Proteins/UNIPROT:Q15699

ALX1

ProteinUNIPROT:Q15699

Sequence-specific DNA-binding transcription factor that binds palindromic sequences within promoters and may activate or repress the transcription of a subset of genes. Most probably regulates the expression of genes involved in the development of mesenchyme-derived craniofacial structures. Early on in development, it plays a role in forebrain mesenchyme survival. May also induce epithelial to mesenchymal transition (EMT) through the expression of SNAI1..

Function from UniProtKB (Q15699), read 2026-09-23. CC BY 4.0.

Curated compounds routed: 0

What the reference databases state

GenCC submitters' classifications

1 row

frontonasal dysplasia - severe microphthalmia - severe facial clefting syndrome has a germline basis in ALX1DiseaseGenCC HGNC:1494|MONDO:0013271Inferred only

Statements

27 statements

27 statements · 3 reference databases · Subject: ALX1 · Sources: gene ontology, Hetionet, WikiPathways

Order

ALX1 covaries with WASHC2AProteinHetionet hetionet:covaries:387680-8092Inferred only
ALX1 interacts with ALX4ProteinHetionet hetionet:interacts:60529-8092Inferred only
EP300 interacts with ALX1ProteinHetionet hetionet:interacts:2033-8092Inferred only
ALX1 interacts with IPO13ProteinHetionet hetionet:interacts:8092-9670Inferred only
ALX1 interacts with SRA1ProteinHetionet hetionet:interacts:10011-8092Inferred only
ALX1 participates in Rubinstein Taybi syndrome 1PathwayWikiPathways WP5367Inferred only
ALX1 regulates negative regulation of DNA-templated transcriptionBiological processgene ontology Q15699|GO:0045892Inferred only
ALX1 regulates negative regulation of transcription by RNA polymerase IIBiological processgene ontology Q15699|GO:0000122Inferred only
ALX1 regulates positive regulation of DNA-templated transcriptionBiological processgene ontology Q15699|GO:0045893Inferred only
ALX1 regulates positive regulation of epithelial to mesenchymal transitionBiological processgene ontology Q15699|GO:0010718Inferred only
ALX1 regulates positive regulation of transcription by RNA polymerase IIBiological processgene ontology Q15699|GO:0045944Inferred only
ALX1 decreases the expression of ADGRE5ProteinHetionet hetionet:regulates:8092-976Inferred only

Show the remaining 15

ALX1 decreases the expression of C2CD5ProteinHetionet hetionet:regulates:8092-9847Inferred only
ALX1 decreases the expression of CDCA4ProteinHetionet hetionet:regulates:8092-55038Inferred only
ALX1 decreases the expression of DNAJA3ProteinHetionet hetionet:regulates:8092-9093Inferred only
ALX1 decreases the expression of GDF15ProteinHetionet hetionet:regulates:8092-9518Inferred only
ALX1 decreases the expression of HOXA10ProteinHetionet hetionet:regulates:8092-3206Inferred only
ALX1 increases the expression of KLHL21ProteinHetionet hetionet:regulates:8092-9903Inferred only
ALX1 decreases the expression of PNPProteinHetionet hetionet:regulates:8092-4860Inferred only
ALX1 decreases the expression of PUF60ProteinHetionet hetionet:regulates:8092-22827Inferred only
ALX1 decreases the expression of PXMP2ProteinHetionet hetionet:regulates:8092-5827Inferred only
ALX1 decreases the expression of PYCR1ProteinHetionet hetionet:regulates:8092-5831Inferred only
ALX1 increases the expression of SATB1ProteinHetionet hetionet:regulates:8092-6304Inferred only
ALX1 increases the expression of SERPINA3ProteinHetionet hetionet:regulates:8092-12Inferred only
ALX1 increases the expression of SLC1A4ProteinHetionet hetionet:regulates:8092-6509Inferred only
TBC1D9B increases the expression of ALX1ProteinHetionet hetionet:regulates:23061-8092Inferred only
UBE2A increases the expression of ALX1ProteinHetionet hetionet:regulates:7319-8092Inferred only

Other names

3 names

Resolves to: ALX1

Also called: CART-1CART1Cartilage homeoprotein 1

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