Proteins/UNIPROT:Q16549

PCSK7

ProteinUNIPROT:Q16549

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Serine endoprotease that processes various proproteins by cleavage at paired basic amino acids, recognizing the RXXX[KR]R consensus motif. Likely functions in the constitutive secretory pathway.

Function from UniProtKB (Q16549), read 2026-09-23. CC BY 4.0.

Curated compounds routed: 0

What the reference databases state

Statements

56 statements

56 statements · 3 reference databases · Subject: PCSK7 · Sources: Hetionet, Reactome, UniProt

Order

EEF2KMT covaries with PCSK7ProteinHetionet hetionet:covaries:196483-9159Inferred only
CSDE1 interacts with PCSK7ProteinHetionet hetionet:interacts:7812-9159Inferred only
HNRNPD interacts with PCSK7ProteinHetionet hetionet:interacts:3184-9159Inferred only
HSPA5 interacts with PCSK7ProteinHetionet hetionet:interacts:3309-9159Inferred only
PCSK7 interacts with PABPC1ProteinHetionet hetionet:interacts:26986-9159Inferred only
PMCH interacts with PCSK7ProteinHetionet hetionet:interacts:5367-9159Inferred only
PCSK7 interacts with SYNCRIPProteinHetionet hetionet:interacts:10492-9159Inferred only
PCSK7 participates in Adherens junctions interactionsPathwayReactome R-HSA-418990Inferred only
PCSK7 participates in Cell junction organizationPathwayReactome R-HSA-446728Inferred only
PCSK7 participates in Cell-Cell communicationPathwayReactome R-HSA-1500931Inferred only
PCSK7 participates in Cell-cell junction organizationPathwayReactome R-HSA-421270Inferred only
PCSK7 participates in Regulation of CDH1 Expression and FunctionPathwayReactome R-HSA-9764265Inferred only

Show the remaining 44

PCSK7 participates in Regulation of CDH1 posttranslational processing and trafficking to plasma membranePathwayReactome R-HSA-9768727Inferred only
PCSK7 participates in Regulation of Expression and Function of Type I Classical CadherinsPathwayReactome R-HSA-9764274Inferred only
PCSK7 participates in Regulation of Homotypic Cell-Cell AdhesionPathwayReactome R-HSA-9759476Inferred only
ABCB6 decreases the expression of PCSK7ProteinHetionet hetionet:regulates:10058-9159Inferred only
BAD decreases the expression of PCSK7ProteinHetionet hetionet:regulates:572-9159Inferred only
PCSK7 decreases the expression of BCL7BProteinHetionet hetionet:regulates:9159-9275Inferred only
PCSK7 decreases the expression of BLMHProteinHetionet hetionet:regulates:9159-642Inferred only
PCSK7 decreases the expression of C2CD5ProteinHetionet hetionet:regulates:9159-9847Inferred only
PCSK7 decreases the expression of CHERPProteinHetionet hetionet:regulates:9159-10523Inferred only
PCSK7 decreases the expression of COX8AProteinHetionet hetionet:regulates:9159-1351Inferred only
PCSK7 decreases the expression of CSRP1ProteinHetionet hetionet:regulates:9159-1465Inferred only
PCSK7 increases the expression of E2F2ProteinHetionet hetionet:regulates:9159-1870Inferred only
EIF2AK3 increases the expression of PCSK7ProteinHetionet hetionet:regulates:9451-9159Inferred only
PCSK7 decreases the expression of EIF4EBP1ProteinHetionet hetionet:regulates:9159-1978Inferred only
PCSK7 increases the expression of ETS2ProteinHetionet hetionet:regulates:9159-2114Inferred only
GSTZ1 increases the expression of PCSK7ProteinHetionet hetionet:regulates:2954-9159Inferred only
PCSK7 decreases the expression of H2BC12ProteinHetionet hetionet:regulates:9159-85236Inferred only
PCSK7 decreases the expression of IFRD2ProteinHetionet hetionet:regulates:9159-7866Inferred only
PCSK7 decreases the expression of LDHBProteinHetionet hetionet:regulates:9159-3945Inferred only
PCSK7 decreases the expression of LIPAProteinHetionet hetionet:regulates:9159-3988Inferred only
PCSK7 decreases the expression of NENFProteinHetionet hetionet:regulates:9159-29937Inferred only
NUCB2 increases the expression of PCSK7ProteinHetionet hetionet:regulates:4925-9159Inferred only
PCSK7 increases the expression of PAK1ProteinHetionet hetionet:regulates:9159-5058Inferred only
PCSK7 decreases the expression of PAK4ProteinHetionet hetionet:regulates:9159-10298Inferred only
PCSK7 decreases the expression of PCBD1ProteinHetionet hetionet:regulates:9159-5092Inferred only
PCSK7 decreases the expression of PGAM1ProteinHetionet hetionet:regulates:9159-5223Inferred only
PCSK7 decreases the expression of PGM1ProteinHetionet hetionet:regulates:9159-5236Inferred only
PCSK7 decreases the expression of PRUNE1ProteinHetionet hetionet:regulates:9159-58497Inferred only
PSMB5 increases the expression of PCSK7ProteinHetionet hetionet:regulates:5693-9159Inferred only
PSMD4 increases the expression of PCSK7ProteinHetionet hetionet:regulates:5710-9159Inferred only
PCSK7 decreases the expression of PYCR1ProteinHetionet hetionet:regulates:9159-5831Inferred only
PCSK7 increases the expression of RBM6ProteinHetionet hetionet:regulates:9159-10180Inferred only
PCSK7 decreases the expression of RPN1ProteinHetionet hetionet:regulates:9159-6184Inferred only
PCSK7 decreases the expression of RPS4Y1ProteinHetionet hetionet:regulates:9159-6192Inferred only
PCSK7 decreases the expression of SMARCD2ProteinHetionet hetionet:regulates:9159-6603Inferred only
PCSK7 increases the expression of ST3GAL5ProteinHetionet hetionet:regulates:9159-8869Inferred only
PCSK7 decreases the expression of ST7ProteinHetionet hetionet:regulates:9159-7982Inferred only
PCSK7 decreases the expression of TIMM17BProteinHetionet hetionet:regulates:9159-10245Inferred only
PCSK7 increases the expression of TIMP2ProteinHetionet hetionet:regulates:9159-7077Inferred only
PCSK7 decreases the expression of TRAPPC3ProteinHetionet hetionet:regulates:9159-27095Inferred only
PCSK7 decreases the expression of TXLNAProteinHetionet hetionet:regulates:9159-200081Inferred only
PCSK7 increases the expression of TXNRD1ProteinHetionet hetionet:regulates:9159-7296Inferred only
PCSK7 decreases the expression of UBR7ProteinHetionet hetionet:regulates:9159-55148Inferred only
PCSK7 requires the cofactor Ca(2+)CompoundUniProt Q16549Inferred only

Other names

10 names

Resolves to: PCSK7

Also called: hPC8LPCLymphoma proprotein convertasePC7PC8Prohormone convertase 7Proprotein convertase 7Proprotein convertase 8SPC7Subtilisin/kexin-like protease PC7

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