Loading the page.
Proteins/UNIPROT:Q9NR50
Acts as a component of the translation initiation factor 2B (eIF2B) complex, which catalyzes the exchange of GDP for GTP on the eukaryotic initiation factor 2 (eIF2) complex gamma subunit. Its guanine nucleotide exchange factor activity is repressed when bound to eIF2 complex phosphorylated on the alpha subunit, thereby limiting the amount of methionyl-initiator methionine tRNA available to the ribosome and consequently global translation is repressed..
Function from UniProtKB (Q9NR50), read 2026-09-23. CC BY 4.0.
Curated compounds routed: 0
3 rows
86 statements
86 statements · 4 reference databases · Subject: EIF2B3 · Sources: gene ontology, Hetionet, Reactome, WikiPathways
2 names
Resolves to: EIF2B3