of noradrenaline (cytosol to extracellular)

  Catalysed by GBA2, SLCO1A2, SLCO1B3extracellular space, cytosolOne of 2 routes

• 20-hydroxy-(5Z,8Z,11Z,14Z)-eicosatetraenoateReach from here →
  1. beta-D-glucosyl-(1->3)-O-chenodeoxycholate + H2O = chenodeoxycholate + D-glucose
  2. solute carrier organic anion transporter (chenodiol)
  3. Resistance-Nodulation-Cell Division (Rnd) Tcdb:2.A.60.1.5

  Catalysed by GBA2, SLCO1A2, SLCO1B3, SLCO1B1extracellular space, cytosolOne of 2 routes

• ursodeoxycholateReach from here →
  1. beta-D-glucosyl-(1->3)-O-chenodeoxycholate + H2O = chenodeoxycholate + D-glucose
  2. solute carrier organic anion transporter (chenodiol)
  3. transport of S-glutathionyl-2-4-dinitrobenzene (cytosol to extracellular)

  Catalysed by GBA2, SLCO1A2, SLCO1B3extracellular space, cytosolOne of 3 routes

• prostaglandin G2Reach from here →
  1. beta-D-glucosyl-(1->3)-O-chenodeoxycholate + H2O = chenodeoxycholate + D-glucose
  2. solute carrier organic anion transporter (chenodiol)
  3. transport of prostaglandin G2 (cytosol to extracellular)

  Catalysed by GBA2, SLCO1A2, SLCO1B3, SLCO1B1extracellular space, cytosolOne of 2 routes

• beta-D-galactosyl-(1->4)-[alpha-L-fucosyl-(1->3)]-D-glucoseReach from here →
  1. beta-D-glucosyl-(1->3)-O-chenodeoxycholate + H2O = chenodeoxycholate + D-glucose
  2. D-glucose + UDP-alpha-D-galactose = lactose + UDP + H(+)
  3. lactose + GDP-beta-L-fucose = beta-D-galactosyl-(1->4)-[alpha-L-fucosyl-(1->3)]-D-glucose + GDP + H(+)

  Catalysed by GBA2, B4GALT2, B4GALT1, FUT3 and 1 more

• thromboxane B2Reach from here →
  1. beta-D-glucosyl-(1->3)-O-chenodeoxycholate + H2O = chenodeoxycholate + D-glucose
  2. solute carrier organic anion transporter (chenodiol)
  3. transport of S-glutathionyl-2-4-dinitrobenzene (cytosol to extracellular)

  Catalysed by GBA2, SLCO1A2, SLCO1B3, SLCO1B1extracellular space, cytosolOne of 2 routes

• taurochenodeoxycholateReach from here →
  1. beta-D-glucosyl-(1->3)-O-chenodeoxycholate + H2O = chenodeoxycholate + D-glucose
  2. chenodeoxycholate:CoA ligase (AMP-forming)
  3. 3alpha,7alpha-dihydroxy-5beta-cholanoyl-CoA:taurine N-choloyltransferase

  Catalysed by GBA2, SLC27A5, BAATcytosol, peroxisomeOne of 5 routes